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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcrdecreases activityEXP 6480464CTDperfluorooctane sulfonic acid results in decreased activity of HMGCR proteinPMID:1327145
Hmgcrdecreases expressionISOHMGCR (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in decreased expression of HMGCR mRNAPMID:32253466 PMID:32588087 PMID:36864359
Hmgcrincreases expressionISOHMGCR (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in increased expression of HMGCR mRNAPMID:23074026
Hmgcrincreases expressionISOHmgcr (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in increased expression of HMGCR mRNAPMID:19429403 PMID:20936131
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