Hras (Harvey rat sarcoma virus oncogene) - Rat Genome Database

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Gene: Hras (Harvey rat sarcoma virus oncogene) Mus musculus
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Symbol: Hras
Name: Harvey rat sarcoma virus oncogene
RGD ID: 10730
MGI Page MGI
Description: Enables GTP binding activity and protein-membrane adaptor activity. Involved in several processes, including Ras protein signal transduction; insulin receptor signaling pathway; and nervous system development. Acts upstream of or within several processes, including defense response to protozoan; intracellular signal transduction; and oncogene-induced cell senescence. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of GTPase complex. Predicted to be active in glutamatergic synapse and plasma membrane. Is expressed in several structures, including central nervous system; early embryo; metanephros; sensory organ; and tooth. Used to study Costello syndrome. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-H-; c-H-ras; c-Ha-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; c-r; c-rasHa; GTPase HRas; H-; H-ras; H-ras 1 protein; H-Ras-1; Ha; Ha-ras; Harv; Harvey rat sarcoma virus oncogene 1; Harvey-ras; Hr; Hra; Hras-1; Hras1; Kras2; p21ras; ras; transforming protein P21
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Hras1-ps1  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,770,839 - 140,773,938 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,769,018 - 140,773,918 (-)EnsemblGRCm39 Ensembl
GRCm387141,189,934 - 141,194,019 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,189,105 - 141,194,005 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,375,833 - 148,379,903 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,042,668 - 141,044,260 (-)NCBIMGSCv36mm8
Celera7140,983,643 - 140,987,701 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.48NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenoid cystic carcinoma  (ISO)
Alzheimer's disease  (ISO)
angiosarcoma  (ISO)
Animal Mammary Neoplasms  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bladder carcinoma  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cardiofaciocutaneous syndrome  (ISO)
Chanarin-Dorfman syndrome  (ISO)
chronic lymphocytic leukemia  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
congenital fibrosis of the extraocular muscles  (ISO)
Congenital Myopathy with Excess of Muscle Spindles  (ISO)
Costello syndrome  (IAGP,ISO)
delta beta-thalassemia  (ISO)
developmental and epileptic encephalopathy  (ISO)
diabetic retinopathy  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
early infantile epileptic encephalopathy  (ISO)
endometrial carcinoma  (ISO)
epidermal nevus  (ISO)
esophageal carcinoma  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Follicular Thyroid Cancer  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (IMP,ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (IEP,ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hydrops Fetalis  (ISO)
Hypophosphatemic Rickets  (ISO)
immunodeficiency 39  (ISO)
intellectual disability  (ISO)
large congenital melanocytic nevus  (ISO)
Leber congenital amaurosis  (ISO)
linear nevus sebaceous syndrome  (ISO)
liver cancer  (IAGP)
liver carcinoma  (ISO)
liver cirrhosis  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
melanoma  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
Neoplastic Processes  (ISO)
neuroblastoma  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO)
Noonan syndrome 3  (ISO)
obsessive-compulsive disorder  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
papilloma  (ISO)
Paraproteinemias  (ISO)
parathyroid adenoma  (ISO)
Penile Neoplasms  (ISO)
phobic disorder  (ISO)
Pigmented Nevus  (ISO)
plasma cell neoplasm  (ISO)
pre-malignant neoplasm  (ISO)
prostate adenocarcinoma  (ISO)
Prostate Cancer, Hereditary, 1  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary valve stenosis  (ISO)
RASopathy  (ISO)
Recurrence  (ISO)
rhabdomyosarcoma  (ISO)
Salivary Gland Neoplasms  (ISO)
Sebaceous Nevus Syndrome and Hemimegalencephaly  (ISO)
seminoma  (ISO)
skin benign neoplasm  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
spermatocytoma  (ISO)
Splenic Neoplasms  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
thymoma  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
Trichilemmoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
uterine cancer  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dichlorobenzene  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-Amino-2,4-dibromoanthraquinone  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3-aminobenzamide  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-nitrophenol  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
8-hydroxy-2'-deoxyguanosine  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
ADP  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (EXP)
alpha-pinene  (ISO)
amitrole  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
aspartame  (EXP)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[c]phenanthrene  (EXP)
Benzoyl peroxide  (EXP)
beryllium atom  (ISO)
beryllium dihydride  (ISO)
beryllium(0)  (ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-amine  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bortezomib  (EXP)
buta-1,3-diene  (EXP)
cadmium dichloride  (ISO)
caffeine  (EXP)
capecitabine  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chloroprene  (EXP)
chromium(6+)  (EXP,ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenzoylmethane  (ISO)
dichlorine  (ISO)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ellagic acid  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
erastin  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
eugenol  (EXP)
farnesol  (ISO)
farnesyl diphosphate  (ISO)
fenofibrate  (EXP)
fenthion  (EXP)
finasteride  (ISO)
fipronil  (ISO)
flurbiprofen  (EXP)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
GDP  (ISO)
geraniol  (EXP)
glafenine  (ISO)
gliotoxin  (EXP)
glucaric acid  (EXP)
glucose  (ISO)
glutathione  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
Goe 6976  (ISO)
GTP  (ISO)
heptachlor  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxyl  (ISO)
iodoacetic acid  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoprenaline  (ISO)
isoprene  (EXP)
ketamine  (EXP)
ketoconazole  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
limonene  (ISO)
lipopolysaccharide  (EXP,ISO)
lonafarnib  (ISO)
lovastatin  (ISO)
LY294002  (EXP,ISO)
Maduramicin  (ISO)
malathion  (ISO)
manumycin A  (EXP,ISO)
MeIQ  (EXP)
MeIQx  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylglyoxal  (ISO)
Mezerein  (EXP)
mifepristone  (ISO)
monosodium L-glutamate  (ISO)
myricetin  (EXP)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (EXP,ISO)
N-hydroxy-4-aminobiphenyl  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
naringin  (ISO)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nitrofurazone  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phlorizin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
plutonium atom  (ISO)
progesterone  (EXP)
quercetin  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
Risedronate sodium  (EXP)
rotenone  (EXP)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
Siomycin A  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
streptozocin  (ISO)
SU6656  (ISO)
sulfur dioxide  (ISO)
superoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
Tetranitromethane  (ISO)
thapsigargin  (EXP)
theaflavin  (EXP)
thyroxine  (ISO)
tipifarnib  (ISO)
toluene  (ISO)
triciribine  (ISO)
trimethyltin  (EXP)
Triptolide  (ISO)
troglitazone  (EXP)
tunicamycin  (EXP)
urethane  (EXP,ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vinyl carbamate  (ISO)
vitamin E  (EXP,ISO)
zearalenone  (EXP)
zidovudine  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (IMP)
cellular response to gamma radiation  (ISO)
cellular senescence  (IBA,IDA,ISO)
defense response to protozoan  (IMP)
endocytosis  (IDA)
ERBB2-ERBB3 signaling pathway  (ISO)
fibroblast proliferation  (IDA)
insulin receptor signaling pathway  (IDA)
insulin-like growth factor receptor signaling pathway  (ISO)
intrinsic apoptotic signaling pathway  (IGI,IMP)
liver development  (ISO)
myelination  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of neuron apoptotic process  (IDA,IGI)
neuron apoptotic process  (IDA,IGI)
oncogene-induced cell senescence  (IDA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IPI,ISO)
positive regulation of DNA replication  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (IDA)
positive regulation of gene expression  (IDA)
positive regulation of JNK cascade  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of miRNA metabolic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of ruffle assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of type II interferon production  (IMP)
positive regulation of wound healing  (ISO)
Ras protein signal transduction  (IBA,IGI,ISO,TAS)
regulation of actin cytoskeleton organization  (ISO)
regulation of cell cycle  (ISO)
regulation of cell population proliferation  (ISO)
regulation of long-term neuronal synaptic plasticity  (IMP)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to isolation stress  (ISO)
Schwann cell development  (IMP)
signal transduction  (IEA)
small GTPase-mediated signal transduction  (IDA)
T cell receptor signaling pathway  (IMP)
T-helper 1 type immune response  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
adenosine signaling pathway  (ISO)
B cell receptor signaling pathway  (IEA)
chronic myeloid leukemia pathway  (IEA)
endocytosis pathway   (IEA)
endometrial cancer pathway  (IEA)
endothelin signaling pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis   (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA,ISO)
erythropoietin signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (ISO)
glioma pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
hepatitis C pathway   (IEA)
insulin signaling pathway  (IEA,ISO)
insulin-like growth factor signaling pathway  (ISO)
interleukin-2 signaling pathway  (ISO)
long term depression  (IEA)
long term potentiation  (IEA)
melanoma pathway   (IEA)
mitogen activated protein kinase signaling pathway   (IEA)
mTOR signaling pathway  (ISO)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway  (IEA)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
platelet-derived growth factor signaling pathway   (ISO)
prostate cancer pathway   (IEA)
renal cell carcinoma pathway  (IEA)
syndecan signaling pathway  (ISO)
T cell receptor signaling pathway   (IEA)
the extracellular signal-regulated Raf/Mek/Erk signaling pathway  (ISO)
thyroid cancer pathway  (IEA)
urinary bladder cancer pathway   (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal ameloblast differentiation  (IAGP)
abnormal ameloblast morphology  (IAGP)
abnormal aorta tunica media morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal cervical loop morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal enamel mineralization  (IAGP)
abnormal enamel morphology  (IAGP)
abnormal enamel rod pattern  (IAGP)
abnormal facial morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal lip morphology  (IAGP)
abnormal mammary gland development  (IAGP)
abnormal stellate reticulum morphology  (IAGP)
abnormal stratum intermedium morphology  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal tooth development  (IAGP)
abnormal vibrissa follicle morphology  (IAGP)
absent enamel  (IAGP)
cardiac fibrosis  (IAGP)
choanal stenosis  (IAGP)
chylous ascites  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased urine creatinine level  (IAGP)
depressed nasal bridge  (IAGP)
deviated nasal septum  (IAGP)
domed cranium  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged aortic valve  (IAGP)
heart left ventricle hypertrophy  (IAGP)
heart right ventricle hypertrophy  (IAGP)
hypertension  (IAGP)
increased circulating angiotensin II level  (IAGP)
increased heart atrium size  (IAGP)
increased heart ventricle size  (IAGP)
increased hemangiosarcoma incidence  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased skin papilloma incidence  (IAGP)
increased stomach tumor incidence  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased thyroid tumor incidence  (IAGP)
jaw cyst  (IAGP)
malocclusion  (IAGP)
mammary gland hyperplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
reduced long-term potentiation  (IAGP)
renal fibrosis  (IAGP)
short maxilla  (IAGP)
short nasal bridge  (IAGP)
short premaxilla  (IAGP)
short zygomatic bone  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Germline mutations in HRAS proto-oncogene cause Costello syndrome. Aoki Y, etal., Nat Genet. 2005 Oct;37(10):1038-40. Epub 2005 Sep 18.
2. c-H-ras and c-K-ras gene hypomethylation in the livers and hepatomas of rats fed methyl-deficient, amino acid-defined diets. Bhave MR, etal., Carcinogenesis. 1988 Mar;9(3):343-8. doi: 10.1093/carcin/9.3.343.
3. Predicting Recurrence and Progression of Noninvasive Papillary Bladder Cancer at Initial Presentation Based on Quantitative Gene Expression Profiles. Birkhahn M, etal., Eur Urol. 2009 Sep 9.
4. Activation of RAS family genes in urothelial carcinoma. Boulalas I, etal., J Urol. 2009 May;181(5):2312-9. Epub 2009 Mar 19.
5. Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide. Cho YM, etal., J Toxicol Sci. 2009 Oct;34(4):407-12.
6. Studies of the c-Harvey-Ras gene in psychiatric disorders. Comings DE, etal., Psychiatry Res. 1996 Jun 26;63(1):25-32.
7. High mutation frequency in ras genes of skin tumors isolated from DNA repair deficient xeroderma pigmentosum patients. Daya-Grosjean L, etal., Cancer Res. 1993 Apr 1;53(7):1625-9.
8. Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors. Goriely A, etal., Nat Genet. 2009 Nov;41(11):1247-52. Epub 2009 Oct 25.
9. TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective study. Gormally E, etal., Cancer Res. 2006 Jul 1;66(13):6871-6.
10. An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences. Gripp KW, etal., Am J Med Genet A. 2015 Sep;167A(9):2085-97. doi: 10.1002/ajmg.a.37128. Epub 2015 Apr 25.
11. Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome. Groesser L, etal., Nat Genet. 2012 Jun 10;44(7):783-7. doi: 10.1038/ng.2316.
12. Possible association of c-Harvey-Ras-1 (HRAS-1) marker with autism. Herault J, etal., Psychiatry Res 1993 Mar;46(3):261-7.
13. Frequency of Ha-ras-1 gene mutations inversely correlated with furan dose in mouse liver tumors. Johansson E, etal., Mol Carcinog. 1997 Apr;18(4):199-205.
14. Investigation of oncogenic cooperation in simple liver-specific transgenic mouse models using noninvasive in vivo imaging. Ju HL, etal., PLoS One. 2013;8(3):e59869. doi: 10.1371/journal.pone.0059869. Epub 2013 Mar 28.
15. Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: implication in the development of retinopathy. Kanwar M and Kowluru RA, Microvasc Res. 2008 Nov;76(3):189-93. Epub 2008 Apr 25.
16. Mouse induced glioma-initiating cell models and therapeutic targets. Kondo T, Anticancer Agents Med Chem. 2010 Jul;10(6):471-80.
17. Modulation of apoptosis, tumorigenesity and metastatic potential with antisense H-ras oligodeoxynucleotides in a high metastatic tumor model of hepatoma: LCI-D20. Liao Y, etal., Hepatogastroenterology. 2000 Mar-Apr;47(32):365-70.
18. Activation of ras oncogene in livers with cirrhosis. Liu P, etal., J Hepatol. 1994 Dec;21(6):1103-8.
19. Aberrant expression of nNOS in pyramidal neurons in Alzheimer's disease is highly co-localized with p21ras and p16INK4a. Luth HJ, etal., Brain Res. 2000 Jan 3;852(1):45-55.
20. Down-regulation of K-ras and H-ras in human brain gliomas. Lymbouridou R, etal., Eur J Cancer. 2009 May;45(7):1294-303. doi: 10.1016/j.ejca.2008.12.028. Epub 2009 Jan 27.
21. Transcriptional activation of H- and N-ras oncogenes in human cervical cancer. Mammas IN, etal., Gynecol Oncol. 2004 Mar;92(3):941-8.
22. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
23. MGDs mouse GO annotations MGD data from the GO Consortium
24. MGD IEA MGD IEA
25. Expression of ras p21 in the stromal cells of human neoplastic endometrium. Miturski R, etal., Eur J Gynaecol Oncol. 1998;19(3):308-11.
26. Enhancement of tongue carcinogenesis in Hras128 transgenic rats treated with 4-nitroquinoline 1-oxide. Naoi K, etal., Oncol Rep. 2010 Feb;23(2):337-44.
27. Increased expression of c-myc and c-Ha-ras in dichloroacetate and trichloroacetate-induced liver tumors in B6C3F1 mice. Nelson MA, etal., Toxicology. 1990 Oct;64(1):47-57.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. [Immunohistochemical detection of p21ras, c-myc and p53 oncoproteins in hepatocellular carcinoma and in non-neoplastic liver tissue]. Pannain VL, etal., Arq Gastroenterol. 2004 Oct-Dec;41(4):225-8. doi: /S0004-28032004000400005. Epub 2005 Mar 29.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
33. Mouse MP Annotation Import Pipeline RGD automated import pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. MEK1/2 dual-specificity protein kinases: Structure and regulation. Roskoski R Jr Biochem Biophys Res Commun. 2012 Jan 6;417(1):5-10. Epub 2011 Dec 8.
37. Assignment of three rat cellular RAS oncogenes to chromosomes 1, 4, and X. Szpirer J, etal., Somat Cell Mol Genet 1985 Jan;11(1):93-7.
38. Frequent activating HRAS mutations in trichilemmoma. Tsai JH, etal., Br J Dermatol. 2014 Nov;171(5):1073-7. doi: 10.1111/bjd.13143. Epub 2014 Sep 30.
39. Susceptibility of experimental autoimmune hepatitis in transgenic mice overexpressing the c-H-ras gene. Tsunematsu S, etal., J Gastroenterol Hepatol. 1997 Apr;12(4):319-24.
40. Diabetes enhances the expression of H-ras and suppresses the expression of EGFR leading to increased cell proliferation. Vairaktaris E, etal., Histol Histopathol. 2009 May;24(5):531-9.
41. Recurring HRAS mutation G12S in Dutch patients with Costello syndrome. van Steensel MA, etal., Exp Dermatol. 2006 Sep;15(9):731-4.
42. ras gene mutations in human endometrial carcinoma. Varras MN, etal., Oncology. 1996 Nov-Dec;53(6):505-10. doi: 10.1159/000227627.
43. MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2. Wang XF, etal., J Cancer Res Clin Oncol. 2012 Apr;138(4):573-84. doi: 10.1007/s00432-011-1114-x. Epub 2011 Dec 30.
Additional References at PubMed
PMID:1347472   PMID:1347942   PMID:1351769   PMID:1354647   PMID:1395719   PMID:1507224   PMID:1594760   PMID:1617216   PMID:1747936   PMID:1887859   PMID:1889815   PMID:1923524  
PMID:1981054   PMID:2185890   PMID:2251261   PMID:2307474   PMID:2463212   PMID:2543942   PMID:3022995   PMID:3074812   PMID:3146546   PMID:3275546   PMID:3416641   PMID:3469670  
PMID:3559163   PMID:3932284   PMID:6087347   PMID:6253810   PMID:6254252   PMID:6265801   PMID:6283384   PMID:6289129   PMID:6318374   PMID:6320193   PMID:6364482   PMID:6594688  
PMID:6641714   PMID:6690234   PMID:6864883   PMID:7487932   PMID:7522983   PMID:7526162   PMID:7576111   PMID:7607680   PMID:7670492   PMID:7676462   PMID:7774957   PMID:7776260  
PMID:7829473   PMID:8095010   PMID:8098216   PMID:8280375   PMID:8286110   PMID:8390964   PMID:8417808   PMID:8475993   PMID:8499656   PMID:8668348   PMID:8787751   PMID:8828504  
PMID:8838320   PMID:8903721   PMID:8922043   PMID:8939998   PMID:9038709   PMID:9144171   PMID:9167944   PMID:9235916   PMID:9261098   PMID:9334313   PMID:9488663   PMID:9852579  
PMID:10085069   PMID:10341706   PMID:10341708   PMID:10374394   PMID:10704452   PMID:10729330   PMID:10814892   PMID:10845775   PMID:10862698   PMID:10869344   PMID:10871846   PMID:10917603  
PMID:10922068   PMID:10926822   PMID:11059761   PMID:11079161   PMID:11134081   PMID:11173924   PMID:11238881   PMID:11285202   PMID:11325859   PMID:11326421   PMID:11370830   PMID:11435472  
PMID:11551927   PMID:11695562   PMID:11695564   PMID:11695570   PMID:11748141   PMID:11749692   PMID:11812828   PMID:11840339   PMID:11853538   PMID:11877426   PMID:11884408   PMID:11964143  
PMID:12016150   PMID:12067982   PMID:12082015   PMID:12105419   PMID:12112317   PMID:12196526   PMID:12242664   PMID:12388208   PMID:12427827   PMID:12446704   PMID:12466851   PMID:12477932  
PMID:12509462   PMID:12515821   PMID:12584202   PMID:12589428   PMID:12684535   PMID:12766907   PMID:12878730   PMID:12907435   PMID:12915131   PMID:12941805   PMID:14500341   PMID:14610273  
PMID:14712229   PMID:14724641   PMID:15064703   PMID:15123632   PMID:15235600   PMID:15305288   PMID:15314658   PMID:15369798   PMID:15558479   PMID:15572682   PMID:15592514   PMID:15601844  
PMID:15603741   PMID:15642358   PMID:15652346   PMID:15710389   PMID:15761837   PMID:15782199   PMID:15800929   PMID:15824104   PMID:15831492   PMID:15860728   PMID:15870287   PMID:15902970  
PMID:15902973   PMID:16102754   PMID:16117800   PMID:16123588   PMID:16223784   PMID:16339563   PMID:16405865   PMID:16448747   PMID:16461771   PMID:16467383   PMID:16469745   PMID:16478791  
PMID:16614081   PMID:16624289   PMID:16644864   PMID:16679559   PMID:16687293   PMID:16717102   PMID:16803888   PMID:16871579   PMID:16889766   PMID:16954213   PMID:16980617   PMID:17050172  
PMID:17054105   PMID:17096025   PMID:17230190   PMID:17254020   PMID:17256055   PMID:17265428   PMID:17272280   PMID:17332061   PMID:17408635   PMID:17439485   PMID:17538944   PMID:17568777  
PMID:17588947   PMID:17638870   PMID:17646168   PMID:17697114   PMID:17699159   PMID:17714917   PMID:17724343   PMID:17906893   PMID:17962350   PMID:17984326   PMID:18021740   PMID:18045915  
PMID:18059342   PMID:18165224   PMID:18215118   PMID:18218323   PMID:18371380   PMID:18391074   PMID:18408766   PMID:18467631   PMID:18483625   PMID:18536715   PMID:18577512   PMID:18591425  
PMID:18596699   PMID:18598255   PMID:18604197   PMID:18636078   PMID:18667617   PMID:18701482   PMID:18757346   PMID:18760695   PMID:18768391   PMID:18823404   PMID:18981410   PMID:18988803  
PMID:19000654   PMID:19015638   PMID:19018287   PMID:19020090   PMID:19029245   PMID:19063885   PMID:19065634   PMID:19114553   PMID:19146951   PMID:19161227   PMID:19182994   PMID:19218240  
PMID:19284475   PMID:19288266   PMID:19319189   PMID:19416908   PMID:19460636   PMID:19521500   PMID:19595712   PMID:19700408   PMID:19802012   PMID:19878719   PMID:19895680   PMID:19936293  
PMID:19961928   PMID:20032959   PMID:20038817   PMID:20067919   PMID:20090846   PMID:20105280   PMID:20150892   PMID:20179099   PMID:20307629   PMID:20354187   PMID:20398060   PMID:20406971  
PMID:20676142   PMID:20703083   PMID:20805985   PMID:20884686   PMID:20926682   PMID:20937865   PMID:20944141   PMID:20971740   PMID:21041952   PMID:21119005   PMID:21220306   PMID:21267068  
PMID:21317241   PMID:21357543   PMID:21444916   PMID:21572967   PMID:21600874   PMID:21677750   PMID:21731673   PMID:21737741   PMID:21747916   PMID:21858071   PMID:21868531   PMID:21873635  
PMID:22094331   PMID:22105357   PMID:22241963   PMID:22355113   PMID:22494971   PMID:22535521   PMID:22576369   PMID:22798674   PMID:22847423   PMID:22847612   PMID:22945650   PMID:22982107  
PMID:23136424   PMID:23151849   PMID:23213349   PMID:23250758   PMID:23380875   PMID:23382219   PMID:23396970   PMID:23468876   PMID:23676667   PMID:23706742   PMID:23831572   PMID:23918800  
PMID:23945586   PMID:24057668   PMID:24213576   PMID:24226523   PMID:24240680   PMID:24469813   PMID:24470255   PMID:24472646   PMID:24569991   PMID:24813943   PMID:24872318   PMID:24968297  
PMID:25003191   PMID:25218146   PMID:25267792   PMID:25288756   PMID:25359213   PMID:25533468   PMID:25535333   PMID:25721469   PMID:25774517   PMID:25788415   PMID:25795707   PMID:25902334  
PMID:25947161   PMID:25977330   PMID:26146073   PMID:26190969   PMID:26203562   PMID:26359368   PMID:26452271   PMID:26568031   PMID:26740656   PMID:27034005   PMID:27155324   PMID:27185863  
PMID:27207659   PMID:27344374   PMID:27357235   PMID:27655119   PMID:27872088   PMID:27911940   PMID:27991921   PMID:28053233   PMID:28117393   PMID:28162272   PMID:28193718   PMID:28378742  
PMID:28434617   PMID:28455524   PMID:28481866   PMID:28584132   PMID:28644741   PMID:28671696   PMID:28856719   PMID:29054855   PMID:29254681   PMID:29502968   PMID:29615452   PMID:29720552  
PMID:29760048   PMID:29844052   PMID:29959233   PMID:30592646   PMID:30655611   PMID:30670749   PMID:31408278   PMID:31685810   PMID:31873167   PMID:31906952   PMID:32165588   PMID:32325033  
PMID:32516567   PMID:32747435   PMID:32792500   PMID:33277484   PMID:33331896   PMID:33393458   PMID:34051011   PMID:34309585   PMID:34321999   PMID:34535655   PMID:34553752   PMID:35230976  
PMID:35822835   PMID:35904492   PMID:36287323   PMID:36306264   PMID:36330334   PMID:36450983   PMID:36835200   PMID:36943390   PMID:37075955   PMID:38452464  


Genomics

Comparative Map Data
Hras
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,770,839 - 140,773,938 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,769,018 - 140,773,918 (-)EnsemblGRCm39 Ensembl
GRCm387141,189,934 - 141,194,019 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,189,105 - 141,194,005 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,375,833 - 148,379,903 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,042,668 - 141,044,260 (-)NCBIMGSCv36mm8
Celera7140,983,643 - 140,987,701 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.48NCBI
HRAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811532,242 - 535,576 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11532,242 - 537,321 (-)EnsemblGRCh38hg38GRCh38
GRCh3711532,242 - 535,576 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611522,242 - 525,550 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411522,242 - 525,550NCBI
Celera11594,708 - 598,010 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11346,981 - 349,115 (-)NCBIHuRef
CHM1_111529,852 - 534,465 (-)NCBICHM1_1
T2T-CHM13v2.011579,238 - 582,554 (-)NCBIT2T-CHM13v2.0
Hras
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,712,625 - 205,729,406 (-)NCBIGRCr8
mRatBN7.21196,290,127 - 196,299,823 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,296,263 - 196,300,615 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,641,764 - 204,645,046 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,768,581 - 211,771,863 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,442,715 - 204,445,997 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,178,404 - 214,181,841 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,178,407 - 214,181,686 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,095,943 - 221,099,362 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,385,705 - 201,388,987 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,540,000 - 201,542,640 (-)NCBI
Celera1193,930,281 - 193,933,583 (-)NCBICelera
RH 3.4 Map11437.21RGD
Cytogenetic Map1q41NCBI
Hras
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,508,126 - 11,510,333 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,508,446 - 11,510,333 (+)NCBIChiLan1.0ChiLan1.0
HRAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v292,909,695 - 2,913,028 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,126,936 - 2,130,261 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011537,488 - 540,810 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111568,305 - 571,078 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11568,305 - 571,078 (-)Ensemblpanpan1.1panPan2
HRAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,642,844 - 25,644,717 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1825,642,844 - 25,644,717 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,291,831 - 25,293,704 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01826,227,144 - 26,230,043 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1826,220,886 - 26,230,059 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11825,736,932 - 25,738,805 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,381,917 - 25,383,790 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01825,994,065 - 25,995,938 (-)NCBIUU_Cfam_GSD_1.0
Hras
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947375,371 - 378,065 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888375,377 - 377,958 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936888375,372 - 378,125 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HRAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2299,660 - 302,501 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12299,662 - 302,539 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HRAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11343,613 - 345,782 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1343,506 - 346,637 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603897,407,188 - 97,410,502 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hras
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,911,241 - 21,913,653 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476621,907,423 - 21,913,414 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hras
85 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2838
Count of miRNA genes:624
Interacting mature miRNAs:787
Transcripts:ENSMUST00000026572, ENSMUST00000097957, ENSMUST00000124314, ENSMUST00000124971, ENSMUST00000128993, ENSMUST00000134008, ENSMUST00000168550
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse

Markers in Region
RH94696  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387141,195,319 - 141,195,570UniSTSGRCm38
MGSCv377148,381,218 - 148,381,469UniSTSGRCm37
Celera7140,989,076 - 140,989,327UniSTS
Cytogenetic Map7F5UniSTS
cM Map772.2UniSTS
PMC112649P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387141,192,700 - 141,193,047UniSTSGRCm38
MGSCv377148,378,599 - 148,378,946UniSTSGRCm37
Celera7140,986,409 - 140,986,756UniSTS
Cytogenetic Map7F5UniSTS
cM Map772.2UniSTS
PMC112649P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387141,192,422 - 141,192,618UniSTSGRCm38
MGSCv377148,378,321 - 148,378,517UniSTSGRCm37
Celera7140,986,131 - 140,986,327UniSTS
Cytogenetic Map7F5UniSTS
cM Map772.2UniSTS
Hras1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
cM Map772.2UniSTS
PMC86690P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387141,192,980 - 141,193,414UniSTSGRCm38
MGSCv377148,378,879 - 148,379,313UniSTSGRCm37
Celera7140,986,689 - 140,987,123UniSTS
Cytogenetic Map7F5UniSTS
cM Map772.2UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001130443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001130444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_178203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_178204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_178205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_178206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003946393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004934018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_389952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB072334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC108908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF268311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ437023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY373386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY490389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI731283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ963436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU924724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK788792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JC006851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S74119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U89950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z50013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000026572   ⟹   ENSMUSP00000026572
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,769,018 - 140,773,873 (-)Ensembl
GRCm38.p6 Ensembl7141,189,105 - 141,193,960 (-)Ensembl
RefSeq Acc Id: ENSMUST00000097957   ⟹   ENSMUSP00000095570
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,770,839 - 140,773,918 (-)Ensembl
GRCm38.p6 Ensembl7141,190,926 - 141,194,005 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124314   ⟹   ENSMUSP00000147731
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,770,840 - 140,772,853 (-)Ensembl
GRCm38.p6 Ensembl7141,190,927 - 141,192,940 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124971   ⟹   ENSMUSP00000138189
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,770,843 - 140,773,795 (-)Ensembl
GRCm38.p6 Ensembl7141,190,930 - 141,193,882 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128993
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,770,839 - 140,773,907 (-)Ensembl
GRCm38.p6 Ensembl7141,190,926 - 141,193,994 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134008   ⟹   ENSMUSP00000147590
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,770,843 - 140,771,890 (-)Ensembl
GRCm38.p6 Ensembl7141,190,930 - 141,191,977 (-)Ensembl
RefSeq Acc Id: ENSMUST00000168550   ⟹   ENSMUSP00000132110
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,769,847 - 140,773,917 (-)Ensembl
GRCm38.p6 Ensembl7141,189,934 - 141,194,004 (-)Ensembl
RefSeq Acc Id: NM_001130443   ⟹   NP_001123915
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,770,839 - 140,773,872 (-)NCBI
GRCm387141,189,934 - 141,194,004 (-)NCBI
MGSCv377148,375,833 - 148,379,903 (-)RGD
Celera7140,983,643 - 140,987,701 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001130444   ⟹   NP_001123916
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,770,839 - 140,773,872 (-)NCBI
GRCm387141,189,934 - 141,194,004 (-)NCBI
MGSCv377148,375,833 - 148,379,903 (-)RGD
Celera7140,983,643 - 140,987,701 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001412478   ⟹   NP_001399407
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,770,839 - 140,773,872 (-)NCBI
RefSeq Acc Id: NM_001412479   ⟹   NP_001399408
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,770,839 - 140,773,452 (-)NCBI
RefSeq Acc Id: NM_001412480   ⟹   NP_001399409
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,770,839 - 140,773,452 (-)NCBI
RefSeq Acc Id: NM_001412481   ⟹   NP_001399410
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,770,839 - 140,773,452 (-)NCBI
RefSeq Acc Id: NM_008284   ⟹   NP_032310
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,770,839 - 140,773,872 (-)NCBI
GRCm387141,189,934 - 141,194,004 (-)NCBI
MGSCv377148,375,833 - 148,379,903 (-)RGD
Celera7140,983,643 - 140,987,701 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_178203
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,770,839 - 140,773,872 (-)NCBI
RefSeq Acc Id: NR_178204
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,770,839 - 140,773,872 (-)NCBI
RefSeq Acc Id: NR_178205
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,770,839 - 140,773,872 (-)NCBI
RefSeq Acc Id: NR_178206
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,770,839 - 140,773,872 (-)NCBI
RefSeq Acc Id: XR_003946393
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,770,839 - 140,773,938 (-)NCBI
GRCm387141,190,926 - 141,194,019 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004934018
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,770,839 - 140,773,938 (-)NCBI
Sequence:
RefSeq Acc Id: XR_389952
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,770,839 - 140,773,938 (-)NCBI
GRCm387141,190,926 - 141,194,019 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001123915 (Get FASTA)   NCBI Sequence Viewer  
  NP_001123916 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399407 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399408 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399409 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399410 (Get FASTA)   NCBI Sequence Viewer  
  NP_032310 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB50559 (Get FASTA)   NCBI Sequence Viewer  
  AAD56718 (Get FASTA)   NCBI Sequence Viewer  
  AAF74295 (Get FASTA)   NCBI Sequence Viewer  
  AAH11083 (Get FASTA)   NCBI Sequence Viewer  
  AAH61885 (Get FASTA)   NCBI Sequence Viewer  
  AAP21090 (Get FASTA)   NCBI Sequence Viewer  
  AAQ81319 (Get FASTA)   NCBI Sequence Viewer  
  AAT72335 (Get FASTA)   NCBI Sequence Viewer  
  BAB88314 (Get FASTA)   NCBI Sequence Viewer  
  BAB88315 (Get FASTA)   NCBI Sequence Viewer  
  BAB88316 (Get FASTA)   NCBI Sequence Viewer  
  CAA90306 (Get FASTA)   NCBI Sequence Viewer  
  CAD24593 (Get FASTA)   NCBI Sequence Viewer  
  CDL93476 (Get FASTA)   NCBI Sequence Viewer  
  EDL18007 (Get FASTA)   NCBI Sequence Viewer  
  EDL18008 (Get FASTA)   NCBI Sequence Viewer  
  EDL18009 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000026572
  ENSMUSP00000026572.5
  ENSMUSP00000095570
  ENSMUSP00000095570.5
  ENSMUSP00000132110
  ENSMUSP00000132110.2
  ENSMUSP00000138189.2
  ENSMUSP00000147590.2
  ENSMUSP00000147731.2
GenBank Protein Q61411 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032310   ⟸   NM_008284
- Peptide Label: isoform 1
- UniProtKB: Q80WD2 (UniProtKB/Swiss-Prot),   Q6P716 (UniProtKB/Swiss-Prot),   F7BIB2 (UniProtKB/Swiss-Prot),   Q811B9 (UniProtKB/Swiss-Prot),   Q61411 (UniProtKB/Swiss-Prot),   Q9R0B8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001123915   ⟸   NM_001130443
- Peptide Label: isoform 1
- UniProtKB: Q80WD2 (UniProtKB/Swiss-Prot),   Q6P716 (UniProtKB/Swiss-Prot),   F7BIB2 (UniProtKB/Swiss-Prot),   Q811B9 (UniProtKB/Swiss-Prot),   Q61411 (UniProtKB/Swiss-Prot),   Q9R0B8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001123916   ⟸   NM_001130444
- Peptide Label: isoform 2
- UniProtKB: A0A0G2JGP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000147731   ⟸   ENSMUST00000124314
RefSeq Acc Id: ENSMUSP00000138189   ⟸   ENSMUST00000124971
RefSeq Acc Id: ENSMUSP00000026572   ⟸   ENSMUST00000026572
RefSeq Acc Id: ENSMUSP00000132110   ⟸   ENSMUST00000168550
RefSeq Acc Id: ENSMUSP00000147590   ⟸   ENSMUST00000134008
RefSeq Acc Id: ENSMUSP00000095570   ⟸   ENSMUST00000097957
RefSeq Acc Id: NP_001399407   ⟸   NM_001412478
- Peptide Label: isoform 1
- UniProtKB: Q80WD2 (UniProtKB/Swiss-Prot),   Q6P716 (UniProtKB/Swiss-Prot),   Q61411 (UniProtKB/Swiss-Prot),   F7BIB2 (UniProtKB/Swiss-Prot),   Q811B9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001399409   ⟸   NM_001412480
- Peptide Label: isoform 1
- UniProtKB: Q80WD2 (UniProtKB/Swiss-Prot),   Q6P716 (UniProtKB/Swiss-Prot),   Q61411 (UniProtKB/Swiss-Prot),   F7BIB2 (UniProtKB/Swiss-Prot),   Q811B9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001399408   ⟸   NM_001412479
- Peptide Label: isoform 1
- UniProtKB: Q80WD2 (UniProtKB/Swiss-Prot),   Q6P716 (UniProtKB/Swiss-Prot),   Q61411 (UniProtKB/Swiss-Prot),   F7BIB2 (UniProtKB/Swiss-Prot),   Q811B9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001399410   ⟸   NM_001412481
- Peptide Label: isoform 1
- UniProtKB: Q80WD2 (UniProtKB/Swiss-Prot),   Q6P716 (UniProtKB/Swiss-Prot),   Q61411 (UniProtKB/Swiss-Prot),   F7BIB2 (UniProtKB/Swiss-Prot),   Q811B9 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61411-F1-model_v2 AlphaFold Q61411 1-189 view protein structure

Promoters
RGD ID:8666077
Promoter ID:EPDNEW_M11070
Type:initiation region
Name:Hras_1
Description:Mus musculus Harvey rat sarcoma virus oncogene , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387141,193,959 - 141,194,019EPDNEW
RGD ID:6841309
Promoter ID:MM_KWN:53227
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:OTTMUST00000039715,   OTTMUST00000039716,   UC009KJV.1,   UC009KJW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367148,378,131 - 148,379,552 (-)MPROMDB
RGD ID:6841472
Promoter ID:MM_KWN:53228
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000026572,   ENSMUST00000106028,   NM_001130444,   NM_001172064,   NM_001172065,   OTTMUST00000039711,   OTTMUST00000039713,   OTTMUST00000039714,   OTTMUST00000056184,   OTTMUST00000056187,   OTTMUST00000056189
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367148,379,891 - 148,380,757 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96224 AgrOrtholog
Ensembl Genes ENSMUSG00000025499 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026572 ENTREZGENE
  ENSMUST00000026572.11 UniProtKB/Swiss-Prot
  ENSMUST00000097957 ENTREZGENE
  ENSMUST00000097957.11 UniProtKB/Swiss-Prot
  ENSMUST00000124314.3 UniProtKB/Swiss-Prot
  ENSMUST00000124971 ENTREZGENE
  ENSMUST00000124971.2 UniProtKB/TrEMBL
  ENSMUST00000134008.2 UniProtKB/TrEMBL
  ENSMUST00000168550 ENTREZGENE
  ENSMUST00000168550.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15461 UniProtKB/Swiss-Prot
MGD MGI:96224 ENTREZGENE
NCBI Gene 15461 ENTREZGENE
PANTHER GTPASE HRAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24070 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HRAS RGD
PhenoGen Hras PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JGP4 ENTREZGENE
  A0A1B0GRN0_MOUSE UniProtKB/TrEMBL
  C0H5X4_MOUSE UniProtKB/TrEMBL
  F7BIB2 ENTREZGENE
  Q61411 ENTREZGENE
  Q6P716 ENTREZGENE
  Q80WD2 ENTREZGENE
  Q811B9 ENTREZGENE
  Q9R0B8 ENTREZGENE, UniProtKB/TrEMBL
  RASH_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary F7BIB2 UniProtKB/Swiss-Prot
  Q6P716 UniProtKB/Swiss-Prot
  Q80WD2 UniProtKB/Swiss-Prot
  Q811B9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-01-29 Hras  Harvey rat sarcoma virus oncogene  Hras1  Harvey rat sarcoma virus oncogene 1  Symbol and/or name change 5135510 APPROVED