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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:36946
Term: thiourea
Definition: The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.
Chemical ID: MESH:D013890
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcrmultiple interactionsEXP 6480464CTDThiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein]PMID:19931295
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