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ONTOLOGY REPORT - ANNOTATIONS

Term:neural tube closure
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Accession:GO:0001843 term browser browse the term
Definition:The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.


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neural tube closure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07063281.1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:87860 (PMID:9883720) RGD PMID:9883720 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:87859 (PMID:9883720) RGD PMID:9883720 NCBI chr13:68,673,702...68,770,846
Ensembl chr13:68,673,722...68,839,742 		JBrowse link
G Adm adrenomedullin acts_upstream_of_or_within ISO MGI:2176598 (PMID:16981008) RGD PMID:16981008 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Alx1 ALX homeobox 1 acts_upstream_of_or_within ISO MGI:1857553 (PMID:8673125) RGD PMID:8673125 NCBI chr 7:38,157,626...38,177,220
Ensembl chr 7:38,147,117...38,177,220 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 acts_upstream_of_or_within ISO MGI:1888997 (PMID:11504943), (PMID:9216040) RGD PMID:9216040 PMID:11504943 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Arhgap35 Rho GTPase activating protein 35 acts_upstream_of_or_within ISO MGI:2448591 (PMID:11044403) RGD PMID:11044403 NCBI chr 1:77,202,436...77,319,298
Ensembl chr 1:77,202,436...77,319,298 		JBrowse link
G Arid1a AT-rich interaction domain 1A acts_upstream_of_or_within ISO MGI:5469314 (PMID:23129809) RGD PMID:23129809 NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564 		JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 acts_upstream_of_or_within ISO MGI:3055492 (PMID:16170314) RGD PMID:16170314 NCBI chr 8:59,731,912...59,765,408
Ensembl chr 8:59,731,912...59,765,607 		JBrowse link
G Bcl10 BCL10, immune signaling adaptor involved_in ISS
ISO		 PMID:11163238
(MGI:1930354|PMID:11163238)		 RGD PMID:11163238 PMID:11163238 MGI:1930354, RGD:734638 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523 		JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:19850029)		 Ensembl
RGD		 PMID:19850029 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Brd2 bromodomain containing 2 acts_upstream_of_or_within ISO MGI:3840071 (PMID:19362612) RGD PMID:19362612 NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388 		JBrowse link
G Cc2d2a coiled-coil and C2 domain containing 2A acts_upstream_of_or_within ISO MGI:5708063 (PMID:24947469) RGD PMID:24947469 NCBI chr14:67,349,004...67,435,883
Ensembl chr14:67,351,353...67,435,949 		JBrowse link
G Cdk20 cyclin-dependent kinase 20 acts_upstream_of_or_within ISO MGI:6113512 (PMID:28817564) RGD PMID:28817564 NCBI chr17:701,122...707,869
Ensembl chr17:701,124...707,826 		JBrowse link
G Cecr2 CECR2, histone acetyl-lysine reader acts_upstream_of_or_within ISO MGI:2135272|MGI:3574034|MGI:4829945 (PMID:15640247), (PMID:20589882), (PMID:21246654) RGD PMID:15640247 PMID:20589882 PMID:21246654 NCBI chr 4:153,890,310...153,998,078
Ensembl chr 4:153,890,206...153,993,451 		JBrowse link
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 involved_in
acts_upstream_of_or_within		 ISO (MGI:2667273|PMID:12842012)
MGI:107926|MGI:2135272 (PMID:17229766)		 RGD PMID:12842012 PMID:17229766 MGI:2667273 NCBI chr 7:116,987,616...117,125,035
Ensembl chr 7:116,987,605...117,125,164 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 acts_upstream_of_or_within ISO MGI:2385355 (PMID:12149478) RGD PMID:12149478 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Cluap1 clusterin associated protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:5523142 (PMID:23742838)		 Ensembl
RGD		 PMID:23742838 GO_REF:0000107 NCBI chr10:11,587,963...11,619,711
Ensembl chr10:11,588,017...11,619,711 		JBrowse link
G Cobl cordon-bleu WH2 repeat protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2135272 (PMID:14512015)		 Ensembl
RGD		 PMID:14512015 GO_REF:0000107 NCBI chr14:86,828,137...87,060,682
Ensembl chr14:86,828,139...87,060,800 		JBrowse link
G Deaf1 DEAF1 transcription factor involved_in ISS
ISO		 GO_REF:0000024
(MGI:3029622|PMID:14966286)		 UniProt
RGD		 PMID:14966286 GO_REF:0000024 MGI:3029622 NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541 		JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein acts_upstream_of_or_within ISO MGI:3529997 (PMID:15710412) RGD PMID:15710412 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439 		JBrowse link
G Dvl2 dishevelled segment polarity protein 2 acts_upstream_of_or_within ISO MGI:2429760 (PMID:12421720) RGD PMID:12421720 NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820 		JBrowse link
G Enah ENAH, actin regulator acts_upstream_of_or_within ISO MGI:109268|MGI:97549 (PMID:10069337), (PMID:15371503) RGD PMID:10069337 PMID:15371503 NCBI chr13:93,617,747...93,738,119
Ensembl chr13:93,626,944...93,740,955 		JBrowse link
G Fuz fuzzy planar cell polarity protein involved_in
acts_upstream_of_or_within		 ISO
ISS		 (PMID:21840926)
MGI:4346364 (PMID:19877275)
(MGI:4438317|PMID:19767740), (MGI:5296277|PMID:21840926)
GO_REF:0000024		 RGD
UniProt		 PMID:19767740 PMID:19877275 PMID:21840926 GO_REF:0000024 MGI:4438317 MGI:5296277 NCBI chr 1:95,379,542...95,384,532
Ensembl chr 1:95,379,587...95,384,530 		JBrowse link
G Fzd3 frizzled class receptor 3 acts_upstream_of_or_within ISO MGI:108474 (PMID:16495441) RGD PMID:16495441 NCBI chr15:39,421,366...39,488,369
Ensembl chr15:39,421,355...39,488,369 		JBrowse link
G Fzd6 frizzled class receptor 6 acts_upstream_of_or_within ISO MGI:108476 (PMID:16495441) RGD PMID:16495441 NCBI chr 7:70,055,012...70,086,781
Ensembl chr 7:70,055,068...70,086,776 		JBrowse link
G Glmn glomulin, FKBP associated protein acts_upstream_of_or_within ISO MGI:3817643 (PMID:22405651) RGD PMID:22405651 NCBI chr14:2,187,144...2,231,295
Ensembl chr14:2,187,642...2,230,420 		JBrowse link
G Grhl2 grainyhead-like transcription factor 2 involved_in
acts_upstream_of_or_within		 ISO (MGI:4835348|PMID:20654612), (MGI:4867118|PMID:20978075)
MGI:4331210 (PMID:21262862)		 RGD PMID:20654612 PMID:20978075 PMID:21262862 MGI:4835348 MGI:4867118 NCBI chr 7:68,400,287...68,530,269
Ensembl chr 7:68,400,477...68,530,258 		JBrowse link
G Grhl3 grainyhead-like transcription factor 3 involved_in ISO (MGI:3689640|PMID:16949565), (MGI:4835348|PMID:20654612) RGD PMID:16949565 PMID:20654612 MGI:3689640 MGI:4835348 NCBI chr 5:147,774,161...147,806,291
Ensembl chr 5:147,774,160...147,806,160 		JBrowse link
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 involved_in
acts_upstream_of_or_within		 ISO (MGI:3714713|PMID:17442300)
MGI:2137552 (PMID:15755804), (PMID:9636176)		 RGD PMID:9636176 PMID:15755804 PMID:17442300 MGI:3714713 NCBI chr 6:69,181,429...69,268,045
Ensembl chr 6:69,181,436...69,268,053 		JBrowse link
G Ift122 intraflagellar transport 122 involved_in ISO (MGI:3827087|PMID:19000668) RGD PMID:19000668 MGI:3827087 NCBI chr 4:148,905,031...148,975,458
Ensembl chr 4:148,905,046...148,975,458 		JBrowse link
G Ift172 intraflagellar transport 172 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3829198 (PMID:18930042)		 Ensembl
RGD		 PMID:18930042 GO_REF:0000107 NCBI chr 6:25,081,933...25,121,271
Ensembl chr 6:25,081,980...25,120,860 		JBrowse link
G Ift57 intraflagellar transport 57 acts_upstream_of_or_within ISO MGI:3707373 (PMID:17027958) RGD PMID:17027958 NCBI chr11:51,051,520...51,124,909
Ensembl chr11:51,059,611...51,124,812 		JBrowse link
G Kat2a lysine acetyltransferase 2A acts_upstream_of_or_within ISO MGI:3711317 (PMID:17325035) RGD PMID:17325035 NCBI chr10:85,632,216...85,640,561
Ensembl chr10:85,632,216...85,640,166 		JBrowse link
G Kdm2a lysine demethylase 2A acts_upstream_of_or_within ISO (PMID:25463925) RGD PMID:25463925 NCBI chr 1:201,612,427...201,682,359
Ensembl chr 1:201,612,453...201,680,787 		JBrowse link
G Kdm6a lysine demethylase 6A acts_upstream_of_or_within ISO MGI:5448825 (PMID:22949634) RGD PMID:22949634 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062 		JBrowse link
G Kif20b kinesin family member 20B acts_upstream_of_or_within ISO MGI:3578531 (PMID:15755804) RGD PMID:15755804 NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787 		JBrowse link
G Lhx2 LIM homeobox 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1890208 (PMID:11719201)		 Ensembl
RGD		 PMID:11719201 GO_REF:0000107 NCBI chr 3:22,113,619...22,143,909
Ensembl chr 3:22,126,007...22,143,908 		JBrowse link
G Lias lipoic acid synthetase acts_upstream_of_or_within ISO MGI:3578174 (PMID:15755804) RGD PMID:15755804 NCBI chr14:42,876,699...42,893,824
Ensembl chr14:42,876,699...42,893,783 		JBrowse link
G Lmo4 LIM domain only 4 involved_in
acts_upstream_of_or_within		 ISO (MGI:3689640|PMID:16949565)
MGI:3035827|MGI:3574586 (PMID:14966285), (PMID:15691703)		 RGD PMID:14966285 PMID:15691703 PMID:16949565 MGI:3689640 NCBI chr 2:233,264,180...233,280,881
Ensembl chr 2:233,264,182...233,280,880 		JBrowse link
G Lrp2 LDL receptor related protein 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5603707|PMID:24639464)		 UniProt
Ensembl
RGD		 PMID:24639464 GO_REF:0000024 GO_REF:0000107 MGI:5603707 NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708 		JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of
acts_upstream_of_or_within		 ISO MGI:98958 (PMID:19056682)
MGI:1861309|MGI:2673982|MGI:4415718|MGI:98958 (PMID:10545599), (PMID:15469977), (PMID:19653321), (PMID:19795512)		 RGD PMID:10545599 PMID:15469977 PMID:19056682 PMID:19653321 PMID:19795512 MGI:61254 NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Med12 mediator complex subunit 12 acts_upstream_of_or_within ISO MGI:4839484 (PMID:20630950) RGD PMID:20630950 NCBI chr  X:66,404,807...66,427,775
Ensembl chr  X:66,404,760...66,428,387 		JBrowse link
G Mks1 MKS transition zone complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:4410614|MGI:4433029 (PMID:19776033), (PMID:23454480)		 Ensembl
RGD		 PMID:19776033 PMID:23454480 GO_REF:0000107 NCBI chr10:72,655,921...72,667,007
Ensembl chr10:72,655,921...72,666,655 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO
IEA		 (MGI:5503248|PMID:23704330)
GO_REF:0000107		 RGD
Ensembl		 PMID:23704330 GO_REF:0000107 MGI:5503248 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like involved_in ISO (MGI:5468075|PMID:23267094) RGD PMID:23267094 MGI:5468075 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase acts_upstream_of ISO (PMID:25855017), (PMID:29222906) RGD PMID:25855017 PMID:29222906 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Nckap1 NCK-associated protein 1 acts_upstream_of_or_within ISO MGI:3578145 (PMID:16831833) RGD PMID:16831833 NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217 		JBrowse link
G Nog noggin involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1856173|MGI:1862000 (PMID:16712836)		 Ensembl
RGD		 PMID:16712836 GO_REF:0000107 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3578528 (PMID:15755804)		 Ensembl
RGD		 PMID:15755804 GO_REF:0000107 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Pax2 paired box 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:84247|PMID:8951055)		 UniProt
RGD		 PMID:8951055 GO_REF:0000024 MGI:84247 NCBI chr 1:243,616,509...243,697,454
Ensembl chr 1:243,616,606...243,695,321 		JBrowse link
G Pax3 paired box 3 acts_upstream_of_or_within ISO MGI:3043030 (PMID:15384171) RGD PMID:15384171 NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042 		JBrowse link
G Pfn1 profilin 1 acts_upstream_of_or_within ISO MGI:108360 (PMID:10069337) RGD PMID:10069337 NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631 		JBrowse link
G Phactr4 phosphatase and actin regulator 4 involved_in ISO (MGI:3719969|PMID:17609112) RGD PMID:17609112 MGI:3719969 NCBI chr 5:144,549,350...144,621,259
Ensembl chr 5:144,549,363...144,620,865 		JBrowse link
G Plxnb2 plexin B2 involved_in ISO (MGI:3712712|PMID:17554007) RGD PMID:17554007 MGI:3712712 NCBI chr 7:120,232,276...120,258,385
Ensembl chr 7:120,232,331...120,258,330 		JBrowse link
G Prickle1 prickle planar cell polarity protein 1 involved_in ISO
IEA		 (PMID:21901791)
MGI:5645931 (PMID:25190059)
GO_REF:0000107		 RGD
Ensembl		 PMID:21901791 PMID:25190059 GO_REF:0000107 NCBI chr 7:124,639,142...124,735,027
Ensembl chr 7:124,639,142...124,658,113 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:97760 (PMID:22007132)		 Ensembl
RGD		 PMID:22007132 GO_REF:0000107 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:97592 (PMID:22007132)		 Ensembl
RGD		 PMID:22007132 GO_REF:0000107 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198 		JBrowse link
G Ptch1 patched 1 acts_upstream_of_or_within ISO MGI:1857447 (PMID:9262482) RGD PMID:9262482 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333 		JBrowse link
G Ptk7 protein tyrosine kinase 7 acts_upstream_of_or_within ISO MGI:2135272|MGI:3046905|MGI:3640803 (PMID:15229603), (PMID:20704721) RGD PMID:15229603 PMID:20704721 NCBI chr 9:14,352,155...14,418,473
Ensembl chr 9:14,351,202...14,418,494 		JBrowse link
G Rab23 RAB23, member RAS oncogene family involved_in
acts_upstream_of_or_within		 ISO (MGI:69552|PMID:7720556)
MGI:2137533 (PMID:9636176)		 RGD PMID:7720556 PMID:9636176 MGI:69552 NCBI chr 9:35,943,522...35,967,367
Ensembl chr 9:35,944,085...35,966,927 		JBrowse link
G Rala RAS like proto-oncogene A involved_in ISO (MGI:5504565|PMID:23063435) RGD PMID:23063435 MGI:5504565 NCBI chr17:47,092,163...47,145,192
Ensembl chr17:47,092,207...47,144,063 		JBrowse link
G Rara retinoic acid receptor, alpha acts_upstream_of_or_within ISO MGI:97858 (PMID:7607067) RGD PMID:7607067 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rarg retinoic acid receptor, gamma acts_upstream_of_or_within ISO MGI:97856 (PMID:7607067) RGD PMID:7607067 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177 		JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a acts_upstream_of_or_within ISO MGI:3029714 (PMID:14749425) RGD PMID:14749425 NCBI chr 1:127,128,934...127,172,918
Ensembl chr 1:127,128,934...127,172,918 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 acts_upstream_of_or_within ISO MGI:1100883|MGI:2135272 (PMID:17229766) RGD PMID:17229766 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Rps7 ribosomal protein S7 acts_upstream_of_or_within ISO MGI:3043039 (PMID:15384171) RGD PMID:15384171 NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145 		JBrowse link
G Sall1 spalt-like transcription factor 1 acts_upstream_of_or_within ISO MGI:2139360 (PMID:16790473) RGD PMID:16790473 NCBI chr19:18,005,782...18,022,705
Ensembl chr19:18,007,503...18,022,705 		JBrowse link
G Sall4 spalt-like transcription factor 4 acts_upstream_of_or_within ISO MGI:1889585|MGI:3699175 (PMID:16790473) RGD PMID:16790473 NCBI chr 3:157,474,067...157,491,055
Ensembl chr 3:157,474,642...157,490,822 		JBrowse link
G Scrib scribble planar cell polarity protein involved_in
acts_upstream_of_or_within		 ISO (PMID:22095531)
MGI:1889322|MGI:2135272|MGI:5056373 (PMID:20643356), (PMID:21515572)		 RGD PMID:20643356 PMID:21515572 PMID:22095531 NCBI chr 7:107,759,343...107,782,364
Ensembl chr 7:107,759,343...107,782,331 		JBrowse link
G Sdc4 syndecan 4 acts_upstream_of_or_within ISO MGI:2135272 (PMID:23760952) RGD PMID:23760952 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580 		JBrowse link
G Sec24b SEC24 homolog B, COPII coat complex component acts_upstream_of_or_within ISO MGI:2135272|MGI:4440621 (PMID:19966784), (PMID:20215345) RGD PMID:19966784 PMID:20215345 NCBI chr 2:218,562,670...218,632,753
Ensembl chr 2:218,562,676...218,632,699 		JBrowse link
G Sema4c semaphorin 4C involved_in ISO (MGI:4881530|PMID:21122816) RGD PMID:21122816 MGI:4881530 NCBI chr 9:38,791,668...38,802,171
Ensembl chr 9:38,791,670...38,802,128 		JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase acts_upstream_of_or_within ISO MGI:4437211 (PMID:20133625) RGD PMID:20133625 NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 acts_upstream_of_or_within ISO MGI:108078 (PMID:19850029) RGD PMID:19850029 NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of_or_within ISO MGI:892014 (PMID:19850029) RGD PMID:19850029 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
G Shroom3 shroom family member 3 acts_upstream_of_or_within ISO MGI:1889778 (PMID:16249236) RGD PMID:16249236 NCBI chr14:15,099,415...15,396,832
Ensembl chr14:15,099,423...15,396,915 		JBrowse link
G Ski Ski proto-oncogene acts_upstream_of_or_within ISO MGI:2177555 (PMID:9284043) RGD PMID:9284043 NCBI chr 5:165,713,525...165,782,134
Ensembl chr 5:165,714,093...165,782,733 		JBrowse link
G Spint1 serine peptidase inhibitor, Kunitz type 1 acts_upstream_of_or_within ISO MGI:1338031|MGI:1338881 (PMID:19592578) RGD PMID:19592578 NCBI chr 3:106,231,082...106,244,121
Ensembl chr 3:106,231,444...106,244,119 		JBrowse link
G Spint2 serine peptidase inhibitor, Kunitz type, 2 acts_upstream_of_or_within ISO MGI:1338033|MGI:1338881|MGI:2156187 (PMID:19592578) RGD PMID:19592578 NCBI chr 1:84,558,159...84,580,616
Ensembl chr 1:84,558,166...84,580,616 		JBrowse link
G St14 ST14 transmembrane serine protease matriptase acts_upstream_of_or_within ISO MGI:1338031|MGI:1338033 (PMID:19592578) RGD PMID:19592578 NCBI chr 8:29,540,805...29,581,704
Ensembl chr 8:29,540,811...29,581,517 		JBrowse link
G Stil STIL, centriolar assembly protein acts_upstream_of_or_within ISO MGI:2152962 (PMID:10385121) RGD PMID:10385121 NCBI chr 5:128,520,837...128,573,732
Ensembl chr 5:128,520,953...128,573,730 		JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling acts_upstream_of_or_within ISO MGI:3512046 (PMID:16155214) RGD PMID:16155214 NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577 		JBrowse link
G Tbxt T-box transcription factor T acts_upstream_of_or_within ISO MGI:1856158 (PMID:16835439) RGD PMID:16835439 NCBI chr 1:52,298,104...52,309,813
Ensembl chr 1:52,298,099...52,305,864 		JBrowse link
G Tead2 TEA domain transcription factor 2 acts_upstream_of_or_within ISO MGI:3763367 (PMID:17868131) RGD PMID:17868131 NCBI chr 1:95,702,366...95,719,186
Ensembl chr 1:95,703,005...95,719,186 		JBrowse link
G Tfap2a transcription factor AP-2 alpha acts_upstream_of_or_within ISO MGI:2176682 (PMID:8622766), (PMID:9811866) RGD PMID:8622766 PMID:9811866 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO (MGI:74339|PMID:7600998) RGD PMID:7600998 MGI:74339 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (MGI:894212|PMID:9217007) RGD PMID:9217007 MGI:894212 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 acts_upstream_of_or_within ISO MGI:3698004 (PMID:17082251) RGD PMID:17082251 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:4456438 (PMID:20178780)		 Ensembl
RGD		 PMID:20178780 GO_REF:0000107 NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903 		JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in ISO
IEA		 (MGI:2181331|PMID:11007897)
GO_REF:0000107		 RGD
Ensembl		 PMID:11007897 GO_REF:0000107 MGI:2181331 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Trim71 tripartite motif containing 71 acts_upstream_of_or_within ISO MGI:4123844 (PMID:19098426) RGD PMID:19098426 NCBI chr 8:114,193,439...114,250,807
Ensembl chr 8:114,199,187...114,250,807 		JBrowse link
G Tsc1 TSC complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2183146 (PMID:11438694)		 Ensembl
RGD		 PMID:11438694 GO_REF:0000107 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674 		JBrowse link
G Tsc2 TSC complex subunit 2 acts_upstream_of_or_within ISO MGI:1926345 (PMID:10096549) RGD PMID:10096549 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Tulp3 TUB like protein 3 acts_upstream_of_or_within ISO MGI:3664273 (PMID:19223390) RGD PMID:19223390 NCBI chr 4:161,590,478...161,632,244
Ensembl chr 4:161,590,479...161,632,149 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 acts_upstream_of_or_within ISO MGI:1857265 (PMID:7729687) RGD PMID:7729687 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO MGI:105056|MGI:107926|MGI:1100883|MGI:1349164|MGI:1857642|MGI:1918711|MGI:1923799|MGI:2139764|MGI:98958 (PMID:11709546), (PMID:12499390), (PMID:14512015), (PMID:15229603), (PMID:17229766), (PMID:17433286), (PMID:19966784), (PMID:21246654), (PMID:23760952) RGD PMID:11709546 PMID:12499390 PMID:14512015 PMID:15229603 PMID:17229766 More... NCBI chr13:84,462,731...84,489,404
Ensembl chr13:84,465,527...84,489,378 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:108360 (PMID:15371503)		 GO_Central
RGD		 PMID:15371503 GO_REF:0000033 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061 		JBrowse link
G Wdr83 WD repeat domain 83 acts_upstream_of_or_within ISO MGI:4367006 (PMID:37509073) RGD PMID:37509073 NCBI chr19:23,076,948...23,082,569
Ensembl chr19:23,077,010...23,082,563 		JBrowse link
G Wnt5a Wnt family member 5A acts_upstream_of_or_within ISO MGI:1298218|MGI:2135272 (PMID:17433286), (PMID:19795512) RGD PMID:17433286 PMID:19795512 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 acts_upstream_of_or_within ISO MGI:2387501 (PMID:16598713) RGD PMID:16598713 NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157 		JBrowse link
G Zic2 Zic family member 2 acts_upstream_of_or_within ISO MGI:1862004 (PMID:15384171) RGD PMID:15384171 NCBI chr15:99,576,697...99,581,522
Ensembl chr15:99,576,697...99,581,522 		JBrowse link
G Zic5 Zic family member 5 acts_upstream_of_or_within ISO MGI:3052154 (PMID:15136147) RGD PMID:15136147 NCBI chr15:99,558,285...99,567,023
Ensembl chr15:99,560,323...99,567,035 		JBrowse link
anterior neural tube closure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 acts_upstream_of_or_within ISO MGI:5056374 (PMID:21515572) RGD PMID:21515572 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Folr1 folate receptor alpha involved_in ISO (MGI:3721767|PMID:17286298) RGD PMID:17286298 MGI:3721767 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667 		JBrowse link
G Grhl2 grainyhead-like transcription factor 2 acts_upstream_of_or_within ISO MGI:5056365 (PMID:21515572) RGD PMID:21515572 NCBI chr 7:68,400,287...68,530,269
Ensembl chr 7:68,400,477...68,530,258 		JBrowse link
G Specc1l sperm antigen with calponin homology and coiled-coil domains 1-like acts_upstream_of_or_within ISO MGI:4124253|MGI:4128888 (PMID:26787558) RGD PMID:26787558 NCBI chr20:13,337,983...13,443,665
Ensembl chr20:13,339,692...13,443,665 		JBrowse link
anterior neuropore closure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gatad2a GATA zinc finger domain containing 2A acts_upstream_of_or_within ISO (PMID:17565372) RGD PMID:17565372 NCBI chr16:19,429,578...19,520,320
Ensembl chr16:19,429,578...19,519,587 		JBrowse link
G Tfap2a transcription factor AP-2 alpha acts_upstream_of_or_within ISO MGI:1888387 (PMID:8622765) RGD PMID:8622765 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
establishment of planar polarity involved in neural tube closure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cthrc1 collagen triple helix repeat containing 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1915838 (PMID:18606138)		 Ensembl
RGD		 PMID:18606138 GO_REF:0000107 NCBI chr 7:70,122,474...70,132,756
Ensembl chr 7:70,122,474...70,132,756 		JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO MGI:1857642 (PMID:18606138) RGD PMID:18606138 NCBI chr13:84,462,731...84,489,404
Ensembl chr13:84,465,527...84,489,378 		JBrowse link
initiation of neural tube closure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm2b lysine demethylase 2B involved_in ISO (MGI:4949568|PMID:21220025) RGD PMID:21220025 MGI:4949568 NCBI chr12:33,566,530...33,701,366
Ensembl chr12:33,574,657...33,701,355 		JBrowse link
negative regulation of planar cell polarity pathway involved in neural tube closure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:98958 (PMID:19056682) RGD PMID:19056682 NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
planar cell polarity pathway involved in neural tube closure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 acts_upstream_of_or_within ISO MGI:1918711|MGI:2135272 (PMID:20704721) RGD PMID:20704721 NCBI chr 7:116,987,616...117,125,035
Ensembl chr 7:116,987,605...117,125,164 		JBrowse link
G Dvl1 dishevelled segment polarity protein 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:106613 (PMID:16571627)		 GO_Central
RGD		 PMID:16571627 GO_REF:0000033 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664 		JBrowse link
G Dvl2 dishevelled segment polarity protein 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:2135272|MGI:2429760|MGI:94941 (PMID:16571627)		 GO_Central
RGD		 PMID:16571627 GO_REF:0000033 NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820 		JBrowse link
G Dvl3 dishevelled segment polarity protein 3 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:2135272 (PMID:19008950)		 GO_Central
RGD		 PMID:19008950 GO_REF:0000033 NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462 		JBrowse link
G Fzd1 frizzled class receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1888513|MGI:2135272 (PMID:20940229)		 Ensembl
RGD		 PMID:20940229 GO_REF:0000107 NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643
Ensembl chr 4:29,310,091...29,312,643 		JBrowse link
G Fzd2 frizzled class receptor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1196625|MGI:2135272 (PMID:20940229)		 Ensembl
RGD		 PMID:20940229 GO_REF:0000107 NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334 		JBrowse link
G Grhl3 grainyhead-like transcription factor 3 acts_upstream_of_or_within ISO MGI:2135272 (PMID:20643356) RGD PMID:20643356 NCBI chr 5:147,774,161...147,806,291
Ensembl chr 5:147,774,160...147,806,160 		JBrowse link
G Ptk7 protein tyrosine kinase 7 acts_upstream_of_or_within ISO MGI:1100883|MGI:2135272 (PMID:20704721) RGD PMID:20704721 NCBI chr 9:14,352,155...14,418,473
Ensembl chr 9:14,351,202...14,418,494 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:108078|MGI:1860298|MGI:2135272 (PMID:18257070)		 Ensembl
RGD		 PMID:18257070 GO_REF:0000107 NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of_or_within ISO MGI:1860298|MGI:2135272|MGI:892014 (PMID:18257070) RGD PMID:18257070 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
G Sfrp5 secreted frizzled-related protein 5 acts_upstream_of_or_within ISO MGI:108078|MGI:2135272|MGI:892014 (PMID:18257070) RGD PMID:18257070 NCBI chr 1:241,006,762...241,011,224
Ensembl chr 1:241,006,762...241,011,224 		JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO MGI:106613|MGI:108078|MGI:108100|MGI:1100883|MGI:1196625|MGI:1857642|MGI:1860298|MGI:1888513|MGI:1918711|MGI:2655333|MGI:892014 (PMID:16571627), (PMID:18257070), (PMID:19008950), (PMID:20643356), (PMID:20704721), (PMID:20940229) RGD PMID:16571627 PMID:18257070 PMID:19008950 PMID:20643356 PMID:20704721 More... NCBI chr13:84,462,731...84,489,404
Ensembl chr13:84,465,527...84,489,378 		JBrowse link
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857617 (PMID:19056682)		 Ensembl
RGD		 PMID:19056682 GO_REF:0000107 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
regulation of establishment of planar polarity involved in neural tube closure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sec24b SEC24 homolog B, COPII coat complex component acts_upstream_of_or_within ISO MGI:4440619|MGI:4440621 (PMID:19966784) RGD PMID:19966784 NCBI chr 2:218,562,670...218,632,753
Ensembl chr 2:218,562,676...218,632,699 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    developmental process 6963
      anatomical structure formation involved in morphogenesis 1366
        tube formation 186
          tube closure 115
            neural tube closure 114
              anterior neural tube closure 4
              cell-cell adhesion involved in neural tube closure + 0
              establishment of planar polarity involved in neural tube closure + 16
              initiation of neural tube closure 1
              neuropore closure + 2
              planar cell polarity pathway involved in neural tube closure + 14
              progression of neural tube closure 0
Path 2
Term Annotations click to browse term
  biological_process 19692
    developmental process 6963
      anatomical structure development 6486
        tissue development 2289
          epithelium development 1428
            morphogenesis of an epithelium 594
              epithelial tube morphogenesis 407
                epithelial tube formation 171
                  embryonic epithelial tube formation 159
                    neural tube formation 134
                      primary neural tube formation 121
                        neural tube closure 114
                          anterior neural tube closure 4
                          cell-cell adhesion involved in neural tube closure + 0
                          establishment of planar polarity involved in neural tube closure + 16
                          initiation of neural tube closure 1
                          neuropore closure + 2
                          planar cell polarity pathway involved in neural tube closure + 14
                          progression of neural tube closure 0
paths to the root