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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1317101 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TBX1 mRNA | CTD | PMID:21354282 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of TBX1 mRNA | CTD | PMID:22504374 | all-trans-retinoic acid | affects abundance | ISO | RGD:1317101 | 6480464 | TBX1 gene mutant form affects the abundance of Tretinoin | CTD | PMID:16399080 | all-trans-retinoic acid | increases expression | ISO | RGD:1317100 | 6480464 | Tretinoin results in increased expression of TBX1 mRNA | CTD | PMID:21934132 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1317101 | 6480464 | [CRKL gene mutant form co-treated with TBX1 gene mutant form] affects the abundance of Tretinoin | CTD | PMID:16399080 | benzo[a]pyrene | decreases expression | ISO | RGD:1317101 | 6480464 | Benzo(a)pyrene results in decreased expression of TBX1 mRNA | CTD | PMID:22228805 | bis(2-chloroethyl) sulfide | decreases expression | ISO | RGD:1317101 | 6480464 | Mustard Gas results in decreased expression of TBX1 mRNA | CTD | PMID:15674843 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of TBX1 mRNA | CTD | PMID:19167457 | chloroprene | increases expression | ISO | RGD:1317101 | 6480464 | Chloroprene results in increased expression of TBX1 mRNA | CTD | PMID:23125180 | choline | multiple interactions | ISO | RGD:1317101 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TBX1 mRNA | CTD | PMID:20938992 | copper atom | multiple interactions | ISO | RGD:1317100 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of TBX1 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RGD:1317100 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of TBX1 mRNA | CTD | PMID:20971185 | folic acid | multiple interactions | ISO | RGD:1317101 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TBX1 mRNA | CTD | PMID:20938992 | hydrogen peroxide | affects expression | ISO | RGD:1317100 | 6480464 | Hydrogen Peroxide affects the expression of TBX1 mRNA | CTD | PMID:20044591 | L-methionine | multiple interactions | ISO | RGD:1317101 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TBX1 mRNA | CTD | PMID:20938992 | manganese(II) chloride | decreases expression | ISO | RGD:1317101 | 6480464 | manganese chloride results in decreased expression of TBX1 mRNA | CTD | PMID:17467022 | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of TBX1 mRNA | CTD | PMID:22504374 | selenomethionine | affects expression | ISO | RGD:1317100 | 6480464 | Selenomethionine affects the expression of TBX1 mRNA | CTD | PMID:17222674 | testosterone enanthate | affects expression | ISO | RGD:1317100 | 6480464 | testosterone enanthate affects the expression of TBX1 mRNA | CTD | PMID:17440010 | trimellitic anhydride | decreases expression | ISO | RGD:1317101 | 6480464 | trimellitic anhydride results in decreased expression of TBX1 mRNA | CTD | PMID:19042947 | vanadyl sulfate | decreases expression | ISO | RGD:1317100 | 6480464 | vanadyl sulfate results in decreased expression of TBX1 mRNA | CTD | PMID:16330358 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated| 1. |
GOA data from the GO Consortium |
| 2. |
Hu T, etal., Development. 2004 Nov;131(21):5491-502. Epub 2004 Oct 6. |
| 3. |
MGD data from the GO Consortium |
| 4. |
RGD automated data pipeline |
| 5. |
RGD automated import pipeline for gene-chemical interactions |
| 6. |
RGD Automated Pipelines |
| 7. |
RGD comprehensive gene curation |
| 8. |
Stoller JZ and Epstein JA, Hum Mol Genet. 2005 Apr 1;14(7):885-92. Epub 2005 Feb 9. |
| 9. |
Xu H, etal., Development. 2005 Oct;132(19):4387-95. Epub 2005 Sep 1. |
RGD Disease Portals| Tbx1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Tbx1 (Rattus norvegicus) |
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| TBX1 (Homo sapiens) |
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| Tbx1 (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001108322 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06069545 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06069546 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01070373 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01070374 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01070375 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473999 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001108322 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001101792 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001101792 | (Get FASTA) |
| GenBank Protein | EDL77947 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000001892 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000002597 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000002597 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 360737 | ENTREZGENE |
| Gene3D-CATH | TF_T-box | UniProtKB/TrEMBL |
| HomoloGene Group ID | 7966 | ENTREZGENE |
| InterPro | p53-like_TF_DNA-bd | UniProtKB/TrEMBL |
| TF_T-box | UniProtKB/TrEMBL | |
| TF_T-box_CS | UniProtKB/TrEMBL | |
| IPI | IPI00870893 | UniProtKB/TrEMBL |
| KEGG Report | rno:360737 | ENTREZGENE, UniProtKB/TrEMBL |
| PANTHER | TF_T-box | UniProtKB/TrEMBL |
| Pfam | T-box | UniProtKB/TrEMBL |
| PRINTS | TBOX | UniProtKB/TrEMBL |
| PROSITE | TBOX_1 | UniProtKB/TrEMBL |
| TBOX_2 | UniProtKB/TrEMBL | |
| TBOX_3 | UniProtKB/TrEMBL | |
| SMART | TBOX | UniProtKB/TrEMBL |
| Superfamily-SCOP | P53_like_DNA_bnd | UniProtKB/TrEMBL |
| UniGene | Rn.41347 | ENTREZGENE |
| UniProt | D4A2E9_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-04-30 | Tbx1 | T-box 1 | Tbx1_predicted | T-box 1 (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2005-01-12 | Tbx1_predicted | T-box 1 (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Tbx1 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1307734 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




