ONTOLOGY REPORT - ANNOTATIONS
Term: ciglitazone
Accession: CHEBI:64227
browse the term
Definition: An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.
Synonyms: exact_synonym: 5-{4-[(1-methylcyclohexyl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione
related_synonym: (+-)-5-(p-((1-Methylcyclohexyl)methoxy)benzyl)-2,4-thiazolidinedione; C18H23NO3S; CC1(CCCCC1)COc1ccc(CC2SC(=O)NC2=O)cc1; InChI=1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21); InChIKey=YZFWTZACSRHJQD-UHFFFAOYSA-N; ciglitazona; ciglitazonum
xref_casrn: 74772-77-3
xref: ChEMBL:101529 "ChEMBL COMPOUND"; ChemIDplus:74772-77-3 "CAS Registry Number"; CiteXplore:20596077 "PubMed citation"; CiteXplore:21067863 "PubMed citation"; CiteXplore:21344384 "PubMed citation"; CiteXplore:21354099 "PubMed citation"; CiteXplore:21485077 "PubMed citation"; CiteXplore:21508362 "PubMed citation"; CiteXplore:21681689 "PubMed citation"; CiteXplore:21882481 "PubMed citation"; CiteXplore:22007221 "PubMed citation"; CiteXplore:22131991 "PubMed citation"; CiteXplore:22174792 "PubMed citation"; CiteXplore:22177955 "PubMed citation"; CiteXplore:22192353 "PubMed citation"; CiteXplore:22193206 "PubMed citation"; CiteXplore:22268140 "PubMed citation"; KEGG DRUG:D03493 "KEGG DRUG"
xref_mesh: MESH:C039671
xref: Reaxys:3623680 "Reaxys Registry Number"; Wikipedia:Ciglitazone "Wikipedia"
ciglitazone
G
Abcb11
ATP-binding cassette, subfamily B (MDR/TAP), member 11
decreases activity
ISO
RGD:6480464
CTD
G
Abhd3
abhydrolase domain containing 3
multiple interactions
ISO
18
2,027,477
2,082,082
RGD:6480464
CTD
G
Acaa1a
acetyl-Coenzyme A acyltransferase 1A
multiple interactions
ISO
8
124,305,097
124,313,887
RGD:6480464
CTD
G
Acaa2
acetyl-CoA acyltransferase 2
multiple interactions
ISO
18
71,587,259
71,632,610
RGD:6480464
CTD
G
Acadm
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
multiple interactions
ISO
2
251,866,645
251,890,729
RGD:6480464
CTD
G
Acadvl
acyl-CoA dehydrogenase, very long chain
multiple interactions
ISO
10
56,856,233
56,861,380
RGD:6480464
CTD
G
Acsl1
acyl-CoA synthetase long-chain family member 1
multiple interactions
ISO
16
49,036,892
49,081,416
RGD:6480464
CTD
G
Acsm3
acyl-CoA synthetase medium-chain family member 3
multiple interactions
ISO
1
178,054,386
178,081,751
RGD:6480464
CTD
G
Agpat2
1-acylglycerol-3-phosphate O-acyltransferase 2
increases expression
ISO
3
4,769,863
4,781,045
RGD:6480464
CTD
G
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
decreases response to substance
EXP
19
54,738,556
54,750,349
RGD:6480464
CTD
G
Akap2
A kinase (PRKA) anchor protein 2
multiple interactions
ISO
5
75,814,965
75,855,492
RGD:6480464
CTD
G
Akr1c1
aldo-keto reductase family 1, member C1
multiple interactions
ISO
17
77,084,306
77,112,994
RGD:6480464
CTD
G
Akr1c2
aldo-keto reductase family 1, member C2
multiple interactions
ISO
17
77,034,737
77,081,406
RGD:6480464
CTD
G
Aldh1a1
aldehyde dehydrogenase 1 family, member A1
decreases expression
EXP
1
223,731,675
223,773,285
RGD:6480464
CTD
G
Ang
angiogenin, ribonuclease, RNase A family, 5
multiple interactions
ISO
15
27,083,089
27,083,526
RGD:6480464
CTD
G
Angptl4
angiopoietin-like 4
multiple interactions
ISO
7
16,261,623
16,267,852
RGD:6480464
CTD
G
Apom
apolipoprotein M
multiple interactions
ISO
20
3,754,604
3,757,204
RGD:6480464
CTD
G
Aqp1
aquaporin 1
decreases expression
EXP
4
84,098,346
84,110,524
RGD:6480464
CTD
G
Aqp3
aquaporin 3
multiple interactions
ISO
5
58,501,642
58,507,159
RGD:6480464
CTD
G
Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
multiple interactions
ISO
2
180,748,313
180,775,656
RGD:6480464
CTD
G
Atf7ip2
activating transcription factor 7 interacting protein 2
multiple interactions
ISO
10
5,356,438
5,399,673
RGD:6480464
CTD
G
Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
decreases expression
EXP
13
80,214,056
80,234,576
RGD:6480464
CTD
G
Atp1b3
ATPase, Na+/K+ transporting, beta 3 polypeptide
decreases expression
EXP
8
101,405,877
101,437,757
RGD:6480464
CTD
G
Bad
BCL2-associated agonist of cell death
increases expression
EXP
1
209,617,373
209,626,292
RGD:6480464
CTD
G
Bax
Bcl2-associated X protein
multiple interactions
ISO
1
95,933,023
95,938,176
RGD:6480464
CTD
G
Bax
Bcl2-associated X protein
increases expression
ISO
1
95,933,023
95,938,176
RGD:6480464
CTD
G
Bax
Bcl2-associated X protein
increases expression
EXP
1
95,933,023
95,938,176
RGD:6480464
CTD
G
Bax
Bcl2-associated X protein
affects response to substance
EXP
1
95,933,023
95,938,176
RGD:6480464
CTD
G
Bcl2
B-cell CLL/lymphoma 2
decreases expression
ISO
13
12,730,736
12,905,108
RGD:6480464
CTD
G
Bcl6
B-cell CLL/lymphoma 6
multiple interactions
ISO
11
79,006,123
79,030,555
RGD:6480464
CTD
G
Bdh1
3-hydroxybutyrate dehydrogenase, type 1
multiple interactions
ISO
11
71,130,561
71,165,695
RGD:6480464
CTD
G
Bhmt
betaine-homocysteine S-methyltransferase
multiple interactions
ISO
2
23,923,651
23,943,320
RGD:6480464
CTD
G
Bid
BH3 interacting domain death agonist
multiple interactions
ISO
4
157,296,383
157,318,481
RGD:6480464
CTD
G
Birc5
baculoviral IAP repeat-containing 5
decreases expression
ISO
RGD:6480464
CTD
G
Blvrb
biliverdin reductase B (flavin reductase (NADPH))
multiple interactions
ISO
1
82,528,943
82,546,606
RGD:6480464
CTD
G
Cadm1
cell adhesion molecule 1
decreases expression
EXP
8
50,765,645
51,108,962
RGD:6480464
CTD
G
Casp3
caspase 3
multiple interactions
ISO
16
48,944,226
48,962,420
RGD:6480464
CTD
G
Casp3
caspase 3
increases expression
ISO
16
48,944,226
48,962,420
RGD:6480464
CTD
G
Casp3
caspase 3
multiple interactions
ISO
16
48,944,226
48,962,420
RGD:6480464
CTD
G
Casp8
caspase 8
multiple interactions
ISO
9
57,389,353
57,437,803
RGD:6480464
CTD
G
Casp8
caspase 8
increases activity
ISO
9
57,389,353
57,437,803
RGD:6480464
CTD
G
Casp9
caspase 9, apoptosis-related cysteine peptidase
multiple interactions
ISO
5
160,704,234
160,721,796
RGD:6480464
CTD
G
Cat
catalase
multiple interactions
ISO
3
88,654,077
88,686,212
RGD:6480464
CTD
G
Ccl20
chemokine (C-C motif) ligand 20
multiple interactions
ISO
9
82,440,965
82,443,542
RGD:6480464
CTD
G
Ccl5
chemokine (C-C motif) ligand 5
multiple interactions
ISO
10
71,605,791
71,610,330
RGD:6480464
CTD
G
Ccna2
cyclin A2
decreases expression
ISO
2
123,062,752
123,069,085
RGD:6480464
CTD
G
Ccnd1
cyclin D1
decreases expression
ISO
1
205,357,235
205,366,757
RGD:6480464
CTD
G
Ccnd1
cyclin D1
decreases expression
ISO
1
205,357,235
205,366,757
RGD:6480464
CTD
G
Cdh1
cadherin 1
multiple interactions
ISO
19
36,442,693
36,512,091
RGD:6480464
CTD
G
Cdh1
cadherin 1
multiple interactions
ISO
19
36,442,693
36,512,091
RGD:6480464
CTD
G
Cdh1
cadherin 1
decreases expression
EXP
19
36,442,693
36,512,091
RGD:6480464
CTD
G
Cdk1
cyclin-dependent kinase 1
decreases expression
ISO
20
20,018,044
20,044,030
RGD:6480464
CTD
G
Cdk1
cyclin-dependent kinase 1
multiple interactions
ISO
20
20,018,044
20,044,030
RGD:6480464
CTD
G
Cdk4
cyclin-dependent kinase 4
decreases expression
ISO
RGD:6480464
CTD
G
Cdk4
cyclin-dependent kinase 4
multiple interactions
ISO
RGD:6480464
CTD
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
decreases expression
ISO
20
7,376,325
7,386,778
RGD:6480464
CTD
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
20
7,376,325
7,386,778
RGD:6480464
CTD
G
Cebpb
CCAAT/enhancer binding protein (C/EBP), beta
increases expression
EXP
3
158,826,021
158,827,848
RGD:6480464
CTD
G
Cebpd
CCAAT/enhancer binding protein (C/EBP), delta
multiple interactions
ISO
RGD:6480464
CTD
G
Chmp5
charged multivesicular body protein 5
multiple interactions
ISO
5
58,342,606
58,359,749
RGD:6480464
CTD
G
Cidec
cell death-inducing DFFA-like effector c
multiple interactions
ISO
4
149,307,986
149,321,303
RGD:6480464
CTD
G
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
multiple interactions
ISO
1
12,721,500
12,723,943
RGD:6480464
CTD
G
Cobll1
cordon-bleu WH2 repeat protein-like 1
multiple interactions
ISO
3
47,024,613
47,035,010
RGD:6480464
CTD
G
Col10a1
collagen, type X, alpha 1
multiple interactions
EXP
20
38,725,164
38,731,513
RGD:6480464
CTD
G
Col11a1
collagen, type XI, alpha 1
decreases expression
EXP
2
209,996,467
210,193,379
RGD:6480464
CTD
G
Col4a1
collagen, type IV, alpha 1
decreases expression
EXP
16
83,045,183
83,157,835
RGD:6480464
CTD
G
Col4a5
collagen, type IV, alpha 5
decreases expression
EXP
X
36,918,697
37,130,659
RGD:6480464
CTD
G
Col5a1
collagen, type V, alpha 1
decreases expression
EXP
3
6,826,169
6,971,054
RGD:6480464
CTD
G
Copa
coatomer protein complex subunit alpha
multiple interactions
ISO
13
88,076,522
88,117,020
RGD:6480464
CTD
G
Cp
ceruloplasmin (ferroxidase)
decreases expression
EXP
2
105,086,278
105,135,367
RGD:6480464
CTD
G
Cpm
carboxypeptidase M
decreases expression
EXP
7
56,931,920
56,992,248
RGD:6480464
CTD
G
Crebbp
CREB binding protein
multiple interactions
ISO
10
11,598,680
11,724,122
RGD:6480464
CTD
G
Crebbp
CREB binding protein
affects response to substance
ISO
10
11,598,680
11,724,122
RGD:6480464
CTD
G
Crebbp
CREB binding protein
multiple interactions
ISO
10
11,598,680
11,724,122
RGD:6480464
CTD
G
Cstb
cystatin B (stefin B)
multiple interactions
ISO
20
10,576,664
10,578,706
RGD:6480464
CTD
G
Ctsc
cathepsin C
multiple interactions
ISO
1
144,629,802
144,661,183
RGD:6480464
CTD
G
Cyb5r3
cytochrome b5 reductase 3
multiple interactions
ISO
7
121,187,821
121,205,382
RGD:6480464
CTD
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
8
61,439,062
61,447,861
RGD:6480464
CTD
G
Ddit3
DNA-damage inducible transcript 3
multiple interactions
ISO
7
67,247,749
67,252,571
RGD:6480464
CTD
G
Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
7
67,247,749
67,252,571
RGD:6480464
CTD
G
Dgat1
diacylglycerol O-acyltransferase 1
increases expression
ISO
7
114,552,051
114,562,423
RGD:6480464
CTD
G
Dkk1
dickkopf WNT signaling pathway inhibitor 1
multiple interactions
ISO
1
234,392,743
234,396,426
RGD:6480464
CTD
G
Dlc1
deleted in liver cancer 1
multiple interactions
ISO
16
59,312,930
59,355,129
RGD:6480464
CTD
G
Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
increases expression
EXP
5
59,437,972
59,446,618
RGD:6480464
CTD
G
Dok4
docking protein 4
multiple interactions
ISO
19
10,585,647
10,596,322
RGD:6480464
CTD
G
Dusp1
dual specificity phosphatase 1
increases expression
EXP
10
16,942,913
16,945,696
RGD:6480464
CTD
G
Efemp1
EGF-containing fibulin-like extracellular matrix protein 1
decreases expression
EXP
14
109,733,625
109,828,630
RGD:6480464
CTD
G
Efna1
ephrin A1
multiple interactions
ISO
2
181,444,599
181,451,944
RGD:6480464
CTD
G
Egfr
epidermal growth factor receptor
multiple interactions
ISO
14
97,617,358
97,788,211
RGD:6480464
CTD
G
Egfr
epidermal growth factor receptor
decreases expression
ISO
14
97,617,358
97,788,211
RGD:6480464
CTD
G
Eif2a
eukaryotic translation initiation factor 2A
increases phosphorylation
ISO
2
147,870,265
147,903,411
RGD:6480464
CTD
G
Eif2a
eukaryotic translation initiation factor 2A
multiple interactions
ISO
2
147,870,265
147,903,411
RGD:6480464
CTD
G
Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
multiple interactions
ISO
4
104,016,940
104,078,261
RGD:6480464
CTD
G
Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
increases phosphorylation
ISO
4
104,016,940
104,078,261
RGD:6480464
CTD
G
Elf5
E74-like factor 5
multiple interactions
ISO
3
88,691,632
88,720,167
RGD:6480464
CTD
G
Emp1
epithelial membrane protein 1
increases expression
EXP
4
172,315,122
172,335,536
RGD:6480464
CTD
G
Epas1
endothelial PAS domain protein 1
multiple interactions
ISO
6
10,203,108
10,297,215
RGD:6480464
CTD
G
Fabp1
fatty acid binding protein 1, liver
multiple interactions
ISO
4
104,412,200
104,415,981
RGD:6480464
CTD
G
Fabp4
fatty acid binding protein 4, adipocyte
increases expression
ISO
2
93,536,133
93,540,734
RGD:6480464
CTD
G
Fads1
fatty acid desaturase 1
multiple interactions
ISO
1
212,670,792
212,685,718
RGD:6480464
CTD
G
Fads1
fatty acid desaturase 1
increases expression
ISO
1
212,670,792
212,685,718
RGD:6480464
CTD
G
Fam115a
family with sequence similarity 115, member A
multiple interactions
ISO
4
70,522,590
70,544,374
RGD:6480464
CTD
G
Fam13a
family with sequence similarity 13, member A
multiple interactions
ISO
4
87,832,159
87,931,440
RGD:6480464
CTD
G
Flnb
filamin B, beta
multiple interactions
ISO
15
18,949,027
19,082,504
RGD:6480464
CTD
G
Flnc
filamin C, gamma
increases expression
EXP
4
56,313,707
56,341,400
RGD:6480464
CTD
G
Fos
FBJ osteosarcoma oncogene
decreases expression
ISO
6
109,559,135
109,562,001
RGD:6480464
CTD
G
Fos
FBJ osteosarcoma oncogene
increases expression
EXP
6
109,559,135
109,562,001
RGD:6480464
CTD
G
Foxo1
forkhead box O1
multiple interactions
ISO
2
141,127,345
141,203,446
RGD:6480464
CTD
G
Gadd45g
growth arrest and DNA-damage-inducible, gamma
increases expression
EXP
17
19,230,896
19,232,641
RGD:6480464
CTD
G
Galnt2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
multiple interactions
ISO
19
54,479,961
54,529,837
RGD:6480464
CTD
G
Gast
gastrin
multiple interactions
ISO
10
89,273,628
89,276,192
RGD:6480464
CTD
G
Gcn1l1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
multiple interactions
ISO
12
42,253,048
42,313,931
RGD:6480464
CTD
G
Gk
glycerol kinase
multiple interactions
ISO
X
72,416,872
72,493,296
RGD:6480464
CTD
G
Gpx3
glutathione peroxidase 3
multiple interactions
ISO
10
40,311,094
40,319,382
RGD:6480464
CTD
G
Gramd3
GRAM domain containing 3
multiple interactions
ISO
18
52,171,662
52,271,700
RGD:6480464
CTD
G
Gstm2
glutathione S-transferase mu 2
decreases expression
EXP
2
203,549,022
203,553,380
RGD:6480464
CTD
G
Gys2
glycogen synthase 2
increases expression
ISO
4
179,984,036
180,018,819
RGD:6480464
CTD
G
Hadha
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
multiple interactions
ISO
6
26,173,798
26,191,433
RGD:6480464
CTD
G
Hamp
hepcidin antimicrobial peptide
multiple interactions
ISO
1
85,978,120
85,980,059
RGD:6480464
CTD
G
Hif1a
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
decreases expression
EXP
6
96,419,024
96,463,891
RGD:6480464
CTD
G
Hmgcs2
3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
multiple interactions
ISO
2
193,128,736
193,143,106
RGD:6480464
CTD
G
Hmox1
heme oxygenase (decycling) 1
multiple interactions
ISO
19
13,963,139
13,969,960
RGD:6480464
CTD
G
Hpn
hepsin
multiple interactions
ISO
1
86,145,615
86,161,091
RGD:6480464
CTD
G
Icam1
intercellular adhesion molecule 1
decreases expression
ISO
8
20,040,177
20,051,939
RGD:6480464
CTD
G
Ier2
immediate early response 2
increases expression
EXP
19
25,159,276
25,160,800
RGD:6480464
CTD
G
Ifng
interferon gamma
multiple interactions
ISO
7
57,621,756
57,625,792
RGD:6480464
CTD
G
Ifng
interferon gamma
multiple interactions
ISO
7
57,621,756
57,625,792
RGD:6480464
CTD
G
Ifng
interferon gamma
decreases secretion
ISO
7
57,621,756
57,625,792
RGD:6480464
CTD
G
Il1b
interleukin 1 beta
multiple interactions
ISO
3
116,964,422
116,970,867
RGD:6480464
CTD
G
Il1b
interleukin 1 beta
increases expression
ISO
3
116,964,422
116,970,867
RGD:6480464
CTD
G
Il1b
interleukin 1 beta
multiple interactions
ISO
3
116,964,422
116,970,867
RGD:6480464
CTD
G
Il1r1
interleukin 1 receptor, type I
multiple interactions
ISO
9
39,434,910
39,473,552
RGD:6480464
CTD
G
Il2
interleukin 2
multiple interactions
ISO
2
123,655,005
123,659,709
RGD:6480464
CTD
G
Il6
interleukin 6
multiple interactions
ISO
4
456,799
461,376
RGD:6480464
CTD
G
Il6st
interleukin 6 signal transducer
multiple interactions
ISO
2
43,806,301
43,842,365
RGD:6480464
CTD
G
Irf1
interferon regulatory factor 1
multiple interactions
ISO
10
39,220,600
39,227,602
RGD:6480464
CTD
G
Itgb5
integrin, beta 5
multiple interactions
ISO
RGD:6480464
CTD
G
Itih3
inter-alpha trypsin inhibitor, heavy chain 3
multiple interactions
ISO
16
6,341,043
6,358,767
RGD:6480464
CTD
G
Jag1
jagged 1
multiple interactions
ISO
3
125,181,063
125,216,481
RGD:6480464
CTD
G
Jun
jun proto-oncogene
increases expression
EXP
5
115,358,166
115,361,259
RGD:6480464
CTD
G
Jun
jun proto-oncogene
multiple interactions
ISO
5
115,358,166
115,361,259
RGD:6480464
CTD
G
Klf4
Kruppel-like factor 4 (gut)
increases expression
EXP
5
73,446,928
73,451,286
RGD:6480464
CTD
G
Lama1
laminin, alpha 1
decreases expression
EXP
9
106,855,708
106,980,651
RGD:6480464
CTD
G
Lamb2
laminin, beta 2
decreases expression
EXP
RGD:6480464
CTD
G
Lgals3
lectin, galactoside-binding, soluble, 3
multiple interactions
ISO
15
23,327,071
23,339,006
RGD:6480464
CTD
G
Lif
leukemia inhibitory factor
multiple interactions
ISO
14
84,887,856
84,890,630
RGD:6480464
CTD
G
Lipc
lipase, hepatic
multiple interactions
ISO
8
75,323,442
75,450,353
RGD:6480464
CTD
G
Lmcd1
LIM and cysteine-rich domains 1
multiple interactions
ISO
4
148,071,431
148,130,313
RGD:6480464
CTD
G
Lox
lysyl oxidase
multiple interactions
ISO
18
47,896,674
47,970,829
RGD:6480464
CTD
G
Lpcat1
lysophosphatidylcholine acyltransferase 1
multiple interactions
ISO
1
30,573,254
30,624,147
RGD:6480464
CTD
G
Lpcat3
lysophosphatidylcholine acyltransferase 3
multiple interactions
ISO
4
160,786,349
160,827,556
RGD:6480464
CTD
G
Map4k3
mitogen-activated protein kinase kinase kinase kinase 3
multiple interactions
ISO
6
3,473,694
3,642,461
RGD:6480464
CTD
G
Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
11
85,968,732
86,030,387
RGD:6480464
CTD
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
11
85,968,732
86,030,387
RGD:6480464
CTD
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
11
85,968,732
86,030,387
RGD:6480464
CTD
G
Mapk14
mitogen activated protein kinase 14
multiple interactions
ISO
20
6,939,249
7,000,378
RGD:6480464
CTD
G
Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
1
185,935,044
185,941,245
RGD:6480464
CTD
G
Mapk3
mitogen activated protein kinase 3
decreases expression
ISO
1
185,935,044
185,941,245
RGD:6480464
CTD
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
1
185,935,044
185,941,245
RGD:6480464
CTD
G
Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
1
185,935,044
185,941,245
RGD:6480464
CTD
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
1
185,935,044
185,941,245
RGD:6480464
CTD
G
Mki67
antigen identified by monoclonal antibody Ki-67
multiple interactions
ISO
1
195,310,027
195,336,224
RGD:6480464
CTD
G
Mogat1
monoacylglycerol O-acyltransferase 1
increases expression
ISO
9
77,901,139
77,908,689
RGD:6480464
CTD
G
Mpc1
mitochondrial pyruvate carrier 1
multiple interactions
ISO
1
47,077,723
47,089,344
RGD:6480464
CTD
G
Mpzl2
myelin protein zero-like 2
multiple interactions
ISO
8
47,991,599
48,003,100
RGD:6480464
CTD
G
Mtmr4
myotubularin related protein 4
multiple interactions
ISO
10
75,883,526
75,906,440
RGD:6480464
CTD
G
Mxra8
matrix-remodelling associated 8
decreases expression
EXP
5
172,698,249
172,702,599
RGD:6480464
CTD
G
Myc
myelocytomatosis oncogene
multiple interactions
ISO
7
98,953,142
98,958,060
RGD:6480464
CTD
G
Myc
myelocytomatosis oncogene
decreases expression
ISO
7
98,953,142
98,958,060
RGD:6480464
CTD
G
Ncoa1
nuclear receptor coactivator 1
multiple interactions
ISO
6
27,224,396
27,473,926
RGD:6480464
CTD
G
Ncoa1
nuclear receptor coactivator 1
affects response to substance
ISO
6
27,224,396
27,473,926
RGD:6480464
CTD
G
Ncoa1
nuclear receptor coactivator 1
affects response to substance
ISO
6
27,224,396
27,473,926
RGD:6480464
CTD
G
Ndrg2
NDRG family member 2
multiple interactions
ISO
15
27,338,552
27,347,196
RGD:6480464
CTD
G
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
multiple interactions
ISO
2
233,091,013
233,187,501
RGD:6480464
CTD
G
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
decreases activity
ISO
2
233,091,013
233,187,501
RGD:6480464
CTD
G
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
decreases expression
ISO
6
75,729,302
75,732,475
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
multiple interactions
ISO
10
65,036,884
65,072,453
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
multiple interactions
ISO
10
65,036,884
65,072,453
RGD:6480464
CTD
G
Npc1
Niemann-Pick disease, type C1
multiple interactions
ISO
18
3,725,415
3,777,707
RGD:6480464
CTD
G
Nr1h3
nuclear receptor subfamily 1, group H, member 3
multiple interactions
ISO
3
75,542,211
75,550,793
RGD:6480464
CTD
G
Nr2f1
nuclear receptor subfamily 2, group F, member 1
multiple interactions
ISO
2
5,765,399
5,794,104
RGD:6480464
CTD
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
affects localization
ISO
18
32,371,496
32,459,145
RGD:6480464
CTD
G
Nrep
neuronal regeneration related protein
multiple interactions
ISO
18
25,842,127
25,868,219
RGD:6480464
CTD
G
Optn
optineurin
multiple interactions
ISO
17
84,298,122
84,348,330
RGD:6480464
CTD
G
Osmr
oncostatin M receptor
multiple interactions
ISO
2
56,080,700
56,121,463
RGD:6480464
CTD
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
13
96,309,670
96,341,486
RGD:6480464
CTD
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
13
96,309,670
96,341,486
RGD:6480464
CTD
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
13
96,309,670
96,341,486
RGD:6480464
CTD
G
Pck1
phosphoenolpyruvate carboxykinase 1 (soluble)
multiple interactions
ISO
3
164,012,410
164,018,359
RGD:6480464
CTD
G
Pdzk1
PDZ domain containing 1
multiple interactions
ISO
2
191,643,593
191,675,995
RGD:6480464
CTD
G
Phka2
phosphorylase kinase, alpha 2
multiple interactions
ISO
X
55,463,178
55,580,783
RGD:6480464
CTD
G
Phlpp1
PH domain and leucine rich repeat protein phosphatase 1
multiple interactions
ISO
13
12,315,824
12,565,692
RGD:6480464
CTD
G
Pim1
pim-1 oncogene
multiple interactions
ISO
20
7,817,403
7,821,800
RGD:6480464
CTD
G
Pla2g2a
phospholipase A2, group IIA (platelets, synovial fluid)
multiple interactions
ISO
5
157,654,786
157,657,360
RGD:6480464
CTD
G
Plac8
placenta-specific 8
multiple interactions
ISO
14
10,302,667
10,325,559
RGD:6480464
CTD
G
Plcxd1
phosphatidylinositol-specific phospholipase C, X domain containing 1
multiple interactions
ISO
12
46,726,350
46,729,517
RGD:6480464
CTD
G
Plin2
perilipin 2
multiple interactions
ISO
5
105,718,496
105,732,817
RGD:6480464
CTD
G
Plod2
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
decreases expression
EXP
8
97,525,279
97,623,152
RGD:6480464
CTD
G
Plscr4
phospholipid scramblase 4
multiple interactions
ISO
8
97,428,403
97,466,096
RGD:6480464
CTD
G
Pmm1
phosphomannomutase 1
multiple interactions
ISO
7
120,323,808
120,334,065
RGD:6480464
CTD
G
Pnrc1
proline-rich nuclear receptor coactivator 1
multiple interactions
ISO
5
49,544,328
49,547,367
RGD:6480464
CTD
G
Por
P450 (cytochrome) oxidoreductase
multiple interactions
ISO
12
22,078,629
22,097,301
RGD:6480464
CTD
G
Potef
POTE ankyrin domain family, member F
multiple interactions
ISO
18
24,420,779
24,422,284
RGD:6480464
CTD
G
Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
7
123,729,774
123,807,090
RGD:6480464
CTD
G
Ppara
peroxisome proliferator activated receptor alpha
increases expression
ISO
7
123,729,774
123,807,090
RGD:6480464
CTD
G
Ppara
peroxisome proliferator activated receptor alpha
decreases expression
ISO
7
123,729,774
123,807,090
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
increases activity
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
affects binding
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
increases activity
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
increases activity
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
EXP
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
increases activity
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
increases activity
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
increases activity
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
EXP
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
increases activity
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
increases localization
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
affects binding
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
decreases response to substance
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Ppargc1a
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
increases expression
ISO
14
64,278,115
64,370,912
RGD:6480464
CTD
G
Ppargc1a
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
multiple interactions
ISO
14
64,278,115
64,370,912
RGD:6480464
CTD
G
Prkcd
protein kinase C, delta
multiple interactions
ISO
16
5,954,218
5,975,743
RGD:6480464
CTD
G
Prodh
proline dehydrogenase (oxidase) 1
increases expression
ISO
11
84,905,060
84,922,229
RGD:6480464
CTD
G
Psd4
pleckstrin and Sec7 domain containing 4
multiple interactions
ISO
3
2,622,918
2,659,328
RGD:6480464
CTD
G
Ptger3
prostaglandin E receptor 3 (subtype EP3)
multiple interactions
ISO
2
255,680,691
255,759,202
RGD:6480464
CTD
G
Ptges
prostaglandin E synthase
multiple interactions
ISO
3
9,946,194
9,957,538
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
affects expression
ISO
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Pxdn
peroxidasin homolog (Drosophila)
decreases expression
EXP
6
47,878,710
47,914,112
RGD:6480464
CTD
G
Raf1
v-raf-leukemia viral oncogene 1
increases activity
ISO
4
151,752,583
151,775,609
RGD:6480464
CTD
G
Rarb
retinoic acid receptor, beta
multiple interactions
ISO
RGD:6480464
CTD
G
Rbms1
RNA binding motif, single stranded interacting protein 1
multiple interactions
ISO
3
42,438,537
42,663,729
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
decreases activity
ISO
1
208,262,669
208,273,148
RGD:6480464
CTD
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
ISO
1
208,262,669
208,273,148
RGD:6480464
CTD
G
Retsat
retinol saturase (all trans retinol 13,14 reductase)
multiple interactions
ISO
4
106,100,103
106,108,866
RGD:6480464
CTD
G
Rnase4
ribonuclease, RNase A family 4
multiple interactions
ISO
15
27,073,756
27,090,441
RGD:6480464
CTD
G
Rnf10
ring finger protein 10
multiple interactions
ISO
12
42,609,879
42,643,662
RGD:6480464
CTD
G
Rnf128
ring finger protein 128, E3 ubiquitin protein ligase
multiple interactions
ISO
X
127,309,082
127,367,165
RGD:6480464
CTD
G
Rps6kc1
ribosomal protein S6 kinase, polypeptide 1
multiple interactions
ISO
13
106,842,538
106,989,914
RGD:6480464
CTD
G
Sec23a
Sec23 homolog A (S. cerevisiae)
multiple interactions
ISO
6
79,660,575
79,706,898
RGD:6480464
CTD
G
Sema3g
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
multiple interactions
ISO
16
6,651,366
6,662,999
RGD:6480464
CTD
G
Serpine1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
multiple interactions
ISO
12
20,931,996
20,942,374
RGD:6480464
CTD
G
Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
decreases expression
EXP
5
106,295,254
106,537,714
RGD:6480464
CTD
G
Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
decreases expression
EXP
6
126,403,837
126,538,501
RGD:6480464
CTD
G
Slc30a10
solute carrier family 30, member 10
multiple interactions
ISO
13
101,474,867
101,492,180
RGD:6480464
CTD
G
Slc4a7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
multiple interactions
ISO
15
12,071,975
12,125,840
RGD:6480464
CTD
G
Slc50a1
solute carrier family 50 (sugar transporter), member 1
multiple interactions
ISO
2
181,440,905
181,443,285
RGD:6480464
CTD
G
Snrk
SNF related kinase
multiple interactions
ISO
8
121,958,351
121,968,989
RGD:6480464
CTD
G
Sod3
superoxide dismutase 3, extracellular
decreases expression
EXP
14
63,381,447
63,387,180
RGD:6480464
CTD
G
Sorl1
sortilin-related receptor, LDLR class A repeats-containing
multiple interactions
ISO
8
44,962,730
45,101,843
RGD:6480464
CTD
G
Sqstm1
sequestosome 1
multiple interactions
ISO
10
35,751,300
35,762,630
RGD:6480464
CTD
G
Srxn1
sulfiredoxin 1
increases expression
EXP
3
142,457,352
142,462,725
RGD:6480464
CTD
G
Stat3
signal transducer and activator of transcription 3 (acute-phase response factor)
multiple interactions
ISO
10
89,821,078
89,872,970
RGD:6480464
CTD
G
Stbd1
starch binding domain 1
multiple interactions
ISO
14
17,031,752
17,035,157
RGD:6480464
CTD
G
Stx7
syntaxin 7
multiple interactions
ISO
1
21,721,897
21,762,024
RGD:6480464
CTD
G
Sun2
Sad1 and UNC84 domain containing 2
multiple interactions
ISO
7
117,962,517
117,978,876
RGD:6480464
CTD
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
1
80,894,705
80,911,020
RGD:6480464
CTD
G
Tgif1
TGFB-induced factor homeobox 1
multiple interactions
ISO
9
110,043,164
110,052,783
RGD:6480464
CTD
G
Thra
thyroid hormone receptor alpha
decreases activity
EXP
10
87,514,443
87,542,306
RGD:6480464
CTD
G
Timp3
TIMP metallopeptidase inhibitor 3
multiple interactions
ISO
7
19,677,144
19,727,072
RGD:6480464
CTD
G
Tmbim1
transmembrane BAX inhibitor motif containing 1
multiple interactions
ISO
9
73,614,825
73,632,005
RGD:6480464
CTD
G
Tmem53
transmembrane protein 53
multiple interactions
ISO
5
137,559,894
137,575,740
RGD:6480464
CTD
G
Tnfrsf12a
tumor necrosis factor receptor superfamily, member 12a
increases expression
EXP
10
12,940,334
12,942,343
RGD:6480464
CTD
G
Tpm3
tropomyosin 3
increases expression
EXP
2
182,303,994
182,324,994
RGD:6480464
CTD
G
Traf3ip2
Traf3 interacting protein 2
multiple interactions
ISO
20
43,747,622
43,792,255
RGD:6480464
CTD
G
Trib3
tribbles homolog 3 (Drosophila)
increases expression
EXP
3
142,664,641
142,670,135
RGD:6480464
CTD
G
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
decreases expression
ISO
1
157,925,514
157,928,222
RGD:6480464
CTD
G
Ucp3
uncoupling protein 3 (mitochondrial, proton carrier)
decreases expression
ISO
1
157,896,001
157,909,608
RGD:6480464
CTD
G
Ugt1a6
UDP glucuronosyltransferase 1 family, polypeptide A6
multiple interactions
ISO
9
87,037,154
87,098,362
RGD:6480464
CTD
G
Ugt1a8
UDP glycosyltransferase 1 family, polypeptide A8
multiple interactions
ISO
9
87,017,029
87,098,362
RGD:6480464
CTD
G
Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
multiple interactions
ISO
9
86,986,915
87,098,362
RGD:6480464
CTD
G
Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
9
10,520,730
10,536,071
RGD:6480464
CTD
G
Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
9
10,520,730
10,536,071
RGD:6480464
CTD
G
Vegfa
vascular endothelial growth factor A
increases expression
ISO
9
10,520,730
10,536,071
RGD:6480464
CTD
G
Vnn1
vanin 1
multiple interactions
ISO
1
22,087,290
22,097,592
RGD:6480464
CTD
G
Xiap
X-linked inhibitor of apoptosis
decreases expression
ISO
X
3,011,520
3,047,798
RGD:6480464
CTD
G
Zfp185
zinc finger protein 185
multiple interactions
ISO
X
158,990,740
159,024,426
RGD:6480464
CTD
Term paths to the root one longest all shortest one shortest all one shortest and longest all longest