Annotation (Toggle Detail/Summary View) Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2,4-trimethylbenzene | increases expression | ISO | RGD:620299 | 6480464 | pseudocumene results in increased expression of EREG protein | CTD | PMID:17337753 | 17beta-estradiol | increases expression | ISO | RGD:730898 | 6480464 | Estradiol results in increased expression of EREG mRNA | CTD | PMID:20106945 | 17beta-estradiol | decreases expression | ISO | RGD:620299 | 6480464 | Estradiol results in decreased expression of EREG mRNA | CTD | PMID:23209616 | 17beta-estradiol | multiple interactions | ISO | RGD:620299 | 6480464 | fulvestrant inhibits the reaction [Estradiol results in decreased expression of EREG mRNA] | CTD | PMID:23209616 | 17beta-estradiol | increases expression | ISO | RGD:730898 | 6480464 | Estradiol results in increased expression of EREG mRNA | CTD | PMID:20106945 PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:730898 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | CTD | PMID:16704738 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:730898 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | CTD | PMID:16704738 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:620299 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | CTD | PMID:20558275 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:620299 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | CTD | PMID:20558275 PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:620299 | 6480464 | Tetrachlorodibenzodioxin affects the expression of EREG mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | CTD | PMID:16192470 more ... | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:730898 | 6480464 | Tetrachlorodibenzodioxin affects the expression of EREG mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | CTD | PMID:16929009 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:730898 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | CTD | PMID:16704738 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | CTD | PMID:16929009 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | CTD | PMID:18691609 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | CTD | PMID:18691609 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:730898 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | CTD | PMID:20064835 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:730898 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | CTD | PMID:20064835 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | CTD | PMID:18691609 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | CTD | PMID:16929009 more ... | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:620299 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to EREG promoter] | CTD | PMID:16192470 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to EREG promoter]; more ... | CTD | PMID:16192470 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of EREG mRNA | CTD | PMID:16962184 | 2,6-di-tert-butyl-4-methylphenol | increases expression | EXP | | 6480464 | Butylated Hydroxytoluene results in increased expression of EREG mRNA | CTD | PMID:19925653 | 3-methylcholanthrene | increases expression | EXP | | 6480464 | Methylcholanthrene results in increased expression of EREG mRNA | CTD | PMID:20713471 | 5-fluorouracil | decreases expression | ISO | RGD:730898 | 6480464 | Fluorouracil results in decreased expression of EREG mRNA | CTD | PMID:16510598 | aflatoxin B1 | affects expression | ISO | RGD:730898 | 6480464 | Aflatoxin B1 affects the expression of EREG protein | CTD | PMID:20106945 | aflatoxin B1 | increases expression | ISO | RGD:730898 | 6480464 | Aflatoxin B1 results in increased expression of EREG mRNA | CTD | PMID:22100608 | all-trans-retinoic acid | increases expression | ISO | RGD:730898 | 6480464 | Tretinoin results in increased expression of EREG mRNA | CTD | PMID:16470170 | ammonium chloride | affects expression | ISO | RGD:620299 | 6480464 | Ammonium Chloride affects the expression of EREG mRNA | CTD | PMID:16483693 | arsenite(3-) | increases methylation | ISO | RGD:730898 | 6480464 | arsenite results in increased methylation of EREG promoter | CTD | PMID:19716837 | arsenite(3-) | increases expression | EXP | | 6480464 | arsenite results in increased expression of EREG mRNA | CTD | PMID:15894712 | arsenite(3-) | multiple interactions | EXP | | 6480464 | [arsenite co-treated with Benzo(a)pyrene] results in increased expression of EREG mRNA | CTD | PMID:15894712 | arsenite(3-) | decreases expression | ISO | RGD:730898 | 6480464 | arsenite results in decreased expression of EREG mRNA | CTD | PMID:19716837 | benzo[a]pyrene | multiple interactions | ISO | RGD:730898 | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene results in increased expression of EREG mRNA] | CTD | PMID:20064835 | benzo[a]pyrene | increases expression | ISO | RGD:730898 | 6480464 | Benzo(a)pyrene results in increased expression of EREG mRNA | CTD | PMID:19181443 more ... | benzo[a]pyrene | increases expression | ISO | RGD:730898 | 6480464 | Benzo(a)pyrene results in increased expression of EREG mRNA | CTD | PMID:19181443 more ... | benzo[a]pyrene | increases expression | ISO | RGD:730898 | 6480464 | Benzo(a)pyrene results in increased expression of EREG mRNA | CTD | PMID:21871943 more ... | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of EREG mRNA | CTD | PMID:15894712 more ... | benzo[a]pyrene | increases expression | ISO | RGD:730898 | 6480464 | Benzo(a)pyrene results in increased expression of EREG mRNA | CTD | PMID:20064835 more ... | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of EREG mRNA | CTD | PMID:20713471 more ... | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of EREG mRNA | CTD | PMID:19770486 more ... | benzo[a]pyrene | increases expression | ISO | RGD:730898 | 6480464 | Benzo(a)pyrene results in increased expression of EREG mRNA | CTD | PMID:19181443 more ... | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of EREG mRNA | CTD | PMID:20713471 more ... | benzo[a]pyrene | increases expression | ISO | RGD:730898 | 6480464 | Benzo(a)pyrene results in increased expression of EREG mRNA | CTD | PMID:20106945 more ... | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of EREG mRNA | CTD | PMID:19770486 more ... | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of EREG mRNA | CTD | PMID:15894712 PMID:20713471 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [arsenite co-treated with Benzo(a)pyrene] results in increased expression of EREG mRNA | CTD | PMID:15894712 | benzo[a]pyrene | increases expression | ISO | RGD:730898 | 6480464 | Benzo(a)pyrene results in increased expression of EREG mRNA | CTD | PMID:19181443 more ... | bifenthrin | multiple interactions | ISO | RGD:620299 | 6480464 | bifenthrin inhibits the reaction [CGA protein results in increased expression of EREG mRNA] | CTD | PMID:21251947 | bisphenol A | increases expression | ISO | RGD:620299 | 6480464 | bisphenol A results in increased expression of EREG mRNA | CTD | PMID:17010207 | cadmium dichloride | decreases methylation | ISO | RGD:620299 | 6480464 | Cadmium Chloride results in decreased methylation of EREG promoter | CTD | PMID:22457795 | crocidolite asbestos | increases expression | ISO | RGD:730898 | 6480464 | Asbestos, Crocidolite results in increased expression of EREG mRNA | CTD | PMID:18687144 | cumene | multiple interactions | EXP | | 6480464 | [cumene co-treated with KRAS gene mutant form] results in increased expression of EREG mRNA | CTD | PMID:18648096 | cycloheximide | increases expression | ISO | RGD:730898 | 6480464 | Cycloheximide results in increased expression of EREG mRNA | CTD | PMID:15228094 | cyclosporin A | increases expression | ISO | RGD:730898 | 6480464 | Cyclosporine results in increased expression of EREG mRNA | CTD | PMID:20106945 | cyclosporin A | increases expression | ISO | RGD:730898 | 6480464 | Cyclosporine results in increased expression of EREG mRNA | CTD | PMID:20106945 PMID:21632981 | dexamethasone | increases expression | ISO | RGD:730898 | 6480464 | Dexamethasone results in increased expression of EREG mRNA | CTD | PMID:16144938 | dextran sulfate | decreases response to substance | EXP | | 6480464 | EREG protein results in decreased susceptibility to Dextran Sulfate | CTD | PMID:15456865 | etoposide | increases expression | ISO | RGD:730898 | 6480464 | Etoposide results in increased expression of EREG mRNA | CTD | PMID:15228094 | ferroheme b | increases expression | EXP | | 6480464 | Heme metabolite results in increased expression of EREG mRNA | CTD | PMID:19191707 | fulvestrant | multiple interactions | ISO | RGD:620299 | 6480464 | fulvestrant inhibits the reaction [Estradiol results in decreased expression of EREG mRNA] | CTD | PMID:23209616 | genistein | increases expression | ISO | RGD:620299 | 6480464 | Genistein results in increased expression of EREG mRNA | CTD | PMID:17010207 | hydrogen peroxide | affects expression | ISO | RGD:730898 | 6480464 | Hydrogen Peroxide affects the expression of EREG mRNA | CTD | PMID:20044591 | manganese atom | increases expression | ISO | RGD:730898 | 6480464 | Manganese results in increased expression of EREG mRNA | CTD | PMID:17175027 | manganese(0) | increases expression | ISO | RGD:730898 | 6480464 | Manganese results in increased expression of EREG mRNA | CTD | PMID:17175027 | manganese(II) chloride | increases expression | ISO | RGD:730898 | 6480464 | manganese chloride results in increased expression of EREG mRNA | CTD | PMID:17175027 | nimesulide | multiple interactions | ISO | RGD:730898 | 6480464 | nimesulide inhibits the reaction [LHB results in increased expression of EREG mRNA] | CTD | PMID:16888076 | ozone | increases expression | ISO | RGD:620299 | 6480464 | Ozone results in increased expression of EREG mRNA | CTD | PMID:16716893 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of EREG mRNA | CTD | PMID:17562736 | phenobarbital | affects expression | ISO | RGD:730898 | 6480464 | Phenobarbital affects the expression of EREG mRNA | CTD | PMID:19159669 | phorbol 13-acetate 12-myristate | multiple interactions | EXP | | 6480464 | Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EREG protein | CTD | PMID:15066986 | phosgene | affects expression | EXP | | 6480464 | Phosgene affects the expression of EREG mRNA | CTD | PMID:16300373 | prostaglandin E2 | increases expression | ISO | RGD:730898 | 6480464 | Dinoprostone results in increased expression of EREG mRNA | CTD | PMID:16888076 | prostaglandin E2 | increases expression | EXP | | 6480464 | Dinoprostone results in increased expression of EREG mRNA | CTD | PMID:18444251 | prostaglandin E2 | multiple interactions | ISO | RGD:730898 | 6480464 | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of EREG mRNA]; more ... | CTD | PMID:16888076 | quercetin | increases expression | ISO | RGD:730898 | 6480464 | Quercetin results in increased expression of EREG mRNA | CTD | PMID:21632981 | troglitazone | increases expression | ISO | RGD:730898 | 6480464 | troglitazone results in increased expression of EREG mRNA | CTD | PMID:19140230 | tunicamycin | increases expression | EXP | | 6480464 | Tunicamycin results in increased expression of EREG mRNA | CTD | PMID:17127020 | vincaleukoblastine | affects response to substance | ISO | RGD:730898 | 6480464 | EREG protein affects the susceptibility to Vinblastine | CTD | PMID:16217747 | vinyl carbamate | increases expression | EXP | | 6480464 | vinyl carbamate results in increased expression of EREG mRNA | CTD | PMID:17849452 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsBiological Process











