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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcrincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of HMGCR mRNA; Lipopolysaccharides results in increased expression of HMGCR proteinPMID:29958987 PMID:33677747
Hmgcrmultiple interactionsEXP 6480464CTDCaffeine promotes the reaction [Lipopolysaccharides results in increased expression of HMGCR mRNA]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Lipopolysaccharides results in increased expression of HMGCR protein]; SREBF2 protein affects the reaction [Lipopolysaccharides results in increased expression of HMGCR protein]PMID:29958987 PMID:33677747
Hmgcrincreases expressionISOHMGCR (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of HMGCR mRNA; Lipopolysaccharides results in increased expression of HMGCR proteinPMID:33677747
Hmgcrmultiple interactionsISOHMGCR (Homo sapiens)6480464CTD[NAT10 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of HMGCR mRNA; MIR590 mRNA inhibits the reaction [Lipopolysaccharides results in increased expression of HMGCR mRNA]; MIR590 mRNA inhibits the reaction [Lipopolysaccharides results in increased expression of HMGCR protein]; UBE2I protein inhibits the reaction [Lipopolysaccharides results in increased expression of HMGCR protein]PMID:33677747 PMID:35877022
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