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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:D-penicillamine
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Accession:CHEBI:7959 term browser browse the term
Definition:An optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning.
Synonyms:exact_synonym: (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid;   3-sulfanyl-D-valine
 related_synonym: (S)-2-amino-3-mercapto-3-methylbutanoic acid;   (S)-3,3-dimethylcysteine;   3-mercapto-D-valine;   Cuprimine;   D-Penamine;   D-beta,beta-dimethylcysteine;   Depen;   Formula=C5H11NO2S;   InChI=1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1;   InChIKey=VVNCNSJFMMFHPL-VKHMYHEASA-N;   PA;   SMILES=CC(C)(S)[C@@H](N)C(O)=O;   penicilamina;   penicillamine;   penicillaminum
 alt_id: CHEBI:469179
 xref: Beilstein:1722375;   CAS:52-67-5;   DrugBank:DB00859;   Drug_Central:2081;   HMDB:HMDB0014997;   KEGG:C07418;   KEGG:D00496
 xref_mesh: MESH:D010396
 xref: PDBeChem:LEI;   PMID:10408968;   PMID:13793949;   PMID:16736232;   PMID:1709917;   PMID:18570451;   PMID:19904729;   PMID:21989991;   PMID:22076732;   PMID:22151785;   PMID:22169274;   PMID:22683336;   PMID:23200399;   PMID:23342748;   PMID:23375251;   PMID:2420897;   PMID:7196231;   Reaxys:1722375;   Wikipedia:Penicillamine
 cyclic_relationship: is_enantiomer_of CHEBI:50869


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D-penicillamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 increases expression ISO Penicillamine results in increased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Ahcy adenosylhomocysteinase increases activity
multiple interactions		 ISO Penicillamine results in increased activity of AHCY protein
Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of AHCY protein]		 CTD PMID:22945834 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type increases expression
decreases expression		 EXP Penicillamine results in increased expression of ALOX12 mRNA
Penicillamine results in decreased expression of ALOX12 mRNA		 CTD PMID:19575532 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression EXP Penicillamine results in increased expression of ALOX5AP mRNA CTD PMID:19575532 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Anxa1 annexin A1 decreases expression
increases expression		 EXP Penicillamine results in decreased expression of ANXA1 mRNA
Penicillamine results in increased expression of ANXA1 mRNA		 CTD PMID:19575532 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Anxa4 annexin A4 increases expression
decreases expression		 EXP Penicillamine results in increased expression of ANXA4 mRNA
Penicillamine results in decreased expression of ANXA4 mRNA		 CTD PMID:19575532 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161 		JBrowse link
G App amyloid beta precursor protein multiple interactions
increases metabolic processing		 ISO Penicillamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Penicillamine inhibits the reaction [APP protein results in increased activity of CASP3 protein]
Penicillamine results in increased metabolism of APP protein		 CTD PMID:10940226 PMID:12963085 PMID:17964426 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Penicillamine results in increased metabolism of and results in increased activity of ATF6 protein CTD PMID:19722195 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein] CTD PMID:21242307 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO [Penicillamine co-treated with ATP7B gene mutant form] results in decreased activity of CAT protein; [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein]; Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Copper]; Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Glutathione]; Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased expression of CP protein]
Penicillamine inhibits the reaction [ATP7B protein mutant form results in increased abundance of Copper]; Penicillamine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of AHCY protein]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of CPT1A protein]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of DNMT3B mRNA]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of HSPA5 protein]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of PPARA mRNA]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of SREBF1 mRNA]		 CTD PMID:21242307 PMID:22945834 PMID:24368744 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636 		JBrowse link
G Bbc3 Bcl-2 binding component 3 decreases expression ISO Penicillamine results in decreased expression of BBC3 protein CTD PMID:22843330 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Penicillamine results in decreased expression of BCL2 mRNA; Penicillamine results in decreased expression of BCL2 protein CTD PMID:22843330 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions EXP andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]]; Penicillamine inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]] CTD PMID:20946909 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G C1s complement C1s multiple interactions ISO Penicillamine inhibits the reaction [C4A protein binds to C1S protein]; Penicillamine inhibits the reaction [C4B protein binds to C1S protein] CTD PMID:8435078 NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303 		JBrowse link
G C3 complement C3 increases expression EXP Penicillamine results in increased expression of C3 mRNA CTD PMID:19575532 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C4a complement C4A multiple interactions ISO Penicillamine inhibits the reaction [C4A protein binds to C1S protein] CTD PMID:8435078 NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080 		JBrowse link
G C4b complement C4B multiple interactions ISO Penicillamine inhibits the reaction [C4B protein binds to C1S protein] CTD PMID:8435078 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 EXP
ISO		 andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]; Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]
Penicillamine inhibits the reaction [APP protein results in increased activity of CASP3 protein]
Penicillamine results in increased cleavage of CASP3 protein		 CTD PMID:12963085 PMID:19722195 PMID:20946909 PMID:22843330 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]; Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]] CTD PMID:20946909 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression
multiple interactions		 ISO Penicillamine results in decreased expression of CAT mRNA
[Penicillamine co-treated with ATP7B gene mutant form] results in decreased activity of CAT protein		 CTD PMID:22843330 PMID:24368744 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Penicillamine results in increased expression of CCL3 mRNA CTD PMID:22843330 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO
EXP		 Penicillamine results in increased expression of CCL4 mRNA CTD PMID:19575532 PMID:22843330 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression EXP Penicillamine results in increased expression of CCL5 mRNA CTD PMID:19575532 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression
decreases expression		 EXP Penicillamine results in increased expression of CCR5 mRNA
Penicillamine results in decreased expression of CCR5 mRNA		 CTD PMID:19575532 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd14 CD14 molecule decreases expression
increases expression		 EXP Penicillamine results in decreased expression of CD14 mRNA
Penicillamine results in increased expression of CD14 mRNA		 CTD PMID:19575532 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd163 CD163 molecule decreases expression
increases expression		 EXP Penicillamine results in decreased expression of CD163 mRNA
Penicillamine results in increased expression of CD163 mRNA		 CTD PMID:19575532 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878 		JBrowse link
G Cd38 CD38 molecule increases expression EXP Penicillamine results in increased expression of CD38 mRNA CTD PMID:19575532 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cd52 CD52 molecule decreases expression EXP Penicillamine results in decreased expression of CD52 mRNA CTD PMID:19575532 NCBI chr 5:146,319,789...146,321,348
Ensembl chr 5:146,319,969...146,321,348 		JBrowse link
G Clu clusterin multiple interactions ISO [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]; [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein] CTD PMID:21242307 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cp ceruloplasmin decreases expression
multiple interactions		 ISO Penicillamine results in decreased expression of CP protein
Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased expression of CP protein]		 CTD PMID:24013775 PMID:24368744 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
multiple interactions		 EXP
ISO		 Penicillamine results in decreased expression of CPT1A mRNA
Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of CPT1A protein]		 CTD PMID:19575532 PMID:22945834 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Crp C-reactive protein decreases expression ISO Penicillamine results in decreased expression of CRP protein CTD PMID:241598 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Csf2 colony stimulating factor 2 increases expression EXP Penicillamine results in increased expression of CSF2 mRNA CTD PMID:19575532 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression
decreases expression		 EXP Penicillamine results in increased expression of CXCR4 mRNA
Penicillamine results in decreased expression of CXCR4 mRNA		 CTD PMID:19575532 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Penicillamine results in increased expression of CYP1A1 mRNA CTD PMID:22843330 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO Penicillamine results in increased expression of CYP2E1 mRNA CTD PMID:22843330 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Penicillamine results in increased expression of DDIT3 mRNA; Penicillamine results in increased expression of DDIT3 protein CTD PMID:19722195 PMID:22843330 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression ISO Penicillamine results in decreased expression of DNMT3A mRNA CTD PMID:22945834 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of DNMT3B mRNA] CTD PMID:22945834 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression EXP Penicillamine results in decreased expression of DUSP1 mRNA CTD PMID:19575532 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression EXP Penicillamine results in increased expression of DUSP6 mRNA CTD PMID:19575532 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Egr1 early growth response 1 increases expression EXP
ISO		 Penicillamine results in increased expression of EGR1 mRNA CTD PMID:19575532 PMID:22843330 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Penicillamine results in increased phosphorylation of and results in increased activity of EIF2AK3 protein CTD PMID:22843330 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Penicillamine results in increased phosphorylation of EIF2S1 protein CTD PMID:22843330 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Eln elastin affects localization ISO Penicillamine affects the localization of ELN protein CTD PMID:3954958 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928 		JBrowse link
G Fcnb ficolin B increases expression EXP Penicillamine results in increased expression of FCNB mRNA CTD PMID:19575532 NCBI chr 3:11,393,713...11,402,198
Ensembl chr 3:11,393,739...11,402,151 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases expression ISO Penicillamine results in increased expression of FMO1 mRNA CTD PMID:22843330 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 increases expression ISO Penicillamine results in increased expression of FMO5 mRNA CTD PMID:22843330 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693 		JBrowse link
G Fn1 fibronectin 1 increases expression EXP Penicillamine results in increased expression of FN1 mRNA CTD PMID:19575532 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Penicillamine results in increased expression of GADD45A mRNA CTD PMID:22843330 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gatm glycine amidinotransferase increases expression EXP Penicillamine results in increased expression of GATM mRNA CTD PMID:19575532 NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO Penicillamine results in increased expression of GSTM3 mRNA CTD PMID:22843330 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
increases expression		 ISO [Penicillamine co-treated with bathocuproine sulfonate] results in increased expression of HMOX1 protein
Penicillamine analog results in decreased expression of HMOX1 protein
Penicillamine results in increased expression of HMOX1 mRNA		 CTD PMID:19323979 PMID:21242307 PMID:22843330 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hp haptoglobin decreases expression ISO Penicillamine results in decreased expression of HP protein CTD PMID:241598 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Penicillamine results in increased expression of HSPA1A mRNA; Penicillamine results in increased expression of HSPA1A protein CTD PMID:22843330 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like increases expression ISO Penicillamine results in increased expression of HSPA1L mRNA CTD PMID:22843330 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression ISO Penicillamine results in increased expression of HSPA2 mRNA CTD PMID:22843330 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 ISO Penicillamine results in increased expression of HSPA5 protein
Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of HSPA5 protein]		 CTD PMID:19722195 PMID:22843330 PMID:22945834 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 increases expression ISO Penicillamine results in increased expression of HSPA6 mRNA CTD PMID:22843330 NCBI chr13:83,273,176...83,274,317 JBrowse link
G Ifng interferon gamma increases expression EXP Penicillamine results in increased expression of IFNG mRNA CTD PMID:19575532 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Penicillamine inhibits the reaction [IGF1 protein results in increased activity of MTR protein] CTD PMID:14745455 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il10 interleukin 10 increases expression EXP Penicillamine results in increased expression of IL10 mRNA CTD PMID:19575532 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 decreases expression
increases expression		 EXP Penicillamine results in decreased expression of IL13 mRNA
Penicillamine results in increased expression of IL13 mRNA		 CTD PMID:19575532 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il15 interleukin 15 increases expression EXP Penicillamine results in increased expression of IL15 mRNA CTD PMID:19575532 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il1b interleukin 1 beta increases expression EXP Penicillamine results in increased expression of IL1B mRNA CTD PMID:19575532 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il21 interleukin 21 increases expression EXP Penicillamine results in increased expression of IL21 mRNA CTD PMID:21227906 NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Il23a interleukin 23 subunit alpha increases expression ISO Penicillamine results in increased expression of IL23A protein CTD PMID:19575532 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il3ra interleukin 3 receptor subunit alpha increases expression EXP Penicillamine results in increased expression of IL3RA mRNA CTD PMID:19575532 NCBI chr12:16,318,081...16,323,781
Ensembl chr12:16,318,081...16,323,484 		JBrowse link
G Il4 interleukin 4 increases expression EXP Penicillamine results in increased expression of IL4 mRNA CTD PMID:9182889 PMID:21227906 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 increases expression EXP
ISO		 Penicillamine results in increased expression of IL6 protein CTD PMID:19575532 PMID:21227906 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Klf4 KLF transcription factor 4 increases expression EXP Penicillamine results in increased expression of KLF4 mRNA CTD PMID:19575532 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Lgals1 galectin 1 increases expression EXP Penicillamine results in increased expression of LGALS1 mRNA CTD PMID:19575532 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Loxl2 lysyl oxidase-like 2 decreases activity ISO Penicillamine results in decreased activity of LOXL2 protein CTD PMID:16023247 NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression		 ISO PMAIP1 mutant form inhibits the reaction [Penicillamine results in decreased expression of MCL1 protein] CTD PMID:22843330 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mpo myeloperoxidase decreases secretion
multiple interactions		 ISO Penicillamine results in decreased secretion of MPO protein
Penicillamine promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Penicillamine promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]		 CTD PMID:6324512 PMID:25614581 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO Penicillamine inhibits the reaction [IGF1 protein results in increased activity of MTR protein] CTD PMID:14745455 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression EXP Penicillamine results in increased expression of NFE2L2 mRNA CTD PMID:19575532 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Penicillamine results in increased expression of NOS2 mRNA CTD PMID:22843330 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression EXP Penicillamine results in increased expression of NR4A1 mRNA CTD PMID:19575532 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Penicillamine results in increased cleavage of PARP1 protein CTD PMID:22843330 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression
multiple interactions		 ISO Penicillamine results in increased expression of PMAIP1 mRNA; Penicillamine results in increased expression of PMAIP1 protein
PMAIP1 mutant form inhibits the reaction [Penicillamine results in decreased expression of MCL1 protein]		 CTD PMID:22843330 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of PPARA mRNA] CTD PMID:22945834 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prl prolactin multiple interactions
increases expression		 ISO Danazol inhibits the reaction [Penicillamine results in increased expression of PRL] CTD PMID:4087275 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Ptger2 prostaglandin E receptor 2 increases expression EXP Penicillamine results in increased expression of PTGER2 mRNA CTD PMID:19575532 NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO Penicillamine results in increased expression of PTGS1 mRNA CTD PMID:22843330 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G RT1-CE16 RT1 class I, locus CE16 affects response to substance ISO HLA-A gene polymorphism affects the susceptibility to Penicillamine CTD PMID:3459889 NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases response to substance ISO HLA-DRB1 gene polymorphism results in increased susceptibility to Penicillamine CTD PMID:6420562 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression EXP Penicillamine results in increased expression of S100A4 mRNA CTD PMID:19575532 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G S100a6 S100 calcium binding protein A6 increases expression EXP Penicillamine results in increased expression of S100A6 mRNA CTD PMID:19575532 NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180 		JBrowse link
G S100a8 S100 calcium binding protein A8 decreases expression
increases expression		 EXP Penicillamine results in decreased expression of S100A8 mRNA
Penicillamine results in increased expression of S100A8 mRNA		 CTD PMID:19575532 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression
increases expression		 EXP Penicillamine results in decreased expression of S100A9 mRNA
Penicillamine results in increased expression of S100A9 mRNA		 CTD PMID:19575532 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression EXP Penicillamine results in decreased expression of SELENBP1 mRNA CTD PMID:19575532 NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 increases expression EXP Penicillamine results in increased expression of SLC11A1 mRNA CTD PMID:19575532 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101 		JBrowse link
G Slc28a2 solute carrier family 28 member 2 decreases expression
increases expression		 EXP Penicillamine results in decreased expression of SLC28A2 mRNA
Penicillamine results in increased expression of SLC28A2 mRNA		 CTD PMID:19575532 NCBI chr 3:109,324,815...109,387,702
Ensembl chr 3:109,366,996...109,387,702 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 decreases expression
increases expression		 EXP Penicillamine results in decreased expression of SLC30A1 mRNA
Penicillamine results in increased expression of SLC30A1 mRNA		 CTD PMID:19575532 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions
increases expression		 ISO [Penicillamine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to Oxaliplatin; [Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; Cisplatin promotes the reaction [Penicillamine results in increased expression of SLC31A1 mRNA]; Penicillamine promotes the reaction [Cisplatin results in increased expression of SLC31A1 mRNA] CTD PMID:22914438 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228 		JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) decreases expression EXP Penicillamine results in decreased expression of SLC4A1 mRNA CTD PMID:19575532 NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117 		JBrowse link
G Sod1 superoxide dismutase 1 decreases activity ISO Penicillamine analog results in decreased activity of SOD1 protein CTD PMID:19323979 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sp1 Sp1 transcription factor increases expression ISO Penicillamine results in increased expression of SP1 mRNA CTD PMID:22914438 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of SREBF1 mRNA] CTD PMID:22945834 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stx3 syntaxin 3 increases expression
decreases expression		 EXP Penicillamine results in increased expression of STX3 mRNA
Penicillamine results in decreased expression of STX3 mRNA		 CTD PMID:19575532 NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805 		JBrowse link
G Tfrc transferrin receptor increases expression EXP Penicillamine results in increased expression of TFRC mRNA CTD PMID:19575532 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO Penicillamine results in increased expression of TNF protein
Penicillamine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA]		 CTD PMID:19575532 PMID:22945834 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression
decreases expression		 ISO Penicillamine results in increased expression of TP53 protein
Penicillamine results in decreased expression of TP53 mRNA		 CTD PMID:22843330 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO Penicillamine results in increased splicing of XBP1 mRNA CTD PMID:19722195 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      chemical role 19457
        ligand 6736
          chelator 6723
            D-penicillamine 105
              benzylpenillamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    main group molecular entity 19792
                      s-block molecular entity 19626
                        hydrogen molecular entity 19613
                          hydrides 19115
                            inorganic hydride 18121
                              pnictogen hydride 18110
                                nitrogen hydride 18017
                                  azane 17823
                                    ammonia 17797
                                      organic amino compound 17822
                                        amino acid 15956
                                          non-proteinogenic amino acid 3988
                                            non-proteinogenic alpha-amino acid 3795
                                              penicillamine 105
                                                D-penicillamine 105
                                                  benzylpenillamine 0
paths to the root