GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmgcr | decreases expression | EXP | | 15045610 | RGD | cholesterol decreases expression of Hmgcr mRNA in liver | | Hmgcr | decreases expression | EXP | | 6480464 | CTD | Cholesterol results in decreased expression of HMGCR mRNA | PMID:16581047 | Hmgcr | multiple interactions | EXP | | 6480464 | CTD | [Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA; [Cholesterol co-treated with Cholic Acid] results in increased activity of HMGCR protein; [turmeric extract co-treated with Cholesterol] results in decreased expression of HMGCR mRNA; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA]; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of HMGCR protein]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of HMGCR protein]; Selenium promotes the reaction [Cholesterol results in decreased expression of HMGCR mRNA] | PMID:16581047 PMID:21535835 PMID:30273964 | Hmgcr | decreases activity | ISO | HMGCR (Homo sapiens) | 6480464 | CTD | Cholesterol results in decreased activity of HMGCR protein | PMID:18024962 | Hmgcr | decreases expression | ISO | HMGCR (Homo sapiens) | 6480464 | CTD | Cholesterol results in decreased expression of HMGCR mRNA | PMID:17516993 | Hmgcr | multiple interactions | ISO | HMGCR (Homo sapiens) | 6480464 | CTD | [25-hydroxycholesterol co-treated with Cholesterol] results in decreased activity of HMGCR protein; [[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA] which results in decreased chemical synthesis of Cholesterol; [[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; [artemisic acid results in decreased expression of HMGCR protein] which results in decreased chemical synthesis of Cholesterol; [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Haloperidol results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; LDLR gene mutant form promotes the reaction [[25-hydroxycholesterol co-treated with Cholesterol] results in decreased activity of HMGCR protein] | PMID:11408283 PMID:12477733 PMID:16027736 PMID:23063590 | | ||||||||||||||||||||||
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