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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcrdecreases expressionEXP 6480464CTDFenofibrate results in decreased expression of HMGCR mRNAPMID:16595124
Hmgcrincreases expressionISOHmgcr (Mus musculus)6480464CTDFenofibrate results in increased expression of HMGCR mRNAPMID:23063693
Hmgcrmultiple interactionsISOHmgcr (Mus musculus)6480464CTDNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA]PMID:23063693
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