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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:estradiol biosynthetic pathway
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Accession:PW:0000781 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis of estradiol, the major C18 steroid hormone. The term generally refers to the 17 beta isomer, the most potent form of estrogen.
Synonyms:related_synonym: 17beta-estradiol biosynthetic pathway
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estradiol biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 ISO RGD PMID:17926129 RGD:4892309 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 ISO RGD PMID:17926129 RGD:4892309 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 ISO RGD PMID:18821018 RGD:2325883 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Fdx1 ferredoxin 1 ISO RGD PMID:18821018 RGD:2325883 NCBI chr 8:61,164,839...61,183,645
Ensembl chr 8:61,164,839...61,183,583 		JBrowse link
G Fdxr ferredoxin reductase ISO RGD PMID:18821018 RGD:2325883 NCBI chr10:101,006,845...101,015,582
Ensembl chr10:101,006,849...101,015,542 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 TAS
ISO 		RGD PMID:15583024 PMID:18821018 RGD:4889549, RGD:2325883 NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,510,011...86,512,210 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 ISO RGD PMID:15583024 RGD:4889549 NCBI chr19:62,662,320...62,733,944
Ensembl chr19:62,662,098...62,733,943 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 ISO RGD PMID:18821018 RGD:2325883 NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 ISO RGD PMID:15583024 RGD:4889549 NCBI chr 2:188,858,574...188,864,694 JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 ISO RGD PMID:15583024 RGD:4889549 NCBI chr 2:188,784,614...188,812,535
Ensembl chr 2:188,784,614...188,790,569 		JBrowse link
G Por cytochrome p450 oxidoreductase ISO RGD PMID:17926129 RGD:4892309 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809 		JBrowse link
G Star steroidogenic acute regulatory protein ISO RGD PMID:18821018 RGD:2325883 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447 		JBrowse link
G Sts steroid sulfatase ISO RGD PMID:21693170 RGD:6893583 NCBI chr  X:46,102,524...46,110,868
Ensembl chr  X:46,102,548...46,111,104 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 ISO RGD PMID:21693170 RGD:6893583 NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,700,292...20,718,716 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 ISO RGD PMID:18821018 RGD:2325883 NCBI chr 1:84,582,011...84,639,001 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    classic metabolic pathway 1853
      lipid metabolic pathway 490
        isoprenoid metabolic pathway 95
          isoprenoid biosynthetic pathway 82
            steroid biosynthetic pathway 82
              steroid hormone biosynthetic pathway 55
                C18-steroid hormone biosynthetic pathway 15
                  estradiol biosynthetic pathway 15
paths to the root