PDE4B (phosphodiesterase 4B) - Rat Genome Database

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Gene: PDE4B (phosphodiesterase 4B) Sus scrofa
Analyze
Symbol: PDE4B
Name: phosphodiesterase 4B
RGD ID: 14208919
Description: ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); cellular response to xenobiotic stimulus (ortholog); leukocyte migration (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); alcohol use disorder (ortholog); amphetamine abuse (ortholog); FOUND IN cell periphery (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cAMP-specific 3',5'-cyclic phosphodiesterase 4B; cAMP-specific phosphodiesterase 4B; phosphodiesterase 4B, cAMP specific; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6146,166,681 - 146,720,127 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16146,167,262 - 146,720,105 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26134,870,996 - 134,913,607 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:18593531  


Genomics

Comparative Map Data
PDE4B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6146,166,681 - 146,720,127 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16146,167,262 - 146,720,105 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26134,870,996 - 134,913,607 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl165,792,514 - 66,374,579 (+)EnsemblGRCh38hg38GRCh38
GRCh38165,792,510 - 66,374,579 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37166,258,193 - 66,840,262 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36166,030,781 - 66,612,850 (+)NCBINCBI36hg18NCBI36
Build 34165,970,884 - 66,551,208NCBI
Celera164,548,796 - 65,130,612 (+)NCBI
Cytogenetic Map1p31.3NCBI
HuRef164,366,982 - 64,949,229 (+)NCBIHuRef
CHM1_1166,374,133 - 66,955,827 (+)NCBICHM1_1
Pde4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394101,944,529 - 102,464,472 (+)NCBIGRCm39mm39
GRCm39 Ensembl4101,944,740 - 102,464,456 (+)Ensembl
GRCm384102,087,332 - 102,607,275 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4102,087,543 - 102,607,259 (+)EnsemblGRCm38mm10GRCm38
MGSCv374101,927,347 - 102,279,867 (+)NCBIGRCm37mm9NCBIm37
MGSCv364101,752,935 - 102,103,771 (+)NCBImm8
Celera4100,608,595 - 100,971,313 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.99NCBI
Pde4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25116,799,827 - 117,367,707 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5116,799,971 - 117,367,696 (+)Ensembl
Rnor_6.05121,759,236 - 122,136,814 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5121,952,977 - 122,136,814 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05125,623,815 - 126,001,128 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45123,158,156 - 123,533,877 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15123,163,381 - 123,539,103 (+)NCBI
Celera5115,579,422 - 115,946,626 (+)NCBICelera
Cytogenetic Map5q33NCBI
Pde4b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542324,463,953 - 24,906,394 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542324,464,503 - 24,906,409 (-)NCBIChiLan1.0ChiLan1.0
PDE4B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1166,924,478 - 67,506,291 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl167,045,911 - 67,506,291 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0165,038,120 - 65,620,764 (+)NCBIMhudiblu_PPA_v0panPan3
PDE4B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1544,063,145 - 44,606,070 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl544,065,106 - 44,500,999 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha544,186,161 - 44,663,652 (-)NCBI
ROS_Cfam_1.0544,251,621 - 44,793,357 (-)NCBI
UMICH_Zoey_3.1544,216,433 - 44,758,769 (-)NCBI
UNSW_CanFamBas_1.0544,161,847 - 44,703,948 (-)NCBI
UU_Cfam_GSD_1.0544,405,153 - 44,947,628 (-)NCBI
Pde4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505878,822,844 - 79,336,912 (+)NCBI
SpeTri2.0NW_0049365915,152,491 - 5,666,728 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE4B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12066,729,561 - 67,297,729 (-)NCBI
ChlSab1.1 Ensembl2066,728,664 - 66,771,691 (-)Ensembl
Vero_WHO_p1.0NW_02366603350,280,843 - 50,864,221 (+)NCBI
Pde4b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474228,557,159 - 29,113,269 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 4 5 2 19 1 2
Low 10 3 4 2 2 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001130018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001130019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021093170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021093172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021093173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021093174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK346358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK346460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU929681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ979873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ990376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU189937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU339284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU339285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU434619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01087575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000004211   ⟹   ENSSSCP00000004116
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6146,167,257 - 146,373,149 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000045816   ⟹   ENSSSCP00000041461
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6146,166,688 - 146,186,991 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000047592   ⟹   ENSSSCP00000048528
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6146,166,681 - 146,549,268 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000065972   ⟹   ENSSSCP00000045277
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6146,166,689 - 146,211,163 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000069874   ⟹   ENSSSCP00000062633
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6146,166,681 - 146,302,856 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000074206   ⟹   ENSSSCP00000074429
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6146,166,681 - 146,720,127 (-)Ensembl
RefSeq Acc Id: NM_001130018   ⟹   NP_001123490
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16146,168,659 - 146,211,201 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001130019   ⟹   NP_001123491
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16146,168,659 - 146,720,085 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093170   ⟹   XP_020948829
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16146,168,648 - 146,720,105 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093172   ⟹   XP_020948831
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16146,168,621 - 146,550,253 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093173   ⟹   XP_020948832
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16146,167,262 - 146,236,257 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093174   ⟹   XP_020948833
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16146,168,621 - 146,192,635 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020948832   ⟸   XM_021093173
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020948831   ⟸   XM_021093172
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020948833   ⟸   XM_021093174
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_020948829   ⟸   XM_021093170
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001123491   ⟸   NM_001130019
- Peptide Label: isoform 1
- UniProtKB: B3TNN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001123490   ⟸   NM_001130018
- Peptide Label: isoform 2
- UniProtKB: B3TNN4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000074429   ⟸   ENSSSCT00000074206
RefSeq Acc Id: ENSSSCP00000045277   ⟸   ENSSSCT00000065972
RefSeq Acc Id: ENSSSCP00000041461   ⟸   ENSSSCT00000045816
RefSeq Acc Id: ENSSSCP00000062633   ⟸   ENSSSCT00000069874
RefSeq Acc Id: ENSSSCP00000004116   ⟸   ENSSSCT00000004211
RefSeq Acc Id: ENSSSCP00000048528   ⟸   ENSSSCT00000047592
Protein Domains
PDEase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003805 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070011577 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000004116 UniProtKB/TrEMBL
  ENSSSCP00000041461 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000045277 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000048528 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000062633 UniProtKB/TrEMBL
  ENSSSCP00000074429 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070018889 UniProtKB/TrEMBL
  ENSSSCP00070018893 UniProtKB/TrEMBL
  ENSSSCP00070018899 UniProtKB/TrEMBL
  ENSSSCP00070018915 UniProtKB/TrEMBL
  ENSSSCP00070018930 UniProtKB/TrEMBL
  ENSSSCP00070018936 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004211 UniProtKB/TrEMBL
  ENSSSCT00000045816 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000047592 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000065972 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000069874 UniProtKB/TrEMBL
  ENSSSCT00000074206 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070022840 UniProtKB/TrEMBL
  ENSSSCT00070022846 UniProtKB/TrEMBL
  ENSSSCT00070022854 UniProtKB/TrEMBL
  ENSSSCT00070022872 UniProtKB/TrEMBL
  ENSSSCT00070022888 UniProtKB/TrEMBL
  ENSSSCT00070022895 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
InterPro HD/PDEase_dom UniProtKB/TrEMBL
  PDE4 UniProtKB/TrEMBL
  PDE4_UCR UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
KEGG Report ssc:100037941 UniProtKB/TrEMBL
NCBI Gene PDE4B ENTREZGENE
PANTHER PTHR11347:SF108 UniProtKB/TrEMBL
Pfam PDE4_UCR UniProtKB/TrEMBL
  PDEase_I UniProtKB/TrEMBL
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART HDc UniProtKB/TrEMBL
UniProt A0A287ACC6_PIG UniProtKB/TrEMBL
  A0A287AN05_PIG UniProtKB/TrEMBL
  A0A287AWL7_PIG UniProtKB/TrEMBL
  A0A4X1TPF4_PIG UniProtKB/TrEMBL
  A0A4X1TU85_PIG UniProtKB/TrEMBL
  A0A4X1TU90_PIG UniProtKB/TrEMBL
  A0A4X1TUB0_PIG UniProtKB/TrEMBL
  A0A4X1TUD0_PIG UniProtKB/TrEMBL
  A0A4X1TUE1_PIG UniProtKB/TrEMBL
  A0A5G2QEL9_PIG UniProtKB/TrEMBL
  A0A5G2RH31_PIG UniProtKB/TrEMBL
  B3TNN3 ENTREZGENE, UniProtKB/TrEMBL
  B3TNN4 ENTREZGENE, UniProtKB/TrEMBL
  B9TRX2_PIG UniProtKB/TrEMBL
  B9U3V2_PIG UniProtKB/TrEMBL
  F1S820_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91255 ENTREZGENE