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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcrdecreases expressionEXP 6480464CTDCyclosporine results in decreased expression of HMGCR mRNAPMID:19224547
Hmgcrdecreases expressionISOHMGCR (Homo sapiens)6480464CTDCyclosporine results in decreased expression of HMGCR mRNAPMID:20106945 PMID:21632981 PMID:25562108 PMID:32253466
Hmgcrincreases expressionISOHMGCR (Homo sapiens)6480464CTDCyclosporine results in increased expression of HMGCR mRNAPMID:17516993
Hmgcrmultiple interactionsISOHMGCR (Homo sapiens)6480464CTD[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine] results in decreased expression of HMGCR mRNAPMID:33819548
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