The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
1,2-naphthoquinone promotes the reaction [AHR protein binds to ARNT protein]; 1,2-naphthoquinone promotes the reaction [AHR protein binds to CYP1A1 enhancer]; AHR protein affects the reaction [1,2-naphthoquinone results in increased expression of CYP1A1 mRNA] 1,2-naphthoquinone results in increased expression of and affects the localization of AHR protein 1,2-naphthoquinone affects the localization of AHR protein
CAT protein inhibits the reaction [1,2-naphthoquinone results in increased expression of CXCL8 mRNA]; CAT protein inhibits the reaction [1,2-naphthoquinone results in increased expression of PTGS2 mRNA]; CAT protein promotes the reaction [1,2-naphthoquinone results in increased expression of HMOX1 mRNA]
1,2-naphthoquinone promotes the reaction [AHR protein binds to CYP1A1 enhancer]; 1,2-naphthoquinone promotes the reaction [POLR2A protein binds to CYP1A1 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [1,2-naphthoquinone results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [1,2-naphthoquinone results in increased expression of CYP1A1 mRNA]
DCXR protein results in increased metabolism of 1,2-naphthoquinone 1,2-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]
1,2-naphthoquinone results in increased phosphorylation of and results in increased activity of EGFR protein; 1,4-naphthoquinone promotes the reaction [1,2-naphthoquinone results in increased phosphorylation of EGFR protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [1,4-naphthoquinone promotes the reaction [1,2-naphthoquinone results in increased phosphorylation of EGFR protein]]
1,2-naphthoquinone results in decreased activity of GAPDH protein 1,2-naphthoquinone binds to GAPDH protein [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone binds to GAPDH protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone results in decreased activity of GAPDH protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [1,2-naphthoquinone results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [1,2-naphthoquinone results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[1,2-naphthoquinone co-treated with 1,4-naphthoquinone] results in increased phosphorylation of MAPK1 protein]; [1,2-naphthoquinone co-treated with 1,4-naphthoquinone] results in increased phosphorylation of MAPK1 protein
1,2-naphthoquinone results in increased phosphorylation of MAPK3 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [1,2-naphthoquinone results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [1,2-naphthoquinone results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[1,2-naphthoquinone co-treated with 1,4-naphthoquinone] results in increased phosphorylation of MAPK3 protein]; [1,2-naphthoquinone co-treated with 1,4-naphthoquinone] results in increased phosphorylation of MAPK3 protein
NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to 1,2-naphthoquinone] 1,2-naphthoquinone results in increased expression of NFE2L2 mRNA 1,2-naphthoquinone results in increased activity of NFE2L2 protein [NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to 1,2-naphthoquinone; NFE2L2 protein affects the susceptibility to 1,2-naphthoquinone
1,2-naphthoquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
1,2-naphthoquinone inhibits the reaction [[lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]
1,2-naphthoquinone results in increased expression of PTGS2 mRNA CAT protein inhibits the reaction [1,2-naphthoquinone results in increased expression of PTGS2 mRNA]
1,2-naphthoquinone results in decreased activity of PTPN1 protein 1,2-naphthoquinone promotes the reaction [1,4-naphthoquinone results in increased metabolism of and results in decreased activity of PTPN1 protein]
1,2-naphthoquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased localization of and results in increased activity of RELA protein]
[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR1 mRNA; Capsaicin inhibits the reaction [[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR1 mRNA]
[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR2 mRNA; Capsaicin inhibits the reaction [[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR2 mRNA]
[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TRPV1 mRNA; Capsaicin inhibits the reaction [[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TRPV1 mRNA]
1,2-naphthoquinone results in increased metabolism of and results in decreased activity of UCHL1 protein; Glutathione inhibits the reaction [1,2-naphthoquinone results in increased metabolism of and results in decreased activity of UCHL1 protein]
[acenaphthenequinone results in increased chemical synthesis of Reactive Oxygen Species] which affects the expression of PTGS2 protein; Acetylcysteine inhibits the reaction [acenaphthenequinone results in increased expression of PTGS2 protein]; BAY 11-7085 inhibits the reaction [acenaphthenequinone results in increased expression of PTGS2 protein]
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [acenaphthenequinone results in increased expression of RELA protein]; acenaphthenequinone affects the localization of and results in increased expression of RELA protein; Acetylcysteine inhibits the reaction [acenaphthenequinone results in increased expression of RELA protein]
benzo(a)pyrene-7,8-dione affects the localization of AHR protein AHR protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA]
AKR1A1 protein results in increased chemical synthesis of benzo(a)pyrene-7,8-dione [AKR1A1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione; AKR1A1 protein results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione; NAD promotes the reaction [AKR1A1 protein affects the chemical synthesis of benzo(a)pyrene-7,8-dione] benzo(a)pyrene-7,8-dione results in increased expression of AKR1A1 mRNA
[AKR1C1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione benzo(a)pyrene-7,8-dione results in increased expression of AKR1C1 mRNA
[[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in decreased abundance of Oxygen; [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in increased chemical synthesis of Hydrogen Peroxide; [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in increased chemical synthesis of Superoxides; [AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione
AHR protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA]; ARNT protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA]
benzo(a)pyrene-7,8-dione results in increased expression of and results in increased activity of CYP1B1 protein benzo(a)pyrene-7,8-dione results in increased expression of CYP1B1 mRNA
alpha-Tocopherol inhibits the reaction [benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein]; Ascorbic Acid inhibits the reaction [benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein] benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 mRNA; benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein
benzo(a)pyrene-7,8-dione results in increased expression of NQO1 mRNA; benzo(a)pyrene-7,8-dione results in increased expression of NQO1 protein [NQO1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione
beta-lapachone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]
beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] beta-lapachone inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]
[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome; Quercetin analog inhibits the reaction [[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome]
[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome; Quercetin analog inhibits the reaction [[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome]
PQQ Cofactor inhibits the reaction [Rotenone affects the expression of BAX protein]; PQQ Cofactor inhibits the reaction [Rotenone results in increased expression of BAX protein] PQQ Cofactor analog results in increased expression of BAX mRNA; PQQ Cofactor results in increased expression of BAX mRNA
PQQ Cofactor inhibits the reaction [Rotenone affects the expression of BCL2 protein]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of BCL2 protein] PQQ Cofactor analog results in decreased expression of BCL2 mRNA; PQQ Cofactor results in decreased expression of BCL2 mRNA
PQQ Cofactor inhibits the reaction [Rotenone results in increased activity of CASP3 protein] PQQ Cofactor analog results in increased cleavage of CASP3 protein; PQQ Cofactor results in increased cleavage of CASP3 protein PQQ Cofactor inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]
PQQ Cofactor inhibits the reaction [Rotenone affects the localization of DNM1L protein]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of DNM1L mRNA]
PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of MFN2 mRNA] PQQ Cofactor inhibits the reaction [Rotenone affects the localization of MFN2 protein]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of MFN2 mRNA]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of NDUFS1 mRNA]]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of NDUFS1 mRNA] NDUFS1 mRNA results in increased susceptibility to PQQ Cofactor
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of NDUFS4 mRNA]]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of NDUFS4 mRNA] NDUFS4 mRNA results in increased susceptibility to PQQ Cofactor
PQQ Cofactor analog results in decreased expression of and results in increased cleavage of PARP1 protein; PQQ Cofactor results in decreased expression of and results in increased cleavage of PARP1 protein
PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of PPARGC1A mRNA]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of PPARGC1A protein]; PQQ Cofactor promotes the reaction [Rotenone results in increased expression of PPARGC1A mRNA] PQQ Cofactor results in increased expression of PPARGC1A mRNA
PQQ Cofactor results in increased expression of TFAM mRNA PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of TFAM protein] PQQ Cofactor results in decreased expression of TFAM mRNA
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