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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | increases expression | ISO | RGD:1346789 | 6480464 | Estradiol results in increased expression of PRICKLE1 mRNA | CTD | PMID:23019147 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1618248 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PRICKLE1 mRNA | CTD | PMID:21570461 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of PRICKLE1 mRNA | CTD | PMID:21346803 | aflatoxin B1 | affects expression | ISO | RGD:1346789 | 6480464 | Aflatoxin B1 affects the expression of PRICKLE1 protein | CTD | PMID:20106945 | all-trans-retinoic acid | increases expression | ISO | RGD:1346789 | 6480464 | Tretinoin results in increased expression of PRICKLE1 mRNA | CTD | PMID:21934132 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of PRICKLE1 mRNA | CTD | PMID:20488242 | benzo[a]pyrene | decreases expression | ISO | RGD:1618248 | 6480464 | Benzo(a)pyrene results in decreased expression of PRICKLE1 mRNA | CTD | PMID:21569818 | benzo[a]pyrene | decreases expression | ISO | RGD:1346789 | 6480464 | Benzo(a)pyrene results in decreased expression of PRICKLE1 mRNA | CTD | PMID:22316170 | choline | multiple interactions | ISO | RGD:1618248 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRICKLE1 gene | CTD | PMID:20938992 | cisplatin | decreases expression | ISO | RGD:1346789 | 6480464 | Cisplatin results in decreased expression of PRICKLE1 mRNA | CTD | PMID:19561079 | cobalt dichloride | decreases expression | ISO | RGD:1346789 | 6480464 | cobaltous chloride results in decreased expression of PRICKLE1 mRNA | CTD | PMID:19320972 | cytarabine | decreases expression | ISO | RGD:1346789 | 6480464 | Cytarabine results in decreased expression of PRICKLE1 mRNA | CTD | PMID:21198554 | dibutyl phthalate | increases expression | ISO | RGD:1618248 | 6480464 | Dibutyl Phthalate results in increased expression of PRICKLE1 mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of PRICKLE1 mRNA | CTD | PMID:21266533 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of PRICKLE1 mRNA | CTD | PMID:21551480 | folic acid | multiple interactions | ISO | RGD:1618248 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRICKLE1 gene | CTD | PMID:20938992 | formaldehyde | decreases expression | ISO | RGD:1346789 | 6480464 | Formaldehyde results in decreased expression of PRICKLE1 mRNA | CTD | PMID:20655997 | L-methionine | multiple interactions | ISO | RGD:1618248 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRICKLE1 gene | CTD | PMID:20938992 | paracetamol | affects expression | ISO | RGD:1618248 | 6480464 | Acetaminophen affects the expression of PRICKLE1 mRNA | CTD | PMID:17562736 | phenobarbital | affects expression | ISO | RGD:1618248 | 6480464 | Phenobarbital affects the expression of PRICKLE1 mRNA | CTD | PMID:23091169 | pirinixic acid | decreases expression | ISO | RGD:1618248 | 6480464 | pirinixic acid results in decreased expression of PRICKLE1 mRNA | CTD | PMID:20813756 | propiconazole | decreases expression | ISO | RGD:1618248 | 6480464 | propiconazole results in decreased expression of PRICKLE1 mRNA | CTD | PMID:21278054 | tetrachloromethane | affects expression | ISO | RGD:1618248 | 6480464 | Carbon Tetrachloride affects the expression of PRICKLE1 mRNA | CTD | PMID:17484886 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Wnt signaling pathway |
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Wnt signaling pathway |
References - curated| 1. |
Jones C and Chen P, Bioessays. 2007 Feb;29(2):120-32. |
| 2. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 3. |
RGD automated data pipeline |
| 4. |
RGD automated import pipeline for gene-chemical interactions |
| 5. |
RGD Automated Pipelines |
| 6. |
Shimojo M and Hersh LB, Mol Cell Biol 2003 Dec;23(24):9025-31. |
References - uncurated| PubMed | 17173866 |
RGD Disease Portals| Prickle1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Prickle1 (Rattus norvegicus) |
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| PRICKLE1 (Homo sapiens) |
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| Prickle1 (Mus musculus) |
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Position Markers| AW215793 |
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| BE114974 |
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| RH143298 |
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| BE099414 |
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| RH138805 |
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| MARC_13855-13856:1032800061:3 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_199396 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06052461 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01052338 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF399843 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474027 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_199396 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_955428 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_955428 | (Get FASTA) |
| GenBank Protein | AAQ03034 | (Get FASTA) |
| EDL76629 | (Get FASTA) | |
| EDL76630 | (Get FASTA) | |
| EDL76631 | (Get FASTA) | |
| Q71QF9 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000022772 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000031476 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000036750 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 315259 | ENTREZGENE |
| Gene3D-CATH | Znf_LIM | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000022772 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 17686 | ENTREZGENE |
| InterPro | PET_domain | UniProtKB/Swiss-Prot |
| Znf_LIM | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:315259 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | LIM | UniProtKB/Swiss-Prot |
| PET | UniProtKB/Swiss-Prot | |
| PROSITE | LIM_DOMAIN_1 | UniProtKB/Swiss-Prot |
| LIM_DOMAIN_2 | UniProtKB/Swiss-Prot | |
| PET | UniProtKB/Swiss-Prot | |
| SMART | LIM | UniProtKB/Swiss-Prot |
| UniGene | Rn.141040 | ENTREZGENE |
| UniProt | G3V8Z4_RAT | UniProtKB/TrEMBL |
| PRIC1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-12-15 | Prickle1 | prickle homolog 1 (Drosophila) | Prickle1 | prickle-like 1 (Drosophila) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-07-08 | Prickle1 | prickle-like 1 (Drosophila) | Symbol and Name status set to approved | 10779 | APPROVED |
| More on Prickle1 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 735090 |
| Created: | 2004-02-05 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




