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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:17580
Term: linalool
Definition: A monoterpenoid that is octa-1,6-diene substituted by methyl groups at positions 3 and 7 and a hydroxy group at position 3. It has been isolated from plants like Ocimum canum.
Chemical ID: MESH:C018584
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcrdecreases expressionISOHMGCR (Homo sapiens)6480464CTDlinalool results in decreased expression of HMGCR mRNA; linalool results in decreased expression of HMGCR proteinPMID:21944868 PMID:24613879
Hmgcrdecreases expressionISOHmgcr (Mus musculus)6480464CTDlinalool results in decreased expression of HMGCR mRNA; linalool results in decreased expression of HMGCR proteinPMID:21944868
Hmgcrmultiple interactionsISOHMGCR (Homo sapiens)6480464CTDlinalool inhibits the reaction [KAT2B protein binds to HMGCR promoter]; linalool inhibits the reaction [SREBF2 protein binds to HMGCR promoter]; linalool results in decreased expression of and results in increased ubiquitination of HMGCR proteinPMID:21944868
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