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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:opiate dependence
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Accession:DOID:2559 term browser browse the term
Definition:A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance. (DO)
Synonyms:exact_synonym: Disorder, Opioid-Related;   Narcotic Abuse;   Narcotic Abuses;   Narcotic Addiction;   Narcotic Dependence;   ODS1;   Opiate Addiction;   Opioid-Related Disorders;   opioid addiction;   opioid dependence;   opioid type dependence
 related_synonym: OPIOID DEPENDENCE, SUSCEPTIBILITY TO, 1
 primary_id: MESH:D009293
 alt_id: OMIM:610064
 xref: EFO:0005611;   ICD10CM:F11.2;   ICD9CM:304.00
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
opiate dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A severity
susceptibility
treatment		 ISO DNA:SNP: :3435C>T (rs1045642) (human)
DNA:SNP:: (rs9282564)
DNA:SNPs::rs1045642, rs2032582(human)
DNA:haplotype::		 RGD PMID:27061230 PMID:24950410 PMID:24086514 PMID:17178268 RGD:401959589, RGD:401827941, RGD:401901242, RGD:401901190 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ankk1 ankyrin repeat and kinase domain containing 1 susceptibility ISO DNA:SNP,haplotype:exon:rs1800497(human) RGD PMID:19373123 RGD:401959309 NCBI chr 8:49,779,862...49,788,024
Ensembl chr 8:49,779,862...49,788,024 		JBrowse link
G Arrb2 arrestin, beta 2 treatment ISO DNA:SNPs: :rs3786047, rs1045280, rs2036657(human)
protein:decreased expression:pre-frontal cortex		 RGD PMID:20514076 PMID:14969742 RGD:401901595, RGD:401901596 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Bdnf brain-derived neurotrophic factor ISO protein:increased expression:serum RGD PMID:21890593 RGD:405850248 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bmper BMP-binding endothelial regulator susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:: (rs731844) (human)		 CTD
RGD		 PMID:18438686 PMID:18438686 RGD:401851917 NCBI chr 8:21,732,225...21,977,261
Ensembl chr 8:21,732,225...21,977,256 		JBrowse link
G C9 complement C9 susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:: (rs476569) (human)		 CTD
RGD		 PMID:18438686 PMID:18438686 RGD:401851917 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Ces1d carboxylesterase 1D ISO CTD Direct Evidence: therapeutic CTD PMID:12679808 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Comt catechol-O-methyltransferase severity
treatment		 ISO DNA:SNP:cd: p.V158M (rs4680) (human) RGD PMID:27061230 PMID:32407152 RGD:401959589, RGD:401959744 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 treatment ISO RGD PMID:10653207 RGD:401901270 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Drd2 dopamine receptor D2 treatment
susceptibility		 ISO DNA:SNP: :rs6275(human)
DNA:SNP,haplotype: :rs1076560,rs6275(human)		 RGD PMID:19373123 PMID:19373123 RGD:401959309, RGD:401959309 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Gal galanin and GMAP prepropeptide susceptibility ISO DNA:SNP: :rs948854(human) RGD PMID:24086514 RGD:401901242 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO protein:decreased expression:pre-frontal cortex RGD PMID:14969742 RGD:401901596 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO protein:decreased expression:pre-frontal cortex RGD PMID:14969742 RGD:401901596 NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644 		JBrowse link
G Nav3 neuron navigator 3 susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:: (rs770124) (human)		 CTD
RGD		 PMID:18438686 PMID:18438686 RGD:401851917 NCBI chr 7:45,052,206...45,840,471
Ensembl chr 7:45,054,296...45,840,698 		JBrowse link
G Ngf nerve growth factor ISO DNA:hypermethylation:promoter,exon:blood
protein:decreased expression:brain		 RGD PMID:29224006 PMID:26440527 RGD:401976280, RGD:401976545 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 susceptibility ISO DNA:SNP, haplotype:enhancer: (rs4128839) (human)
DNA:SNP, haplotype:intron: (rs4691910) (human)		 RGD PMID:31689297 PMID:32757697 RGD:402463939, RGD:402463942 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Oprd1 opioid receptor, delta 1 susceptibility
treatment		 ISO DNA:SNP: :rs1042114 (human)
DNA:SNPs, haplotype:intron 1:multiple (human)
associated with neonatal abstinence syndrome in offspring;DNA:SNP:intron (rs204076) (human)
associated with African American;DNA:SNP:intron (rs678849) (human)
associated with methadone treatment;DNA:SNP:intron (rs204076) (human)
DNA:SNP:intron (rs10753331, rs581111) (human)
DNA:SNP,haplotype:multiple (multiple)(human)
DNA:SNP, haplotype: (rs678849|rs2236857|rs2236855|rs760589) (human)
DNA:SNP: :rs2236861(human)		 RGD PMID:28656735 PMID:24533225 PMID:26233486 PMID:23612435 PMID:37531661 More... RGD:401850580, RGD:402525443, RGD:11079504, RGD:402463973, RGD:401977581, RGD:401976559, RGD:401976552, RGD:401976541, RGD:401901242 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 no_association ISO DNA:SNP: :rs702764 (human)
DNA:SNP,haplotype:multiple (multiple GGCTTCT) (human)		 RGD PMID:28656735 PMID:17622222 RGD:401850580, RGD:401976552 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 susceptibility
treatment
no_association		 ISO ClinVar Annotator: match by term: Opioid dependence, susceptibility to, 1
protein:decreased expression:pre-frontal cortex
DNA:SNP: :rs9479757(human)
DNA:SNP, haplotype:3' utr:rs10485058 (human)
associated with Chronic Pain;DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human)
DNA:altered methylation:promoter
DNA:SNPs: :multiple
associated with alcohol dependence:DNA:SNP, haplotypes: :-2044C>A (human)
DNA:SNPs: :172G>T (rs6912029), 1510G>A (rs12205732) (human)
DNA:hypermethylation:promoter
DNA:SNP:exon:17C>T (rs 1799972) (human)
DNA:SNP:exon:118A>G (rs 1799971) (human)		 ClinVar
RGD		 PMID:9193881 PMID:9689128 PMID:11134674 PMID:11773858 PMID:11773859 More... RGD:401901596, RGD:401901242, RGD:401831043, RGD:401831042, RGD:401831040, RGD:401827954, RGD:401827948, RGD:401827945, RGD:401827942, RGD:401827937, RGD:401827935, RGD:401827933, RGD:401827929, RGD:401827929 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdyn prodynorphin sexual_dimorphism
no_association
susceptibility		 ISO DNA:SNP: :rs1022563 (human)
DNA:SNPs:promoter, 3' utr:rs1997794, rs102256
DNA:SNP: :rs199774, rs1022563 (human)
DNA:SNP: :rs910080 (human)
DNA:SNP: :rs910080, rs199774 (human)		 RGD PMID:22443215 PMID:19298317 PMID:28656735 PMID:28656735 PMID:22443215 RGD:401850569, RGD:401850586, RGD:401850580, RGD:401850580, RGD:401850569 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10321497 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Ttc9 tetratricopeptide repeat domain 9 susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:: (rs8688) (human)		 CTD
RGD		 PMID:18438686 PMID:18438686 RGD:401851917 NCBI chr 6:101,333,274...101,368,110
Ensembl chr 6:101,333,141...101,368,110 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO DNA:hypermethylation:exon:blood RGD PMID:29224006 RGD:401976280 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
heroin dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase IMP RGD PMID:10900239 RGD:10046064 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A treatment ISO associated with methadone treatment;DNA:SNP:intron (rs1128503) (human) RGD PMID:29173032 RGD:401976557 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO CTD Direct Evidence: marker/mechanism CTD PMID:15717844 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adra1a adrenoceptor alpha 1A susceptibility ISO DNA:SNP:exon 4: p.R347C (rs1048101) (human) RGD PMID:33577997 RGD:401940110 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member susceptibility ISO DNA:polymorphism: : RGD PMID:21723677 RGD:401959204 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Ankk1 ankyrin repeat and kinase domain containing 1 onset
susceptibility		 ISO DNA:SNPS:exon:rs17115439, rs7118900, rs1800497 (human)
DNA:SNPs:5'UTR,exon:rs877138, rs4938013(human)
DNA:SNP:exon:rs1800497(human)
DNA:SNPs, haplotypes:intron, 3'flanking:rs11214598, rs2859545(human)		 RGD PMID:28854834 PMID:23303482 PMID:23840506 PMID:29550268 RGD:401959202, RGD:401959304, RGD:401959223, RGD:401959205 NCBI chr 8:49,779,862...49,788,024
Ensembl chr 8:49,779,862...49,788,024 		JBrowse link
G Arrb2 arrestin, beta 2 treatment ISO DNA:polymorphism: :rs1045280(human)
associated with methadone treatment;DNA:SNP:intron (rs1045280) (human)		 RGD PMID:33783060 PMID:29173032 RGD:401901593, RGD:401976557 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Bche butyrylcholinesterase ISO protein:increased activity:blood plasma (human) RGD PMID:30707402 RGD:401960085 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bdnf brain-derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:serum		 CTD
RGD		 PMID:17715210 PMID:17715210 RGD:401976440 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 ISO DNA:SNP:intron:rs2350780 (human) RGD PMID:19500151 RGD:5509583 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Comt catechol-O-methyltransferase severity
onset
susceptibility		 ISO DNA:SNP:exon 5: (rs769224) (human)
DNA:SNP:cd: p.V158M (human)
DNA:SNP:: (rs737866) (Human)
DNA:SNP:-287A>G (human)
DNA:SNP:exon 1: (rs737866) (Human)
DNA:SNP:exon 4: (rs4680) p.V158M (human)		 RGD PMID:33577997 PMID:33544778 PMID:23155402 PMID:12476424 PMID:21857968 More... RGD:401940110, RGD:401959602, RGD:401959234, RGD:401940154, RGD:401940140, RGD:401940113 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment IDA
ISO		 DNA:SNP:exon:rs35349697 RGD PMID:21362452 PMID:24704376 PMID:23062870 RGD:401901181, RGD:401938627, RGD:401901182 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 treatment ISO DNA:polymorphisms: :785A>G (rs2279343), 516G>T (rs3745274)(human) RGD PMID:21790905 RGD:11097675 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 treatment ISO DNA:SNP:exon:CYP2C19*2 (681G>A,rs4244285)(human)
DNA:SNPs::CYP2C19*2, CYP2C19*3(human)		 RGD PMID:24016178 PMID:24956251 RGD:401960868, RGD:401960881 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Drd1 dopamine receptor D1 IEP RGD PMID:28598964 RGD:13506959 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 susceptibility
onset		 ISO
IEP		 CTD Direct Evidence: marker/mechanism
DNA:SNP:intron:rs1079597(human)
DNA:SNPS:exon, intron:multiples(human)		 CTD
RGD		 PMID:11751029 PMID:23840506 PMID:28854834 PMID:28598964 RGD:401959223, RGD:401959202, RGD:13506959 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 IEP RGD PMID:28598964 RGD:13506959 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Drd4 dopamine receptor D4 susceptibility
onset		 ISO DNA:SNPs:5promoter:rs1800955,rs936462(human)
DNA:SNP,methylation::rs3758653(human)
DNA:polymorphism:promoter:-521G>A(human)		 RGD PMID:23840506 PMID:34864042 PMID:18991844 RGD:401959223, RGD:401959595, RGD:401959594 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Fas Fas cell surface death receptor IEP protein:increased expression:cerebral cortex (rat) RGD PMID:14530904 RGD:8686423 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 susceptibility ISO DNA:SNPs:intron,3'utr: (rs1360780,rs3800373) (human) RGD PMID:24845178 RGD:401976498 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ameliorates IDA RGD PMID:21362452 PMID:23062870 RGD:401901181, RGD:401901182 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 susceptibility ISO DNA:SNP:intron: C>G (rs29220) (human) RGD PMID:26727527 RGD:11552767 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19833324 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 ISO DNA:SNP:intron: (rs211014) (human) RGD PMID:17440936 RGD:402525444 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gad1 glutamate decarboxylase 1 treatment
susceptibility		 ISO DNA:SNPs, haplotype:multiple:
DNA:SNP,haplotype: :rs2058725(human)
DNA:SNPs,haplotypes:promoter,exon:rs1978340, rs3791878, rs11542313 (human)		 RGD PMID:31866536 PMID:19500151 PMID:22564729 RGD:401900128, RGD:5509583, RGD:401900156 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 susceptibility ISO DNA:SNP: ::rs8190646(human) RGD PMID:19500151 RGD:5509583 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO DNA:SNP: :rs2910709 RGD PMID:24022000 RGD:405849398 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 treatment ISO
IEP		 mRNA:increased expression:ventral striatum (human) RGD PMID:27863698 PMID:19940171 RGD:405096665, RGD:4107717 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A susceptibility ISO DNA:repeats,SNPs,haplotype:introns:(GT)26, rs3219790,rs1102972,rs1650420,rs3104703 (human)
DNA:repeats: :(GT)26 (human)		 RGD PMID:23940648 PMID:25366762 RGD:401938628, RGD:401938629 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grm2 glutamate metabotropic receptor 2 IMP RGD PMID:30283001 RGD:38501063 NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146 		JBrowse link
G Grm2em1 glutamate metabotropic receptor 2; endonuclease induced mutant 1 IMP KO compared to wild-type rats RGD PMID:30283001 RGD:38501063
G Hcrt hypocretin neuropeptide precursor treatment ISO RGD PMID:35984180 RGD:401960075 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A ISO DSNA:SNPs:promoter, intron, CDS:g.113974819C>T, g.113985089A>G, g.113989703A>G (rs1150226, rs897687, rs1176713) (human)
DNA:SNPs, haplotype:multiple (human)		 RGD PMID:26227246 PMID:19500151 RGD:405096480, RGD:5509583 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 ISO DNA:SNP: :rs2070995 (human) RGD PMID:20220551 RGD:6483055 NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758 		JBrowse link
G Lep leptin ISO CTD Direct Evidence: marker/mechanism CTD PMID:15717844 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Ngf nerve growth factor treatment ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:serum
DNA:SNP:intron:rs2239622		 CTD
RGD		 PMID:17715210 PMID:17715210 PMID:21358750 RGD:401976440, RGD:401965390 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 susceptibility ISO DNA:SNP, haplotype:intron: (rs4234955) (human)
DNA:SNP:intron: (rs4518200) (human)		 RGD PMID:29465008 PMID:24845178 RGD:402463944, RGD:401976498 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Oprd1 opioid receptor, delta 1 onset
treatment		 ISO DNA:SNP: :rs508448 (human)
associated with stress-related disorder;DNA:SNP:coding synonymous,intron (rs2234918, rs2236857) (human)
associated with methadone treatment;DNA:SNP:intron (rs529520) (human)
DNA:SNP, haplotype:intron 1 (multiple) (human)
DNA:SNP, haplotype:multiple (multiple) (human)
DNA:SNP:CDS:intron 1 (rs204047|rs797397) (human)		 RGD PMID:28692418 PMID:30171993 PMID:29173032 PMID:22500942 PMID:34031368 More... RGD:401831045, RGD:401977579, RGD:401976557, RGD:401976535, RGD:401976533, RGD:401976443 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 treatment IMP
ISO		 DNA:SNP: :rs3802279, rs3802281, and rs963549 (human) RGD PMID:24725195 PMID:24305833 PMID:31940240 RGD:9831447, RGD:401850592, RGD:401827951 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 susceptibility
no_association
severity		 ISO CTD Direct Evidence: marker/mechanism
mRNA:splice variants:prefrontal cortex
DNA:SNPs, haplotypes: :multiple
DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human)
DNA:SNP, haplotype: :rs483481 (human)
DNA:SNPs, haplotypes: :rs696522, rs1381376, rs3778151 (human)		 CTD
RGD		 PMID:20201854 PMID:32506472 PMID:28692418 PMID:28976288 PMID:11424981 More... RGD:401831047, RGD:401831045, RGD:401831044, RGD:401827953, RGD:401827950, RGD:401827940 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdyn prodynorphin onset
susceptibility
no_association		 ISO DNA:repeat:promoter:rs35286251 (human)
DNA:VNTR, SNPs:rs1022563, rs2235749, rs910080 (human)
DNA:VNTR:promoter
DNA:SNPs, repeat:promoter:rs2281285, rs2235749, rs35286251 (human)
DNA:SNP: :rs910080 (human)
mRNA:decreased expression:periamygdaloid cortex		 RGD PMID:30936032 PMID:21382455 PMID:30138645 PMID:29911117 PMID:29911117 More... RGD:401850549, RGD:401850577, RGD:401850562, RGD:401850561, RGD:401850561, RGD:401850556, RGD:401850554 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin IMP RGD PMID:22683090 RGD:10003025 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18201294 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Retn resistin ISO CTD Direct Evidence: marker/mechanism CTD PMID:15717844 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 IEP RGD PMID:28598964 RGD:13506959 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Ttc12 tetratricopeptide repeat domain 12 susceptibility ISO DNA:SNP:5'UTR,intron:rs7130431(human) RGD PMID:23303482 RGD:401959304 NCBI chr 8:49,799,916...49,847,940
Ensembl chr 8:49,799,920...49,847,087 		JBrowse link
morphine dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A IEP mRNA:increases expression:cerebral cortex (rat) RGD PMID:9105684 RGD:401976538 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 IEP RGD PMID:23927484 RGD:401900655 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein ameliorates IMP RGD PMID:21549764 PMID:25746394 RGD:401851922, RGD:11087075 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IDA RGD PMID:24906198 RGD:10054248 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP RGD PMID:24906198 RGD:10054248 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor treatment ISO
IEP		 protein:decreased expression:nucleus accumbens RGD PMID:27461790 PMID:32428531 RGD:401940145, RGD:401959372 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cnr1 cannabinoid receptor 1 treatment ISO RGD PMID:27461790 RGD:401940145 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Comt catechol-O-methyltransferase susceptibility ISO DNA:SNP:cd: (rs4680) p.V158M (human) RGD PMID:30211780 RGD:401940137 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment ISO
IDA
IEP		 CTD Direct Evidence: marker/mechanism
protein:increased expression:neuron, brain
protein:increased phosphorylation:central amygdaloid nucleus
protein:increased phosphorylation:hypothalamus, ventral tegmental area
mRNA, protein:increased expression:hippocampus, prefrontal cortex		 CTD
RGD		 PMID:11717377 PMID:27053349 PMID:29024786 PMID:19108758 PMID:19052216 More... RGD:401959748, RGD:401959607, RGD:401959375, RGD:401959374, RGD:401950487, RGD:401940184, RGD:401940182, RGD:401940145, RGD:401940122, RGD:401940121, RGD:401940119 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Drd2 dopamine receptor D2 IEP protein:decreased expression:hippocampus (rat) RGD PMID:18276072 RGD:2311587 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Fadd Fas associated via death domain severity IDA RGD PMID:21088039 RGD:11341805 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment IDA
IEP
IMP		 RGD PMID:27053349 PMID:12225868 PMID:10998122 RGD:401959748, RGD:405255651, RGD:405100721 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ameliorates IEP protein:increased expression:brain (rat)
associated with pregnancy complications; protein:increased expression:brain (rat)		 RGD PMID:23185589 PMID:33592274 RGD:401851068, RGD:401901281 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gad1 glutamate decarboxylase 1 IEP mRNA:increased expression:dentate gyrus granule cell layer RGD PMID:15673448 RGD:401900167 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 treatment
exacerbates		 ISO
IEP
IMP		 CTD Direct Evidence: marker/mechanism
protein:increased expression:shell of nucleus accumbens, cell surface (rat)
protein:decreased phosphorylation:caudate-putamen, nucleus accumbens (rat)
protein:altered expression:prefrontal cortex, membrane (rat)
rat gene in a mouse model
protein:increased phosphorylation:nucleus accumbens (rat)		 CTD
RGD		 PMID:11404432 PMID:25746394 PMID:34390773 PMID:15287884 PMID:31209728 More... RGD:11087075, RGD:405818276, RGD:405650198, RGD:405649863, RGD:405649739, RGD:405101690, RGD:405100728, RGD:405100238, RGD:405096668, RGD:401976466 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12878694 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B treatment ISO RGD PMID:35447543 RGD:405650692 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A ISO protein:increased expression:prefrontal cortex RGD PMID:28082900 RGD:401900741 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment ISO
IDA		 protein:increased phosphorylation:central amygdaloid nucleus RGD PMID:33609567 PMID:29024786 PMID:19052216 PMID:18772347 PMID:27461790 RGD:401940121, RGD:401959607, RGD:401959374, RGD:401950487, RGD:401940145 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment ISO
IDA		 protein:increased phosphorylation:central amygdaloid nucleus RGD PMID:33609567 PMID:29024786 PMID:19052216 PMID:18772347 PMID:27461790 RGD:401940121, RGD:401959607, RGD:401959374, RGD:401950487, RGD:401940145 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20519536 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 IEP protein:decreased expression, altered form:hippocampus (rat) RGD PMID:15673448 RGD:401900167 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Ngf nerve growth factor IEP mRNA,protein:increased expression:central amygdaloid nucleus RGD PMID:22871918 RGD:401965392 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17989510 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nps neuropeptide S IDA RGD PMID:23684726 RGD:9831198 NCBI chr 1:190,077,040...190,080,821
Ensembl chr 1:190,077,040...190,080,821 		JBrowse link
G Npsr1 neuropeptide S receptor 1 IEP RGD PMID:23684726 RGD:9831198 NCBI chr 8:22,606,946...22,831,558
Ensembl chr 8:22,606,946...22,831,558 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 treatment IMP RGD PMID:22304485 RGD:401965468 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11027224 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:3720824 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdyn prodynorphin treatment IEP RGD PMID:15976090 RGD:401850590 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Rack1 receptor for activated C kinase 1 ISO mRNA, protein:increased expression:hippocampus, prefrontal cortex RGD PMID:19341783 RGD:401940119 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18976
    Chemically-Induced Disorders 1394
      substance-related disorder 713
        Narcotic-Related Disorders 80
          opiate dependence 77
            heroin dependence 47
            morphine dependence 31
Path 2
Term Annotations click to browse term
  disease 18976
    disease of anatomical entity 18260
      nervous system disease 14116
        central nervous system disease 12429
          brain disease 11666
            disease of mental health 8318
              substance-related disorder 713
                substance dependence 149
                  drug dependence 97
                    opiate dependence 77
                      heroin dependence 47
                      morphine dependence 31
paths to the root