RGD Reference Report - The effect of statins on mortality in patients with bacteremia. - Rat Genome Database

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The effect of statins on mortality in patients with bacteremia.

Authors: Liappis, AP  Kan, VL  Rochester, CG  Simon, GL 
Citation: Liappis AP, etal., Clin Infect Dis. 2001 Oct 15;33(8):1352-7. Epub 2001 Sep 20.
RGD ID: 5508478
Pubmed: PMID:11565076   (View Abstract at PubMed)
DOI: DOI:10.1086/323334   (Journal Full-text)

The statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, act to regulate the biosynthesis of cholesterol. Statins also deplete nonsterol cholesterol precursors, the isoprenoids, which are necessary for prenylation of critical membrane proteins that regulate cellular communication, including the inflammatory response. In a retrospective review of 388 bacteremic infections due to aerobic gram-negative bacilli and Staphylococcus aureus, there was a significant reduction in both overall (6% vs. 28%; P=.002) and attributable (3% vs. 20%; P=.010) mortality among patients taking statins compared with patients not taking statins. This reduction in mortality persisted in a multivariate analysis (odds ratio, 7.6; 95% confidence interval, 1.01-57.5). Among the statin group, diabetes, hypertension, and coronary artery disease were more prevalent (P<.001), and there were more skin and soft tissue infections identified as sources of bacteremia (P=.008). These data suggest a potential clinical role of statins in bacteremic infection; however, the mechanism by which mortality is reduced remains undefined.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Bacteremia severityIMP 5508478 RGD 
Bacteremia severityISOHMGCR (Homo sapiens)5508478; 5508478 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hmgcr  (3-hydroxy-3-methylglutaryl-CoA reductase)

Genes (Mus musculus)
Hmgcr  (3-hydroxy-3-methylglutaryl-Coenzyme A reductase)

Genes (Homo sapiens)
HMGCR  (3-hydroxy-3-methylglutaryl-CoA reductase)


Additional Information