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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:beta-hydroxy ketone
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Accession:CHEBI:55380 term browser browse the term
Definition:A ketone containing a hydroxy group on the beta-carbon relative to the C=O group.
Synonyms:related_synonym: beta-hydroxy ketones;   beta-hydroxyketone;   beta-hydroxyketones


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epothilone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression
multiple interactions		 ISO epothilone A results in increased expression of CASP3 mRNA
[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA; Sodium Salicylate promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]		 CTD PMID:29117515 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression		 ISO [epothilone A co-treated with Metformin] results in increased expression of H2AX mRNA
epothilone A results in increased expression of H2AX mRNA		 CTD PMID:29117515 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression		 ISO [epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA; Sodium Salicylate inhibits the reaction [epothilone A results in increased expression of PARP1 mRNA]; triciribine inhibits the reaction [epothilone A results in increased expression of PARP1 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA] CTD PMID:29117515 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
epothilone B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha decreases expression
multiple interactions		 EXP epothilone B results in decreased expression of CALCA protein
epothilone B affects the reaction [[Capsaicin co-treated with NGF protein] results in increased secretion of CALCA protein]; epothilone B inhibits the reaction [Potassium results in increased secretion of CALCA protein]; epothilone B promotes the reaction [[Potassium co-treated with NGF protein] results in increased secretion of CALCA protein]		 CTD PMID:26883566 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP epothilone B affects the reaction [[Capsaicin co-treated with NGF protein] results in increased secretion of CALCA protein]; epothilone B promotes the reaction [[Potassium co-treated with NGF protein] results in increased secretion of CALCA protein] CTD PMID:26883566 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
gingerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO gingerol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:18385293 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] CTD PMID:18577375 PMID:21851089 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein] CTD PMID:27451028 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO gingerol results in increased expression of APAF1 mRNA; gingerol results in increased expression of APAF1 protein CTD PMID:19481070 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BAX protein]; gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BCL2 protein]; gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CASP3 protein]; gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of RELA protein]; gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TRP53 protein] CTD PMID:37121058 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein] CTD PMID:18577375 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [gingerol results in increased expression of BAX protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of BAX protein]
gingerol inhibits the reaction [hypoxia-reoxygenation increases expression of Bax protein in neural crest-derived cells]
gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BAX protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of BAX protein]; gingerol inhibits the reaction [TNF protein results in increased expression of BAX protein]
gingerol results in increased expression of BAX mRNA; gingerol results in increased expression of BAX protein		 CTD
RGD		 PMID:18030663 PMID:19481070 PMID:25034532 PMID:28249781 PMID:37121058 More... RGD:155882488 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO gingerol results in decreased expression of BCL2 mRNA; gingerol results in decreased expression of BCL2 protein
gingerol inhibits the reaction [hypoxia-reoxygenation decreases expression of Bcl2 protein in neural crest-derived cells]
gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BCL2 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein]; gingerol inhibits the reaction [TNF protein results in decreased expression of BCL2 protein]
[gingerol co-treated with Hydrogen Peroxide] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BCL2 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein]		 CTD
RGD		 PMID:18030663 PMID:19481070 PMID:25034532 PMID:27451028 PMID:28249781 More... RGD:155882488 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO gingerol inhibits the reaction [hypoxia-reoxygenation decreases expression of Bdnf protein in neural crest-derived cells] RGD PMID:34962339 RGD:155882488 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO [gingerol co-treated with Hydrogen Peroxide] results in increased expression of BECN1 protein CTD PMID:27451028 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BID protein] CTD PMID:25034532 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BIRC5 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BIRC5 protein] CTD PMID:18030663 PMID:25034532 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
multiple interactions
affects activity		 ISO
EXP		 gingerol results in increased expression of CASP3 mRNA; gingerol results in increased expression of CASP3 protein
gingerol results in increased cleavage of CASP3 protein
gingerol inhibits the reaction [Chlorpyrifos results in increased activity of CASP3 protein]
gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CASP3 protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased activity of CASP3 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein]; gingerol inhibits the reaction [TNF protein results in increased expression of CASP3 protein]
gingerol affects the activity of CASP3 protein
[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein]		 CTD PMID:17454143 PMID:18030663 PMID:19481070 PMID:25034532 PMID:28249781 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
affects activity		 ISO [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]
gingerol results in increased cleavage of CASP8 protein
gingerol affects the activity of CASP8 protein		 CTD PMID:17454143 PMID:25034532 PMID:28249781 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases expression
increases cleavage
multiple interactions
affects activity		 ISO gingerol results in increased expression of CASP9 mRNA; gingerol results in increased expression of CASP9 protein
gingerol results in increased cleavage of CASP9 protein
gingerol inhibits the reaction [Testosterone results in decreased expression of CASP9 protein]
gingerol affects the activity of CASP9 protein		 CTD PMID:17454143 PMID:18030663 PMID:19481070 PMID:28249781 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 gingerol inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; gingerol inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]; gingerol inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
gingerol inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]		 CTD PMID:22285432 PMID:28373059 PMID:28421826 PMID:31004597 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO gingerol results in decreased expression of CCNB1 mRNA; gingerol results in decreased expression of CCNB1 protein CTD PMID:28249781 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
decreases expression		 ISO [gingerol co-treated with Cycloheximide] results in increased degradation of CCND1 protein
gingerol results in increased expression of CCND1 mRNA; gingerol results in increased expression of CCND1 protein
gingerol results in decreased expression of CCND1 mRNA; gingerol results in decreased expression of CCND1 protein		 CTD PMID:18058799 PMID:26498061 PMID:28249781 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO gingerol results in decreased expression of CCNE1 mRNA; gingerol results in decreased expression of CCNE1 protein CTD PMID:28249781 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO gingerol results in decreased expression of CDK1 mRNA CTD PMID:28249781 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO gingerol results in decreased expression of CDK4 protein CTD PMID:18058799 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO gingerol results in decreased expression of CDKN1A mRNA CTD PMID:28249781 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO gingerol results in decreased expression of CDKN1B mRNA CTD PMID:28249781 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression
multiple interactions		 ISO gingerol results in decreased expression of CEBPA mRNA; gingerol results in decreased expression of CEBPA protein
GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein]		 CTD PMID:26498061 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [gingerol results in decreased expression of CFLAR protein] CTD PMID:25034532 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO gingerol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CHEK2 protein] CTD PMID:28988496 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Ctnnb1 catenin beta 1 affects localization
increases expression
multiple interactions		 ISO gingerol affects the localization of CTNNB1 protein
gingerol results in increased expression of CTNNB1 mRNA
gingerol results in increased expression of and affects the localization of CTNNB1 protein
gingerol promotes the reaction [IL1B protein results in increased expression of CTNNB1 protein]		 CTD PMID:18058799 PMID:26498061 PMID:27645308 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases response to substance ISO CYP2C19 mRNA results in increased susceptibility to gingerol CTD PMID:29555536 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO gingerol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:18385293 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO gingerol results in increased expression of DUSP10 mRNA CTD PMID:17151092 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Dvl2 dishevelled segment polarity protein 2 increases expression ISO gingerol results in increased expression of DVL2 mRNA CTD PMID:26498061 NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820 		JBrowse link
G Fas Fas cell surface death receptor affects activity ISO gingerol affects the activity of FAS protein CTD PMID:17454143 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO gingerol results in decreased expression of FASN mRNA; gingerol results in decreased expression of FASN protein CTD PMID:26498061 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO gingerol inhibits the reaction [Glucose results in increased secretion of FN1 protein] CTD PMID:21829520 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO gingerol inhibits the reaction [Dextran Sulfate results in decreased expression of FSHB protein] CTD PMID:28421826 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions		 ISO gingerol results in increased expression of GDF15 mRNA; gingerol results in increased expression of GDF15 protein
GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]; PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein]; Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein]		 CTD PMID:18058799 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases response to substance
increases phosphorylation
increases expression		 ISO gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]; GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]
GSK3B protein results in increased susceptibility to gingerol
GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein]
gingerol results in increased phosphorylation of GSK3B protein
gingerol results in increased expression of GSK3B protein		 CTD PMID:18058799 PMID:26498061 PMID:27645308 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA] CTD PMID:21382473 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A decreases activity ISO gingerol results in decreased activity of HTR3A protein CTD PMID:26456648 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]; gingerol promotes the reaction [IL1B protein results in increased expression of CTNNB1 protein]
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]		 CTD PMID:27645308 PMID:28421826 PMID:31004597 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA] CTD PMID:22285432 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO gingerol inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of INS1 protein]; gingerol inhibits the reaction [sodium arsenite results in decreased secretion of INS1 protein] CTD PMID:21851089 PMID:22285432 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] CTD PMID:22285432 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 protein] CTD PMID:22285432 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] CTD PMID:18577375 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Klkb1 kallikrein B1 multiple interactions
decreases expression		 ISO gingerol inhibits the reaction [Testosterone results in increased expression of KLKB1 protein]
gingerol results in decreased expression of KLKB1 protein		 CTD PMID:18030663 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053 		JBrowse link
G Lats1 large tumor suppressor kinase 1 increases expression ISO gingerol results in increased expression of LATS1 protein CTD PMID:32926756 NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640 		JBrowse link
G Ldhc lactate dehydrogenase C multiple interactions ISO gingerol inhibits the reaction [Dextran Sulfate results in increased activity of LDHC protein] CTD PMID:28421826 NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378 		JBrowse link
G Lep leptin multiple interactions ISO gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]; gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21851089 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO gingerol inhibits the reaction [Dextran Sulfate results in decreased expression of LHB protein] CTD PMID:28421826 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lrp6 LDL receptor related protein 6 increases expression ISO gingerol results in increased expression of LRP6 mRNA CTD PMID:26498061 NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [gingerol co-treated with Hydrogen Peroxide] results in increased expression of MAP1LC3B protein modified form CTD PMID:27451028 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein] CTD PMID:18577375 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Mir210 microRNA 210 multiple interactions ISO gingerol inhibits the reaction [hypoxia-reoxygenation increases expression of Mir210 miRNA in neural crest-derived cells] RGD PMID:34962339 RGD:155882488 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
decreases activity		 ISO gingerol results in decreased expression of MMP2 mRNA; gingerol results in decreased expression of MMP2 protein
gingerol inhibits the reaction [YAP1 protein results in increased expression of MMP2 protein]
gingerol results in decreased activity of MMP2 protein		 CTD PMID:17683926 PMID:32926756 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
decreases activity		 ISO gingerol results in decreased expression of MMP9 mRNA
gingerol results in decreased activity of MMP9 protein		 CTD PMID:17683926 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP
ISO		 gingerol inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]
gingerol inhibits the reaction [Benzo(a)pyrene results in increased activity of MPO protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]		 CTD PMID:28373059 PMID:28421826 PMID:31004597 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases expression		 ISO gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MTOR protein]
gingerol results in decreased expression of MTOR protein modified form		 CTD PMID:27451028 PMID:28249781 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:18683823 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO gingerol affects the phosphorylation of and affects the activity of NFKBIA protein CTD PMID:17454143 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] CTD PMID:18683823 PMID:31004597 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein] CTD PMID:25034532 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression		 ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein]
gingerol results in decreased expression of PPARG mRNA; gingerol results in decreased expression of PPARG protein		 CTD PMID:22285432 PMID:26498061 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein] CTD PMID:18058799 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Ptges prostaglandin E synthase decreases expression
increases expression		 ISO gingerol results in decreased expression of PTGES protein
gingerol results in increased expression of PTGES mRNA		 CTD PMID:27645308 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression
multiple interactions		 ISO gingerol affects the expression of PTGS2 mRNA; gingerol affects the expression of PTGS2 protein
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]		 CTD PMID:17454143 PMID:18683823 PMID:31004597 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO gingerol results in decreased phosphorylation of RB1 protein CTD PMID:18058799 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects expression
multiple interactions
affects localization		 ISO gingerol affects the expression of RELA protein
gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of RELA protein]; gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; gingerol inhibits the reaction [TNF protein results in increased expression of RELA protein]
gingerol affects the localization of RELA protein		 CTD PMID:17454143 PMID:18683823 PMID:37121058 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO gingerol results in decreased expression of RPS6KB1 protein modified form CTD PMID:28249781 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 protein] CTD PMID:22285432 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO gingerol inhibits the reaction [Glucose results in increased expression of SNAI1 mRNA] CTD PMID:21829520 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression
multiple interactions		 ISO gingerol results in decreased expression of SNAI2 protein
gingerol inhibits the reaction [YAP1 protein results in increased expression of SNAI2 protein]		 CTD PMID:32926756 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA] CTD PMID:21382473 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA] CTD PMID:21382473 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF mRNA]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein]; gingerol inhibits the reaction [TNF protein results in decreased expression of BCL2 protein]; gingerol inhibits the reaction [TNF protein results in increased expression of BAX protein]; gingerol inhibits the reaction [TNF protein results in increased expression of CASP3 protein]; gingerol inhibits the reaction [TNF protein results in increased expression of RELA protein]; gingerol inhibits the reaction [TNF protein results in increased expression of TRP53 protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein]
gingerol inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]		 CTD PMID:18577375 PMID:21851089 PMID:22285432 PMID:28373059 PMID:28421826 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases response to substance		 ISO [gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein] CTD PMID:25034532 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO gingerol results in increased expression of TP53 protein
gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TRP53 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of TRP53 protein]; gingerol inhibits the reaction [TNF protein results in increased expression of TRP53 protein]
[gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [Testosterone co-treated with gingerol] results in increased expression of TP53 protein; gingerol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of TP53 protein]; TP53 protein affects the reaction [gingerol results in increased expression of TNFRSF10B protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein]		 CTD PMID:18030663 PMID:25034532 PMID:28988496 PMID:37121058 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vim vimentin decreases expression
multiple interactions		 ISO gingerol results in decreased expression of VIM protein
gingerol inhibits the reaction [YAP1 protein results in increased expression of VIM protein]		 CTD PMID:32926756 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO gingerol results in decreased expression of XIAP protein CTD PMID:25034532 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator affects localization
multiple interactions		 ISO gingerol affects the localization of YAP1 protein
[gingerol co-treated with YAP1 protein] results in increased phosphorylation of YAP1 protein; gingerol inhibits the reaction [YAP1 protein results in increased expression of MMP2 protein]; gingerol inhibits the reaction [YAP1 protein results in increased expression of SNAI2 protein]; gingerol inhibits the reaction [YAP1 protein results in increased expression of VIM protein]; gingerol results in decreased expression of and results in increased phosphorylation of YAP1 protein		 CTD PMID:32926756 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
lasalocid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta increases expression ISO Lasalocid results in increased expression of ACTB protein CTD PMID:37788135 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Anxa1 annexin A1 increases expression ISO Lasalocid results in increased expression of ANXA1 protein CTD PMID:37788135 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Anxa2 annexin A2 increases expression ISO Lasalocid results in increased expression of ANXA2 protein CTD PMID:37788135 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Dsp desmoplakin increases expression ISO Lasalocid results in increased expression of DSP protein CTD PMID:37788135 NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 increases expression ISO Lasalocid results in increased expression of HNRNPA1 protein CTD PMID:37788135 NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 increases expression ISO Lasalocid results in increased expression of HNRNPA2B1 protein CTD PMID:37788135 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO Lasalocid results in increased expression of HSPB1 protein CTD PMID:37788135 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Ivl involucrin increases expression ISO Lasalocid results in increased expression of IVL protein CTD PMID:37788135 NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100 		JBrowse link
G Jup junction plakoglobin increases expression ISO Lasalocid results in increased expression of JUP protein CTD PMID:37788135 NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057 		JBrowse link
G Krt5 keratin 5 increases expression ISO Lasalocid results in increased expression of KRT5 protein CTD PMID:37788135 NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Lasalocid results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Pkp1 plakophilin 1 increases expression ISO Lasalocid results in increased expression of PKP1 protein CTD PMID:37788135 NCBI chr13:47,309,607...47,357,432
Ensembl chr13:47,309,614...47,357,465 		JBrowse link
G Ppl periplakin increases expression ISO Lasalocid results in increased expression of PPL protein CTD PMID:37788135 NCBI chr10:10,450,919...10,496,575
Ensembl chr10:10,450,919...10,496,575 		JBrowse link
G S100a10 S100 calcium binding protein A10 increases expression ISO Lasalocid results in increased expression of S100A10 protein CTD PMID:37788135 NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661 		JBrowse link
G S100a11 S100 calcium binding protein A11 increases expression ISO Lasalocid results in increased expression of S100A11 protein CTD PMID:37788135 NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044 		JBrowse link
G S100a16 S100 calcium binding protein A16 increases expression ISO Lasalocid results in increased expression of S100A16 protein CTD PMID:37788135 NCBI chr 2:176,016,405...176,022,117
Ensembl chr 2:176,016,268...176,022,117 		JBrowse link
G Serpinb2 serpin family B member 2 increases expression ISO Lasalocid results in increased expression of SERPINB2 protein CTD PMID:37788135 NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408 		JBrowse link
G Sprr1a small proline-rich protein 1A increases expression ISO Lasalocid results in increased expression of SPRR1A protein CTD PMID:37788135 NCBI chr 2:178,055,096...178,057,012
Ensembl chr 2:178,055,096...178,057,063 		JBrowse link
G Sprr1b small proline-rich protein 1B increases expression ISO Lasalocid results in increased expression of SPRR1B protein CTD PMID:37788135 NCBI chr 2:178,008,844...178,010,742
Ensembl chr 2:178,009,130...178,009,567 		JBrowse link
G Sprr2d small proline-rich protein 2D increases expression ISO Lasalocid results in increased expression of SPRR2D protein CTD PMID:37788135 NCBI chr 2:177,870,082...177,870,679
Ensembl chr 2:177,870,434...177,870,679 		JBrowse link
misoprostol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 multiple interactions EXP Misoprostol inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine] CTD PMID:11164953 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Misoprostol inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:18602972 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Misoprostol inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:18602972 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP Misoprostol inhibits the reaction [Cisplatin results in decreased expression of CAT protein] CTD PMID:21458517 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions EXP Misoprostol inhibits the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to and results in increased activity of CHRM1 protein] CTD PMID:2459756 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Gast gastrin multiple interactions
decreases activity		 EXP Misoprostol inhibits the reaction [GAST protein results in increased secretion of Histamine]
Misoprostol results in decreased activity of GAST protein		 CTD PMID:2459756 PMID:11164953 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Misoprostol inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10] CTD PMID:19273625 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Misoprostol inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10] CTD PMID:19273625 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions
increases expression		 ISO Misoprostol inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10]
Misoprostol results in increased expression of IL23A mRNA		 CTD PMID:19273625 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Ptger1 prostaglandin E receptor 1 multiple interactions ISO [L-335677 binds to and results in decreased activity of PTGER1 protein] inhibits the reaction [Misoprostol results in increased susceptibility to Formaldehyde] CTD PMID:16360148 NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559 		JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid binds to and results in decreased activity of PTGER2 protein] inhibits the reaction [Misoprostol results in increased susceptibility to Formaldehyde] CTD PMID:16360148 NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714 		JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions ISO [L-826266 binds to and results in decreased activity of PTGER3 protein] inhibits the reaction [Misoprostol results in decreased susceptibility to Formaldehyde] CTD PMID:16360148 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Misoprostol results in increased expression of PTGS2 protein]; Indomethacin inhibits the reaction [Misoprostol results in increased expression of PTGS2 protein] CTD PMID:12428691 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Misoprostol promotes the reaction [Kallidin results in increased secretion of TAC1 protein] CTD PMID:16039053 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Misoprostol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF] CTD PMID:9298541 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Pramanicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator affects response to substance
increases expression		 ISO BAX protein affects the susceptibility to pramanicin analog
pramanicin analog results in increased expression of BAX protein		 CTD PMID:23441183 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
affects response to substance		 ISO pramanicin analog results in decreased expression of BCL2 mRNA; pramanicin analog results in decreased expression of BCL2 protein
BCL2 protein affects the susceptibility to pramanicin		 CTD PMID:23441183 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l11 Bcl2-like 11 affects response to substance
increases expression		 ISO BCL2L11 protein affects the susceptibility to pramanicin
pramanicin analog results in increased expression of BCL2L11 protein		 CTD PMID:23441183 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO pramanicin analog results in increased cleavage of BID protein CTD PMID:23441183 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 increases activity ISO pramanicin analog results in increased activity of CASP3 protein CTD PMID:23441183 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO pramanicin analog results in increased activity of CASP9 protein CTD PMID:23441183 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      group 19765
        inorganic group 19360
          hydroxy group 19299
            beta-hydroxy ketone 113
              (+)-6-Hydroxy-2,6-dimethyl-7-octen-4-one 0
              (+)-Aspermytin A 0
              (-)-(S)-chlorizidine A 0
              (10)-Gingerol 0
              (2R)-N-[(2S)-7-[(1-acetylcyclopropyl)amino]-5,7-dioxoheptan-2-yl]-2-(tetradecanoylamino)butanediamide 0
              (3S,4S,5S)-3-[(E)-3-(3-heptyloxiran-2-yl)prop-2-enoyl]-3,4-dihydroxy-5-methylpyrrolidin-2-one 0
              (5R)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one 0
              (5R)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one 0
              (5R)-5-hydroxy-7-(4''-hydroxy-3''-methoxyphenyl)-1-phenyl-3-heptanone 0
              (8)-Gingerol 0
              (S)-[10]-Gingerol 0
              (S)-[8]-Gingerol 0
              (Z,S)-cinerolone 0
              (Z,S)-jasmolone 0
              1-deacetylpallidopenilline B 0
              1-hydroxy-5-phenyl-3-pentanone 0
              12beta-hydroxychaetoviridin C 0
              17-phenyl-18,19,20-trinor-prostaglandin D2 0
              17-phenyl-18,19,20-trinor-prostaglandin E2 0
              19-[(1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl]-4,5-dihydrogeldanamycin 0
              2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one 0
              2-hydroxy-2-methylheptan-4-one 0
              3,4-dihydroxy-3,4-dimethyl-2,5-Hexanedione 0
              3-Hydroxy-3-(3,4-dihydroxy-4-methylpentanoyl)-5-(3-methylbutyl)-1,2,4-cyclopentanetrione 0
              3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl]glutarimide 0
              3-dehydrosphingosine 0
              3-deoxy-keto-D-fructose 0
              3-hydroxy-N-(1-hydroxy-3-methylpentan-2-yl)-5-oxohexanamide 0
              3-hydroxyhexane-2,5-dione 0
              4'-epichaetoviridin A 0
              4-Gingerol 0
              4-Hydroxy-3-methyl-2-butanone 0
              4-hydroxy-2-oxobutanal 0
              4-hydroxybutan-2-one 0
              5'-epichaetoviridin A 0
              5R-Hydroxy-4S-methylheptan-3-one 0
              6-[1'-oxo-3'(R)-hydroxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran 0
              Asenjonamide A 0
              Asenjonamide B 0
              Cladosporiumin F 0
              Cladosporiumin L 0
              Craterellone F 0
              Decumbenone A 0
              Decumbenone B 0
              Decumbenone C 0
              Enaminomycin B 0
              Epopromycin A 0
              Eujavanicol A 0
              Eujavanicol B 0
              FK17-P2a 0
              Hamavellone C 0
              Hydroxyiso-9-methylstreptimidone 0
              Libertalide I 0
              Libertalide M 0
              Methyl-10-gingerol 0
              Pallidopenilline A 0
              Pallidopenilline C 0
              Pallidopenilline H 0
              Peaurantiogriseol A 0
              Peaurantiogriseol B 0
              Peaurantiogriseol C 0
              Peaurantiogriseol D 0
              Peaurantiogriseol F 0
              Phosphonothrixin 0
              Pramanicin 6
              Streptenol E 0
              Trichoharzianol 0
              Virgaricin B 0
              Viridicatumone A 0
              Zosteropenilline F 0
              Zosteropenilline G 0
              Zosteropenilline H 0
              Zosteropenilline I 0
              Zosteropenilline J 0
              Zosteropenilline L 0
              [12]-Gingerol 0
              atrochrysone 0
              bidenlignaside A 0
              chaetoviridin A 0
              chaetoviridin C + 0
              cytosporic acid 0
              diacetone alcohol 0
              dihydro-nogalonic acid methyl ester 0
              dihydrostemphyloxin I 0
              epothilone + 5
              flavaspidic acid AB 0
              flavaspidic acid PB 0
              gingerol 80
              ixabepilone 0
              lasalocid 20
              lavendiol 0
              methyl (13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate + 15
              myriaporone 3 0
              pyoluteorin 0
              scytalone 0
              shanorellin 0
              trigoheterin E, (rel)- 0
              trinexapac + 0
              trinexapac-ethyl 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbonyl compound 18869
                                    ketone 17165
                                      beta-hydroxy ketone 113
                                        (+)-6-Hydroxy-2,6-dimethyl-7-octen-4-one 0
                                        (+)-Aspermytin A 0
                                        (-)-(S)-chlorizidine A 0
                                        (10)-Gingerol 0
                                        (2R)-N-[(2S)-7-[(1-acetylcyclopropyl)amino]-5,7-dioxoheptan-2-yl]-2-(tetradecanoylamino)butanediamide 0
                                        (3S,4S,5S)-3-[(E)-3-(3-heptyloxiran-2-yl)prop-2-enoyl]-3,4-dihydroxy-5-methylpyrrolidin-2-one 0
                                        (5R)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one 0
                                        (5R)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one 0
                                        (5R)-5-hydroxy-7-(4''-hydroxy-3''-methoxyphenyl)-1-phenyl-3-heptanone 0
                                        (8)-Gingerol 0
                                        (S)-[10]-Gingerol 0
                                        (S)-[8]-Gingerol 0
                                        (Z,S)-cinerolone 0
                                        (Z,S)-jasmolone 0
                                        1-deacetylpallidopenilline B 0
                                        1-hydroxy-5-phenyl-3-pentanone 0
                                        12beta-hydroxychaetoviridin C 0
                                        17-phenyl-18,19,20-trinor-prostaglandin D2 0
                                        17-phenyl-18,19,20-trinor-prostaglandin E2 0
                                        19-[(1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl]-4,5-dihydrogeldanamycin 0
                                        2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one 0
                                        2-hydroxy-2-methylheptan-4-one 0
                                        3,4-dihydroxy-3,4-dimethyl-2,5-Hexanedione 0
                                        3-Hydroxy-3-(3,4-dihydroxy-4-methylpentanoyl)-5-(3-methylbutyl)-1,2,4-cyclopentanetrione 0
                                        3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl]glutarimide 0
                                        3-dehydrosphingosine 0
                                        3-deoxy-keto-D-fructose 0
                                        3-hydroxy-N-(1-hydroxy-3-methylpentan-2-yl)-5-oxohexanamide 0
                                        3-hydroxyhexane-2,5-dione 0
                                        4'-epichaetoviridin A 0
                                        4-Gingerol 0
                                        4-Hydroxy-3-methyl-2-butanone 0
                                        4-hydroxy-2-oxobutanal 0
                                        4-hydroxybutan-2-one 0
                                        5'-epichaetoviridin A 0
                                        5R-Hydroxy-4S-methylheptan-3-one 0
                                        6-[1'-oxo-3'(R)-hydroxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran 0
                                        Asenjonamide A 0
                                        Asenjonamide B 0
                                        Cladosporiumin F 0
                                        Cladosporiumin L 0
                                        Craterellone F 0
                                        Decumbenone A 0
                                        Decumbenone B 0
                                        Decumbenone C 0
                                        Enaminomycin B 0
                                        Epopromycin A 0
                                        Eujavanicol A 0
                                        Eujavanicol B 0
                                        FK17-P2a 0
                                        Hamavellone C 0
                                        Hydroxyiso-9-methylstreptimidone 0
                                        Libertalide I 0
                                        Libertalide M 0
                                        Methyl-10-gingerol 0
                                        Pallidopenilline A 0
                                        Pallidopenilline C 0
                                        Pallidopenilline H 0
                                        Peaurantiogriseol A 0
                                        Peaurantiogriseol B 0
                                        Peaurantiogriseol C 0
                                        Peaurantiogriseol D 0
                                        Peaurantiogriseol F 0
                                        Phosphonothrixin 0
                                        Pramanicin 6
                                        Streptenol E 0
                                        Trichoharzianol 0
                                        Virgaricin B 0
                                        Viridicatumone A 0
                                        Zosteropenilline F 0
                                        Zosteropenilline G 0
                                        Zosteropenilline H 0
                                        Zosteropenilline I 0
                                        Zosteropenilline J 0
                                        Zosteropenilline L 0
                                        [12]-Gingerol 0
                                        atrochrysone 0
                                        bidenlignaside A 0
                                        chaetoviridin A 0
                                        chaetoviridin C + 0
                                        cytosporic acid 0
                                        diacetone alcohol 0
                                        dihydro-nogalonic acid methyl ester 0
                                        dihydrostemphyloxin I 0
                                        epothilone + 5
                                        flavaspidic acid AB 0
                                        flavaspidic acid PB 0
                                        gingerol 80
                                        ixabepilone 0
                                        lasalocid 20
                                        lavendiol 0
                                        methyl (13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate + 15
                                        myriaporone 3 0
                                        pyoluteorin 0
                                        scytalone 0
                                        shanorellin 0
                                        trigoheterin E, (rel)- 0
                                        trinexapac + 0
                                        trinexapac-ethyl 0
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