Gene: Nr1h2 (nuclear receptor subfamily 1, group H, member 2)
Mus musculus
Symbol:
Nr1h2
Name:
nuclear receptor subfamily 1, group H, member 2
Description:
ENCODES a protein that exhibits DNA binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; retinoid X receptor binding; INVOLVED IN cellular lipid metabolic process; cholesterol homeostasis; intracellular receptor signaling pathway; ASSOCIATED WITH abnormal astrocyte morphology; abnormal bone marrow cell physiology; abnormal brain ependyma morphology; ASSOCIATED WITH Arthritis, Experimental; Encephalomyelitis, Autoimmune, Experimental; Gallbladder Neoplasms; FOUND IN nucleus; cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-linolenic acid; caprylic acid
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
AI194859; liver X receptor beta; LXR; LXR beta; LXRB; LXRbeta; NER1; OR-1; OTTMUSP00000026678; OTTMUSP00000026679; OTTMUSP00000026680; OTTMUSP00000026720; oxysterols receptor LXR-beta; retinoid X receptor-interacting protein No.15; RIP15; ubiquitously-expressed nuclear receptor 2; Unr; Unr2; UR
Orthologs:
Homo sapiens : NR1H2
(nuclear receptor subfamily 1, group H, member 2)
HGNC
Rattus norvegicus : Nr1h2
(nuclear receptor subfamily 1, group H, member 2)
Related Pseudogenes:
Nr1h2-ps
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 7 44,549,632 - 44,553,923 - NCBI Mouse cM Map 7 - NCBI Mouse Celera Assembly 7 39,999,761 - 40,004,052 - NCBI Mouse Genome Assembly Build 37 7 51,805,002 - 51,809,293 - NCBI Mouse Genome Assembly Build 36.1 7 51,805,002 - 51,809,293 - NCBI Mouse Cytogenetic Map 7 B4 NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
17beta-estradiol decreases expression ISO RGD:1352469 6480464 Estradiol results in decreased expression of NR1H2 mRNA CTD PMID:16029874 PMID:15223131 17beta-estradiol decreases expression ISO RGD:1352469 6480464 Estradiol results in decreased expression of NR1H2 mRNA CTD PMID:15223131 PMID:16029874 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1352469 6480464 Tetrachlorodibenzodioxin results in decreased expression of NR1H2 mRNA CTD PMID:19684285 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of NR1H2 mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression ISO RGD:61906 6480464 2,4-dinitrotoluene affects the expression of NR1H2 mRNA CTD PMID:21346803 2,6-di-tert-butyl-4-methylphenol multiple interactions ISO RGD:1352469 6480464 Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H2 mRNA] CTD PMID:17070507 8-bromo-3',5'-cyclic AMP decreases expression ISO RGD:1352469 6480464 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of NR1H2 mRNA CTD PMID:22079614 9-cis-retinoic acid multiple interactions ISO RGD:1352469 6480464 [alitretinoin co-treated with 22-hydroxycholesterol] affects the localization of NR1H2 protein CTD PMID:16888799 alpha-linolenic acid multiple interactions EXP 6480464 alpha-Linolenic Acid binds to and results in increased activity of NR1H2 protein CTD PMID:16731579 ammonium chloride affects expression ISO RGD:61906 6480464 Ammonium Chloride affects the expression of NR1H2 mRNA CTD PMID:16483693 arsenic atom increases methylation ISO RGD:1352469 6480464 Arsenic results in increased methylation of NR1H2 promoter CTD PMID:21291286 bezafibrate increases expression ISO RGD:1352469 6480464 Bezafibrate results in increased expression of NR1H2 mRNA CTD PMID:19201410 bisphenol A decreases expression ISO RGD:1352469 6480464 bisphenol A results in decreased expression of NR1H2 mRNA CTD PMID:15223131 caprylic acid multiple interactions EXP 6480464 caprylic acid binds to and results in increased activity of NR1H2 protein; more ... CTD PMID:16731579 cholesterol increases activity ISO RGD:1352469 6480464 Cholesterol results in increased activity of NR1H2 protein CTD PMID:21543282 cholesterol multiple interactions EXP 6480464 [RXRB protein binds to NR1H2 protein] which affects the metabolism of Cholesterol CTD PMID:14993927 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NR1H2 gene CTD PMID:20938992 dexamethasone affects response to substance EXP 6480464 NR1H2 affects the susceptibility to Dexamethasone CTD PMID:21123945 diarsenic trioxide increases expression EXP 6480464 arsenic trioxide results in increased expression of NR1H2 mRNA CTD PMID:15073043 diarsenic trioxide multiple interactions ISO RGD:61906 6480464 Cholesterol, Dietary promotes the reaction [arsenic trioxide results in decreased expression of NR1H2 protein] CTD PMID:21851829 diarsenic trioxide decreases expression ISO RGD:61906 6480464 arsenic trioxide results in decreased expression of NR1H2 protein CTD PMID:21851829 ezetimibe decreases expression ISO RGD:1352469 6480464 ezetimibe results in decreased expression of NR1H2 mRNA CTD PMID:16177187 fenofibrate increases expression ISO RGD:1352469 6480464 Fenofibrate results in increased expression of NR1H2 mRNA CTD PMID:19201410 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NR1H2 gene CTD PMID:20938992 gemfibrozil increases expression ISO RGD:1352469 6480464 Gemfibrozil results in increased expression of NR1H2 mRNA CTD PMID:19201410 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NR1H2 gene CTD PMID:20938992 lansoprazole increases activity ISO RGD:1352469 6480464 lansoprazole results in increased activity of NR1H2 protein CTD PMID:20060385 N-nitrosodiethylamine multiple interactions ISO RGD:61906 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of NR1H2 mRNA CTD PMID:18164116 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of NR1H2 mRNA CTD PMID:17562736 pioglitazone increases expression ISO RGD:1352469 6480464 pioglitazone results in increased expression of NR1H2 mRNA CTD PMID:19201410 uranium atom decreases expression ISO RGD:61906 6480464 Uranium results in decreased expression of NR1H2 mRNA CTD PMID:17118558
Biological Process
cellular lipid metabolic process IDA 2290270 MGI:MGI:3038048|PMID:14739254 MGI MGI:MGI:3038048 PMID:14739254 cholesterol homeostasis IDA 2290270 MGI:MGI:3720271|PMID:17657314 BHF-UCL MGI:MGI:3720271 PMID:17657314 intracellular receptor signaling pathway IDA 2290270 MGI:MGI:3038048|PMID:14739254 GOC MGI:MGI:3038048 PMID:14739254 lipid homeostasis IMP 2290270 MGI:MGI:3822255|PMID:18806227 BHF-UCL MGI:MGI:3822255 PMID:18806227 negative regulation of cholesterol storage ISO UniProtKB:P55055 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 negative regulation of gene expression ISO UniProtKB:Q62755 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of lipid transport ISO UniProtKB:P55055 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 negative regulation of pinocytosis ISO UniProtKB:P55055 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 negative regulation of proteolysis IMP 2290270 MGI:MGI:3822255|PMID:18806227 BHF-UCL MGI:MGI:3822255 PMID:18806227 negative regulation of transcription from RNA polymerase II promoter IMP 2290270 MGI:MGI:4418599|PMID:19329817 BHF-UCL MGI:MGI:4418599 PMID:19329817 negative regulation of transcription, DNA-dependent ISO UniProtKB:P55055 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of cellular protein metabolic process ISO UniProtKB:P55055 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of cholesterol efflux IDA 2290270 MGI:MGI:3720271|PMID:17657314 BHF-UCL MGI:MGI:3720271 PMID:17657314 positive regulation of cholesterol efflux ISO UniProtKB:P55055 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of cholesterol efflux IDA 2290270 MGI:MGI:3794353|PMID:16825483 BHF-UCL MGI:MGI:3794353 PMID:16825483 positive regulation of cholesterol transport ISO UniProtKB:P55055 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of fatty acid biosynthetic process ISO UniProtKB:P55055 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of gene expression ISO UniProtKB:Q62755 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of high-density lipoprotein particle assembly IDA 2290270 MGI:MGI:3794353|PMID:16825483 BHF-UCL MGI:MGI:3794353 PMID:16825483 positive regulation of high-density lipoprotein particle assembly IDA 2290270 MGI:MGI:3720271|PMID:17657314 BHF-UCL MGI:MGI:3720271 PMID:17657314 positive regulation of lipid storage IMP 2290270 MGI:MGI:3822255|PMID:18806227 BHF-UCL MGI:MGI:3822255 PMID:18806227 positive regulation of lipoprotein lipase activity ISO UniProtKB:P55055 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of pancreatic juice secretion IMP 2290270 MGI:MGI:3822255|PMID:18806227 BHF-UCL MGI:MGI:3822255 PMID:18806227 positive regulation of secretion of lysosomal enzymes IMP 2290270 MGI:MGI:3822255|PMID:18806227 BHF-UCL MGI:MGI:3822255 PMID:18806227 positive regulation of transcription from RNA polymerase II promoter IDA 2290270 MGI:MGI:3794353|PMID:16825483 BHF-UCL MGI:MGI:3794353 PMID:16825483 positive regulation of transcription from RNA polymerase II promoter ISO UniProtKB:P55055 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of transcription from RNA polymerase II promoter IDA 2290270 MGI:MGI:4399022|PMID:16141411 BHF-UCL MGI:MGI:4399022 PMID:16141411 positive regulation of triglyceride biosynthetic process ISO UniProtKB:P55055 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of transcription from RNA polymerase II promoter IGI MGI:MGI:98214 2290270 MGI:MGI:70873|PMID:7760852 MGI MGI:MGI:70873 PMID:7760852 regulation of transcription, DNA-dependent IDA 2290270 MGI:MGI:3038048|PMID:14739254 MGI MGI:MGI:3038048 PMID:14739254 retinoic acid receptor signaling pathway ISO UniProtKB:Q62755 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 steroid hormone mediated signaling pathway IEA InterPro:IPR000536 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 transcription, DNA-dependent IEA UniProtKB-KW:KW-0804 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
Cellular Component
cytoplasm ISO UniProtKB:P55055 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 nucleus IDA 2290270 MGI:MGI:3822255|PMID:18806227 BHF-UCL MGI:MGI:3822255 PMID:18806227 nucleus ISO UniProtKB:P55055 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177
Molecular Function
DNA binding IDA 2290270 MGI:MGI:3038048|PMID:14739254 MGI MGI:MGI:3038048 PMID:14739254 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA 2290270 MGI:MGI:3038048|PMID:14739254 MGI MGI:MGI:3038048 PMID:14739254 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 protein binding IPI UniProtKB:Q96EB6 2290270 MGI:MGI:3790014|PMID:17936707 IntAct MGI:MGI:3790014 PMID:17936707 retinoid X receptor binding IDA 2290270 MGI:MGI:70873|PMID:7760852 MGI MGI:MGI:70873 PMID:7760852 retinoid X receptor binding ISO UniProtKB:Q62755 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 sequence-specific DNA binding contributes_to ISO UniProtKB:Q62755 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 sequence-specific DNA binding transcription factor activity IDA 2290270 MGI:MGI:3038048|PMID:14739254 MGI MGI:MGI:3038048 PMID:14739254 sequence-specific DNA binding transcription factor activity IGI MGI:MGI:98214 2290270 MGI:MGI:70873|PMID:7760852 MGI MGI:MGI:70873 PMID:7760852 sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity ISO UniProtKB:Q62755 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 steroid hormone receptor activity IEA InterPro:IPR008946|InterPro:IPR000536|InterPro:IPR001723 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 zinc ion binding IEA InterPro:IPR001628|InterPro:IPR013088 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098
1559023 Gbrln_m granular brain lesions (mouse) Not determined 7 48754442 82754587 Mouse 4141929 Chlq18_m circulating hormone level QTL 18 (mouse) Not determined 7 48754442 82754587 Mouse 1357724 Fmgty6_m femur geometry 6 (mouse) Not determined 7 48754442 82754587 Mouse 1300878 Skts1_m skin tumor susceptibility 1 (mouse) Not determined 7 45497008 79497204 Mouse 1357586 Mdmsc3_m modifier of muscularity 3 (mouse) Not determined 7 42053491 76053640 Mouse 1300757 Cocia9_m cocaine induced activation 9 (mouse) Not determined 7 42053491 76053640 Mouse 4142288 Mcvq1_m mean corpuscular volume QTL 1 (mouse) Not determined 7 42053491 76053640 Mouse 1559000 Ossc1_m osteosarcoma susceptibility 1 (mouse) Not determined 7 41658647 75658845 Mouse 1300996 Aorls2_m aortic lesion size 2 (mouse) Not determined 7 40000154 74000303 Mouse 4141059 Ciaaq1_m collagen induced arthritis autoantibody QTL 1 (mouse) Not determined 7 40000154 74000303 Mouse 1301175 Ap7q_m alcohol preference 7 QTL (mouse) Not determined 7 39320467 73320699 Mouse 1558814 Ducm1_m dsRNA-induced UCM 1 (mouse) Not determined 7 39320467 73320699 Mouse 1357445 Dyscalc1_m dystrophic cardiac calcinosis 1 (mouse) Not determined 7 35942350 69942472 Mouse 1301709 Bdt4_m bone density traits 4 (mouse) Not determined 7 30494518 64494662 Mouse 4141204 Wtlr4_m weight loss response 4 (mouse) Not determined 7 30287212 64287356 Mouse 1301711 Tbrs3_m tuberculosis resistance 3 (mouse) Not determined 7 30287212 64287356 Mouse 4141960 Rosq1_m reactive oxygen species QTL 1 (mouse) Not determined 7 30279833 64279979 Mouse 1301052 Bhr6_m bronchial hyperresponsiveness 6 (mouse) Not determined 7 20927844 54927961 Mouse 1357714 Hdl38_m HDL level 38 (mouse) Not determined 7 20365609 54365698 Mouse 1301622 Eae12_m susceptibility to experimental allergic encephalomyelitis 12 (mouse) Not determined 7 20365609 54365698 Mouse