Kcnh6 (potassium voltage-gated channel subfamily H member 6) - Rat Genome Database

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Gene: Kcnh6 (potassium voltage-gated channel subfamily H member 6) Rattus norvegicus
Analyze
Symbol: Kcnh6
Name: potassium voltage-gated channel subfamily H member 6
RGD ID: 620304
Description: Enables inward rectifier potassium channel activity. Involved in potassium ion transport. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to human KCNH6 (potassium voltage-gated channel subfamily H member 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Eag-related gene member 2; eag-related protein 2; ERG-2; Erg2; ether-a-go-go-related gene potassium channel 2; ether-a-go-go-related protein 2; potassium channel, voltage gated eag related subfamily H, member 6; potassium voltage-gated channel, subfamily H (eag-related), member 6; voltage-gated potassium channel subunit Kv11.2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,449,025 - 91,471,012 (+)NCBIGRCr8
mRatBN7.21090,949,240 - 90,970,746 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1090,949,846 - 90,970,701 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,003,974 - 96,025,091 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,467,143 - 95,488,263 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01090,878,334 - 90,899,206 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,207,336 - 94,228,236 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,207,314 - 94,228,236 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01093,958,627 - 93,979,152 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,400,862 - 95,421,678 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11095,421,300 - 95,436,048 (+)NCBI
Celera1089,628,057 - 89,648,511 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Fast erg K+ currents in rat embryonic serotonergic neurones. Hirdes W, etal., J Physiol. 2005 Apr 1;564(Pt 1):33-49. Epub 2005 Jan 27.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Identification of two nervous system-specific members of the erg potassium channel gene family. Shi W, etal., J Neurosci 1997 Dec 15;17(24):9423-32.
9. Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers. Wimmers S, etal., Pflugers Arch. 2001 Jan;441(4):450-5.
Additional References at PubMed
PMID:10718922   PMID:11425889   PMID:21044070  


Genomics

Comparative Map Data
Kcnh6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,449,025 - 91,471,012 (+)NCBIGRCr8
mRatBN7.21090,949,240 - 90,970,746 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1090,949,846 - 90,970,701 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,003,974 - 96,025,091 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,467,143 - 95,488,263 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01090,878,334 - 90,899,206 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,207,336 - 94,228,236 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,207,314 - 94,228,236 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01093,958,627 - 93,979,152 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,400,862 - 95,421,678 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11095,421,300 - 95,436,048 (+)NCBI
Celera1089,628,057 - 89,648,511 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
KCNH6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381763,523,358 - 63,548,992 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1763,523,334 - 63,548,977 (+)EnsemblGRCh38hg38GRCh38
GRCh371761,600,719 - 61,626,353 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361758,954,427 - 58,980,070 (+)NCBINCBI36Build 36hg18NCBI36
Build 341758,954,426 - 58,980,070NCBI
Celera1755,988,522 - 56,014,428 (+)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1756,966,852 - 56,992,787 (+)NCBIHuRef
CHM1_11761,664,820 - 61,690,751 (+)NCBICHM1_1
T2T-CHM13v2.01764,393,673 - 64,419,606 (+)NCBIT2T-CHM13v2.0
Kcnh6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911105,898,871 - 105,926,421 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11105,898,950 - 105,925,375 (+)EnsemblGRCm39 Ensembl
GRCm3811106,008,044 - 106,035,595 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,008,124 - 106,034,549 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,869,517 - 105,895,378 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611105,824,293 - 105,850,154 (+)NCBIMGSCv36mm8
Celera11117,739,753 - 117,760,293 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.87NCBI
Kcnh6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554788,243,949 - 8,263,336 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554788,242,953 - 8,263,369 (-)NCBIChiLan1.0ChiLan1.0
KCNH6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21979,694,849 - 79,720,406 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11784,512,403 - 84,537,957 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01757,603,039 - 57,626,964 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11762,749,240 - 62,772,544 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1762,749,216 - 62,772,544 (+)Ensemblpanpan1.1panPan2
KCNH6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,538,506 - 11,559,303 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,538,205 - 11,559,319 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha912,498,958 - 12,519,775 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0913,201,806 - 13,222,832 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,201,609 - 13,222,833 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,146,396 - 12,167,428 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0915,364,422 - 15,385,338 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0915,367,399 - 15,388,227 (-)NCBIUU_Cfam_GSD_1.0
Kcnh6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,974,734 - 14,996,783 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365414,197,751 - 4,220,076 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365414,197,826 - 4,219,864 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNH6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,353,867 - 15,374,858 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,352,765 - 15,374,763 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,340,202 - 15,361,582 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNH6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11657,733,032 - 57,759,292 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1657,735,861 - 57,758,421 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607728,349,032 - 28,372,393 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnh6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248491,043,045 - 1,062,891 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248491,043,045 - 1,063,371 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnh6
221 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:196
Count of miRNA genes:130
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000010816
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
RH135087  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21090,970,533 - 90,970,725 (+)MAPPERmRatBN7.2
Rnor_6.01094,228,024 - 94,228,215NCBIRnor6.0
Rnor_5.01093,978,940 - 93,979,131UniSTSRnor5.0
RGSC_v3.41095,421,511 - 95,421,702UniSTSRGSC3.4
Celera1089,648,344 - 89,648,535UniSTS
RH 3.4 Map10980.9UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low 21 50 6 6 203 55 24
Below cutoff 46 31 21 5 21 47 51 75 31

Sequence


Ensembl Acc Id: ENSRNOT00000010816   ⟹   ENSRNOP00000010816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1090,949,846 - 90,970,701 (+)Ensembl
Rnor_6.0 Ensembl1094,207,336 - 94,228,236 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092779   ⟹   ENSRNOP00000076037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1090,949,846 - 90,970,701 (+)Ensembl
Rnor_6.0 Ensembl1094,207,314 - 94,227,716 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117789   ⟹   ENSRNOP00000080419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1090,949,846 - 90,970,701 (+)Ensembl
RefSeq Acc Id: NM_053937   ⟹   NP_446389
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,449,651 - 91,470,506 (+)NCBI
mRatBN7.21090,949,846 - 90,970,701 (+)NCBI
Rnor_6.01094,207,336 - 94,228,191 (+)NCBI
Rnor_5.01093,958,627 - 93,979,152 (+)NCBI
RGSC_v3.41095,400,862 - 95,421,678 (+)RGD
Celera1089,628,057 - 89,648,511 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247555   ⟹   XP_006247617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,449,025 - 91,471,012 (+)NCBI
mRatBN7.21090,949,240 - 90,970,746 (+)NCBI
Rnor_6.01094,207,339 - 94,228,236 (+)NCBI
Rnor_5.01093,958,627 - 93,979,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085055   ⟹   XP_038940983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,449,025 - 91,468,088 (+)NCBI
mRatBN7.21090,949,240 - 90,968,283 (+)NCBI
RefSeq Acc Id: XM_039085057   ⟹   XP_038940985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,449,025 - 91,468,102 (+)NCBI
mRatBN7.21090,949,240 - 90,968,297 (+)NCBI
RefSeq Acc Id: NP_446389   ⟸   NM_053937
- UniProtKB: O54853 (UniProtKB/Swiss-Prot),   A6HJZ7 (UniProtKB/TrEMBL),   G3V720 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247617   ⟸   XM_006247555
- Peptide Label: isoform X1
- UniProtKB: A0A1B0GWV8 (UniProtKB/TrEMBL),   A6HJZ7 (UniProtKB/TrEMBL),   G3V720 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000076037   ⟸   ENSRNOT00000092779
Ensembl Acc Id: ENSRNOP00000010816   ⟸   ENSRNOT00000010816
RefSeq Acc Id: XP_038940985   ⟸   XM_039085057
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038940983   ⟸   XM_039085055
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000080419   ⟸   ENSRNOT00000117789
Protein Domains
Cyclic nucleotide-binding   PAC   PAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54853-F1-model_v2 AlphaFold O54853 1-950 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620304 AgrOrtholog
BioCyc Gene G2FUF-22967 BioCyc
Ensembl Genes ENSRNOG00000008078 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055029484 UniProtKB/Swiss-Prot
  ENSRNOG00060013787 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010816.5 UniProtKB/TrEMBL
  ENSRNOT00000092779.2 UniProtKB/TrEMBL
  ENSRNOT00000117789.1 UniProtKB/TrEMBL
  ENSRNOT00055051091 UniProtKB/Swiss-Prot
  ENSRNOT00060023554 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1200.260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_ERG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNH_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116745 UniProtKB/Swiss-Prot
NCBI Gene 116745 ENTREZGENE
PANTHER PTHR10217:SF468 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnh6 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERGCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008078 RatGTEx
  ENSRNOG00055029484 RatGTEx
  ENSRNOG00060013787 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GWV8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZQL4_RAT UniProtKB/TrEMBL
  A6HJZ7 ENTREZGENE, UniProtKB/TrEMBL
  G3V720 ENTREZGENE, UniProtKB/TrEMBL
  KCNH6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnh6  potassium voltage-gated channel subfamily H member 6  Kcnh6  potassium channel, voltage gated eag related subfamily H, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnh6  potassium channel, voltage gated eag related subfamily H, member 6  Kcnh6  potassium voltage-gated channel, subfamily H (eag-related), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kcnh6  potassium voltage-gated channel, subfamily H (eag-related), member 6  Erg2  Eag-related gene member 2  Symbol and Name updated 1299863 APPROVED
2002-08-07 Erg2  Eag-related gene member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the fundus and antrum of the rat stomach and in the brain 625508
gene_expression enriched in the nervous system 632747