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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:satavaptan
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Accession:CHEBI:194402 term browser browse the term
Definition:A vasopressin V2 receptor antagonist that has been shown to improve hyponatremia in patients with cirrhosis, congestive heart failure, and syndrome of inappropriate antidiuresis.
Synonyms:exact_synonym: N-tert-butyl-4-[5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indole]-1'-yl]sulfonyl-3-methoxybenzamide
 related_synonym: Aquilda;   Formula=C33H45N3O8S;   InChI=1S/C33H45N3O8S/c1-6-43-25-8-9-27-26(22-25)33(13-11-24(12-14-33)44-20-17-35-15-18-42-19-16-35)31(38)36(27)45(39,40)29-10-7-23(21-28(29)41-5)30(37)34-32(2,3)4/h7-10,21-22,24H,6,11-20H2,1-5H3,(H,34,37)/t24-,33+;   InChIKey=QKXJWFOKVQWEDZ-VCCCEUOBSA-N;   SMILES=CCOC1=CC=C2N(C(=O)[C@@]3(CC[C@@H](CC3)OCCN3CCOCC3)C2=C1)S(=O)(=O)C1=C(OC)C=C(C=C1)C(=O)NC(C)(C)C;   SR 121463;   SR121463;   satavaptanum
 xref: CAS:185913-78-4;   DrugBank:DB14923;   HMDB:HMDB0257503;   PMID:10991964;   PMID:11890358;   PMID:24259510;   PMID:35972345;   PMID:8981918;   Wikipedia:Satavaptan


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satavaptan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases phosphorylation EXP Satavaptan decreases phosphorylation of Map3k7 protein in inner medullary collecting duct RGD PMID:24259510 RGD:401827158 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      application 19730
        pharmaceutical 19564
          drug 19564
            diuretic 4109
              aquaretic 17
                satavaptan 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            heteroorganic entity 19549
                              organochalcogen compound 19309
                                organooxygen compound 19204
                                  carbon oxoacid 18689
                                    carboxylic acid 18686
                                      carboacyl group 17723
                                        univalent carboacyl group 17704
                                          carbamoyl group 17574
                                            carboxamide 17574
                                              monocarboxylic acid amide 15749
                                                arenecarboxamide 8258
                                                  benzamides 8258
                                                    satavaptan 1
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