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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcrdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of HMGCR mRNA; Benzo(a)pyrene results in decreased expression of HMGCR proteinPMID:19931295
Hmgcrmultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; AHR mutant form inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein]; Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein]PMID:19931295
Hmgcrdecreases expressionISOHMGCR (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of HMGCR mRNAPMID:16269432 PMID:20064835 PMID:20106945 PMID:21632981 PMID:26238291 PMID:32234424
Hmgcrincreases expressionISOHmgcr (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of HMGCR mRNAPMID:19770486 PMID:21569818
Hmgcrmultiple interactionsISOHMGCR (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of HMGCR mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of HMGCR mRNAPMID:17690111
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