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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Tolvaptan
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Accession:CHEBI:32246 term browser browse the term
Synonyms:related_synonym: Formula=C26H25ClN2O3;   InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31);   InChIKey=GYHCTFXIZSNGJT-UHFFFAOYSA-N;   OPC 41061;   SMILES=C(=O)(N1C=2C(=CC(=CC2)Cl)C(CCC1)O)C3=C(C)C=C(C=C3)NC(=O)C4=C(C)C=CC=C4;   jinarc;   samsca
 xref: CAS:150683-30-0;   Drug_Central:4110;   KEGG:D01213
 xref_mesh: MESH:C116664



show annotations for term's descendants           Sort by:
 
Tolvaptan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCB11 protein; tolvaptan results in decreased activity of ABCB11 protein CTD PMID:23956101 PMID:26507107 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCC2 protein CTD PMID:26507107 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCC3 protein CTD PMID:26507107 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCC4 protein CTD PMID:26507107 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Alb albumin decreases expression ISO Tolvaptan results in decreased expression of ALB protein CTD PMID:33022361 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Mir122 microRNA 122 increases export ISO tolvaptan results in increased export of MIR122 CTD PMID:29029277 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases activity ISO tolvaptan metabolite results in decreased activity of SLC10A1 protein CTD PMID:26507107 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO tolvaptan results in increased expression of SLPI mRNA; tolvaptan results in increased expression of SLPI protein CTD PMID:28115652 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 multiple interactions ISO Cyclosporine promotes the reaction [SULT1C3 protein results in increased sulfation of and results in increased activity of and results in increased susceptibility to tolvaptan]; SULT1C3 protein results in increased sulfation of and results in increased activity of and results in increased susceptibility to tolvaptan CTD PMID:26660633 NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          carbon atom 19609
            organic molecular entity 19609
              Tolvaptan 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            Tolvaptan 9
paths to the root