Pde4b (phosphodiesterase 4B) - Rat Genome Database

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Gene: Pde4b (phosphodiesterase 4B) Rattus norvegicus
Analyze
Symbol: Pde4b
Name: phosphodiesterase 4B
RGD ID: 3280
Description: Enables 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in T cell receptor signaling pathway; negative regulation of cAMP/PKA signal transduction; and positive regulation of cytokine production. Predicted to act upstream of or within several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and neutrophil homeostasis. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human PDE4B (phosphodiesterase 4B); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3',5'-cyclic AMP phosphodiesterase; 3',5'-cyclic-AMP phosphodiesterase 4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; cAMP-specific phosphodiesterase 4B; DPDE4; MGC93193; PDE4/IVb; Pde4B1; Pde4B2; Pde4B3; Pde4B4; Pde4b5; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4; Phosphodiesterase 4B cAMP-specific (dunce; Phosphodiesterase 4B cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4); phosphodiesterase 4B, cAMP specific; Phosphodiesterase 4B, cAMP-specific (dunce; phosphodiesterase 4B, variant 1; phosphodiesterase 4B, variant 2; phosphodiesterase 4B, variant 3; phosphodiesterase 4B, variant 4; phosphodiesterase type 4B5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Pde4bem1Sage
Genetic Models: SD-Pde4bem1Sage
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85122,028,956 - 122,598,267 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5122,135,174 - 122,598,267 (+)EnsemblGRCr8
mRatBN7.25116,799,819 - 117,369,155 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5116,799,971 - 117,367,696 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5119,427,039 - 120,003,548 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05121,152,375 - 121,728,874 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05121,203,684 - 121,780,134 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05121,759,236 - 122,136,814 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5121,952,977 - 122,136,814 (+)Ensemblrn6Rnor6.0
Rnor_5.05125,623,815 - 126,001,128 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45123,158,156 - 123,533,877 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5115,579,422 - 115,946,626 (+)NCBICelera
RGSC_v3.15123,163,381 - 123,539,103 (+)NCBI
Cytogenetic Map5q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-butoxyethanol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
albuterol  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
cisplatin  (ISO)
clozapine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
crocidolite asbestos  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cytarabine  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
Genipin  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
histamine  (ISO)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
irinotecan  (EXP,ISO)
iron dichloride  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium chloride  (ISO)
lithium hydride  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N(6)-dimethylallyladenine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nimesulide  (EXP)
oxycodone  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
roflumilast  (ISO)
rolipram  (EXP,ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topiramate  (EXP)
torcetrapib  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. Acin-Perez R, etal., J Biol Chem. 2011 Sep 2;286(35):30423-32. doi: 10.1074/jbc.M111.266379. Epub 2011 Jul 1.
2. Phosphodiesterase 4B (PDE4B) and cAMP-level regulation within different tissue fractions of rat hippocampal slices during long-term potentiation in vitro. Ahmed T and Frey JU, Brain Res. 2005 Apr 18;1041(2):212-22.
3. Phosphodiesterase 4B knockout prevents skeletal muscle atrophy in rats with burn injury. Balasubramaniam A, etal., Am J Physiol Regul Integr Comp Physiol. 2018 Aug 1;315(2):R429-R433. doi: 10.1152/ajpregu.00042.2018. Epub 2018 Apr 25.
4. Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases. Bolger GB, etal., Gene 1994 Nov 18;149(2):237-44.
5. Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase. Colicelli J, etal., Proc Natl Acad Sci U S A 1989 May;86(10):3599-603.
6. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3. Huston E, etal., Biochem J 1997 Dec 1;328 ( Pt 2):549-58.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases. Multiple mRNA variants originate from alternative splicing and multiple start sites. Monaco L, etal., J Biol Chem 1994 Jan 7;269(1):347-57.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform. Shepherd M, etal., Biochem J 2003 Mar 1;370(Pt 2):429-38.
18. Properties and hormonal regulation of two structurally related cAMP phosphodiesterases from the rat Sertoli cell. Swinnen JV, etal., J Biol Chem 1991 Sep 25;266(27):18370-7.
19. Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes. Swinnen JV, etal., Proc Natl Acad Sci U S A 1989 Jul;86(14):5325-9.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Substance dependence low-density whole genome association study in two distinct American populations. Yu Y, etal., Hum Genet. 2008 Jun;123(5):495-506. doi: 10.1007/s00439-008-0501-0. Epub 2008 Apr 26.
22. Activation and induction of cyclic AMP phosphodiesterase (PDE4) in rat pulmonary microvascular endothelial cells. Zhu B, etal., Biochem Pharmacol. 2004 Aug 1;68(3):479-91.
Additional References at PubMed
PMID:8413254   PMID:11267656   PMID:12477932   PMID:12617967   PMID:14519662   PMID:15026126   PMID:15585880   PMID:15993984   PMID:16641100   PMID:17204557   PMID:17404263   PMID:17917586  
PMID:18227403   PMID:18455876   PMID:18571642   PMID:18923023   PMID:18983980   PMID:21670503   PMID:22384243   PMID:22865690   PMID:23008439   PMID:23080174   PMID:23887098   PMID:24413164  
PMID:25931508   PMID:30053369   PMID:30628641   PMID:32212953   PMID:32699940   PMID:36495666  


Genomics

Comparative Map Data
Pde4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85122,028,956 - 122,598,267 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5122,135,174 - 122,598,267 (+)EnsemblGRCr8
mRatBN7.25116,799,819 - 117,369,155 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5116,799,971 - 117,367,696 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5119,427,039 - 120,003,548 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05121,152,375 - 121,728,874 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05121,203,684 - 121,780,134 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05121,759,236 - 122,136,814 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5121,952,977 - 122,136,814 (+)Ensemblrn6Rnor6.0
Rnor_5.05125,623,815 - 126,001,128 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45123,158,156 - 123,533,877 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5115,579,422 - 115,946,626 (+)NCBICelera
RGSC_v3.15123,163,381 - 123,539,103 (+)NCBI
Cytogenetic Map5q33NCBI
PDE4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38165,792,510 - 66,374,579 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl165,792,514 - 66,374,579 (+)Ensemblhg38GRCh38
GRCh37166,258,193 - 66,840,262 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36166,030,781 - 66,612,850 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34165,970,884 - 66,551,208NCBI
Celera164,548,796 - 65,130,612 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef164,366,982 - 64,949,229 (+)NCBIHuRef
CHM1_1166,374,133 - 66,955,827 (+)NCBICHM1_1
T2T-CHM13v2.0165,669,985 - 66,252,011 (+)NCBIT2T-CHM13v2.0
Pde4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394101,944,529 - 102,464,459 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4101,944,740 - 102,464,456 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384102,087,332 - 102,607,275 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4102,087,543 - 102,607,259 (+)Ensemblmm10GRCm38
MGSCv374101,927,347 - 102,279,867 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364101,752,935 - 102,103,771 (+)NCBIMGSCv36mm8
Celera4100,608,595 - 100,971,313 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.99NCBI
Pde4b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542324,463,953 - 24,906,394 (-)Ensembl
ChiLan1.0NW_00495542324,464,503 - 24,906,409 (-)NCBIChiLan1.0ChiLan1.0
PDE4B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21160,488,841 - 161,071,557 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11159,649,043 - 160,231,740 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0165,038,120 - 65,620,764 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1166,924,478 - 67,506,291 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl167,045,911 - 67,506,291 (+)EnsemblpanPan2panpan1.1
PDE4B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1544,063,145 - 44,606,070 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl544,065,106 - 44,500,999 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha544,186,161 - 44,663,652 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0544,251,621 - 44,793,357 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl544,251,983 - 44,793,329 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1544,216,433 - 44,758,769 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0544,161,847 - 44,703,948 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0544,405,153 - 44,947,628 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pde4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505878,822,844 - 79,336,912 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365915,152,441 - 5,573,129 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365915,152,491 - 5,666,728 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE4B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6146,166,688 - 146,719,682 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16146,167,262 - 146,720,105 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26134,870,996 - 134,913,607 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE4B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12066,729,561 - 67,297,729 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2066,728,664 - 66,771,691 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603350,280,843 - 50,864,221 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde4b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474228,557,283 - 29,016,844 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474228,557,159 - 29,113,269 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pde4b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1151,955,219 - 52,491,140 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pde4b
4115 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:344
Count of miRNA genes:170
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000007738, ENSRNOT00000008278, ENSRNOT00000068158
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)5104018576124314782Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
Pde4b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25116,993,488 - 116,993,688 (+)MAPPERmRatBN7.2
Rnor_6.05121,759,289 - 121,759,488NCBIRnor6.0
Rnor_5.05125,623,868 - 125,624,067UniSTSRnor5.0
RGSC_v3.45123,158,209 - 123,158,408UniSTSRGSC3.4
Celera5115,579,475 - 115,579,674UniSTS
Cytogenetic Map5q32UniSTS
D5Got246  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,177,749 - 117,177,900 (+)MAPPERmRatBN7.2
Rnor_6.05121,944,611 - 121,944,761NCBIRnor6.0
Rnor_5.05125,809,190 - 125,809,340UniSTSRnor5.0
RGSC_v3.45123,343,387 - 123,343,537UniSTSRGSC3.4
Celera5115,756,656 - 115,756,806UniSTS
Cytogenetic Map5q32UniSTS
PMC25763P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,367,073 - 117,367,228 (+)MAPPERmRatBN7.2
Rnor_6.05122,136,205 - 122,136,359NCBIRnor6.0
Rnor_5.05126,000,519 - 126,000,673UniSTSRnor5.0
RGSC_v3.45123,533,268 - 123,533,422UniSTSRGSC3.4
Celera5115,946,017 - 115,946,171UniSTS
Cytogenetic Map5q32UniSTS
22.MMHAP70FRH7.seq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,266,911 - 117,267,059 (+)MAPPERmRatBN7.2
Rnor_6.05122,036,069 - 122,036,216NCBIRnor6.0
Rnor_5.05125,900,383 - 125,900,530UniSTSRnor5.0
RGSC_v3.45123,433,113 - 123,433,260UniSTSRGSC3.4
Celera5115,845,753 - 115,845,900UniSTS
Cytogenetic Map5q32UniSTS
BE120216  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,158,884 - 117,159,036 (+)MAPPERmRatBN7.2
Rnor_6.05121,925,748 - 121,925,899NCBIRnor6.0
Rnor_5.05125,790,327 - 125,790,478UniSTSRnor5.0
RGSC_v3.45123,324,524 - 123,324,675UniSTSRGSC3.4
Celera5115,737,826 - 115,737,977UniSTS
RH 3.4 Map5787.2UniSTS
Cytogenetic Map5q32UniSTS
AI535520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25116,993,789 - 116,994,039 (+)MAPPERmRatBN7.2
Rnor_6.05121,759,590 - 121,759,839NCBIRnor6.0
Rnor_5.05125,624,169 - 125,624,418UniSTSRnor5.0
RGSC_v3.45123,158,510 - 123,158,759UniSTSRGSC3.4
Celera5115,579,776 - 115,580,025UniSTS
Cytogenetic Map5q32UniSTS
RH138005  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,153,278 - 117,153,442 (+)MAPPERmRatBN7.2
Rnor_6.05121,920,142 - 121,920,305NCBIRnor6.0
Rnor_5.05125,784,721 - 125,784,884UniSTSRnor5.0
RGSC_v3.45123,318,918 - 123,319,081UniSTSRGSC3.4
Celera5115,732,220 - 115,732,383UniSTS
RH 3.4 Map5786.4UniSTS
Cytogenetic Map5q32UniSTS
RH138148  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,080,708 - 117,080,897 (+)MAPPERmRatBN7.2
Rnor_6.05121,846,522 - 121,846,710NCBIRnor6.0
Rnor_5.05125,711,101 - 125,711,289UniSTSRnor5.0
RGSC_v3.45123,246,482 - 123,246,670UniSTSRGSC3.4
Celera5115,666,495 - 115,666,683UniSTS
RH 3.4 Map5786.8UniSTS
Cytogenetic Map5q32UniSTS
RH138697  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,271,304 - 117,271,535 (+)MAPPERmRatBN7.2
Rnor_6.05122,040,462 - 122,040,692NCBIRnor6.0
Rnor_5.05125,904,776 - 125,905,006UniSTSRnor5.0
RGSC_v3.45123,437,506 - 123,437,736UniSTSRGSC3.4
Celera5115,850,146 - 115,850,376UniSTS
RH 3.4 Map5786.8UniSTS
Cytogenetic Map5q32UniSTS
BF390420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,327,502 - 117,327,652 (+)MAPPERmRatBN7.2
Rnor_6.05122,096,658 - 122,096,807NCBIRnor6.0
Rnor_5.05125,960,972 - 125,961,121UniSTSRnor5.0
RGSC_v3.45123,493,703 - 123,493,852UniSTSRGSC3.4
Celera5115,906,356 - 115,906,505UniSTS
Cytogenetic Map5q32UniSTS


Genetic Models
This gene Pde4b is modified in the following models/strains:
SD-Pde4bem1Sage    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
17 12 71 190 91 90 59 152 59 6 458 257 12 177 117 97 31 29 29

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001398935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF202732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF202733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH000840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ288997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L27058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M28413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000007738   ⟹   ENSRNOP00000007738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5122,580,164 - 122,598,245 (+)Ensembl
mRatBN7.2 Ensembl5117,351,429 - 117,367,696 (+)Ensembl
Rnor_6.0 Ensembl5122,100,099 - 122,136,769 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000008278   ⟹   ENSRNOP00000008278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5122,222,870 - 122,598,267 (+)Ensembl
mRatBN7.2 Ensembl5117,186,058 - 117,367,418 (+)Ensembl
Rnor_6.0 Ensembl5121,952,977 - 122,136,554 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000068158   ⟹   ENSRNOP00000059858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5122,478,701 - 122,598,267 (+)Ensembl
mRatBN7.2 Ensembl5117,249,580 - 117,367,696 (+)Ensembl
Rnor_6.0 Ensembl5122,019,301 - 122,136,814 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098470   ⟹   ENSRNOP00000096704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5122,415,212 - 122,598,245 (+)Ensembl
mRatBN7.2 Ensembl5116,993,132 - 117,367,696 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099065   ⟹   ENSRNOP00000084515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5122,135,174 - 122,598,267 (+)Ensembl
mRatBN7.2 Ensembl5116,799,971 - 117,367,696 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108780   ⟹   ENSRNOP00000083508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5122,222,870 - 122,544,536 (+)Ensembl
mRatBN7.2 Ensembl5116,993,132 - 117,315,418 (+)Ensembl
RefSeq Acc Id: NM_001398935   ⟹   NP_001385864
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85122,028,956 - 122,598,267 (+)NCBI
mRatBN7.25116,799,819 - 117,369,155 (+)NCBI
RefSeq Acc Id: NM_017031   ⟹   NP_058727
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85122,222,573 - 122,596,795 (+)NCBI
mRatBN7.25116,993,436 - 117,367,683 (+)NCBI
Rnor_6.05121,759,236 - 122,136,814 (+)NCBI
Rnor_5.05125,623,815 - 126,001,128 (+)NCBI
RGSC_v3.45123,158,156 - 123,533,877 (+)RGD
Celera5115,579,422 - 115,946,626 (+)RGD
Sequence:
RefSeq Acc Id: XM_039109272   ⟹   XP_038965200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85122,414,835 - 122,598,251 (+)NCBI
mRatBN7.25117,182,584 - 117,367,707 (+)NCBI
RefSeq Acc Id: XM_039109274   ⟹   XP_038965202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85122,566,427 - 122,598,251 (+)NCBI
mRatBN7.25117,347,420 - 117,367,707 (+)NCBI
RefSeq Acc Id: XM_039109275   ⟹   XP_038965203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85122,029,003 - 122,592,498 (+)NCBI
mRatBN7.25116,799,937 - 117,363,494 (+)NCBI
RefSeq Acc Id: XM_063287160   ⟹   XP_063143230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85122,588,693 - 122,598,251 (+)NCBI
RefSeq Acc Id: NP_058727   ⟸   NM_017031
- Peptide Label: isoform 2
- UniProtKB: A0A8I6AT13 (UniProtKB/TrEMBL),   A6JRQ9 (UniProtKB/TrEMBL),   F1M1T9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008278   ⟸   ENSRNOT00000008278
Ensembl Acc Id: ENSRNOP00000007738   ⟸   ENSRNOT00000007738
Ensembl Acc Id: ENSRNOP00000059858   ⟸   ENSRNOT00000068158
RefSeq Acc Id: XP_038965203   ⟸   XM_039109275
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038965200   ⟸   XM_039109272
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038965202   ⟸   XM_039109274
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q3F0 (UniProtKB/TrEMBL),   A6JRR2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096704   ⟸   ENSRNOT00000098470
Ensembl Acc Id: ENSRNOP00000083508   ⟸   ENSRNOT00000108780
Ensembl Acc Id: ENSRNOP00000084515   ⟸   ENSRNOT00000099065
RefSeq Acc Id: NP_001385864   ⟸   NM_001398935
- Peptide Label: isoform 1
- UniProtKB: Q8VD82 (UniProtKB/Swiss-Prot),   Q8VD81 (UniProtKB/Swiss-Prot),   Q5RKL0 (UniProtKB/Swiss-Prot),   P14646 (UniProtKB/Swiss-Prot),   A0A8I5ZY41 (UniProtKB/TrEMBL),   A6JRQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143230   ⟸   XM_063287160
- Peptide Label: isoform X4
Protein Domains
PDEase   Phosphodiesterase 4 upstream conserved regions

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14646-F1-model_v2 AlphaFold P14646 1-736 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693863
Promoter ID:EPDNEW_R4388
Type:initiation region
Name:Pde4b_1
Description:phosphodiesterase 4B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05122,100,631 - 122,100,691EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3280 AgrOrtholog
BioCyc Gene G2FUF-40525 BioCyc
Ensembl Genes ENSRNOG00000005905 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000007738 ENTREZGENE
  ENSRNOT00000008278 ENTREZGENE
  ENSRNOT00000098470 ENTREZGENE
  ENSRNOT00000099065 ENTREZGENE
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7189628 IMAGE-MGC_LOAD
InterPro HD/PDEase_dom UniProtKB/Swiss-Prot
  PDE4_UCR UniProtKB/Swiss-Prot
  PDEase UniProtKB/Swiss-Prot
  PDEase_catalytic_dom UniProtKB/Swiss-Prot
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot
  PDEase_CS UniProtKB/Swiss-Prot
KEGG Report rno:24626 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93193 IMAGE-MGC_LOAD
NCBI Gene 24626 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/Swiss-Prot
Pfam PDE4_UCR UniProtKB/Swiss-Prot
  PDEase_I UniProtKB/Swiss-Prot
PhenoGen Pde4b PhenoGen
PRINTS PDIESTERASE1 UniProtKB/Swiss-Prot
PROSITE PDEASE_I_1 UniProtKB/Swiss-Prot
  PDEASE_I_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005905 RatGTEx
SMART HDc UniProtKB/Swiss-Prot
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/Swiss-Prot
TIGR TC206247
  TC206248
UniProt A0A8I5ZX49_RAT UniProtKB/TrEMBL
  A0A8I5ZY41 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AT13 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q3F0 ENTREZGENE, UniProtKB/TrEMBL
  A6JRQ8 ENTREZGENE, UniProtKB/TrEMBL
  A6JRQ9 ENTREZGENE, UniProtKB/TrEMBL
  A6JRR1 ENTREZGENE, UniProtKB/TrEMBL
  A6JRR2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZLB2 ENTREZGENE, UniProtKB/TrEMBL
  F1M1T9 ENTREZGENE, UniProtKB/TrEMBL
  P14646 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5RKL0 ENTREZGENE
  Q8VD81 ENTREZGENE
  Q8VD82 ENTREZGENE
UniProt Secondary Q5RKL0 UniProtKB/Swiss-Prot
  Q8VD81 UniProtKB/Swiss-Prot
  Q8VD82 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-22 Pde4b  phosphodiesterase 4B  Pde4b_v4  phosphodiesterase 4B, variant 4  Data merged from RGD:1599565 737654 PROVISIONAL
2015-11-30 Pde4b  phosphodiesterase 4B  Pde4b  phosphodiesterase 4B, cAMP specific  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Pde4b  phosphodiesterase 4B, cAMP specific      Name updated 1299863 APPROVED
2002-06-10 Pde4b  Phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation activation by increased cAMP levels is associated with Pde4B4 Ser56 phosphorylation 633623