Annotation (Toggle Detail/Summary View) | |||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | activation of Rac GTPase activity | | ISO | RGD:1321471 | 1624291 | PMID:19041750 | RGD | PMID:19041750 | activation of Rac GTPase activity | | IEA | Ensembl:ENSP00000349486 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | apoptotic process involved in morphogenesis | | ISO | RGD:1321471 | 1624291 | PMID:19041750 | RGD | PMID:19041750 | apoptotic process involved in morphogenesis | | IEA | Ensembl:ENSP00000349486 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | astrocyte cell migration | | IMP | | 2303059 | | RGD | | asymmetric protein localization | | ISO | RGD:1321472 | 1624291 | MGI:MGI:1889322 | RGD | MGI:MGI:3624469 PMID:16687519 | asymmetric protein localization | | IEA | Ensembl:ENSMUSP00000002603 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | cell migration | | ISO | RGD:1321472 | 1624291 | MGI:MGI:3812202|PMID:18716323 | RGD | MGI:MGI:3812202 PMID:18716323 | cell migration | | ISO | RGD:1321471 | 1624291 | PMID:18716323 | RGD | PMID:18716323 | cell proliferation | | ISO | RGD:1321471 | 1624291 | PMID:16965391 | RGD | PMID:16965391 | cell proliferation | | IEA | Ensembl:ENSP00000349486 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | cell-cell adhesion | | ISO | RGD:1321471 | 1624291 | PMID:16344308 | RGD | PMID:16344308 | cell-cell adhesion | | IEA | Ensembl:ENSP00000349486 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | establishment of apical/basal cell polarity | | ISO | RGD:1321471 | 1624291 | PMID:19041750 | RGD | PMID:19041750 | establishment of apical/basal cell polarity | | IEA | Ensembl:ENSP00000349486 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | mammary gland duct morphogenesis | | ISO | RGD:1321472 | 1624291 | MGI:MGI:4359580|PMID:19041750 | RGD | MGI:MGI:4359580 PMID:19041750 | mammary gland duct morphogenesis | | IEA | Ensembl:ENSMUSP00000002603 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | morphogenesis of embryonic epithelium | | ISO | RGD:1321472 | 1624291 | MGI:MGI:1889322 | RGD | MGI:MGI:2449213 PMID:12499390 | negative regulation of mitotic cell cycle | | ISO | RGD:1321471 | 1624291 | PMID:16965391 | RGD | PMID:16965391 | negative regulation of mitotic cell cycle | | IEA | Ensembl:ENSP00000349486 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | neural tube closure | | ISO | RGD:1321472 | 1624291 | MGI:MGI:1889322 | RGD | MGI:MGI:4819429 PMID:20643356 | neural tube closure | | IEA | Ensembl:ENSMUSP00000002603 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | neural tube closure | | IEA | Ensembl:ENSP00000349486 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | neural tube closure | | ISO | RGD:1321471 | 1624291 | PMID:22095531 | RGD | PMID:22095531 | positive chemotaxis | | ISO | RGD:1321472 | 1624291 | MGI:MGI:3812202|PMID:18716323 | RGD | MGI:MGI:3812202 PMID:18716323 | positive chemotaxis | | IEA | Ensembl:ENSMUSP00000002603 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive chemotaxis | | IEA | Ensembl:ENSP00000349486 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive chemotaxis | | ISO | RGD:1321471 | 1624291 | PMID:18716323 | RGD | PMID:18716323 | positive regulation of apoptotic process | | ISO | RGD:1321471 | 1624291 | PMID:19041750 | RGD | PMID:19041750 | positive regulation of apoptotic process | | IEA | Ensembl:ENSP00000349486 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of receptor recycling | | ISO | RGD:1321471 | 1624291 | PMID:15775968 | RGD | PMID:15775968 | positive regulation of receptor recycling | | IEA | Ensembl:ENSP00000349486 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | protein localization to adherens junction | | ISO | RGD:1321471 | 1624291 | PMID:16611247 | RGD | PMID:16611247 | protein localization to adherens junction | | IEA | Ensembl:ENSP00000349486 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | synaptic vesicle endocytosis | | ISO | RGD:1321472 | 1624291 | MGI:MGI:4365512|PMID:19458197 | RGD | MGI:MGI:4365512 PMID:19458197 | synaptic vesicle endocytosis | | IEA | Ensembl:ENSMUSP00000002603 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | synaptic vesicle targeting | | ISO | RGD:1321472 | 1624291 | MGI:MGI:4365512|PMID:19458197 | RGD | MGI:MGI:4365512 PMID:19458197 | synaptic vesicle targeting | | IEA | Ensembl:ENSMUSP00000002603 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | wound healing | | ISO | RGD:1321472 | 1624291 | MGI:MGI:2655333|MGI:MGI:1100883|MGI:MGI:1918711|MGI:MGI:2135272 | RGD | MGI:MGI:4819429 PMID:20643356 | wound healing | | IEA | Ensembl:ENSMUSP00000002603 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Hippo signaling pathway |
| Viral carcinogenesis | |
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
|
|
Molecular Pathway Annotations
|
| External Database Links | |
| KEGG Pathway | Hippo signaling pathway |
| Viral carcinogenesis | |
References - curated| 1. |
Jones C and Chen P, Bioessays. 2007 Feb;29(2):120-32. |
| 2. |
Osmani N, etal., Curr Biol. 2006 Dec 19;16(24):2395-405. Epub 2006 Nov 2. |
| 3. |
RGD automated import pipeline for gene-chemical interactions |
References - uncurated
RGD Disease Portals| Scrib has been annotated in the following RGD Disease Portals. |
|||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
Comparative Map Data| Scrib (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| SCRIB (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Scrib (Mus musculus) |
|
Position Markers| RH141209 |
|
||||||||||||||||||||||||||||||
| BE119987 |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| RefSeq Acc Id: | XM_002726940 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Position: |
|
| RefSeq Acc Id: | XM_002726941 |
| RefSeq Status: | |
| Type: | CODING |
| Position: | No map positions available. |
| RefSeq Acc Id: | XM_002726942 |
| RefSeq Status: | |
| Type: | CODING |
| Position: | No map positions available. |
| RefSeq Acc Id: | XM_001074724 |
| RefSeq Status: | |
| Type: | CODING |
| Position: | No map positions available. |
| RefSeq Acc Id: | XM_002726943 |
| RefSeq Status: | |
| Type: | CODING |
| Position: | No map positions available. |
| RefSeq Acc Id: | XM_002729823 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Position: |
|
| RefSeq Acc Id: | XM_002729824 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Position: |
|
| RefSeq Acc Id: | XM_002729825 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Position: |
|
| RefSeq Acc Id: | XM_343266 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Position: |
|
| RefSeq Acc Id: | XM_002729826 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Position: |
|
| RefSeq Acc Id: | NM_001191879 | ||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | NP_001178808 | ||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_001178808 | (Get FASTA) |
| GenBank Protein | EDM16017 | (Get FASTA) |
| EDM16018 | (Get FASTA) | |
| EDM16019 | (Get FASTA) | |
| EDM16020 | (Get FASTA) | |
| EDM16021 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000032574 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000044022 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000045280 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 362938 | ENTREZGENE |
| HomoloGene Group ID | 44228 | ENTREZGENE |
| InterPro | Leu-rich_rpt | UniProtKB/TrEMBL |
| Leu-rich_rpt_2_copies | UniProtKB/TrEMBL | |
| Leu-rich_rpt_typical-subtyp | UniProtKB/TrEMBL | |
| PDZ/DHR/GLGF | UniProtKB/TrEMBL | |
| IPI | IPI00366277 | UniProtKB/TrEMBL |
| KEGG Report | rno:362938 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | LRR_4 | UniProtKB/TrEMBL |
| PDZ | UniProtKB/TrEMBL | |
| PROSITE | LRR | UniProtKB/TrEMBL |
| PDZ | UniProtKB/TrEMBL | |
| SMART | LRR_TYP | UniProtKB/TrEMBL |
| PDZ | UniProtKB/TrEMBL | |
| Superfamily-SCOP | PDZ | UniProtKB/TrEMBL |
| UniGene | Rn.138068 | ENTREZGENE |
| UniProt | D3ZWS0_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2013-03-20 | Scrib | scribbled planar cell polarity protein | Scrib | scribbled homolog (Drosophila) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2009-06-15 | Scrib | scribbled homolog (Drosophila) | Scrib_predicted | scribbled homolog (Drosophila) (predicted) | Data Merged | 23187 | APPROVED |
| 2008-03-06 | Scrib | scribbled homolog (Drosophila) | RGD1565055_predicted | similar to PDZ-domain protein scribble (predicted) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2006-03-07 | RGD1565055_predicted | similar to PDZ-domain protein scribble (predicted) | LOC362938 | similar to PDZ-domain protein scribble | Symbol and Name status set to approved | 10779 | APPROVED |
| 2006-02-09 | LOC362938 | similar to PDZ-domain protein scribble | Symbol and Name status set to provisional | 1724 | PROVISIONAL | ||
| 2005-01-12 | Scrib_predicted | scribbled homolog (Drosophila) (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Scrib | |
![]() |
Entrez Gene |
![]() |
Ensembl Gene |
![]() | Genome Browser |
![]() |
NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1565055 |
| Created: | 2006-02-09 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




