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ONTOLOGY REPORT - ANNOTATIONS

Term:thymus development
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Accession:GO:0048538 term browser browse the term
Definition:The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
Comment:Note that this term is reserved for annotation of gene products involved in the formation of the thymus itself, not for gene products involved in T cell differentiation in the thymus or elsewhere.


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thymus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:2153718 (PMID:2065352) RGD PMID:2065352 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Adrm1 ADRM1 26S proteasome ubiquitin receptor involved_in ISO (MGI:4849324|PMID:21048919) RGD PMID:21048919 MGI:4849324 NCBI chr 3:167,265,435...167,270,197
Ensembl chr 3:167,265,296...167,270,195 		JBrowse link
G Apc APC regulator of WNT signaling pathway acts_upstream_of_or_within ISO MGI:3589207|MGI:3688435 (PMID:16025118), (PMID:17002498) RGD PMID:16025118 PMID:17002498 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Asxl1 ASXL transcriptional regulator 1 acts_upstream_of_or_within ISO MGI:4418244 (PMID:19861679) RGD PMID:19861679 NCBI chr 3:141,814,012...141,881,526
Ensembl chr 3:141,813,433...141,881,538 		JBrowse link
G Atm ATM serine/threonine kinase acts_upstream_of_or_within ISO MGI:1926343 (PMID:8843194) RGD PMID:8843194 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Bcl11b BCL11 transcription factor B acts_upstream_of_or_within ISO MGI:2663971 (PMID:12717433) RGD PMID:12717433 NCBI chr 6:126,834,531...126,927,720
Ensembl chr 6:126,834,531...126,928,224 		JBrowse link
G Bcl2 BCL2, apoptosis regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1197519|MGI:1857134|MGI:2156165 (PMID:15818405), (PMID:9241272)		 Ensembl
RGD		 PMID:9241272 PMID:15818405 GO_REF:0000107 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l11 Bcl2-like 11 acts_upstream_of_or_within ISO MGI:88138 (PMID:15818405) RGD PMID:15818405 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO MGI:97847 (PMID:18952847) RGD PMID:18952847 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 acts_upstream_of_or_within ISO MGI:1856936 (PMID:5037658) RGD PMID:5037658 NCBI chr 3:36,906,771...37,169,165
Ensembl chr 3:36,910,427...37,168,944 		JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 acts_upstream_of_or_within ISO MGI:5547539 (PMID:23793062) RGD PMID:23793062 NCBI chr19:33,571,255...33,586,783
Ensembl chr19:33,574,257...33,586,965 		JBrowse link
G Ccnb2 cyclin B2 acts_upstream_of_or_within ISO MGI:2429974 (PMID:9539739) RGD PMID:9539739 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 acts_upstream_of_or_within ISO MGI:109360|MGI:2179740 (PMID:20549734) RGD PMID:20549734 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein acts_upstream_of_or_within ISO MGI:98493 (PMID:16399080) RGD PMID:16399080 NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238 		JBrowse link
G Ctc1 CST telomere replication complex component 1 acts_upstream_of_or_within ISO MGI:5427642 (PMID:22531781) RGD PMID:22531781 NCBI chr10:53,714,614...53,735,298
Ensembl chr10:53,714,644...53,735,298 		JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1858008 (PMID:16025118)		 Ensembl
RGD		 PMID:16025118 GO_REF:0000107 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ephb3 Eph receptor B3 involved_in ISO (MGI:4366231|PMID:19598115) RGD PMID:19598115 MGI:4366231 NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370 		JBrowse link
G Fadd Fas associated via death domain involved_in ISS
ISO		 GO_REF:0000024
UniProtKB:Q9QZL0 (MGI:5291865|PMID:21876153)		 UniProt
RGD		 PMID:21876153 GO_REF:0000024 MGI:5291865 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fgf10 fibroblast growth factor 10 involved_in ISO (PMID:17969154) RGD PMID:17969154 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fgf3 fibroblast growth factor 3 acts_upstream_of_or_within ISO MGI:3027990 (PMID:17000704) RGD PMID:17000704 NCBI chr 1:200,001,162...200,005,539
Ensembl chr 1:200,001,261...200,005,187 		JBrowse link
G Foxe1 forkhead box E1 involved_in ISO (PMID:15494458) RGD PMID:15494458 NCBI chr 5:60,630,027...60,632,835
Ensembl chr 5:60,630,027...60,632,835 		JBrowse link
G Foxi3 forkhead box I3 involved_in ISO (MGI:6360100|PMID:31412026) RGD PMID:31412026 MGI:6360100 NCBI chr 4:102,933,487...102,937,655
Ensembl chr 4:102,933,409...102,937,655 		JBrowse link
G Foxn1 forkhead box N1 acts_upstream_of_or_within IMP
ISO		 MGI:5297717 (PMID:22072979) RGD PMID:22072979 PMID:8790387 RGD:1300512 NCBI chr10:63,251,400...63,273,710
Ensembl chr10:63,251,400...63,273,710 		JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within ISO MGI:2683927 (PMID:17082577) RGD PMID:17082577 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:4413411|PMID:19008477)		 Ensembl
RGD		 PMID:19008477 GO_REF:0000107 MGI:4413411 NCBI chr16:32,917,448...32,920,791
Ensembl chr16:32,917,823...32,919,891 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:4453944|PMID:20122914)		 Ensembl
RGD		 PMID:20122914 GO_REF:0000107 MGI:4453944 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K IEP RGD PMID:16488668 RGD:10002779 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Hoxa3 homeobox A3 acts_upstream_of_or_within ISO MGI:1857992|MGI:96184|MGI:96207|MGI:97485 (PMID:11476574), (PMID:7635047), (PMID:9520319) RGD PMID:7635047 PMID:9520319 PMID:11476574 NCBI chr 4:81,269,243...81,313,218
Ensembl chr 4:81,269,243...81,313,218 		JBrowse link
G Ikzf1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO MGI:2158738 (PMID:7923373) RGD PMID:7923373 NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416 		JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 acts_upstream_of_or_within ISO MGI:1856923 (PMID:9376320) RGD PMID:9376320 NCBI chr17:19,777,487...19,957,696
Ensembl chr17:19,777,266...19,955,690 		JBrowse link
G Lmo4 LIM domain only 4 acts_upstream_of_or_within ISO MGI:1306784 (PMID:20549734) RGD PMID:20549734 NCBI chr 2:233,264,180...233,280,881
Ensembl chr 2:233,264,182...233,280,880 		JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 acts_upstream_of_or_within ISO (PMID:11313860) RGD PMID:11313860 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703 		JBrowse link
G Mafb MAF bZIP transcription factor B acts_upstream_of_or_within ISO MGI:3663168 (PMID:19164599) RGD PMID:19164599 NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1346867 (PMID:18952847)		 Ensembl
RGD		 PMID:18952847 GO_REF:0000107 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1346866 (PMID:18952847)		 Ensembl
RGD		 PMID:18952847 GO_REF:0000107 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1346859 (PMID:18952847)		 Ensembl
RGD		 PMID:18952847 GO_REF:0000107 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 acts_upstream_of_or_within ISO MGI:1346858 (PMID:18952847) RGD PMID:18952847 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Myb MYB proto-oncogene, transcription factor acts_upstream_of_or_within ISO MGI:3047076 (PMID:17927961) RGD PMID:17927961 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 acts_upstream_of_or_within ISO MGI:2182778 (PMID:9768749) RGD PMID:9768749 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 IEP RGD PMID:17341476 RGD:401827282 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Pax1 paired box 1 acts_upstream_of_or_within ISO MGI:96175 (PMID:11476574) RGD PMID:11476574 NCBI chr 3:134,792,330...134,801,637
Ensembl chr 3:134,789,182...134,801,636 		JBrowse link
G Pbx1 PBX homeobox 1 acts_upstream_of_or_within ISO MGI:2155612 (PMID:15581866) RGD PMID:15581866 NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594 		JBrowse link
G Prdx2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2668456 (PMID:15259009)		 Ensembl
RGD		 PMID:15259009 GO_REF:0000107 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Psen1 presenilin 1 acts_upstream_of_or_within ISO MGI:109284|MGI:1930934 (PMID:17698590) RGD PMID:17698590 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO MGI:1202717 (PMID:17698590) RGD PMID:17698590 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Psmb9 proteasome 20S subunit beta 9 IEP RGD PMID:18457575 RGD:9850287 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:88190 (PMID:18952847)		 Ensembl
RGD		 PMID:18952847 GO_REF:0000107 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rag1 recombination activating 1 acts_upstream_of_or_within ISO MGI:1353616 (PMID:18684012) RGD PMID:18684012 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISS
ISO		 GO_REF:0000024
UniProtKB:Q61160 (MGI:5291865|PMID:21876153)		 UniProt
RGD		 PMID:21876153 GO_REF:0000024 MGI:5291865 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:3836494|PMID:19109233)		 UniProt
Ensembl
RGD		 PMID:19109233 GO_REF:0000024 GO_REF:0000107 MGI:3836494 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Six1 SIX homeobox 1 acts_upstream_of_or_within ISO MGI:106034|MGI:2655195 (PMID:16530750) RGD PMID:16530750 NCBI chr 6:91,746,739...91,751,975
Ensembl chr 6:91,746,739...91,751,975 		JBrowse link
G Six4 SIX homeobox 4 acts_upstream_of_or_within ISO MGI:102780 (PMID:16530750) RGD PMID:16530750 NCBI chr 6:91,802,328...91,816,002
Ensembl chr 6:91,802,329...91,815,992 		JBrowse link
G Slc46a2 solute carrier family 46, member 2 acts_upstream_of_or_within ISO MGI:97848 (PMID:18684012) RGD PMID:18684012 NCBI chr 5:74,800,226...74,808,128
Ensembl chr 5:74,800,226...74,808,128 		JBrowse link
G Srf serum response factor acts_upstream_of_or_within ISO MGI:3522206 (PMID:18952847) RGD PMID:18952847 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733 		JBrowse link
G Tbx1 T-box transcription factor 1 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:3664784 (PMID:17916582)
(MGI:6360100|PMID:31412026)
(PMID:14585638)		 UniProt
RGD		 PMID:14585638 PMID:17916582 PMID:31412026 GO_REF:0000024 MGI:6360100 NCBI chr11:82,409,275...82,419,058
Ensembl chr11:82,409,275...82,418,380 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2386570|MGI:2388050 (PMID:17078885)		 Ensembl
RGD		 PMID:17078885 GO_REF:0000107 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tyr tyrosinase acts_upstream_of_or_within ISO MGI:1856308 (PMID:10890980) RGD PMID:10890980 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 involved_in ISO (MGI:5300225|PMID:22201126) RGD PMID:22201126 MGI:5300225 NCBI chr 6:95,096,838...95,125,811
Ensembl chr 6:95,096,387...95,118,996 		JBrowse link
G Zmpste24 zinc metallopeptidase STE24 acts_upstream_of_or_within ISO MGI:2180033 (PMID:11923874) RGD PMID:11923874 NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110 		JBrowse link
thymus epithelium morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aire autoimmune regulator involved_in ISO
IBA		 (MGI:3818193|PMID:19015306)
GO_REF:0000033		 RGD
GO_Central		 PMID:19015306 GO_REF:0000033 MGI:3818193 NCBI chr20:10,636,058...10,651,060
Ensembl chr20:10,636,123...10,651,060 		JBrowse link
G Foxn1 forkhead box N1 involved_in ISO (MGI:5437206|PMID:21109991) RGD PMID:21109991 MGI:5437206 NCBI chr10:63,251,400...63,273,710
Ensembl chr10:63,251,400...63,273,710 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    immune system process 2823
      immune system development 233
        hematopoietic or lymphoid organ development 127
          thymus development 61
            neural crest cell differentiation involved in thymus development 0
            thymus epithelium morphogenesis + 2
Path 2
Term Annotations click to browse term
  biological_process 19694
    developmental process 6963
      anatomical structure development 6486
        multicellular organism development 5239
          system development 4526
            immune system development 233
              hematopoietic or lymphoid organ development 127
                thymus development 61
                  neural crest cell differentiation involved in thymus development 0
                  thymus epithelium morphogenesis + 2
paths to the root