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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcrdecreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of HMGCR mRNAPMID:18246545 PMID:33387578
Hmgcrincreases expressionEXP 6480464CTDAcetaminophen results in increased expression of HMGCR mRNAPMID:17202762
Hmgcraffects expressionISOHmgcr (Mus musculus)6480464CTDAcetaminophen affects the expression of HMGCR mRNAPMID:15030884 PMID:17562736
Hmgcrdecreases expressionISOHMGCR (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of HMGCR mRNAPMID:29067470
Hmgcrmultiple interactionsISOHMGCR (Homo sapiens)6480464CTD[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of HMGCR mRNAPMID:33819548
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