Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase) - Rat Genome Database

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Gene: Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase) Rattus norvegicus
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Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
RGD ID: 2803
Description: Enables identical protein binding activity and protein phosphatase 2A binding activity. Involved in several processes, including cholesterol homeostasis; positive regulation of MAPK cascade; and regulation of striated muscle cell apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Used to study Wilson disease; drug-induced hepatitis; end stage renal disease; pulmonary hypertension; and type 2 diabetes mellitus. Biomarker of chronic kidney disease; end stage renal disease; metabolic dysfunction-associated steatotic liver disease; and premature menopause. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase); PARTICIPATES IN metabolic syndrome X pathway; alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; (R,R,R)-alpha-tocopherol; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3H3M; HMG-CoA reductase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8229,732,163 - 29,754,276 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl229,720,553 - 29,754,533 (-)EnsemblGRCr8
mRatBN7.2227,997,523 - 28,018,983 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl227,997,525 - 28,019,703 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx235,045,191 - 35,066,504 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0233,145,271 - 33,166,584 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0227,959,454 - 27,980,761 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0227,480,224 - 27,500,654 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,480,226 - 27,500,654 (-)Ensemblrn6Rnor6.0
Rnor_5.0246,592,881 - 46,614,276 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4227,127,504 - 27,149,580 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera224,043,814 - 24,065,183 (-)NCBICelera
RGSC_v3.1227,047,872 - 27,069,949 (-)NCBI
RH 3.4 Map213.3RGD
Cytogenetic Map2q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinic acid  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (EXP,ISO)
1,2,3-trilinolenoylglycerol  (ISO)
1,2,3-trilinoleoylglycerol  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1,3-dichloropropan-2-ol  (ISO)
1,8-cineole  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2,4-dibromophenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
22-Hydroxycholesterol  (ISO)
24,25-dihydrolanosterol  (ISO)
25-hydroxycholesterol  (EXP,ISO)
26-hydroxycholesterol  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3beta-hydroxy-5alpha-cholest-8(14)-en-15-one  (ISO)
3beta-hydroxylanost-8-en-32-al  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxy-TEMPO  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (ISO)
7alpha-hydroxycholesterol  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
Actein  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alliin  (EXP,ISO)
alpha-naphthoflavone  (EXP)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
arachidonic acid  (ISO)
Archazolid B  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
atorvastatin calcium  (EXP,ISO)
atropine  (EXP)
avobenzone  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzofurans  (ISO)
beta-ionone  (EXP)
beta-naphthoflavone  (EXP,ISO)
betulin  (ISO)
bezafibrate  (EXP,ISO)
bilirubin IXalpha  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
cafestol  (EXP)
caffeine  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGS-21680  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chitosan  (EXP)
chlorogenic acid  (EXP,ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
cholic acid  (EXP)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colesevelam hydrochloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corilagin  (EXP)
corn oil  (EXP)
cortisol  (ISO)
coumarin  (EXP)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (ISO)
D-gluconic acid  (EXP)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desmosterol  (ISO)
dexamethasone  (EXP,ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (ISO)
Diallyl sulfide  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorvos  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
difenoconazole  (EXP)
diisobutyl phthalate  (EXP)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (EXP,ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
disodium selenite  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
elemental selenium  (EXP,ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
enniatin  (ISO)
entinostat  (ISO)
Epomediol  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
ezetimibe  (ISO)
farnesol  (EXP,ISO)
farnesyl diphosphate  (ISO)
fenarimol  (EXP)
fenofibrate  (EXP,ISO)
fentin chloride  (EXP)
fenvalerate  (EXP)
ferulic acid  (ISO)
fingolimod hydrochloride  (ISO)
flumequine  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
furan  (EXP,ISO)
Ganoderic acid A  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
geranyl diphosphate  (ISO)
geranylgeraniol  (ISO)
glafenine  (EXP)
glutathione  (EXP)
Glycidyl stearate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
haloperidol  (ISO)
Heptachlor epoxide  (ISO)
hesperidin  (EXP,ISO)
hexadecanoic acid  (ISO)
HT-2 toxin  (ISO)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
imidacloprid  (ISO)
isobutanol  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ketamine  (EXP)
ketoconazole  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lanost-8-ene-3beta,30-diol  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP,ISO)
lead(0)  (EXP)
lead(II) chloride  (ISO)
leflunomide  (EXP)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
loperamide  (ISO)
losartan  (EXP)
lovastatin  (ISO)
m-xylene  (EXP)
magnesium atom  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methimazole  (EXP,ISO)
methyl methanesulfonate  (ISO)
metronidazole  (ISO)
mevalonic acid  (EXP,ISO)
mevalonolactone  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
myricetin  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
naringin  (EXP,ISO)
nefazodone  (EXP)
neohesperidin  (ISO)
neomycin  (ISO)
nickel dichloride  (ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nimesulide  (EXP)
obeticholic acid  (ISO)
Octicizer  (ISO)
octocrylene  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP,ISO)
oleic acid  (ISO)
orlistat  (EXP)
oxybenzone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perflubron  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenformin  (EXP)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
phosphatidylcholine  (EXP)
phytosterols  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
piperine  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
proanthocyanidin  (EXP)
progesterone  (ISO)
propamocarb  (ISO)
propiconazole  (EXP,ISO)
puerarin  (EXP)
pyrethrins  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (EXP,ISO)
risperidone  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (EXP,ISO)
senecionine  (ISO)
silibinin  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium cholate  (ISO)
Sodium oleate  (ISO)
Soman  (EXP)
soybean oil  (EXP)
stigmasterol  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetrahydrocurcumin  (EXP)
thapsigargin  (EXP,ISO)
thiazolidinediones  (ISO)
thioacetamide  (EXP)
thiourea  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trans-caffeic acid  (ISO)
trans-cinnamic acid  (ISO)
triacsin C  (ISO)
triadimefon  (EXP,ISO)
tributyl phosphate  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
trimellitic anhydride  (ISO)
triolein  (ISO)
triphenyl phosphate  (EXP,ISO)
triphenylstannane  (EXP)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tunicamycin  (ISO)
umbelliferone  (EXP)
undecane  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
warfarin  (EXP)
Yessotoxin  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zingerone  (EXP)
ziprasidone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cholesterol biosynthetic process  (IEA,ISO)
cholesterol biosynthetic process via desmosterol  (IEA,ISO)
cholesterol biosynthetic process via lathosterol  (IEA,ISO)
cholesterol homeostasis  (IEP)
cholesterol metabolic process  (IEA)
coenzyme A metabolic process  (IEA)
farnesyl diphosphate biosynthetic process, mevalonate pathway  (IEA,ISO)
geranylgeranyl diphosphate biosynthetic process  (IEA,ISO)
isopentenyl diphosphate biosynthetic process, mevalonate pathway  (IEA,ISO)
isoprenoid biosynthetic process  (IBA,IEA)
lipid metabolic process  (IEA)
long-term synaptic potentiation  (ISO)
myoblast differentiation  (IEP)
negative regulation of amyloid-beta clearance  (IEA,ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
negative regulation of MAP kinase activity  (ISO)
negative regulation of protein catabolic process  (IEA,ISO)
negative regulation of protein secretion  (IEA,ISO)
negative regulation of striated muscle cell apoptotic process  (IMP)
positive regulation of cardiac muscle cell apoptotic process  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of skeletal muscle tissue development  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of stress-activated MAPK cascade  (IMP)
positive regulation of vasoconstriction  (IMP)
regulation of ERK1 and ERK2 cascade  (IEA,ISO)
response to cholesterol  (IEP)
response to ethanol  (IEP)
response to nutrient  (IEP)
response to nutrient levels  (IEP)
steroid biosynthetic process  (IEA)
steroid metabolic process  (IEA)
sterol biosynthetic process  (IBA,IEA)
triglyceride homeostasis  (IEP)
ubiquinone metabolic process  (IMP)
visual learning  (ISO)
zymosterol biosynthetic process  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides. Abe M, etal., Drug Metab Pharmacokinet. 2010;25(3):274-82.
2. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats. Alauddin M, etal., BMC Complement Altern Med. 2016 Nov 8;16(1):442. doi: 10.1186/s12906-016-1427-z.
3. A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. Chen CW and Cheng HH, J Nutr. 2006 Jun;136(6):1472-6.
4. Combination therapy with fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on experimental traumatic brain injury. Chen XR, etal., J Pharmacol Exp Ther. 2008 Sep;326(3):966-74. Epub 2008 Jun 18.
5. Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin. Cheng XW, etal., J Hypertens. 2011 Mar;29(3):542-52.
6. Contribution of increased HMG-CoA reductase gene expression to hypercholesterolemia in experimental chronic renal failure. Chmielewski M, etal., Mol Cell Biochem 2003 Apr;246(1-2):187-91.
7. Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat. Cho K, etal., J Med Food. 2009 Dec;12(6):1293-301.
8. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
9. Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? Côté I, etal., Br J Nutr. 2014 Nov 28;112(10):1592-600. doi: 10.1017/S0007114514002517. Epub 2014 Sep 29.
10. An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation: effect of endurance training. Côté I, etal., Eur J Nutr. 2013 Aug;52(5):1523-32. doi: 10.1007/s00394-012-0459-5. Epub 2012 Nov 2.
11. Integrin expression on monocytes and lymphocytes in unstable angina short term effects of atorvastatin. Dobreanu M, etal., Rom J Intern Med. 2007;45(2):193-9.
12. Functional size of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by radiation inactivation. Edwards PA, etal., J Biol Chem. 1985 Aug 25;260(18):10278-82.
13. Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/cyclin E expression. Ferri N, etal., Mol Pharmacol. 2008 Jul;74(1):144-53. Epub 2008 Apr 15.
14. Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI study. Floris S, etal., Brain. 2004 Mar;127(Pt 3):616-27. Epub 2003 Dec 22.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction. Gegg ME, etal., J Immunol. 2005 Feb 15;174(4):2327-35.
17. Attenuation of chronic hypoxic pulmonary hypertension by simvastatin. Girgis RE, etal., Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H938-45. Epub 2003 May 15.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism. Gupta SD, etal., J Lipid Res. 1999 Sep;40(9):1572-84.
20. Inflammatory markers in nondiabetic and diabetic rat retinas exposed to ischemia followed by reperfusion. Gustavsson C, etal., Retina. 2008 Apr;28(4):645-52.
21. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
22. Simvastatin improves wound strength after intestinal anastomosis in the rat. Karadeniz Cakmak G, etal., J Gastrointest Surg. 2009 Sep;13(9):1707-16. Epub 2009 Jul 4.
23. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
24. Post-ischemic delivery of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin protects against focal cerebral ischemia in mice via inhibition of extracellular-regulated kinase-1/-2. Kilic U, etal., Neuroscience. 2005;134(3):901-6.
25. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
26. Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease. Levy E, etal., Life Sci. 2007 Mar 27;80(16):1472-83. Epub 2007 Jan 20.
27. Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Li G, etal., Neurology. 2007 Aug 28;69(9):878-85.
28. The effect of statins on mortality in patients with bacteremia. Liappis AP, etal., Clin Infect Dis. 2001 Oct 15;33(8):1352-7. Epub 2001 Sep 20.
29. Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing. Liu Y, etal., Hum Mol Genet. 2022 Nov 10;31(22):3769-3776. doi: 10.1093/hmg/ddac129.
30. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy. Mammen AL, etal., Arthritis Rheum. 2011 Mar;63(3):713-21. doi: 10.1002/art.30156.
31. Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice. Marmugi A, etal., Toxicology. 2014 Nov 5;325:133-43. doi: 10.1016/j.tox.2014.08.006. Epub 2014 Aug 26.
32. 3-hydroxy 3-methylglutaryl coenzyme A reductase increase is essential for rat muscle differentiation. Martini C, etal., J Cell Physiol. 2009 Aug;220(2):524-30.
33. Comparison of the short-term efficacy and tolerability of lovastatin and pravastatin in the management of primary hypercholesterolemia. McPherson R, etal., Clin Ther. 1992 Mar-Apr;14(2):276-91.
34. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
35. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE. Mix E, etal., J Autoimmun. 2006 Dec;27(4):251-65. Epub 2006 Nov 3.
36. Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocin-induced diabetes. Miyahara S, etal., Am J Pathol. 2004 May;164(5):1697-706.
37. Effects of combined olmesartan and pravastatin on glucose intolerance and cardiovascular remodeling in a metabolic-syndrome model. Mizukawa M, etal., Hypertens Res. 2009 Jul;32(7):617-24. Epub 2009 May 22.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin. Neuvonen PJ, etal., Clin Pharmacokinet. 2008;47(7):463-74.
40. LDL receptor and Pcsk9 transcripts are decreased in liver of ovariectomized rats: effects of exercise training. Ngo Sock ET, etal., Horm Metab Res. 2014 Jul;46(8):550-5. doi: 10.1055/s-0034-1370910. Epub 2014 Mar 11.
41. Synergistic action of statins and nitrogen-containing bisphosphonates in the development of rhabdomyolysis in L6 rat skeletal myoblasts. Nishiguchi T, etal., J Pharm Pharmacol. 2009 Jun;61(6):781-8.
42. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
43. The effect of statin therapy on allergic patients with asthma. Ostroukhova M, etal., Ann Allergy Asthma Immunol. 2009 Dec;103(6):463-8.
44. Rat HMGCoA reductase activation in thioacetamide-induced liver injury is related to an increased reactive oxygen species content. Pallottini V, etal., J Hepatol. 2006 Feb;44(2):368-74. Epub 2005 Jul 11.
45. Mechanisms underlying the impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in aged rat liver. Pallottini V, etal., Mech Ageing Dev. 2004 Sep;125(9):633-9.
46. Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation. Pallottini V, etal., Mech Ageing Dev. 2007 Nov-Dec;128(11-12):688-95. Epub 2007 Oct 16.
47. Diabetic and dyslipidaemic morbidly obese exhibit more liver alterations compared with healthy morbidly obese. Pardina E, etal., BBA Clin. 2016 Jan 8;5:54-65. doi: 10.1016/j.bbacli.2015.12.002. eCollection 2016 Jun.
48. Expression of cholesterol homeostasis genes in the brain of the male rat is affected by age and dietary restriction. Perovic M, etal., Biogerontology. 2009 Mar 7.
49. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
50. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
51. Reduced incidence of new-onset diabetes mellitus after renal transplantation with 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors (statins). Prasad GV, etal., Am J Transplant. 2004 Nov;4(11):1897-903.
52. GOA pipeline RGD automated data pipeline
53. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
54. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
55. Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells. Rombouts K, etal., J Hepatol. 2003 May;38(5):564-72.
56. Progesterone-receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro. Rung E, etal., Biol Reprod. 2005 Mar;72(3):538-45. Epub 2004 Sep 22.
57. Lovastatin attenuates nerve injury in an animal model of Guillain-Barre syndrome. Sarkey JP, etal., J Neurochem. 2007 Mar;100(5):1265-77. Epub 2006 Dec 22.
58. White blood cell count predicts reduction in coronary heart disease mortality with pravastatin. Stewart RA, etal., Circulation. 2005 Apr 12;111(14):1756-62. Epub 2005 Apr 4.
59. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
60. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
61. Atorvastatin restores endothelial function in offspring of protein-restricted rats in a cholesterol-independent manner. Torrens C, etal., Hypertension. 2009 Apr;53(4):661-7. Epub 2009 Feb 16.
62. Mechanism underlying long-term regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase during L6 myoblast differentiation. Trapani L, etal., J Cell Biochem. 2010 May 15;110(2):392-8.
63. Effects of statin treatment and withdrawal on angiotensin II-induced phosphorylation of p38 MAPK and ERK1/2 in cultured vascular smooth muscle cells. Tristano AG, etal., Biochem Biophys Res Commun. 2007 Feb 2;353(1):11-7. Epub 2006 Nov 17.
64. Rosuvastatin, a new generation 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, reduces ischemia/reperfusion-induced spinal cord tissue injury in rats. Ucak A, etal., Ann Vasc Surg. 2011 Jul;25(5):686-95.
65. Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease. Valenza M, etal., Neurobiol Dis. 2007 Oct;28(1):133-42. Epub 2007 Jul 10.
66. Adverse signaling of scavenger receptor class B1 and PGC1s in alcoholic hepatosteatosis and steatohepatitis and protection by betaine in rat. Varatharajalu R, etal., Am J Pathol. 2014 Jul;184(7):2035-44. doi: 10.1016/j.ajpath.2014.03.005. Epub 2014 May 6.
67. Ameliorative effect of Chlorophytum borivilianum root on lipid metabolism in hyperlipaemic rats. Visavadiya NP and Narasimhacharya AV, Clin Exp Pharmacol Physiol. 2007 Mar;34(3):244-9.
68. Hydroxymethylglutaryl coenzyme a reductase inhibitors down-regulate chemokines and chemokine receptors in patients with coronary artery disease. Waehre T, etal., J Am Coll Cardiol. 2003 May 7;41(9):1460-7.
69. Statin use and the risk of Parkinson disease. Wahner AD, etal., Neurology. 2008 Apr 15;70(16 Pt 2):1418-22. Epub 2008 Jan 9.
70. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
71. Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. Wolozin B, etal., BMC Med. 2007 Jul 19;5:20.
72. Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells. Wong DH, etal., Fertil Steril. 2011 Sep 9.
73. Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat. Xie Z, etal., Metabolism. 2010 Apr;59(4):554-60. Epub 2009 Nov 14.
74. Synergism of simvastatin with losartan prevents angiotensin II-induced cardiomyocyte apoptosis in vitro. Xu J, etal., J Pharm Pharmacol. 2009 Apr;61(4):503-10.
75. Effects of pravastatin in murine collagen-induced arthritis. Yamagata T, etal., Rheumatol Int. 2007 May;27(7):631-9. Epub 2006 Nov 21.
76. Influence of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ubiquinone levels in rat skeletal muscle and heart: relationship to cytotoxicity and inhibitory activity for cholesterol synthesis in human skeletal muscle cells. Yamazaki H, etal., J Atheroscler Thromb. 2006 Dec;13(6):295-307.
77. Protective effects of pravastatin in murine lipopolysaccharide-induced acute lung injury. Yao HW, etal., Clin Exp Pharmacol Physiol. 2006 Sep;33(9):793-7.
78. Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects. Yasuda H, etal., Kidney Int. 2006 May;69(9):1535-42.
79. Effect of ScrF I polymorphism in the 2nd intron of the HMGCR gene on lipid-lowering response to simvastatin in Chinese diabetic patients. Ying S, etal., Biochem Biophys Res Commun. 2007 Nov 16;363(2):395-8. Epub 2007 Sep 10.
80. Effects of pravastatin on progression of glucose intolerance and cardiovascular remodeling in a type II diabetes model. Yu Y, etal., J Am Coll Cardiol. 2004 Aug 18;44(4):904-13.
81. Multitargeted effects of statin-enhanced thrombolytic therapy for stroke with recombinant human tissue-type plasminogen activator in the rat. Zhang L, etal., Circulation. 2005 Nov 29;112(22):3486-94.
Additional References at PubMed
PMID:1352323   PMID:1628744   PMID:2369897   PMID:2991281   PMID:7798939   PMID:8647961   PMID:9186920   PMID:10698924   PMID:11792727   PMID:12114517   PMID:12409258   PMID:12920113  
PMID:15090540   PMID:15337832   PMID:15489334   PMID:15845870   PMID:15919082   PMID:16100574   PMID:16636304   PMID:16741953   PMID:17180682   PMID:17327468   PMID:19470373   PMID:19895880  
PMID:20435455   PMID:20876579   PMID:22405826   PMID:22871113   PMID:23063590   PMID:23280554   PMID:23617777   PMID:24319730   PMID:24694611   PMID:28938515   PMID:33412161   PMID:34081950  


Genomics

Comparative Map Data
Hmgcr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8229,732,163 - 29,754,276 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl229,720,553 - 29,754,533 (-)EnsemblGRCr8
mRatBN7.2227,997,523 - 28,018,983 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl227,997,525 - 28,019,703 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx235,045,191 - 35,066,504 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0233,145,271 - 33,166,584 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0227,959,454 - 27,980,761 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0227,480,224 - 27,500,654 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,480,226 - 27,500,654 (-)Ensemblrn6Rnor6.0
Rnor_5.0246,592,881 - 46,614,276 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4227,127,504 - 27,149,580 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera224,043,814 - 24,065,183 (-)NCBICelera
RGSC_v3.1227,047,872 - 27,069,949 (-)NCBI
RH 3.4 Map213.3RGD
Cytogenetic Map2q12NCBI
HMGCR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38575,336,529 - 75,362,116 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl575,336,329 - 75,364,241 (+)Ensemblhg38GRCh38
GRCh37574,632,993 - 74,657,941 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36574,668,855 - 74,693,681 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34574,668,854 - 74,693,681NCBI
Celera570,526,169 - 70,551,102 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef569,838,165 - 69,863,098 (+)NCBIHuRef
CHM1_1574,065,715 - 74,090,648 (+)NCBICHM1_1
T2T-CHM13v2.0575,817,189 - 75,843,009 (+)NCBIT2T-CHM13v2.0
Hmgcr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391396,785,470 - 96,807,444 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1396,785,475 - 96,807,444 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381396,648,962 - 96,670,936 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1396,648,967 - 96,670,936 (-)Ensemblmm10GRCm38
MGSCv371397,418,917 - 97,440,891 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361397,750,033 - 97,771,547 (-)NCBIMGSCv36mm8
Celera13100,288,206 - 100,310,264 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.65NCBI
Hmgcr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542525,359,884 - 25,380,745 (-)Ensembl
ChiLan1.0NW_00495542525,362,165 - 25,380,611 (-)NCBIChiLan1.0ChiLan1.0
HMGCR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2439,937,829 - 39,962,461 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1538,091,460 - 38,116,092 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0539,936,630 - 39,961,519 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1540,548,919 - 40,573,785 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl540,548,919 - 40,573,785 (-)EnsemblpanPan2panpan1.1
HMGCR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1330,970,037 - 30,988,987 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl330,970,037 - 30,990,294 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha332,211,759 - 32,233,728 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0330,898,455 - 30,920,631 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl330,898,248 - 30,921,069 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1330,828,548 - 30,850,686 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0330,798,860 - 30,820,987 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0331,177,224 - 31,199,407 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hmgcr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213189,458,452 - 189,480,240 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365491,378,736 - 1,400,532 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365491,378,536 - 1,400,501 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGCR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl284,380,224 - 84,402,957 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1284,380,245 - 84,401,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2285,967,367 - 85,988,242 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q22NCBI
HMGCR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1469,664,784 - 69,690,343 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl469,665,417 - 69,688,686 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604918,450,156 - 18,475,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmgcr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624951682,178 - 711,474 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624951681,559 - 711,476 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hmgcr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13199,829,135 - 199,850,278 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hmgcr
151 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:191
Count of miRNA genes:143
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000022055
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2142977529Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358144538110Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
RH129199  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2227,997,953 - 27,998,133 (+)MAPPERmRatBN7.2
Rnor_6.0227,480,655 - 27,480,834NCBIRnor6.0
Rnor_5.0246,593,312 - 46,593,491UniSTSRnor5.0
RGSC_v3.4227,127,933 - 27,128,112UniSTSRGSC3.4
Celera224,044,243 - 24,044,422UniSTS
RH 3.4 Map220.1UniSTS
Cytogenetic Map2q12UniSTS
Hmgcr  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8229,733,360 - 29,734,196 (+)Marker Load Pipeline
mRatBN7.2227,998,720 - 27,999,556 (+)MAPPERmRatBN7.2
Rnor_6.0227,481,422 - 27,482,257NCBIRnor6.0
Rnor_5.0246,594,079 - 46,594,914UniSTSRnor5.0
RGSC_v3.4227,128,700 - 27,129,535UniSTSRGSC3.4
Celera224,045,010 - 24,045,845UniSTS
Cytogenetic Map2q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022055   ⟹   ENSRNOP00000022055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl229,732,165 - 29,753,623 (-)Ensembl
mRatBN7.2 Ensembl227,997,527 - 28,019,012 (-)Ensembl
Rnor_6.0 Ensembl227,480,226 - 27,500,654 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096437   ⟹   ENSRNOP00000097467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl229,732,165 - 29,754,533 (-)Ensembl
mRatBN7.2 Ensembl227,997,525 - 28,019,703 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101787   ⟹   ENSRNOP00000096084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl229,732,165 - 29,753,623 (-)Ensembl
mRatBN7.2 Ensembl227,997,525 - 28,019,056 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112347   ⟹   ENSRNOP00000087297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl229,732,165 - 29,753,358 (-)Ensembl
mRatBN7.2 Ensembl227,997,525 - 28,016,019 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000128811   ⟹   ENSRNOP00000106905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl229,721,931 - 29,753,623 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000165922   ⟹   ENSRNOP00000108611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl229,720,553 - 29,753,623 (-)Ensembl
RefSeq Acc Id: NM_013134   ⟹   NP_037266
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8229,732,165 - 29,753,623 (-)NCBI
mRatBN7.2227,997,525 - 28,018,983 (-)NCBI
Rnor_6.0227,480,226 - 27,500,654 (-)NCBI
Rnor_5.0246,592,881 - 46,614,276 (-)NCBI
RGSC_v3.4227,127,504 - 27,149,580 (-)RGD
Celera224,043,814 - 24,065,183 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231826   ⟹   XP_006231888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8229,732,163 - 29,753,607 (-)NCBI
mRatBN7.2227,997,523 - 28,018,943 (-)NCBI
Rnor_6.0227,480,224 - 27,500,616 (-)NCBI
Rnor_5.0246,592,881 - 46,614,276 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063281376   ⟹   XP_063137446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8229,732,163 - 29,754,276 (-)NCBI
RefSeq Acc Id: NP_037266   ⟸   NM_013134
- UniProtKB: Q64601 (UniProtKB/Swiss-Prot),   Q6P2A6 (UniProtKB/Swiss-Prot),   P51639 (UniProtKB/Swiss-Prot),   A6I512 (UniProtKB/TrEMBL),   A0A8L2QCN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231888   ⟸   XM_006231826
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AUL2 (UniProtKB/TrEMBL),   A0A8L2QCN8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022055   ⟸   ENSRNOT00000022055
Ensembl Acc Id: ENSRNOP00000096084   ⟸   ENSRNOT00000101787
Ensembl Acc Id: ENSRNOP00000087297   ⟸   ENSRNOT00000112347
Ensembl Acc Id: ENSRNOP00000097467   ⟸   ENSRNOT00000096437
RefSeq Acc Id: XP_063137446   ⟸   XM_063281376
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QCN8 (UniProtKB/TrEMBL),   A0A8I6AV02 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108611   ⟸   ENSRNOT00000165922
Ensembl Acc Id: ENSRNOP00000106905   ⟸   ENSRNOT00000128811
Protein Domains
SSD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51639-F1-model_v2 AlphaFold P51639 1-887 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691084
Promoter ID:EPDNEW_R1609
Type:initiation region
Name:Hmgcr_1
Description:3-hydroxy-3-methylglutaryl-CoA reductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0227,500,681 - 27,500,741EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2803 AgrOrtholog
BioCyc Gene G2FUF-54777 BioCyc
BioCyc Pathway PWY-922 [mevalonate pathway I (eukaryotes and bacteria)] BioCyc
BioCyc Pathway Image PWY-922 BioCyc
Ensembl Genes ENSRNOG00000016122 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000096437 ENTREZGENE
  ENSRNOT00000101787 ENTREZGENE
  ENSRNOT00000112347 ENTREZGENE
Gene3D-CATH 1.10.3270.10 UniProtKB/Swiss-Prot
  3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2 UniProtKB/Swiss-Prot
  3.30.70.420 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5600023 IMAGE-MGC_LOAD
InterPro HMG_CoA_Rdtase UniProtKB/Swiss-Prot
  HMG_CoA_Rdtase_cat_sf UniProtKB/Swiss-Prot
  HMG_CoA_Rdtase_CS UniProtKB/Swiss-Prot
  HMG_CoA_Rdtase_eu_arc UniProtKB/Swiss-Prot
  HMG_CoA_Rdtase_metazoan UniProtKB/Swiss-Prot
  HMG_CoA_Rdtase_N UniProtKB/Swiss-Prot
  HMG_CoA_Rdtase_NAD(P)-bd_sf UniProtKB/Swiss-Prot
  HMG_CoA_Rdtase_sub-bd_dom_sf UniProtKB/Swiss-Prot
  HMGCR/SNAP/NPC1-like_SSD UniProtKB/Swiss-Prot
  SSD UniProtKB/Swiss-Prot
KEGG Report rno:25675 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72532 IMAGE-MGC_LOAD
NCBI Gene 25675 ENTREZGENE
PANTHER 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE UniProtKB/Swiss-Prot
  PTHR10572 UniProtKB/Swiss-Prot
Pfam HMG-CoA_red UniProtKB/Swiss-Prot
  Sterol-sensing UniProtKB/Swiss-Prot
PharmGKB HMGCR RGD
PhenoGen Hmgcr PhenoGen
PRINTS HMGCOARDTASE UniProtKB/Swiss-Prot
PROSITE HMG_COA_REDUCTASE_1 UniProtKB/Swiss-Prot
  HMG_COA_REDUCTASE_2 UniProtKB/Swiss-Prot
  HMG_COA_REDUCTASE_3 UniProtKB/Swiss-Prot
  HMG_COA_REDUCTASE_4 UniProtKB/Swiss-Prot
  SSD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016122 RatGTEx
Superfamily-SCOP Multidrug efflux transporter AcrB transmembrane domain UniProtKB/Swiss-Prot
  SSF55035 UniProtKB/Swiss-Prot
  SSF56542 UniProtKB/Swiss-Prot
TIGR TC238888
UniProt A0A8I6A6Z9_RAT UniProtKB/TrEMBL
  A0A8I6AUL2 ENTREZGENE
  A0A8I6AV02 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QCN8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LD67_RAT UniProtKB/TrEMBL
  A0ABK0LYE8_RAT UniProtKB/TrEMBL
  A6I512 ENTREZGENE, UniProtKB/TrEMBL
  HMDH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64601 ENTREZGENE
  Q6P2A6 ENTREZGENE
UniProt Secondary Q64601 UniProtKB/Swiss-Prot
  Q6P2A6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Hmgcr  3-hydroxy-3-methylglutaryl-CoA reductase  Hmgcr  3-hydroxy-3-methylglutaryl-Coenzyme A reductase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hmgcr  3-hydroxy-3-methylglutaryl-Coenzyme A reductase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function rate limiting enzyme in the cholesterologenesis pathway 1300058