GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmgcr | increases activity | ISO | HMGCR (Homo sapiens) | 6480464 | CTD | troglitazone results in increased activity of HMGCR protein | PMID:12044893 | Hmgcr | increases expression | ISO | HMGCR (Homo sapiens) | 6480464 | CTD | troglitazone results in increased expression of HMGCR mRNA | PMID:12044893 | Hmgcr | multiple interactions | ISO | HMGCR (Homo sapiens) | 6480464 | CTD | [[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased expression of HMGCR mRNA; [troglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of HMGCR mRNA | PMID:12044893 PMID:16946405 | |
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