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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcrincreases activityISOHMGCR (Homo sapiens)6480464CTDtroglitazone results in increased activity of HMGCR proteinPMID:12044893
Hmgcrincreases expressionISOHMGCR (Homo sapiens)6480464CTDtroglitazone results in increased expression of HMGCR mRNAPMID:12044893
Hmgcrmultiple interactionsISOHMGCR (Homo sapiens)6480464CTD[[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased expression of HMGCR mRNA; [troglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of HMGCR mRNAPMID:12044893 PMID:16946405
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