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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,6-di-tert-butyl-4-methylphenol
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Accession:CHEBI:34247 term browser browse the term
Definition:A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.
Synonyms:related_synonym: 1-hydroxy-4-methyl-2,6-di-tert-butylbenzene;   2,6-bis(1,1-dimethylethyl)-4-methylphenol;   2,6-di-t-butyl-4-methylphenol;   2,6-di-t-butyl-p-cresol;   2,6-di-tert-butyl-1-hydroxy-4-methylbenzene;   2,6-di-tert-butyl-4-cresol;   2,6-di-tert-butyl-4-hydroxytoluene;   2,6-di-tert-butyl-4-methylhydroxybenzene;   2,6-di-tert-butyl-p-cresol;   BHT;   FEMA 2184;   Formula=C15H24O;   InChI=1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3;   InChIKey=NLZUEZXRPGMBCV-UHFFFAOYSA-N;   SMILES=Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C;   butylated hydroxytoluene;   butylhydroxytoluene;   o-di-tert-butyl-p-methylphenol
 xref: Beilstein:1911640;   CAS:128-37-0;   Chemspider:13835296;   FooDB:FDB011992;   HMDB:HMDB0033826;   KEGG:C14693;   KEGG:D02413;   LINCS:LSM-19020
 xref_mesh: MESH:D002084
 xref: PMID:11837686;   PMID:24612426;   PMID:24617543;   PMID:29864697;   PMID:31029976;   PMID:31780362;   PMID:32304926;   PMID:32322261;   PMID:32387881;   PMID:32397407;   PMID:32963880;   PMID:33039371;   PMID:33091556;   PMID:33519739;   PMID:33792845;   PMID:34013795;   PMID:34041400;   PMID:34443068;   PMID:448040;   Reaxys:1911640;   Wikipedia:Butylated_hydroxytoluene


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2,6-di-tert-butyl-4-methylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A930009A15Rik RIKEN cDNA A930009A15 gene multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [DCD protein results in increased phosphorylation of NFKBIA protein] CTD PMID:17532611 NCBI chr10:115,399,555...115,418,359
Ensembl chr10:115,405,891...115,418,353 		JBrowse link
G Abca1 ATP-binding cassette, sub-family A member 1 multiple interactions
increases expression		 ISO [Butylated Hydroxytoluene co-treated with iron(II)-ascorbic acid complex] results in increased expression of ABCA1 protein; Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA]; Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein]
Butylated Hydroxytoluene results in increased expression of ABCA1 mRNA		 CTD PMID:17070507 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Actg1 actin, gamma, cytoplasmic 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of ACTG1 mRNA CTD PMID:12082028 NCBI chr11:120,236,513...120,239,321
Ensembl chr11:120,236,516...120,239,368 		JBrowse link
G Agt angiotensinogen multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased expression of PSMC6 protein]; Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein] CTD PMID:17532611 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Aifm2 apoptosis-inducing factor, mitochondrion-associated 2 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased secretion of AIFM2 protein]; Butylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased secretion of AIFM2 protein] CTD PMID:14987999 NCBI chr10:61,551,042...61,575,474
Ensembl chr10:61,551,042...61,575,039 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation ISO Butylated Hydroxytoluene results in increased phosphorylation of AKT1 protein CTD PMID:17604070 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase affects localization
multiple interactions		 EXP Butylated Hydroxytoluene affects the localization of ALOX5 protein
celecoxib inhibits the reaction [Butylated Hydroxytoluene affects the localization of ALOX5 protein]		 CTD PMID:12376474 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139 		JBrowse link
G Apoa1 apolipoprotein A-I multiple interactions ISO [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein]; Butylated Hydroxytoluene inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein] CTD PMID:12576517 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Apoa2 apolipoprotein A-II multiple interactions ISO [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]; Butylated Hydroxytoluene inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein] CTD PMID:12576517 NCBI chr 1:171,049,133...171,053,948
Ensembl chr 1:171,052,623...171,053,948 		JBrowse link
G Apoa4 apolipoprotein A-IV increases expression ISO Butylated Hydroxytoluene results in increased expression of APOA4 mRNA CTD PMID:12082028 NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757 		JBrowse link
G Ar androgen receptor multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein] CTD PMID:10696776 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Arg1 arginase, liver increases expression EXP Butylated Hydroxytoluene results in increased expression of ARG1 mRNA CTD PMID:19925653 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382 		JBrowse link
G Atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]; Butylated Hydroxytoluene inhibits the reaction [Free Radicals results in decreased activity of ATP2A1 protein] CTD PMID:12870653 NCBI chr 7:126,045,032...126,062,245
Ensembl chr 7:126,045,030...126,062,280 		JBrowse link
G Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A multiple interactions EXP
ISO		 Butylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of ATP6V1A protein]
Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of ATP6V1A protein]		 CTD PMID:12470298 NCBI chr16:43,905,765...43,960,055
Ensembl chr16:43,905,765...43,960,068 		JBrowse link
G Capn2 calpain 2 affects expression EXP Butylated Hydroxytoluene affects the expression of CAPN2 protein CTD PMID:7716780 NCBI chr 1:182,294,818...182,345,175
Ensembl chr 1:182,294,825...182,345,173 		JBrowse link
G Caprin1 cell cycle associated protein 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of CAPRIN1 mRNA CTD PMID:19925653 NCBI chr 2:103,593,292...103,627,946
Ensembl chr 2:103,593,286...103,627,994 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Butylated Hydroxytoluene results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity		 ISO
EXP		 [Butylated Hydroxyanisole co-treated with Butylated Hydroxytoluene] results in decreased activity of CASP3 protein
Butylated Hydroxytoluene results in decreased activity of CASP3 protein
[Butylated Hydroxytoluene co-treated with Oxygen] results in increased cleavage of CASP3 protein; zAsp(Ome)-Arg-His-Asp(Ome)-fluoromethyl ketone inhibits the reaction [[Butylated Hydroxytoluene co-treated with Oxygen] results in increased cleavage of CASP3 protein]
Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased cleavage of and results in increased activity of CASP3 protein]; Butylated Hydroxytoluene inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein]		 CTD PMID:10783138 PMID:14981915 PMID:16272459 PMID:27588890 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein] CTD PMID:9306888 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccdc116 coiled-coil domain containing 116 increases expression EXP Butylated Hydroxytoluene results in increased expression of CCDC116 mRNA CTD PMID:19925653 NCBI chr16:16,956,928...16,965,459
Ensembl chr16:16,956,928...16,965,093 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 increases expression EXP Butylated Hydroxytoluene results in increased expression of CCL17 mRNA CTD PMID:19925653 NCBI chr 8:95,535,996...95,538,666
Ensembl chr 8:95,537,081...95,538,664 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
increases expression		 EXP Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]
Butylated Hydroxytoluene results in increased secretion of CCL2 protein
Butylated Hydroxytoluene results in increased expression of CCL2 protein		 CTD PMID:16443645 PMID:16822543 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression EXP Butylated Hydroxytoluene results in decreased expression of CCL5 mRNA CTD PMID:19925653 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccna2 cyclin A2 increases expression EXP [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNA2 mRNA; Butylated Hydroxytoluene results in increased expression of CCNA2 mRNA CTD PMID:12867420 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccnb1 cyclin B1 increases expression EXP [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNB1 mRNA; Butylated Hydroxytoluene results in increased expression of CCNB1 mRNA CTD PMID:12867420 PMID:19000923 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of CCND1 protein CTD PMID:16272459 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccne1 cyclin E1 increases expression EXP [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNE1 mRNA; Butylated Hydroxytoluene results in increased expression of CCNE1 mRNA CTD PMID:12867420 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959 		JBrowse link
G Ccnf cyclin F increases expression EXP [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNF mRNA; Butylated Hydroxytoluene results in increased expression of CCNF mRNA CTD PMID:12867420 NCBI chr17:24,441,518...24,470,333
Ensembl chr17:24,441,172...24,470,458 		JBrowse link
G Cd19 CD19 antigen decreases expression EXP Butylated Hydroxytoluene results in decreased expression of CD19 mRNA CTD PMID:19925653 NCBI chr 7:126,007,620...126,016,401
Ensembl chr 7:126,007,622...126,014,061 		JBrowse link
G Cd37 CD37 antigen decreases expression EXP Butylated Hydroxytoluene results in decreased expression of CD37 mRNA CTD PMID:19925653 NCBI chr 7:44,883,056...44,888,701
Ensembl chr 7:44,883,056...44,888,539 		JBrowse link
G Cd3d CD3 antigen, delta polypeptide decreases expression EXP Butylated Hydroxytoluene results in decreased expression of CD3D mRNA CTD PMID:19925653 NCBI chr 9:44,893,067...44,898,350
Ensembl chr 9:44,893,084...44,898,637 		JBrowse link
G Cd44 CD44 antigen multiple interactions EXP [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of CD44 mRNA alternative form CTD PMID:15390079 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010 		JBrowse link
G Cd81 CD81 antigen increases expression ISO Butylated Hydroxytoluene results in increased expression of CD81 mRNA CTD PMID:12082028 NCBI chr 7:142,606,487...142,621,667
Ensembl chr 7:142,606,476...142,621,671 		JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP [Butylated Hydroxytoluene co-treated with Oxygen] results in decreased expression of CDH1 protein CTD PMID:16272459 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdk2ap2 cyclin dependent kinase 2 associated protein 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of CDK2AP2 mRNA CTD PMID:12082028 NCBI chr19:4,146,204...4,149,019
Ensembl chr19:4,147,182...4,149,019 		JBrowse link
G Cfi complement component factor i increases expression EXP Butylated Hydroxytoluene results in increased expression of CFI mRNA CTD PMID:19925653 NCBI chr 3:129,630,432...129,668,978
Ensembl chr 3:129,629,533...129,668,981 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of CHEK1 mRNA CTD PMID:19000923 NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361 		JBrowse link
G Cldn2 claudin 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of CLDN2 mRNA CTD PMID:19925653 NCBI chr  X:138,701,552...138,712,135
Ensembl chr  X:138,701,577...138,712,135 		JBrowse link
G Col18a1 collagen, type XVIII, alpha 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of COL18A1 mRNA CTD PMID:19925653 NCBI chr10:76,888,013...77,002,351
Ensembl chr10:76,888,012...77,002,382 		JBrowse link
G Cox6b2 cytochrome c oxidase subunit 6B2 increases expression EXP Butylated Hydroxytoluene results in increased expression of COX6B2 mRNA CTD PMID:19925653 NCBI chr 7:4,754,791...4,756,093
Ensembl chr 7:4,754,791...4,756,093 		JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein] CTD PMID:16822543 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Butylated Hydroxytoluene co-treated with Oxygen] affects the localization of CTNNB1 protein; [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of CTNNB1 protein CTD PMID:16272459 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [cholestane-3,5,6-triol affects the localization of CYCS protein] CTD PMID:19121293 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 EXP Butylated Hydroxytoluene results in increased expression of CYP1A1 mRNA
Butylated Hydroxytoluene affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]		 CTD PMID:19925653 PMID:21094198 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression ISO Butylated Hydroxytoluene results in increased expression of CYP2B6 mRNA CTD PMID:18570159 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases expression ISO Butylated Hydroxytoluene results in increased expression of CYP2B2 mRNA; Butylated Hydroxytoluene results in increased expression of CYP2B2 protein CTD PMID:12082028 PMID:15110098 PMID:18539377 NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases expression ISO Butylated Hydroxytoluene results in increased expression of CYP2C6 mRNA CTD PMID:18539377 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 increases expression ISO Butylated Hydroxytoluene results in increased expression of CYP2J2 mRNA CTD PMID:24021950 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815 		JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 increases expression ISO Butylated Hydroxytoluene results in increased expression of CYP3A9 mRNA CTD PMID:18539377 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881 		JBrowse link
G Dcx doublecortin multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Ethanol results in decreased expression of DCX protein] CTD PMID:17067360 NCBI chr  X:142,638,838...142,716,392
Ensembl chr  X:142,638,838...142,716,307 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased secretion of DIABLO protein]; Butylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased secretion of DIABLO protein] CTD PMID:14987999 NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239 		JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression EXP Butylated Hydroxytoluene results in increased expression of DNAJC3 mRNA CTD PMID:19925653 NCBI chr14:119,175,371...119,219,114
Ensembl chr14:119,175,388...119,219,109 		JBrowse link
G Dock2 dedicator of cyto-kinesis 2 decreases expression EXP Butylated Hydroxytoluene results in decreased expression of DOCK2 mRNA CTD PMID:19925653 NCBI chr11:34,176,815...34,674,732
Ensembl chr11:34,176,815...34,674,719 		JBrowse link
G Elavl1 ELAV like RNA binding protein 1 affects localization EXP Butylated Hydroxytoluene affects the localization of ELAVL1 protein CTD PMID:10900464 NCBI chr 8:4,334,781...4,375,104
Ensembl chr 8:4,335,382...4,375,413 		JBrowse link
G Eln elastin multiple interactions EXP [Oxygen co-treated with Butylated Hydroxytoluene] results in increased expression of ELN mRNA CTD PMID:10761639 NCBI chr 5:134,731,449...134,776,300
Ensembl chr 5:134,731,447...134,776,177 		JBrowse link
G Epor erythropoietin receptor increases expression EXP Butylated Hydroxytoluene results in increased expression of EPOR mRNA CTD PMID:19925653 NCBI chr 9:21,870,193...21,874,915
Ensembl chr 9:21,870,193...21,874,802 		JBrowse link
G Ereg epiregulin increases expression EXP Butylated Hydroxytoluene results in increased expression of EREG mRNA CTD PMID:19925653 NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505 		JBrowse link
G Evpl envoplakin increases expression EXP Butylated Hydroxytoluene results in increased expression of EVPL mRNA CTD PMID:19925653 NCBI chr11:116,111,385...116,128,983
Ensembl chr11:116,111,385...116,128,903 		JBrowse link
G F3 coagulation factor III multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Copper results in increased activity of F3 protein] CTD PMID:7600656 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Fosl1 fos-like antigen 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of FOSL1 mRNA CTD PMID:19000923 PMID:19925653 NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974 		JBrowse link
G Foxf1 forkhead box F1 decreases expression EXP Butylated Hydroxytoluene results in decreased expression of FOXF1 mRNA CTD PMID:11238010 NCBI chr 8:121,811,100...121,814,883
Ensembl chr 8:121,811,125...121,814,883 		JBrowse link
G Foxm1 forkhead box M1 affects localization
increases expression
affects response to substance		 EXP Butylated Hydroxytoluene affects the localization of FOXM1 mRNA
[Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNA2 mRNA; [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNB1 mRNA; [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNE1 mRNA; [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNF mRNA; Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA; Butylated Hydroxytoluene results in increased expression of FOXM1 protein
FOXM1 protein affects the susceptibility to Butylated Hydroxytoluene		 CTD PMID:11238010 PMID:12867420 PMID:18345025 PMID:19672312 NCBI chr 6:128,339,957...128,352,849
Ensembl chr 6:128,339,930...128,353,109 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP Butylated Hydroxytoluene results in increased expression of GCLC protein CTD PMID:21536018 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gfpt2 glutamine fructose-6-phosphate transaminase 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of GFPT2 mRNA CTD PMID:19925653 NCBI chr11:49,684,981...49,729,448
Ensembl chr11:49,685,005...49,729,440 		JBrowse link
G Ggta1 glycoprotein galactosyltransferase alpha 1, 3 increases expression EXP Butylated Hydroxytoluene results in increased expression of GGTA1 mRNA CTD PMID:19925653 NCBI chr 2:35,290,191...35,354,393
Ensembl chr 2:35,290,191...35,353,243 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases phosphorylation EXP
ISO		 Butylated Hydroxytoluene results in decreased phosphorylation of GJA1 protein CTD PMID:7586169 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gnmt glycine N-methyltransferase increases expression ISO Butylated Hydroxytoluene results in increased expression of GNMT mRNA CTD PMID:12082028 NCBI chr17:47,036,590...47,040,091
Ensembl chr17:47,036,590...47,040,094 		JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 increases expression ISO Butylated Hydroxytoluene results in increased expression of GPLD1 mRNA CTD PMID:12082028 NCBI chr13:25,127,135...25,175,919
Ensembl chr13:25,127,135...25,176,484 		JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) increases activity
multiple interactions		 ISO Butylated Hydroxytoluene results in increased activity of GSTA5 protein
Butylated Hydroxytoluene promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Butylated Hydroxytoluene results in increased expression of and results in increased activity of GSTA5 protein		 CTD PMID:8198522 PMID:9328168 NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966 		JBrowse link
G Gstm2 glutathione S-transferase, mu 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of GSTM2 mRNA CTD PMID:12082028 PMID:18539377 NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 increases expression
multiple interactions		 ISO
EXP		 Butylated Hydroxytoluene results in increased expression of GSTP1 mRNA
Butylated Hydroxytoluene results in increased alkylation of and results in decreased activity of GSTP1 protein		 CTD PMID:15110098 PMID:21536018 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Gstt1 glutathione S-transferase, theta 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of GSTT1 mRNA CTD PMID:15110098 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418 		JBrowse link
G Gzma granzyme A decreases expression EXP Butylated Hydroxytoluene results in decreased expression of GZMA mRNA CTD PMID:19925653 NCBI chr13:113,230,358...113,237,515
Ensembl chr13:113,230,359...113,237,515 		JBrowse link
G Hc hemolytic complement increases expression ISO Butylated Hydroxytoluene results in increased expression of HC mRNA CTD PMID:12082028 NCBI chr 2:34,873,341...34,958,518
Ensembl chr 2:34,873,343...34,951,450 		JBrowse link
G Hck hemopoietic cell kinase affects expression ISO Butylated Hydroxytoluene affects the expression of HCK mRNA CTD PMID:18539377 NCBI chr 2:152,950,388...152,993,361
Ensembl chr 2:152,950,388...152,993,361 		JBrowse link
G Hells helicase, lymphoid specific increases expression EXP Butylated Hydroxytoluene results in increased expression of HELLS mRNA CTD PMID:19000923 NCBI chr19:38,913,282...38,958,914
Ensembl chr19:38,919,359...38,959,495 		JBrowse link
G Hexb hexosaminidase B multiple interactions ISO zinc chloride inhibits the reaction [Butylated Hydroxytoluene results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr13:97,312,839...97,334,865
Ensembl chr13:97,312,839...97,334,865 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase increases activity ISO Butylated Hydroxytoluene results in increased activity of HMGCR protein CTD PMID:9199277 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression
increases expression		 ISO Butylated Hydroxytoluene affects the expression of HMOX1 mRNA
Butylated Hydroxytoluene results in increased expression of HMOX1 mRNA		 CTD PMID:8743975 PMID:12420312 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hnf1a HNF1 homeobox A multiple interactions EXP [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of HNF1A mRNA CTD PMID:16272459 NCBI chr 5:115,087,039...115,109,121
Ensembl chr 5:115,087,039...115,109,153 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 affects localization
multiple interactions
increases expression		 EXP Butylated Hydroxytoluene affects the localization of HNRNPA1 protein
[Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of HNRNPA1 protein; [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of HNRNPA1 protein
Butylated Hydroxytoluene results in increased expression of HNRNPA1 protein		 CTD PMID:15390079 NCBI chr15:103,148,840...103,155,119
Ensembl chr15:103,148,859...103,155,119 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 multiple interactions EXP [Methylcholanthrene co-treated with Butylated Hydroxytoluene] affects the expression of HNRNPA2B1 protein CTD PMID:17477362 NCBI chr 6:51,437,414...51,448,054
Ensembl chr 6:51,437,912...51,446,874 		JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects localization EXP Butylated Hydroxytoluene affects the localization of HNRNPD protein CTD PMID:10900464 NCBI chr 5:100,103,794...100,126,926
Ensembl chr 5:100,103,794...100,126,797 		JBrowse link
G Hras Harvey rat sarcoma virus oncogene decreases methylation
increases response to substance		 ISO
EXP		 Butylated Hydroxytoluene results in decreased methylation of HRAS gene
HRAS protein results in increased susceptibility to Butylated Hydroxytoluene		 CTD PMID:9780227 PMID:11599794 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918 		JBrowse link
G Hspa9 heat shock protein 9 increases expression EXP Butylated Hydroxytoluene results in increased expression of HSPA9 mRNA CTD PMID:19925653 NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein] CTD PMID:16822543 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il15 interleukin 15 affects expression ISO Butylated Hydroxytoluene affects the expression of IL15 mRNA CTD PMID:18539377 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] CTD PMID:8435107 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of IL1RL1 mRNA CTD PMID:19000923 NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein] CTD PMID:16822543 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein] CTD PMID:16822543 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Ilk integrin linked kinase multiple interactions EXP [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of ILK protein CTD PMID:16272459 NCBI chr 7:105,385,797...105,392,132
Ensembl chr 7:105,385,799...105,392,132 		JBrowse link
G Junb jun B proto-oncogene increases expression EXP Butylated Hydroxytoluene results in increased expression of JUNB mRNA CTD PMID:19000923 NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347 		JBrowse link
G Kng1 kininogen 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of KNG1 mRNA CTD PMID:19925653 NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828 		JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog increases mutagenesis EXP Butylated Hydroxytoluene results in increased mutagenesis of KRAS gene CTD PMID:20101149 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions EXP [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of LEF1 mRNA CTD PMID:16272459 NCBI chr 3:130,903,972...131,018,006
Ensembl chr 3:130,904,120...131,018,005 		JBrowse link
G Lep leptin multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] CTD PMID:16822543 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 increases expression EXP Butylated Hydroxytoluene results in increased expression of MAPK14 mRNA CTD PMID:19925653 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mbp myelin basic protein increases expression EXP Butylated Hydroxytoluene results in increased expression of MBP mRNA CTD PMID:19925653 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression EXP Butylated Hydroxytoluene results in increased expression of MCM3 mRNA CTD PMID:19000923 NCBI chr 1:20,873,188...20,890,536
Ensembl chr 1:20,873,192...20,890,536 		JBrowse link
G mt-Co2 cytochrome c oxidase II, mitochondrial multiple interactions ISO
EXP		 Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of COX2 protein]
Butylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of COX2 protein]		 CTD PMID:12470298 NCBI chr MT:7,013...7,696
Ensembl chr MT:7,013...7,696 		JBrowse link
G Myl3 myosin, light polypeptide 3 increases expression EXP Butylated Hydroxytoluene results in increased expression of MYL3 mRNA CTD PMID:19925653 NCBI chr 9:110,592,746...110,598,870
Ensembl chr 9:110,570,929...110,598,866 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 decreases response to substance EXP NFE2L2 protein results in decreased susceptibility to Butylated Hydroxytoluene CTD PMID:10535991 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15713255 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP
ISO		 Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein]; Butylated Hydroxytoluene inhibits the reaction [DCD protein results in increased phosphorylation of NFKBIA protein]
Butylated Hydroxytoluene inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of NFKBIA protein]; Butylated Hydroxytoluene inhibits the reaction [Cadmium results in decreased phosphorylation of NFKBIA protein]		 CTD PMID:16478757 PMID:17532611 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Streptozocin results in increased expression of NGF mRNA] CTD PMID:9748608 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases activity
increases expression		 ISO Butylated Hydroxytoluene results in increased activity of NQO1 protein
Butylated Hydroxytoluene results in increased expression of NQO1 mRNA		 CTD PMID:16045903 PMID:20308224 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H2 mRNA] CTD PMID:17070507 NCBI chr 7:44,199,040...44,204,928
Ensembl chr 7:44,199,040...44,203,375 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H3 mRNA] CTD PMID:17070507 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Butylated Hydroxytoluene binds to and results in decreased activity of NR1I3 protein alternative form; Butylated Hydroxytoluene binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Nras neuroblastoma ras oncogene increases activity ISO Butylated Hydroxytoluene results in increased activity of NRAS CTD PMID:3040652 NCBI chr 3:102,965,643...102,975,230
Ensembl chr 3:102,965,601...102,975,230 		JBrowse link
G Nrbf2 nuclear receptor binding factor 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of NRBF2 mRNA CTD PMID:12082028 NCBI chr10:67,102,463...67,121,076
Ensembl chr10:67,102,468...67,121,084 		JBrowse link
G Nup54 nucleoporin 54 increases expression EXP Butylated Hydroxytoluene results in increased expression of NUP54 mRNA CTD PMID:19000923 NCBI chr 5:92,563,399...92,583,117
Ensembl chr 5:92,563,399...92,583,078 		JBrowse link
G Parn poly(A)-specific ribonuclease (deadenylation nuclease) decreases expression EXP Butylated Hydroxytoluene results in decreased expression of PARN mRNA CTD PMID:19925653 NCBI chr16:13,355,828...13,486,035
Ensembl chr16:13,355,824...13,486,034 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Benzoyl Peroxide results in increased activity of PARP1 protein]; Butylated Hydroxytoluene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PARP1 protein] CTD PMID:2126186 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP Butylated Hydroxytoluene results in increased expression of PCNA protein CTD PMID:11238010 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Per2 period circadian clock 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of PER2 mRNA CTD PMID:19925653 NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein] CTD PMID:18603805 NCBI chr  X:105,230,706...105,247,305
Ensembl chr  X:105,230,706...105,247,305 		JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression EXP Butylated Hydroxytoluene results in increased expression of PHEX mRNA CTD PMID:19000923 NCBI chr  X:155,945,071...156,198,282
Ensembl chr  X:155,945,071...156,198,308 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 increases expression EXP Butylated Hydroxytoluene results in increased expression of PIK3R5 mRNA CTD PMID:19000923 NCBI chr11:68,322,951...68,388,675
Ensembl chr11:68,322,947...68,388,675 		JBrowse link
G Pknox2 Pbx/knotted 1 homeobox 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of PKNOX2 mRNA CTD PMID:19925653 NCBI chr 9:36,802,278...37,058,637
Ensembl chr 9:36,802,278...37,058,703 		JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) increases expression EXP Butylated Hydroxytoluene results in increased expression of PLA2G4A protein CTD PMID:16443645 NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041 		JBrowse link
G Plat plasminogen activator, tissue multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein]; Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in increased expression of PLAT protein] CTD PMID:10856522 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Pomp proteasome maturation protein increases expression ISO Butylated Hydroxytoluene results in increased expression of POMP mRNA CTD PMID:12082028 NCBI chr 5:147,797,438...147,812,594
Ensembl chr 5:147,797,271...147,813,266 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [[Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein] CTD PMID:16052486 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946 		JBrowse link
G Pon2 paraoxonase 2 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein] CTD PMID:17916643 NCBI chr 6:5,264,620...5,298,408
Ensembl chr 6:5,264,147...5,298,455 		JBrowse link
G Pou2f1 POU domain, class 2, transcription factor 1 decreases expression EXP Butylated Hydroxytoluene results in decreased expression of POU2F1 mRNA CTD PMID:19925653 NCBI chr 1:165,692,719...165,830,318
Ensembl chr 1:165,692,723...165,830,247 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of PPAR mRNA] CTD PMID:17070507 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression
multiple interactions		 EXP
ISO		 Butylated Hydroxytoluene results in increased expression of PPARG mRNA
Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of PPARG mRNA]		 CTD PMID:17070507 PMID:19925653 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Prkca protein kinase C, alpha decreases expression EXP Butylated Hydroxytoluene results in decreased expression of PRKCA protein CTD PMID:7716780 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754 		JBrowse link
G Prl2c3 prolactin family 2, subfamily c, member 3 increases expression EXP Butylated Hydroxytoluene results in increased expression of PRL2C3 mRNA CTD PMID:19000923 NCBI chr13:12,805,705...12,814,982
Ensembl chr13:12,805,705...12,814,968 		JBrowse link
G Psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 multiple interactions EXP
ISO		 Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased expression of PSMC6 protein]; Butylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of PSMC6 mRNA]
Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of PSMC6 mRNA]		 CTD PMID:12470298 PMID:17532611 NCBI chr14:45,567,285...45,587,150
Ensembl chr14:45,567,245...45,587,162 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of PTGS1 protein CTD PMID:11696405 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP
ISO		 Butylated Hydroxytoluene results in increased expression of PTGS2 protein
Butylated Hydroxytoluene inhibits the reaction [Ethanol results in increased expression of PTGS2 mRNA]		 CTD PMID:11696405 PMID:17067360 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Pthlh parathyroid hormone-like peptide increases expression EXP Butylated Hydroxytoluene results in increased expression of PTHLH mRNA CTD PMID:19925653 NCBI chr 6:147,153,607...147,165,511
Ensembl chr 6:147,153,599...147,165,681 		JBrowse link
G Rab31 RAB31, member RAS oncogene family decreases expression EXP Butylated Hydroxytoluene results in decreased expression of RAB31 mRNA CTD PMID:19925653 NCBI chr17:65,958,721...66,079,747
Ensembl chr17:65,958,724...66,079,747 		JBrowse link
G Rad21 RAD21 cohesin complex component increases expression EXP Butylated Hydroxytoluene results in increased expression of RAD21 mRNA CTD PMID:19000923 NCBI chr15:51,826,000...51,856,934
Ensembl chr15:51,825,636...51,855,143 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of RAD51AP1 mRNA CTD PMID:19000923 NCBI chr 6:126,900,378...126,916,664
Ensembl chr 6:126,900,013...126,916,550 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Cadmium Chloride results in decreased activity of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [Cadmium results in decreased activity of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein affects the localization of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:15713255 PMID:16478757 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rif1 replication timing regulatory factor 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of RIF1 mRNA CTD PMID:19000923 NCBI chr 2:51,962,725...52,016,781
Ensembl chr 2:51,962,844...52,012,395 		JBrowse link
G Rnf112 ring finger protein 112 affects expression ISO Butylated Hydroxytoluene affects the expression of RNF112 mRNA CTD PMID:18539377 NCBI chr11:61,339,243...61,345,014
Ensembl chr11:61,339,268...61,344,957 		JBrowse link
G Sell selectin, lymphocyte decreases expression EXP Butylated Hydroxytoluene results in decreased expression of SELL mRNA CTD PMID:19925653 NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [LPA protein results in decreased expression of SERPINE1 protein]; Butylated Hydroxytoluene inhibits the reaction [LPA protein results in increased expression of SERPINE1 protein] CTD PMID:10856522 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of SERPINH1 mRNA CTD PMID:19925653 NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446 		JBrowse link
G Shisa2 shisa family member 2 decreases expression EXP Butylated Hydroxytoluene results in decreased expression of SHISA2 mRNA CTD PMID:19925653 NCBI chr14:59,862,730...59,869,109
Ensembl chr14:59,862,757...59,869,109 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of SLC2A1 mRNA CTD PMID:19000923 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180 		JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 decreases expression EXP Butylated Hydroxytoluene results in decreased expression of SLC2A3 mRNA CTD PMID:19925653 NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599 		JBrowse link
G Slc39a11 solute carrier family 39 (metal ion transporter), member 11 increases expression EXP Butylated Hydroxytoluene results in increased expression of SLC39A11 mRNA CTD PMID:19925653 NCBI chr11:113,135,677...113,541,050
Ensembl chr11:113,135,679...113,540,905 		JBrowse link
G Slfn4 schlafen 4 decreases expression EXP Butylated Hydroxytoluene results in decreased expression of SLFN4 mRNA CTD PMID:19925653 NCBI chr11:83,066,001...83,081,042
Ensembl chr11:83,066,012...83,081,042 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO [Butylated Hydroxyanisole co-treated with Butylated Hydroxytoluene] results in decreased expression of SOD2 mRNA CTD PMID:14981915 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Spib Spi-B transcription factor (Spi-1/PU.1 related) decreases expression EXP Butylated Hydroxytoluene results in decreased expression of SPIB mRNA CTD PMID:19925653 NCBI chr 7:44,175,419...44,181,511
Ensembl chr 7:44,175,417...44,181,495 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of SPP1 mRNA CTD PMID:19925653 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Srsf1 serine and arginine-rich splicing factor 1 multiple interactions
affects localization
increases expression		 EXP [Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of SRSF1 protein; [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of SRSF1 protein
Butylated Hydroxytoluene affects the localization of SRSF1 protein
Butylated Hydroxytoluene results in increased expression of SRSF1 protein		 CTD PMID:15390079 NCBI chr11:87,937,325...87,944,583
Ensembl chr11:87,938,199...87,944,581 		JBrowse link
G Stmn1 stathmin 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of STMN1 mRNA CTD PMID:19000923 NCBI chr 4:134,195,631...134,201,154
Ensembl chr 4:134,195,631...134,201,154 		JBrowse link
G Stom stomatin increases expression EXP Butylated Hydroxytoluene results in increased expression of STOM mRNA CTD PMID:19925653 NCBI chr 2:35,204,002...35,227,021
Ensembl chr 2:35,203,998...35,226,988 		JBrowse link
G Tac1 tachykinin 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Streptozocin results in increased expression of TAC1 mRNA] CTD PMID:9748608 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase affects expression
increases expression		 ISO
EXP		 Butylated Hydroxytoluene affects the expression of TDO2 mRNA
Butylated Hydroxytoluene results in increased expression of TDO2 mRNA		 CTD PMID:18539377 PMID:19925653 NCBI chr 3:81,865,719...81,883,035
Ensembl chr 3:81,864,397...81,883,509 		JBrowse link
G Tfrc transferrin receptor increases expression EXP Butylated Hydroxytoluene results in increased expression of TFRC mRNA CTD PMID:19000923 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612 		JBrowse link
G Tgfa transforming growth factor alpha decreases response to substance ISO Butylated Hydroxytoluene results in decreased susceptibility to TGFA protein CTD PMID:7593635 NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Thpo thrombopoietin multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein] CTD PMID:16822543 NCBI chr16:20,543,204...20,553,261
Ensembl chr16:20,543,204...20,553,261 		JBrowse link
G Tmem45b transmembrane protein 45b decreases expression EXP Butylated Hydroxytoluene results in decreased expression of TMEM45B mRNA CTD PMID:19925653 NCBI chr 9:31,336,445...31,375,534
Ensembl chr 9:31,337,492...31,375,758 		JBrowse link
G Tnc tenascin C increases expression EXP Butylated Hydroxytoluene results in increased expression of TNC mRNA CTD PMID:19925653 NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
increases response to substance		 ISO
EXP		 Butylated Hydroxytoluene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Butylated Hydroxytoluene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of ATP6V1A protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of COX2 protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of PSMC6 mRNA]
Butylated Hydroxytoluene results in decreased expression of TNF protein
Butylated Hydroxytoluene inhibits the reaction [Dextran Sulfate promotes the reaction [Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]]]; Butylated Hydroxytoluene inhibits the reaction [Dextran Sulfate promotes the reaction [Quartz results in increased secretion of TNF protein]]; Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]
Butylated Hydroxytoluene inhibits the reaction [TNF protein affects the localization of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased uptake of Excitatory Amino Acid Agents]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of RELA protein]
Butylated Hydroxytoluene results in increased susceptibility to TNF protein		 CTD PMID:9721806 PMID:12470298 PMID:15713255 PMID:16822543 PMID:16910777 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trp53 transformation related protein 53 increases expression ISO Butylated Hydroxytoluene results in increased expression of TP53 mRNA CTD PMID:9780227 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Ttr transthyretin increases expression ISO Butylated Hydroxytoluene results in increased expression of TTR mRNA CTD PMID:12082028 NCBI chr18:20,797,266...20,807,383
Ensembl chr18:20,798,337...20,807,378 		JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of UBE2G2 mRNA CTD PMID:19925653 NCBI chr10:77,458,155...77,481,824
Ensembl chr10:77,458,109...77,481,827 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 EXP Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]
Butylated Hydroxytoluene results in increased expression of VEGFA mRNA		 CTD PMID:16822543 PMID:19000923 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22210
    role 22195
      application 21776
        food additive 17247
          2,6-di-tert-butyl-4-methylphenol 169
Path 2
Term Annotations click to browse term
  CHEBI ontology 22210
    subatomic particle 22202
      composite particle 22202
        hadron 22202
          baryon 22202
            nucleon 22202
              atomic nucleus 22202
                atom 22202
                  main group element atom 22136
                    p-block element atom 22136
                      carbon group element atom 21936
                        carbon atom 21861
                          organic molecular entity 21861
                            organic molecule 21678
                              organic cyclic compound 21285
                                organic aromatic compound 20769
                                  phenols 19238
                                    phenol 1417
                                      2,6-di-tert-butyl-4-methylphenol 169
paths to the root