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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dehydroepiandrosterone sulfate
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Accession:CHEBI:16814 term browser browse the term
Definition:A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone.
Synonyms:exact_synonym: 17-oxoandrost-5-en-3beta-yl hydrogen sulfate
 related_synonym: (3-beta)-3-(Sulfooxy)androst-5-en-17-one;   17-Ketoandrost-5-en-3beta-yl sulfate;   17-oxoandrost-5-en-3beta-yl hydrogen sulphate;   3-O-Sulfodehydroepiandrosterone;   3beta-Hydroxyandrost-5-en-17-one 3-sulfate;   Androst-5-en-17-on-3beta-yl sulfuric acid;   DHEA sulfate;   DHEA-S;   DHEAS;   Dehydroepiandrosterone 3-sulfate;   Dehydroepiandrosterone monosulfate;   Dehydroepiandrosterone sulphate;   Dehydroisoandrosterone sulfate;   Dehydroisoandrosterone-3-sulfate;   Formula=C19H28O5S;   InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/t13-,14-,15-,16-,18-,19-/m0/s1;   InChIKey=CZWCKYRVOZZJNM-USOAJAOKSA-N;   Prasterone sulfate;   SMILES=C1[C@@]2([C@@]([C@@]3(C(C[C@@H](OS(O)(=O)=O)CC3)=C1)C)(CC[C@]4([C@]2(CCC4=O)[H])C)[H])[H]
 alt_id: CHEBI:11912;   CHEBI:1724;   CHEBI:20247;   CHEBI:61003
 xref: CAS:651-48-9;   Drug_Central:4049;   HMDB:HMDB0001032;   KEGG:C04555;   LIPID_MAPS_instance:LMST05020010
 xref_mesh: MESH:D019314
 xref: MetaCyc:DEHYDRO-EPIANDROSTERONE-SULFATE;   PMID:15374110;   PMID:18307294;   PMID:20797618;   PMID:22770225;   PMID:9661815;   Reaxys:2227078;   Wikipedia:Dehydroepiandrosterone_sulfate
 cyclic_relationship: is_conjugate_acid_of CHEBI:57905


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dehydroepiandrosterone sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 EXP Dehydroepiandrosterone Sulfate results in decreased activity of ABCB11 protein
Dehydroepiandrosterone Sulfate inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:24014644 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G ACOX1 acyl-CoA oxidase 1 increases expression
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]		 CTD PMID:8700121 NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177 		JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein]		 CTD PMID:16407456 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 increases expression
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein]		 CTD PMID:16407456 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions
increases expression		 ISO [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CPT1A protein
Dehydroepiandrosterone Sulfate results in increased expression of CPT1A protein		 CTD PMID:25786523 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 multiple interactions ISO [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C11 protein CTD PMID:25786523 NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions ISO
EXP		 [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C6 protein
CYP2C19 gene SNP affects the reaction [1-naphthol affects the abundance of Dehydroepiandrosterone Sulfate]		 CTD PMID:25786523 PMID:33771511 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) multiple interactions EXP CYP2D6 gene SNP affects the reaction [1-naphthol affects the abundance of Dehydroepiandrosterone Sulfate] CTD PMID:33771511 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 affects metabolic processing
multiple interactions		 EXP
ISO		 CYP3A4 protein affects the metabolism of Dehydroepiandrosterone Sulfate
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP3A2 protein		 CTD PMID:2271712 PMID:25786523 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A7 cytochrome P450 family 3 subfamily A member 7 affects abundance
multiple interactions
increases oxidation
increases hydroxylation		 EXP CYP3A7 promoter polymorphism affects the abundance of Dehydroepiandrosterone Sulfate
Ritonavir inhibits the reaction [CYP3A7 protein results in increased oxidation of Dehydroepiandrosterone Sulfate]
CYP3A7 protein results in increased hydroxylation of Dehydroepiandrosterone Sulfate		 CTD PMID:15985487 PMID:33821626 NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196 		JBrowse link
G CYP4A22 cytochrome P450 family 4 subfamily A member 22 increases expression
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA; Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 protein
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP4A1 protein		 CTD PMID:8700121 PMID:25786523 NCBI chr 1:47,137,441...47,149,727
Ensembl chr 1:47,137,435...47,149,727 		JBrowse link
G EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]		 CTD PMID:8700121 NCBI chr 3:185,190,624...185,254,049
Ensembl chr 3:185,190,624...185,281,990 		JBrowse link
G FABP1 fatty acid binding protein 1 increases expression
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA]		 CTD PMID:8700121 NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein CTD PMID:15196791 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190 		JBrowse link
G IL1B interleukin 1 beta increases abundance
multiple interactions		 EXP IL1B protein results in increased abundance of Dehydroepiandrosterone Sulfate
Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dehydroepiandrosterone Sulfate]		 CTD PMID:12548226 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein CTD PMID:15196791 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G NAT1 N-acetyltransferase 1 multiple interactions EXP Dehydroepiandrosterone Sulfate inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]; Dehydroepiandrosterone Sulfate promotes the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid] CTD PMID:11470991 NCBI chr 8:18,170,467...18,223,689
Ensembl chr 8:18,170,477...18,223,689 		JBrowse link
G POMC proopiomelanocortin increases abundance EXP POMC results in increased abundance of Dehydroepiandrosterone Sulfate CTD PMID:2161262 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions
increases response to substance		 ISO PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA]
PPARA protein results in increased susceptibility to Dehydroepiandrosterone Sulfate		 CTD PMID:8700121 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PRL prolactin increases abundance EXP PRL protein results in increased abundance of Dehydroepiandrosterone Sulfate CTD PMID:2943108 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G SIRT1 sirtuin 1 increases expression ISO Dehydroepiandrosterone Sulfate results in increased expression of SIRT1 protein CTD PMID:25786523 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SIRT6 sirtuin 6 increases expression ISO Dehydroepiandrosterone Sulfate results in increased expression of SIRT6 protein CTD PMID:25786523 NCBI chr19:4,174,109...4,182,563
Ensembl chr19:4,174,109...4,182,566 		JBrowse link
G SLC10A6 solute carrier family 10 member 6 increases transport ISO SLC10A6 protein results in increased transport of Dehydroepiandrosterone Sulfate CTD PMID:23562556 NCBI chr 4:86,823,468...86,849,384
Ensembl chr 4:86,823,468...86,849,384 		JBrowse link
G SLC22A11 solute carrier family 22 member 11 affects transport EXP SLC22A11 protein affects the transport of Dehydroepiandrosterone Sulfate CTD PMID:10660625 NCBI chr11:64,555,941...64,572,875
Ensembl chr11:64,555,690...64,572,875 		JBrowse link
G SLC22A12 solute carrier family 22 member 12 multiple interactions ISO Potassium promotes the reaction [SLC22A12 protein results in increased uptake of Dehydroepiandrosterone Sulfate] CTD PMID:15284287 NCBI chr11:64,591,220...64,602,344
Ensembl chr11:64,590,641...64,602,353 		JBrowse link
G SLC22A24 solute carrier family 22 member 24 affects transport ISO SLC22A19 protein affects the transport of Dehydroepiandrosterone Sulfate CTD PMID:16079298 NCBI chr11:63,079,940...63,144,221
Ensembl chr11:63,079,940...63,144,221 		JBrowse link
G SLC22A7 solute carrier family 22 member 7 increases transport EXP SLC22A7 protein results in increased transport of Dehydroepiandrosterone Sulfate CTD PMID:15901346 NCBI chr 6:43,295,714...43,305,538
Ensembl chr 6:43,295,694...43,305,538 		JBrowse link
G SLC22A8 solute carrier family 22 member 8 affects transport
increases uptake		 EXP SLC22A8 protein affects the transport of Dehydroepiandrosterone Sulfate
SLC22A8 protein results in increased uptake of Dehydroepiandrosterone Sulfate		 CTD PMID:11306713 PMID:16098483 PMID:17255469 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841 		JBrowse link
G SLC22A9 solute carrier family 22 member 9 multiple interactions
increases uptake		 EXP
ISO		 Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]
SLC22A9 protein results in increased uptake of Dehydroepiandrosterone Sulfate		 CTD PMID:17132213 PMID:18441515 NCBI chr11:63,369,785...63,410,294
Ensembl chr11:63,369,785...63,410,294 		JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 multiple interactions EXP Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B1 protein results in increased susceptibility to cyanoginosin LR]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B1 protein results in increased susceptibility to Okadaic Acid] CTD PMID:26134461 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796 		JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 multiple interactions EXP Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid] CTD PMID:26134461 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation ISO Dehydroepiandrosterone Sulfate results in increased phosphorylation of SRC protein CTD PMID:16407456 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G STS steroid sulfatase affects metabolic processing EXP STS protein affects the metabolism of Dehydroepiandrosterone Sulfate CTD PMID:16054388 NCBI chr  X:7,147,290...7,354,641
Ensembl chr  X:7,147,237...7,804,358 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26504
    role 26326
      chemical role 24361
        catalyst 8772
          sulfuric acid 8724
            sulfuric acid derivative 8724
              organic sulfate 2350
                steroid sulfate 68
                  dehydroepiandrosterone sulfate 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 26504
    subatomic particle 26480
      composite particle 26480
        hadron 26480
          baryon 26480
            nucleon 26480
              atomic nucleus 26480
                atom 26480
                  main group element atom 26217
                    p-block element atom 26217
                      chalcogen 25126
                        oxygen atom 24933
                          oxygen molecular entity 24933
                            hydroxides 24116
                              oxoacid 23051
                                chalcogen oxoacid 14561
                                  sulfur oxoacid 14311
                                    sulfuric acid 8724
                                      sulfuric acid derivative 8724
                                        sulfates 8719
                                          organic sulfate 2350
                                            steroid sulfate 68
                                              dehydroepiandrosterone sulfate 33
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