Pon1 (paraoxonase 1) - Rat Genome Database

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Gene: Pon1 (paraoxonase 1) Mus musculus
Analyze
Symbol: Pon1
Name: paraoxonase 1
RGD ID: 733240
MGI Page MGI
Description: Enables arylesterase activity. Acts upstream of or within cholesterol metabolic process and response to toxic substance. Predicted to be located in extracellular region. Predicted to be part of spherical high-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to human PON1 (paraoxonase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A-esterase 1; aromatic esterase 1; Pon; PON 1; serum aryldialkylphosphatase 1; serum paraoxonase/arylesterase 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3965,168,101 - 5,193,824 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl65,168,090 - 5,193,946 (-)EnsemblGRCm39 Ensembl
GRCm3865,168,090 - 5,193,987 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl65,168,090 - 5,193,946 (-)EnsemblGRCm38mm10GRCm38
MGSCv3765,118,090 - 5,143,946 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3665,118,105 - 5,143,824 (-)NCBIMGSCv36mm8
Celera65,314,337 - 5,340,485 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map61.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
acute lymphoblastic leukemia  (ISO)
Agricultural Workers' Diseases  (ISO)
Albuminuria  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
anemia  (ISO)
arteriosclerosis  (ISO)
Arteritis  (ISO)
atherosclerosis  (IDA,IMP,ISO)
autistic disorder  (ISO)
Behcet's disease  (ISO)
beta thalassemia  (ISO)
beta-thalassemia major  (ISO)
Birth Weight  (ISO)
bone disease  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
capillary leak syndrome  (ISO)
cardiovascular system disease  (ISO)
cataract  (ISO)
celiac disease  (ISO)
cerebral cavernous malformation  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
chronic lymphocytic leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
Constipation  (ISO)
coronary artery disease  (ISO)
coronary artery vasospasm  (ISO)
Coronary Disease  (ISO)
Crohn's disease  (ISO)
dementia  (ISO)
depressive disorder  (ISO)
Diabetes Complications  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disease of metabolism  (ISO)
exfoliation syndrome  (ISO)
Experimental Diabetes Mellitus  (IAGP,ISO)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hematologic Neoplasms  (ISO)
hemorrhoid  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
Hyperlipoproteinemia Type II  (ISO)
Hyperlipoproteinemias  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Hypertriglyceridemia  (ISO)
Insulin Resistance  (ISO)
iron deficiency anemia  (ISO)
keratoconus  (ISO)
Kuhnt-Junius degeneration  (ISO)
Lung Neoplasms  (ISO)
lymphoma  (ISO)
macular degeneration  (ISO)
male infertility  (ISO)
membranoproliferative glomerulonephritis  (ISO)
Metabolic Syndrome  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (ISO)
Nasal Polyps  (ISO)
non-Hodgkin lymphoma  (ISO)
Occupational Diseases  (ISO)
open-angle glaucoma  (ISO)
Organophosphate Poisoning  (ISO)
periodontal disease  (ISO)
persian gulf syndrome  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary open angle glaucoma  (ISO)
Primitive Neuroectodermal Tumors  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
secondary Parkinson disease  (ISO)
sickle cell anemia  (ISO)
Sjogren's syndrome  (ISO)
spina bifida  (ISO)
Spinal Cord Injuries  (ISO)
steatotic liver disease  (ISO)
toxic encephalopathy  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
vitamin B12 deficiency  (ISO)
Yin Deficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dilauroyl-sn-glycero-3-phosphocholine(1+)  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-dihydrocoumarin  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nitrophenol  (ISO)
4-nitrophenyl acetate  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
albuterol  (ISO)
aldicarb  (ISO)
alendronic acid  (ISO)
ammonium chloride  (ISO)
ampicillin  (EXP,ISO)
angelica lactone  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
bexarotene  (ISO)
bifenthrin  (EXP)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
cadmium atom  (ISO)
calcium atom  (ISO)
calcium dichloride  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
cholic acid  (EXP,ISO)
chromium(3+) trichloride  (EXP)
ciprofibrate  (EXP)
ciprofloxacin  (EXP,ISO)
cisplatin  (ISO)
clindamycin phosphate  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP,ISO)
clopidogrel  (ISO)
cobalt atom  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarins  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
desogestrel  (EXP)
dexamethasone  (ISO)
Diallyl sulfide  (EXP)
diazinon  (EXP,ISO)
diazoxon  (EXP,ISO)
dichlorvos  (EXP,ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diiodine  (ISO)
diisopropyl fluorophosphate  (ISO)
dimethylarsinic acid  (EXP)
dioleoyl phosphatidylcholine  (ISO)
dioxygen  (ISO)
dipalmitoyl phosphatidylglycerol  (ISO)
disodium selenite  (ISO)
doramapimod  (ISO)
dorsomorphin  (ISO)
edaravone  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
erucic acid  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
farnesyl diphosphate  (ISO)
fenitrothion  (ISO)
fenofibrate  (ISO)
flavone  (ISO)
fluticasone  (ISO)
fluvastatin  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gabapentin  (ISO)
gamma-decalactone  (ISO)
glutathione  (ISO)
graphene oxide  (EXP)
GW 4064  (ISO)
high-density lipoprotein cholesterol  (ISO)
homocysteine  (EXP)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isorhamnetin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
levetiracetam  (ISO)
levonorgestrel  (EXP)
linoleic acid  (ISO)
lysophosphatidylglycerol  (ISO)
malaoxon  (EXP)
malonaldehyde  (ISO)
mefenamic acid  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methapyrilene  (ISO)
methidathion  (EXP)
methimazole  (ISO)
methotrexate  (ISO)
methylglyoxal  (ISO)
mevalonic acid  (ISO)
mithramycin  (ISO)
montelukast  (ISO)
moxifloxacin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (ISO)
Nandrolone decanoate  (ISO)
naphthalene  (EXP,ISO)
nickel atom  (EXP,ISO)
nicotine  (ISO)
nitrofen  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
organophosphorus compound  (EXP,ISO)
orlistat  (ISO)
oxamyl  (ISO)
ozone  (EXP,ISO)
palladium  (ISO)
palmitoleic acid  (ISO)
pamidronate  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP,ISO)
Paraoxon-methyl  (ISO)
parathion  (EXP,ISO)
parathion-methyl  (ISO)
pentane-2,3-dione  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenyl acetate  (ISO)
phenylacetic acid  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
potassium dichromate  (EXP)
pralidoxime  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
primidone  (ISO)
proanthocyanidin  (ISO)
propanal  (ISO)
pyrrolidine  (ISO)
quercetin  (EXP,ISO)
quinolin-2(1H)-one  (ISO)
quinolin-2-ol  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
Risedronate sodium  (ISO)
ritonavir  (ISO)
rutin  (ISO)
salicylates  (ISO)
saquinavir  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenic acid  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sodium perchlorate  (ISO)
sodium selenate  (ISO)
Soman  (EXP,ISO)
squalene  (ISO)
streptozocin  (ISO)
sulfisomidine  (ISO)
sulfisoxazole  (ISO)
tamoxifen  (EXP)
taurocholic acid  (EXP)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (ISO)
tiotropium bromide  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
tyloxapol  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
varenicline  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
VX nerve agent  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zingerone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Effects of rosiglitazone and aspirin on experimental model of induced type 2 diabetes in rats: focus on insulin resistance and inflammatory markers. Abdin AA, etal., J Diabetes Complications. 2009 Mar 26.
2. Serum PON1 arylesterase activity in relation to hyperhomocysteinaemia and oxidative stress in young adult central retinal venous occlusion patients. Angayarkanni N, etal., Eye (Lond). 2008 Jul;22(7):969-74. Epub 2007 Dec 14.
3. Assessment of paraoxonase and arylesterase activities in patients with iron deficiency anemia. Aslan M, etal., Atherosclerosis. 2007 Apr;191(2):397-402. Epub 2006 May 8.
4. Decreased serum paraoxonase 1 activity and increased serum homocysteine and malondialdehyde levels in age-related macular degeneration. Ates O, etal., Tohoku J Exp Med. 2009 Jan;217(1):17-22.
5. Risk of myocardial infarction associated with Gln/Arg 192 polymorphism in the human paraoxonase gene and diabetes mellitus. The REGICOR Investigators. Aubo C, etal., Eur Heart J. 2000 Jan;21(1):33-8.
6. Association of lipids, lipoproteins, apolipoproteins and paraoxonase enzyme activity with premature coronary artery disease. Azizi F, etal., Coron Artery Dis. 2002 Feb;13(1):9-16.
7. Association of the M55L and Q192R paraoxonase gene polymorphisms with age-related macular degeneration. Baird PN, etal., Am J Ophthalmol. 2004 Oct;138(4):665-6.
8. LL-paraoxonase genotype is associated with a more severe degree of homeostasis model assessment IR in healthy subjects. Barbieri M, etal., J Clin Endocrinol Metab. 2002 Jan;87(1):222-5.
9. Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice. Bradshaw G, etal., Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11029-34. Epub 2005 Jul 25.
10. [Comparative plasma proteomic analysis of patients with multiple myeloma treated with bortezomib-based regimens]. Cumova J, etal., Klin Onkol. 2012;25(1):17-25.
11. NQO1 rs1800566 (C609T), PON1 rs662 (Q192R), and PON1 rs854560 (L55M) polymorphisms segregate the risk of childhood acute leukemias according to age range distribution. de Aguiar Goncalves BA, etal., Cancer Causes Control. 2012 Nov;23(11):1811-9. doi: 10.1007/s10552-012-0060-5. Epub 2012 Sep 14.
12. Paraoxonase-1 L55M polymorphism is associated with an abnormal oral glucose tolerance test and differentiates high risk coronary disease families. Deakin S, etal., J Clin Endocrinol Metab. 2002 Mar;87(3):1268-73.
13. Association of combined genetic variations in SOD3, GPX3, PON1, and GSTT1 with hypertension and severity of coronary artery disease. Decharatchakul N, etal., Heart Vessels. 2020 Jul;35(7):918-929. doi: 10.1007/s00380-020-01564-6. Epub 2020 Feb 8.
14. Identification of proteins found to be significantly altered when comparing the serum proteome from Multiple Myeloma patients with varying degrees of bone disease. Dowling P, etal., BMC Genomics. 2014 Oct 17;15:904. doi: 10.1186/1471-2164-15-904.
15. Oxidant-antioxidant status in Egyptian children with sickle cell anemia: a single center based study. El-Ghamrawy MK, etal., J Pediatr (Rio J). 2014 May-Jun;90(3):286-92. doi: 10.1016/j.jped.2013.09.005. Epub 2014 Feb 5.
16. Decreased HDL-dependent paraoxonase and arylesterase enzyme activity may indicate a worse prognosis in multiple myeloma. Ellidag HY, etal., Asian Pac J Cancer Prev. 2014;15(22):9847-51.
17. Polymorphisms in the PON gene cluster are associated with Alzheimer disease. Erlich PM, etal., Hum Mol Genet. 2006 Jan 1;15(1):77-85. Epub 2005 Nov 30.
18. Enhanced HDL-cholesterol-associated anti-oxidant PON-1 activity in prostate cancer patients. Eroglu M, etal., Kaohsiung J Med Sci. 2013 Jul;29(7):368-73. doi: 10.1016/j.kjms.2012.11.004. Epub 2013 Jan 16.
19. Association study of detoxification genes in age related macular degeneration. Esfandiary H, etal., Br J Ophthalmol. 2005 Apr;89(4):470-4.
20. Paraoxonase 1 gene polymorphisms and enzyme activities in diabetes mellitus. Flekac M, etal., Physiol Res. 2008;57(5):717-26. Epub 2007 Oct 11.
21. Body mass, polymorphisms in obesity-related genes, and the risk of developing breast cancer among women with benign breast disease. Gallicchio L, etal., Cancer Detect Prev. 2007;31(2):95-101. Epub 2007 Apr 10.
22. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. Giusti B, etal., J Med Genet. 2008 Nov;45(11):721-30. doi: 10.1136/jmg.2008.057851. Epub 2008 Jul 17.
23. Relationship between paraoxonase-1 (PON1) activity and lipoprotein (a) levels in Turkish coronary artery disease patients living in the Antalya region. Gocmen YA, etal., Eur J Cardiovasc Prev Rehabil. 2005 Apr;12(2):185-6.
24. Serum paraoxonase, arylesterase activity, and oxidative status in patients with nasal polyp. Hao W, etal., Eur Arch Otorhinolaryngol. 2013 May;270(6):1861-5. doi: 10.1007/s00405-012-2307-x. Epub 2012 Dec 13.
25. Expression and activity of paraoxonase 1 in human cataractous lens tissue. Hashim Z, etal., Free Radic Biol Med. 2009 Apr 15;46(8):1089-95. doi: 10.1016/j.freeradbiomed.2009.01.012. Epub 2009 Jan 23.
26. Paraoxonase 1 gene polymorphisms and dementia in humans. Helbecque N, etal., Neurosci Lett 2004 Mar 18;358(1):41-4.
27. Association between PON 1 polymorphisms, PON activity and diabetes complications. Hofer SE, etal., J Diabetes Complications. 2006 Sep-Oct;20(5):322-8.
28. Serum paraoxonase activity and its relationship to diabetic complications in patients with non-insulin-dependent diabetes mellitus. Ikeda Y, etal., Metabolism. 1998 May;47(5):598-602.
29. Evidence for association between paraoxonase gene polymorphisms and atherosclerotic diseases. Imai Y, etal., Atherosclerosis. 2000 Apr;149(2):435-42.
30. Paraoxonase 1 gene polymorphisms influence clinical features of open-angle glaucoma. Inagaki Y, etal., Graefes Arch Clin Exp Ophthalmol. 2006 Aug;244(8):984-90. Epub 2006 Jan 13.
31. Trace elements and oxidative stress in chronic obstructive pulmonary disease. Isik B, etal., Saudi Med J. 2005 Dec;26(12):1882-5.
32. Current understanding of the mechanisms involved in metabolic detoxification of warfare nerve agents. Jokanovic M Toxicol Lett. 2009 Jul 10;188(1):1-10. doi: 10.1016/j.toxlet.2009.03.017. Epub 2009 Mar 31.
33. Serum paraoxonase activity is decreased in the active stage of Behcet's disease. Karakucuk S, etal., Br J Ophthalmol. 2004 Oct;88(10):1256-8.
34. Association between xenobiotic gene polymorphisms and non-Hodgkin's lymphoma risk. Kerridge I, etal., Br J Haematol. 2002 Aug;118(2):477-81.
35. The Gln-Arg 191 polymorphism of the human paraoxonase gene is not associated with the risk of coronary artery disease among Chinese in Taiwan. Ko YL, etal., Atherosclerosis. 1998 Dec;141(2):259-64.
36. Paraoxonase and arylesterase activities in children with iron deficiency anemia and vitamin B12 deficiency anemia. Koc A, etal., Pediatr Hematol Oncol. 2012 May;29(4):345-53. doi: 10.3109/08880018.2011.645185.
37. Relationship between the paraoxonase 1 (PON1) M55L and Q192R polymorphisms and lymphohaematopoietic cancers in a Greek agricultural population. Kokouva M, etal., Toxicology. 2013 May 10;307:12-6. doi: 10.1016/j.tox.2012.07.003. Epub 2012 Jul 16.
38. Paraoxonase 1 (PON1) status in gastroesophageal malignancies and associated paraneoplastic syndromes - connection with inflammation. Krzystek-Korpacka M, etal., Clin Biochem. 2008 Jul;41(10-11):804-11. doi: 10.1016/j.clinbiochem.2008.03.012. Epub 2008 Apr 4.
39. Paraoxonase-1 and oxidative status in common Mediterranean beta-thalassaemia mutations trait, and their relations to atherosclerosis. Labib HA, etal., J Clin Pathol. 2011 May;64(5):437-42. doi: 10.1136/jcp.2011.090209. Epub 2011 Mar 22.
40. The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis. Lawlor DA, etal., BMC Genet. 2004 Jun 23;5:17.
41. Protective effect of paraoxonase 1 of high-density lipoprotein in type 2 diabetic patients with nephropathy. Li C and Gu Q, Nephrology (Carlton). 2009 Aug;14(5):514-20. Epub 2008 Feb 3.
42. Xenobiotic gene polymorphisms and susceptibility to multiple myeloma. Lincz LF, etal., Haematologica. 2004 May;89(5):628-9.
43. Serum Protein KNG1, APOC3, and PON1 as Potential Biomarkers for Yin-Deficiency-Heat Syndrome. Liu C, etal., Evid Based Complement Alternat Med. 2016;2016:5176731. doi: 10.1155/2016/5176731. Epub 2016 Oct 24.
44. The relationships between PON1 activity as well as oxLDL levels and coronary artery lesions in CHD patients with diabetes mellitus or impaired fasting glucose. Lu C, etal., Coron Artery Dis. 2008 Dec;19(8):565-73.
45. Human paraoxonase-1 overexpression inhibits atherosclerosis in a mouse model of metabolic syndrome. Mackness B, etal., Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1545-50. Epub 2006 Apr 20.
46. Low paraoxonase activity in type II diabetes mellitus complicated by retinopathy. Mackness B, etal., Clin Sci (Lond). 2000 Mar;98(3):355-63.
47. Administration of exogenous erythropoietin beta affects lipid peroxidation and serum paraoxonase-1 activity and concentration in predialysis patients with chronic renal disease and anaemia. Marsillach J, etal., Clin Exp Pharmacol Physiol. 2007 Apr;34(4):347-9.
48. Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia. Merono T, etal., Clin Nutr. 2016 Feb 13. pii: S0261-5614(16)00059-5. doi: 10.1016/j.clnu.2016.02.003.
49. MGDs mouse GO annotations MGD data from the GO Consortium
50. MGD IEA MGD IEA
51. Paraoxonase 1 Gln/Arg polymorphism is associated with the risk of microangiopathy in Type 2 diabetes mellitus. Murata M, etal., Diabet Med. 2004 Aug;21(8):837-44.
52. Antioxidant potential, paraoxonase 1, ceruloplasmin activity and C-reactive protein concentration in diabetic retinopathy. Nowak M, etal., Clin Exp Med. 2010 Sep;10(3):185-92. doi: 10.1007/s10238-009-0084-7. Epub 2009 Dec 11.
53. Regulatory regions of the paraoxonase 1 (PON1) gene are associated with neovascular age-related macular degeneration (AMD). Oczos J, etal., Age (Dordr). 2013 Oct;35(5):1651-62. doi: 10.1007/s11357-012-9467-x. Epub 2012 Sep 7.
54. Paraoxonase polymorphism (Gln192-Arg) is associated with coronary heart disease in Japanese noninsulin-dependent diabetes mellitus. Odawara M, etal., J Clin Endocrinol Metab. 1997 Jul;82(7):2257-60.
55. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
56. The gln-Arg192 polymorphism of human paraoxonase gene is not associated with coronary artery disease in italian patients. Ombres D, etal., Arterioscler Thromb Vasc Biol. 1998 Oct;18(10):1611-6.
57. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
58. Protective effect of paraoxonase 1 gene variant L55M in retinal vein occlusion. Ortak H, etal., Mol Vis. 2013;19:486-xxx. Epub 2013 Feb 25.
59. Plasma paraoxonase activity and oxidative stress and their relationship to disease severity in children with allergic rhinitis. Ozkaya E, etal., Am J Rhinol Allergy. 2013 Jan;27(1):13-7. doi: 10.2500/ajra.2013.27.3837.
60. Effect of short term treatment with simvastatin and atorvastatin on lipids and paraoxonase activity in patients with hyperlipoproteinaemia. Paragh G, etal., Curr Med Res Opin. 2004 Aug;20(8):1321-7.
61. Protective effect of paraoxonase 1 gene variant Gln192Arg in age-related macular degeneration. Pauer GJ, etal., Am J Ophthalmol. 2010 Mar;149(3):513-22. doi: 10.1016/j.ajo.2009.09.024. Epub 2009 Dec 30.
62. Paraoxonase and platelet-activating factor acetylhydrolase activities in lipoproteins of beta-thalassemia/hemoglobin E patients. Phumala Morales N, etal., Clin Chem Lab Med. 2007;45(7):884-9.
63. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
64. Paraoxonase 1 status in keratoconus: a preliminary study of activity and polymorphism. Poh R, etal., West Indian Med J. 2012 Sep;61(6):569-73.
65. Mouse MP Annotation Import Pipeline RGD automated import pipeline
66. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
67. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
68. GLYOXALASE I A111E, PARAOXONASE 1 Q192R AND L55M POLYMORPHISMS IN ITALIAN PATIENTS WITH SPORADIC CEREBRAL CAVERNOUS MALFORMATIONS: A PILOT STUDY. Rinaldi C, etal., J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):493-500.
69. Paraoxonases are associated with intestinal inflammatory diseases and intracellularly localized to the endoplasmic reticulum. Rothem L, etal., Free Radic Biol Med. 2007 Sep 1;43(5):730-9. Epub 2007 May 10.
70. Paraoxonase 1 (PON1) attenuates diabetes development in mice through its antioxidative properties. Rozenberg O, etal., Free Radic Biol Med. 2008 Jun 1;44(11):1951-9. Epub 2008 Mar 8.
71. Assessment of early atherosclerotic findings in patients with nasal polyposis. Sagit M, etal., Auris Nasus Larynx. 2013 Oct 19. pii: S0385-8146(13)00182-X. doi: 10.1016/j.anl.2013.07.013.
72. Tobacco smoking modifies association between Gln-Arg192 polymorphism of human paraoxonase gene and risk of myocardial infarction. Sen-Banerjee S, etal., Arterioscler Thromb Vasc Biol. 2000 Sep;20(9):2120-6.
73. Antioxidant paraoxonase 1 activity in the metabolic syndrome. Senti M, etal., J Clin Endocrinol Metab. 2003 Nov;88(11):5422-6.
74. Dietary antioxidants (selenium and N-acetylcysteine) modulate paraoxonase 1 (PON1) in PCB 126-exposed rats. Shen H, etal., Environ Sci Pollut Res Int. 2014 May;21(10):6384-99. doi: 10.1007/s11356-013-1690-1. Epub 2013 May 4.
75. The effects of cranberry juice on serum glucose, apoB, apoA-I, Lp(a), and Paraoxonase-1 activity in type 2 diabetic male patients. Shidfar F, etal., J Res Med Sci. 2012 Apr;17(4):355-60.
76. Association of paraoxonase 1 L55M and Q192R single-nucleotide polymorphisms with age-related macular degeneration. Sogut E, etal., Retina. 2013 Oct;33(9):1836-42. doi: 10.1097/IAE.0b013e318287da59.
77. Decreased human paraoxonase-1 activity in patients with Sjogren's syndrome. Szanto A, etal., Int Immunol. 2010 Jul;22(7):605-9. doi: 10.1093/intimm/dxq045. Epub 2010 May 24.
78. Q192R and L55M Polymorphisms of Paraoxonase 1 Gene in Chronic Myelogenous Leukemia and Chronic Lymphocytic Leukemia. Tomatir AG, etal., Anticancer Res. 2015 Sep;35(9):4807-12.
79. Effects of prostaglandin E1, melatonin, and oxytetracycline on lipid peroxidation, antioxidant defense system, paraoxonase (PON1) activities, and homocysteine levels in an animal model of spinal cord injury. Topsakal C, etal., Spine (Phila Pa 1976). 2003 Aug 1;28(15):1643-52.
80. Oxidative stress and anti-oxidative defence in patients with age-related macular degeneration. Ugurlu N, etal., Curr Eye Res. 2013 Apr;38(4):497-502. doi: 10.3109/02713683.2013.774023. Epub 2013 Feb 22.
81. Paraoxonase 1 phenotype distribution and activity differs in subjects with newly diagnosed Type 2 diabetes (the CODAM Study). van den Berg SW, etal., Diabet Med. 2008 Feb;25(2):186-93.
82. Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy. Wang J, etal., Mol Med Rep. 2013 Dec;8(6):1845-51. doi: 10.3892/mmr.2013.1710. Epub 2013 Oct 2.
83. Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm. Wang T, etal., Front Immunol. 2022 May 27;13:843408. doi: 10.3389/fimmu.2022.843408. eCollection 2022.
84. Dietary blueberries attenuate atherosclerosis in apolipoprotein E-deficient mice by upregulating antioxidant enzyme expression. Wu X, etal., J Nutr. 2010 Sep;140(9):1628-32. doi: 10.3945/jn.110.123927. Epub 2010 Jul 21.
85. Genome-wide SNP analysis of the Systemic Capillary Leak Syndrome (Clarkson disease). Xie Z, etal., Rare Dis. 2013 Dec 12;1(1). pii: e27445.
86. The activities of paraoxonase, xanthine oxidase, adenosine deaminase and the level of nitrite in pseudoexfoliation syndrome. Yagci R, etal., Ophthalmic Res. 2009;42(3):155-9. doi: 10.1159/000229306. Epub 2009 Jul 23.
87. No association of paraoxonase genotype or atherosclerosis with cerebral amyloid angiopathy. Yamada M, etal., Stroke. 2002 Apr;33(4):896-900.
88. Effect of paraoxonase 1 gene polymorphisms on clinical course of Henoch-Schonlein purpura. Yilmaz A, etal., J Nephrol. 2009 Nov-Dec;22(6):726-32.
89. Studies on protective effects of human paraoxonases 1 and 3 on atherosclerosis in apolipoprotein E knockout mice. Zhang C, etal., Gene Ther. 2010 May;17(5):626-33. Epub 2010 Feb 25.
90. Single nucleotide polymorphisms of metabolic syndrome-related genes in primary open angle glaucoma. Zhou G and Liu B, Int J Ophthalmol. 2010;3(1):36-42. doi: 10.3980/j.issn.2222-3959.2010.01.09. Epub 2010 Mar 18.
91. Serum Paraoxonase Activity and Malondialdehyde Serum Concentrations Remain Unaffected in Response to Hydroxyurea Therapy in beta-Thalassemia Patients. Zohaib M, etal., J Clin Pharmacol. 2016 Jul;56(7):869-74. doi: 10.1002/jcph.675. Epub 2015 Dec 28.
Additional References at PubMed
PMID:7638166   PMID:8601628   PMID:8661009   PMID:8811508   PMID:8812495   PMID:8825627   PMID:8827514   PMID:9170151   PMID:9176667   PMID:9457688   PMID:9475163   PMID:9685159  
PMID:9745924   PMID:10349636   PMID:10393212   PMID:10748217   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11798161   PMID:11893784   PMID:12135950   PMID:12477932   PMID:12633754  
PMID:12654470   PMID:12840045   PMID:14681479   PMID:14703510   PMID:15213869   PMID:15388641   PMID:15721011   PMID:15977192   PMID:16141072   PMID:16141073   PMID:16260097   PMID:16284190  
PMID:16341224   PMID:16407304   PMID:16602821   PMID:16682028   PMID:17122353   PMID:17330941   PMID:17717299   PMID:18356571   PMID:18402813   PMID:18597495   PMID:18678600   PMID:18757308  
PMID:18762170   PMID:19034653   PMID:19082953   PMID:19371602   PMID:19474728   PMID:19556304   PMID:20149374   PMID:20189567   PMID:20221870   PMID:20221873   PMID:20221875   PMID:20221879  
PMID:20931267   PMID:21044894   PMID:21267068   PMID:21530644   PMID:21673326   PMID:21677750   PMID:21862013   PMID:21873635   PMID:22001906   PMID:22096492   PMID:22406444   PMID:22653878  
PMID:22916088   PMID:23207871   PMID:23405202   PMID:23448543   PMID:23582715   PMID:23620511   PMID:23639858   PMID:23772025   PMID:23908111   PMID:24844689   PMID:24971380   PMID:25028362  
PMID:25069821   PMID:25070982   PMID:25230879   PMID:25347084   PMID:25958017   PMID:26176406   PMID:26993251   PMID:27010443   PMID:28657647   PMID:30389914   PMID:30572120   PMID:30905786  
PMID:32976529   PMID:33838286   PMID:36899882  


Genomics

Comparative Map Data
Pon1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3965,168,101 - 5,193,824 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl65,168,090 - 5,193,946 (-)EnsemblGRCm39 Ensembl
GRCm3865,168,090 - 5,193,987 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl65,168,090 - 5,193,946 (-)EnsemblGRCm38mm10GRCm38
MGSCv3765,118,090 - 5,143,946 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3665,118,105 - 5,143,824 (-)NCBIMGSCv36mm8
Celera65,314,337 - 5,340,485 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map61.99NCBI
PON1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38795,297,676 - 95,324,532 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl795,297,676 - 95,324,532 (-)EnsemblGRCh38hg38GRCh38
GRCh37794,926,988 - 94,953,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36794,764,924 - 94,791,780 (-)NCBINCBI36Build 36hg18NCBI36
Build 34794,571,638 - 94,598,495NCBI
Celera789,626,366 - 89,652,590 (-)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef789,534,701 - 89,560,922 (-)NCBIHuRef
CHM1_1794,857,684 - 94,883,916 (-)NCBICHM1_1
T2T-CHM13v2.0796,533,832 - 96,560,687 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2794,256,665 - 94,282,884 (-)NCBI
Pon1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8434,261,312 - 34,292,327 (-)NCBIGRCr8
mRatBN7.2433,294,737 - 33,325,759 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl433,294,722 - 33,321,360 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx438,253,781 - 38,280,327 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0434,179,920 - 34,206,462 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0432,589,698 - 32,616,248 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0430,249,749 - 30,276,297 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl430,249,742 - 30,276,372 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0430,156,712 - 30,183,204 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4429,936,314 - 29,964,821 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1429,975,057 - 30,003,299 (-)NCBI
Celera428,821,674 - 28,848,125 (-)NCBICelera
Cytogenetic Map4q21NCBI
Pon1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543211,893,473 - 11,923,339 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543211,893,473 - 11,923,035 (-)NCBIChiLan1.0ChiLan1.0
PON1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26113,137,448 - 113,164,333 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17161,402,051 - 161,428,972 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0787,253,476 - 87,279,650 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17100,841,286 - 100,867,493 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7100,841,286 - 100,867,493 (-)Ensemblpanpan1.1panPan2
PON1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11420,565,620 - 20,600,774 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1420,565,641 - 20,642,985 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1420,124,634 - 20,159,679 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01420,388,041 - 20,423,054 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1420,388,051 - 20,422,924 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11420,532,696 - 20,567,711 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01420,267,821 - 20,302,851 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01420,525,175 - 20,560,208 (-)NCBIUU_Cfam_GSD_1.0
Pon1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511833,883,628 - 33,908,421 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365854,954,869 - 4,979,591 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365854,954,871 - 4,979,560 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PON1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl974,926,048 - 74,974,723 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1974,943,646 - 74,974,720 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2982,327,318 - 82,339,633 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PON1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12153,713,434 - 53,739,658 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2153,714,012 - 53,739,875 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604250,595,418 - 50,621,447 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pon1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248131,949,614 - 1,979,882 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248131,953,796 - 1,979,846 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pon1
852 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:389
Count of miRNA genes:312
Interacting mature miRNAs:345
Transcripts:ENSMUST00000002663, ENSMUST00000176933, ENSMUST00000176945, ENSMUST00000177159
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14746985Manh59_mmandible shape 59 (mouse)6120847193Mouse
1301178Lith10_mlithogenic gene 10 (mouse)Not determined6121465015Mouse
10043884Bhr8_mbronchial hyperresponsiveness 8 (mouse)Not determined6121465015Mouse
10044000Mobq9_mmultigenetic obesity QTL 9 (mouse)Not determined6121465015Mouse
1357503Nhdlq5_mnon-HDL QTL 5 (mouse)Not determined6121465015Mouse
12904934Edlmmq4_mextensor digitorum longus muscle mass QTL 4 (mouse)6125514064Mouse
12904942Tammq3_mtibialis anterior muscle mass QTL 3 (mouse)6125514064Mouse
12904955Gmmq3_mgastrocnemius muscle mass QTL 3 (mouse)6125514064Mouse
1301131Chol2_mcholesterol 2 (mouse)Not determined6132144495Mouse
5491191Mobq2_mmultigenic obesity QTL 2 (mouse)Not determined6132144495Mouse
1302024Skull7_mskull morphology 7 (mouse)Not determined6132144495Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633435476334Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
14700782Syncq6_msynovial calcification QTL 6 (mouse)641770005219000Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920638249325Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
11353836Bmiq1_mbody mass index QTL 1 (mouse)6450382329751333Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse

Markers in Region
U32684  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3865,168,184 - 5,168,288UniSTSGRCm38
MGSCv3765,118,184 - 5,118,288UniSTSGRCm37
Celera65,314,431 - 5,314,535UniSTS
Cytogenetic Map6A2UniSTS
cM Map60.5UniSTS
Whitehead_YAC6 UniSTS
Pon1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv3765,118,250 - 5,118,379UniSTSGRCm37
MGSCv3765,118,157 - 5,118,439UniSTSGRCm37
Celera65,314,404 - 5,314,686UniSTS
Celera65,314,497 - 5,314,626UniSTS
Cytogenetic Map6A2UniSTS
cM Map60.5UniSTS
cM Map60.5UniSTS
cM Map60.5UniSTS
cM Map60.5UniSTS
Pon1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3865,168,250 - 5,168,379UniSTSGRCm38
MGSCv3765,118,250 - 5,118,379UniSTSGRCm37
Celera65,314,497 - 5,314,626UniSTS
Cytogenetic Map6A2UniSTS
cM Map60.5UniSTS
Pon1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6A2UniSTS
cM Map60.5UniSTS
Pon1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3865,168,157 - 5,168,439UniSTSGRCm38
MGSCv3765,118,157 - 5,118,439UniSTSGRCm37
Celera65,314,404 - 5,314,686UniSTS
Cytogenetic Map6A2UniSTS
cM Map60.5UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001410259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001410260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001410261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC074225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI194741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB870662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L40488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U32684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U72636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000002663   ⟹   ENSMUSP00000002663
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl65,168,090 - 5,193,946 (-)Ensembl
GRCm38.p6 Ensembl65,168,090 - 5,193,946 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176933
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl65,185,549 - 5,193,763 (-)Ensembl
GRCm38.p6 Ensembl65,185,549 - 5,193,763 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176945   ⟹   ENSMUSP00000135728
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl65,171,783 - 5,193,784 (-)Ensembl
GRCm38.p6 Ensembl65,171,783 - 5,193,784 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177159   ⟹   ENSMUSP00000135195
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl65,168,435 - 5,193,784 (-)Ensembl
GRCm38.p6 Ensembl65,168,435 - 5,193,784 (-)Ensembl
RefSeq Acc Id: NM_001410259   ⟹   NP_001397188
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3965,169,889 - 5,193,824 (-)NCBI
RefSeq Acc Id: NM_001410260   ⟹   NP_001397189
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3965,168,101 - 5,193,824 (-)NCBI
RefSeq Acc Id: NM_001410261   ⟹   NP_001397190
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3965,169,889 - 5,193,824 (-)NCBI
RefSeq Acc Id: NM_011134   ⟹   NP_035264
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3965,168,101 - 5,193,824 (-)NCBI
GRCm3865,168,090 - 5,193,946 (-)NCBI
MGSCv3765,118,090 - 5,143,946 (-)RGD
Celera65,314,337 - 5,340,485 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_035264   ⟸   NM_011134
- Peptide Label: isoform 1 precursor
- UniProtKB: Q91X30 (UniProtKB/Swiss-Prot),   P52430 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000135195   ⟸   ENSMUST00000177159
RefSeq Acc Id: ENSMUSP00000002663   ⟸   ENSMUST00000002663
RefSeq Acc Id: ENSMUSP00000135728   ⟸   ENSMUST00000176945
RefSeq Acc Id: NP_001397189   ⟸   NM_001410260
- Peptide Label: isoform 3 precursor
- UniProtKB: H3BK03 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001397190   ⟸   NM_001410261
- Peptide Label: isoform 4 precursor
- UniProtKB: H3BK03 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001397188   ⟸   NM_001410259
- Peptide Label: isoform 2 precursor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52430-F1-model_v2 AlphaFold P52430 1-355 view protein structure

Promoters
RGD ID:6848022
Promoter ID:MM_ACW:40428
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:PON1.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3665,121,546 - 5,122,046 (-)MPROMDB
RGD ID:6839770
Promoter ID:MM_KWN:45099
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_011134
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3665,143,496 - 5,143,996 (-)MPROMDB
RGD ID:6888944
Promoter ID:EPDNEW_M7923
Type:initiation region
Name:Pon1_1
Description:Mus musculus paraoxonase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3865,193,772 - 5,193,832EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103295 AgrOrtholog
Ensembl Genes ENSMUSG00000002588 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000002663 ENTREZGENE
  ENSMUST00000002663.12 UniProtKB/Swiss-Prot
  ENSMUST00000176945.2 UniProtKB/TrEMBL
  ENSMUST00000177159 ENTREZGENE
  ENSMUST00000177159.9 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arylesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Paraoxonase1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18979 UniProtKB/Swiss-Prot
MGD MGI:103295 ENTREZGENE
NCBI Gene 18979 ENTREZGENE
PANTHER PARAOXONASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11799:SF16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arylesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PON1 RGD
PhenoGen Pon1 PhenoGen
PRINTS PARAOXONASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PARAOXONASE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Calcium-dependent phosphotriesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H3BK03 ENTREZGENE, UniProtKB/TrEMBL
  H3BLB8_MOUSE UniProtKB/TrEMBL
  P52430 ENTREZGENE, UniProtKB/Swiss-Prot
  Q91X30 ENTREZGENE
UniProt Secondary Q91X30 UniProtKB/Swiss-Prot