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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:40303
Term: lovastatin
Definition: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
Chemical ID: MESH:D008148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcraffects expressionISOHmgcr (Mus musculus)6480464CTDLovastatin affects the expression of HMGCR mRNAPMID:27208389
Hmgcrdecreases activityISOHMGCR (Homo sapiens)6480464CTDLovastatin results in decreased activity of HMGCR proteinPMID:17208200 PMID:19699819 PMID:8593127
Hmgcrincreases expressionISOHMGCR (Homo sapiens)6480464CTDLovastatin results in increased expression of HMGCR mRNAPMID:19260826 PMID:8517861
Hmgcrincreases expressionISOHmgcr (Mus musculus)6480464CTDLovastatin results in increased expression of HMGCR mRNAPMID:19260826
Hmgcrmultiple interactionsISOHMGCR (Homo sapiens)6480464CTD[Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate; [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of geranylgeranyl pyrophosphate; Lovastatin inhibits the reaction [HMGCR protein results in increased abundance of geranyl diphosphate]PMID:17208200 PMID:19856009
Hmgcrmultiple interactionsISOHmgcr (Mus musculus)6480464CTD[Dietary Fats co-treated with Lovastatin] affects the expression of HMGCR mRNAPMID:29852127
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