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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3,5-diethoxycarbonyl-1,4-dihydrocollidine
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Accession:CHEBI:83605 term browser browse the term
Definition:A dihydropyridine that is 2,4,6-trimethyl-1,4-dihydropyridine substituted by ethoxycarbonyl groups at positions 3 and 5.
Synonyms:exact_synonym: diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate
 related_synonym: 3,5-bis(ethoxycarbonyl)-1,4-dihydrocollidine;   DDC;   Formula=C14H21NO4;   InChI=1S/C14H21NO4/c1-6-18-13(16)11-8(3)12(14(17)19-7-2)10(5)15-9(11)4/h8,15H,6-7H2,1-5H3;   InChIKey=CDVAIHNNWWJFJW-UHFFFAOYSA-N;   SMILES=CCOC(=O)C1=C(C)NC(C)=C(C1C)C(=O)OCC;   dicarbethoxydihydrocollidine
 alt_id: MESH:C530773
 xref: CAS:632-93-9
 xref_mesh: MESH:D003997
 xref: PMID:21843714;   Reaxys:227619


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3,5-diethoxycarbonyl-1,4-dihydrocollidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of ABCB1A mRNA CTD PMID:8707270 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of ABCB4 mRNA CTD PMID:8707270 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Acads acyl-CoA dehydrogenase short chain decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of ACADS mRNA CTD PMID:20512997 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of ACTA2 protein] CTD PMID:37544346 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Afp alpha-fetoprotein increases expression
multiple interactions		 ISO Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA]		 CTD PMID:18098314 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Alb albumin increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of ALB protein CTD PMID:17585168 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression		 ISO fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CASP1 protein] CTD PMID:37544346 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Cd44 CD44 molecule increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CD44 mRNA
SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CD44 mRNA]		 CTD PMID:27052460 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of CPT2 mRNA CTD PMID:20512997 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of CSF2 protein CTD PMID:30825315 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases response to substance
decreases expression		 ISO CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine affects the localization of FOXO3 protein]; CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SGK1 protein]
CTNNB1 protein results in decreased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine
3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of CTNNB1 protein		 CTD PMID:23620592 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CYP2B10 mRNA CTD PMID:21826054 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of DNMT1 mRNA CTD PMID:18098314 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha increases expression
multiple interactions		 ISO Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA]		 CTD PMID:18098314 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EEF2 mRNA CTD PMID:20512997 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Epcam epithelial cell adhesion molecule increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein
GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein]		 CTD PMID:21826054 PMID:27052460 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127 		JBrowse link
G Fabp3 fatty acid binding protein 3 decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of FABP3 mRNA CTD PMID:20512997 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
affects localization		 ISO CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine affects the localization of FOXO3 protein] CTD PMID:23620592 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GJA1 mRNA
SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GJA1 mRNA]		 CTD PMID:27052460 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GOT1 protein
cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GOT1 protein]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GOT1 protein]		 CTD PMID:38104874 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GPT protein
cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GPT protein]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GPT protein]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GPT protein]		 CTD PMID:37544346 PMID:38104874 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased phosphorylation of and results in decreased activity of GSK3B protein CTD PMID:20512997 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression
multiple interactions		 ISO Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA]		 CTD PMID:18098314 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Hdac7 histone deacetylase 7 increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of HDAC7 mRNA CTD PMID:18098314 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Hdac9 histone deacetylase 9 increases expression
multiple interactions		 ISO Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA]		 CTD PMID:18098314 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A protein
cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A protein]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A mRNA]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A protein]		 CTD PMID:38104874 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IFNG protein CTD PMID:30825315 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12A protein CTD PMID:30825315 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12B protein CTD PMID:30825315 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il17a interleukin 17A multiple interactions
increases expression		 ISO NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL17A protein] CTD PMID:30825315 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion		 ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL1B protein; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of IL1B protein]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B mRNA]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B protein]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B mRNA]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of IL1B protein]
3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B protein		 CTD PMID:30825315 PMID:37544346 PMID:38104874 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions
increases expression		 ISO NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1RN mRNA] CTD PMID:30825315 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il3 interleukin 3 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL3 protein CTD PMID:30825315 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL5 protein CTD PMID:30825315 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
increases secretion		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein
cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of IL6 protein]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 mRNA]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of IL6 protein]		 CTD PMID:27052460 PMID:37544346 PMID:38104874 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST protein
SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST protein]		 CTD PMID:27052460 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP [3,5-diethoxycarbonyl-1,4-dihydrocollidine co-treated with Allylisopropylacetamide] results in increased expression of INS1 protein CTD PMID:21889565 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Kat2b lysine acetyltransferase 2B decreases expression ISO Dicarbethoxydihydrocollidine results in decreased expression of KAT2B mRNA CTD PMID:18098314 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects response to substance
multiple interactions
decreases response to substance		 ISO KEAP1 gene affects the susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine
KEAP1 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]
KEAP1 gene mutant form results in decreased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine		 CTD PMID:30215777 PMID:30825315 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions
increases expression		 ISO SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KIT mRNA] CTD PMID:27052460 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Klf6 KLF transcription factor 6 increases expression
multiple interactions		 ISO Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA]		 CTD PMID:18098314 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570 		JBrowse link
G Krt18 keratin 18 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT18 mRNA CTD PMID:10751352 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Krt19 keratin 19 increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein; Dicarbethoxydihydrocollidine results in increased expression of KRT19 protein
GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein]; KEAP1 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein]		 CTD PMID:17585168 PMID:27052460 PMID:30825315 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt8 keratin 8 increases expression
decreases response to substance		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT8 mRNA
KRT8 protein results in decreased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine		 CTD PMID:10751352 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728 		JBrowse link
G Lep leptin decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of LEP protein CTD PMID:20512997 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mapt microtubule-associated protein tau increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MAPT mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MAPT mRNA alternative form; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MAPT protein CTD PMID:10051481 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mat2a methionine adenosyltransferase 2A increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of MAT2A mRNA CTD PMID:18098314 NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions
increases expression		 ISO fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MYD88 mRNA]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MYD88 protein]
3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MYD88 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MYD88 protein		 CTD PMID:37544346 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Myh7 myosin heavy chain 7 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MYH7 mRNA CTD PMID:20512997 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases response to substance		 ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of CSF2 protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IFNG protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12A protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12B protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL1B protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL3 protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL5 protein; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL17A protein]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1RN mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA] CTD PMID:30825315 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression		 ISO fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NFKB1 mRNA] CTD PMID:37544346 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NFKB2 mRNA
fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NFKB2 mRNA]		 CTD PMID:37544346 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NLRP3 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NLRP3 protein
fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NLRP3 mRNA]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NLRP3 protein]		 CTD PMID:37544346 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nppb natriuretic peptide B increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NPPB mRNA CTD PMID:20512997 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
affects response to substance		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased activity of and affects the localization of NR1I3 protein
NR1I3 protein affects the susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine		 CTD PMID:21826054 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions
increases expression		 ISO GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PKM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PKM protein] CTD PMID:27052460 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Prom1 prominin 1 increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of PROM1 protein CTD PMID:17585168 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527 		JBrowse link
G Pycard PYD and CARD domain containing increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PYCARD protein
fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PYCARD protein]		 CTD PMID:37544346 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation		 ISO fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased phosphorylation of RELA protein] CTD PMID:37544346 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SGK1 protein
CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SGK1 protein]		 CTD PMID:23620592 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Sirt3 sirtuin 3 decreases expression ISO Dicarbethoxydihydrocollidine results in decreased expression of SIRT3 mRNA CTD PMID:18098314 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SLC2A1 mRNA CTD PMID:20512997 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SLC2A4 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SLC2A4 protein CTD PMID:20512997 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases expression		 ISO cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 protein]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 mRNA]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 protein]
3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 protein		 CTD PMID:38104874 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sult2b1 sulfotransferase family 2B member 1 increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SULT2B1 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SULT2B1 protein
SULT2B1 protein inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased abundance of 22-hydroxycholesterol]; SULT2B1 protein inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased abundance of 24,25-epoxycholesterol]; SULT2B1 protein inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased abundance of 25-hydroxycholesterol]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CD44 mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GJA1 mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KIT mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PKM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of THY1 mRNA]		 CTD PMID:27052460 NCBI chr 1:96,200,155...96,261,295
Ensembl chr 1:96,200,156...96,261,295 		JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TACSTD2 mRNA CTD PMID:21826054 NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650 		JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions
increases expression		 ISO SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of THY1 mRNA] CTD PMID:27052460 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TLR4 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TLR4 protein
fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TLR4 mRNA]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TLR4 protein]		 CTD PMID:37544346 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion		 ISO cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF protein]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of TNF protein]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF protein]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of TNF protein]
3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF protein		 CTD PMID:30825315 PMID:37544346 PMID:38104874 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ubd ubiquitin D increases expression
multiple interactions		 ISO Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA]		 CTD PMID:18098314 NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639 		JBrowse link
G Ucp3 uncoupling protein 3 decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of UCP3 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of UCP3 protein CTD PMID:20512997 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        aetiopathogenetic role 19166
          hepatotoxic agent 16269
            hepatic steatosis inducing agent 2495
              3,5-diethoxycarbonyl-1,4-dihydrocollidine 71
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      chalcogen 19513
                        oxygen atom 19488
                          oxygen molecular entity 19488
                            hydroxides 19299
                              organic hydroxy compound 18923
                                alcohol 15686
                                  primary alcohol 14647
                                    ethanols 8804
                                      ethanol 8804
                                        ethyl ester 4135
                                          3,5-diethoxycarbonyl-1,4-dihydrocollidine 71
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