Ap2m1 (adaptor related protein complex 2 subunit mu 1) - Rat Genome Database

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Gene: Ap2m1 (adaptor related protein complex 2 subunit mu 1) Rattus norvegicus
Analyze
Symbol: Ap2m1
Name: adaptor related protein complex 2 subunit mu 1
RGD ID: 620135
Description: Enables low-density lipoprotein particle receptor binding activity and signal sequence binding activity. Involved in positive regulation of endocytosis; protein-containing complex assembly; and vesicle-mediated transport in synapse. Located in terminal bouton. Part of AP-2 adaptor complex. Is active in glutamatergic synapse and synaptic vesicle. Is extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1); PARTICIPATES IN Arf family mediated signaling pathway; clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adapter-related protein complex 2 mu subunit; adapter-related protein complex 2 subunit mu; adaptor protein complex AP-2 subunit mu; adaptor-related protein complex 2 subunit mu; adaptor-related protein complex 2, mu 1 subunit; AP-2 complex subunit mu; AP-2 mu chain; Ap50; Clapm1; clathrin assembly protein complex 2 medium chain; clathrin assembly protein complex 2 mu medium chain; clathrin coat assembly protein AP50; clathrin coat-associated protein AP50; coat assembly protein complex 50 kD; coat assembly protein complex, 50 kD; MGC105352; mu2; mu2-adaptin; plasma membrane adaptor AP-2 50 kDa protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,859,690 - 93,868,600 (-)NCBIGRCr8
mRatBN7.21180,355,307 - 80,364,218 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,328,041 - 80,364,140 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,077,793 - 89,086,551 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,731,213 - 81,739,971 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,792,278 - 80,801,037 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,041,184 - 84,047,542 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,041,184 - 84,047,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,113,496 - 87,119,854 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,585,474 - 82,591,832 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,643,062 - 82,649,421 (-)NCBI
Celera1179,194,852 - 79,201,210 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
caffeine  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
coumarin  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fipronil  (EXP)
fluoxetine  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
glutathione  (EXP)
haloperidol  (ISO)
imipramine  (ISO)
ivermectin  (ISO)
ketamine  (ISO)
L-ethionine  (EXP)
lead(0)  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nilotinib  (ISO)
nitroglycerin  (EXP)
omeprazole  (EXP)
ozone  (EXP,ISO)
parathion  (ISO)
Phenelzine  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
rolipram  (ISO)
rotenone  (EXP,ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
triphenyl phosphate  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional domain mapping of the clathrin-associated adaptor medium chains mu1 and mu2. Aguilar RC, etal., J Biol Chem. 1997 Oct 24;272(43):27160-6.
2. The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppO sorting signals at distinct sites. Boll W, etal., Traffic. 2002 Aug;3(8):590-600.
3. Molecular architecture and functional model of the endocytic AP2 complex. Collins BM, etal., Cell. 2002 May 17;109(4):523-35.
4. Selective integrin endocytosis is driven by interactions between the integrin alpha-chain and AP2. De Franceschi N, etal., Nat Struct Mol Biol. 2016 Feb;23(2):172-9. doi: 10.1038/nsmb.3161. Epub 2016 Jan 18.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex. Jackson LP, etal., Cell. 2010 Jun 25;141(7):1220-9. doi: 10.1016/j.cell.2010.05.006.
7. Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2. Kastning K, etal., Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2991-6. Epub 2007 Feb 8.
8. The phosphorylation of coated membrane proteins in intact neurons. Keen JH and Black MM, J Cell Biol. 1986 Apr;102(4):1325-33.
9. Clathrin adaptors. AP2 controls clathrin polymerization with a membrane-activated switch. Kelly BT, etal., Science. 2014 Jul 25;345(6195):459-63. doi: 10.1126/science.1254836.
10. A distributed set of interactions controls mu2 functionality in the role of AP-2 as a sorting adaptor in synaptic vesicle endocytosis. Kim SH and Ryan TA, J Biol Chem. 2009 Nov 20;284(47):32803-12. doi: 10.1074/jbc.M109.039149. Epub 2009 Sep 17.
11. Synaptic vesicle recycling at CNS snapses without AP-2. Kim SH and Ryan TA, J Neurosci. 2009 Mar 25;29(12):3865-74. doi: 10.1523/JNEUROSCI.5639-08.2009.
12. Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Kittler JT, etal., Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14871-6. Epub 2005 Sep 28.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2). Nakatsu F, etal., Cytogenet Cell Genet 1999;87(1-2):53-8.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Identification of a non-canonical tyrosine-based endocytic motif in an ionotropic receptor. Royle SJ, etal., J Biol Chem. 2002 Sep 20;277(38):35378-85. doi: 10.1074/jbc.M204844200. Epub 2002 Jul 8.
21. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
22. Serine 331 and tyrosine 333 are both involved in the interaction between the cytosolic domain of TGN38 and the mu2 subunit of the AP2 clathrin adaptor complex. Stephens DJ, etal., J Biol Chem. 1997 May 30;272(22):14104-9.
23. The synaptic vesicle cycle: a single vesicle budding step involving clathrin and dynamin. Takei K, etal., J Cell Biol. 1996 Jun;133(6):1237-50. doi: 10.1083/jcb.133.6.1237.
24. Hidden proteome of synaptic vesicles in the mammalian brain. Taoufiq Z, etal., Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33586-33596. doi: 10.1073/pnas.2011870117. Epub 2020 Dec 21.
25. Molecular cloning and complete amino acid sequence of AP50, an assembly protein associated with clathrin-coated vesicles. Thurieau C, etal., DNA 1988 Dec;7(10):663-9.
26. Recognition of the tryptophan-based endocytosis signal in the neonatal Fc Receptor by the mu subunit of adaptor protein-2. Wernick NL, etal., J Biol Chem. 2005 Feb 25;280(8):7309-16. doi: 10.1074/jbc.M410752200. Epub 2004 Dec 14.
27. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
28. Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Yu A, etal., Structure. 2010 Oct 13;18(10):1311-20. doi: 10.1016/j.str.2010.07.010.
Additional References at PubMed
PMID:8918456   PMID:9171339   PMID:9812899   PMID:10908605   PMID:11247301   PMID:12070130   PMID:12234931   PMID:12477932   PMID:14651853   PMID:14726597   PMID:15489334   PMID:15985462  
PMID:18305175   PMID:18321067   PMID:19056867   PMID:19581412   PMID:21499258   PMID:22262466   PMID:22871113   PMID:23529131   PMID:23676497   PMID:24217640   PMID:25898166   PMID:28139716  
PMID:28755400   PMID:29476059   PMID:30053369   PMID:31104773   PMID:32357304  


Genomics

Comparative Map Data
Ap2m1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,859,690 - 93,868,600 (-)NCBIGRCr8
mRatBN7.21180,355,307 - 80,364,218 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,328,041 - 80,364,140 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,077,793 - 89,086,551 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,731,213 - 81,739,971 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,792,278 - 80,801,037 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,041,184 - 84,047,542 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,041,184 - 84,047,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,113,496 - 87,119,854 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,585,474 - 82,591,832 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,643,062 - 82,649,421 (-)NCBI
Celera1179,194,852 - 79,201,210 (-)NCBICelera
Cytogenetic Map11q23NCBI
AP2M1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383184,174,855 - 184,184,091 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3184,174,689 - 184,184,214 (+)EnsemblGRCh38hg38GRCh38
GRCh373183,892,643 - 183,901,879 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,375,328 - 185,384,573 (+)NCBINCBI36Build 36hg18NCBI36
Build 343185,375,357 - 185,384,580NCBI
Celera3182,334,345 - 182,343,591 (+)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3181,299,526 - 181,308,773 (+)NCBIHuRef
CHM1_13183,857,039 - 183,866,284 (+)NCBICHM1_1
T2T-CHM13v2.03186,983,791 - 186,993,030 (+)NCBIT2T-CHM13v2.0
Ap2m1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,354,230 - 20,363,659 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,354,228 - 20,363,659 (+)EnsemblGRCm39 Ensembl
GRCm381620,535,480 - 20,544,909 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,535,478 - 20,544,909 (+)EnsemblGRCm38mm10GRCm38
MGSCv371620,535,577 - 20,544,126 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361620,449,047 - 20,457,596 (+)NCBIMGSCv36mm8
Celera1621,099,579 - 21,108,128 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.46NCBI
Ap2m1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,281,720 - 23,290,430 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,281,720 - 23,290,430 (-)NCBIChiLan1.0ChiLan1.0
AP2M1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22182,046,087 - 182,055,438 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13182,050,873 - 182,060,155 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03181,210,045 - 181,219,327 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13189,692,898 - 189,702,261 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,692,898 - 189,702,261 (+)Ensemblpanpan1.1panPan2
AP2M1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,071,199 - 17,080,445 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3417,071,235 - 17,080,445 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3421,158,482 - 21,167,628 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03416,979,339 - 16,988,512 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3416,979,372 - 16,989,773 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13417,016,696 - 17,025,849 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03417,012,627 - 17,021,768 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03417,242,835 - 17,251,997 (+)NCBIUU_Cfam_GSD_1.0
Ap2m1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,588,894 - 119,599,828 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365785,682,541 - 5,689,521 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365785,680,748 - 5,691,666 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP2M1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,094,437 - 122,104,802 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113122,094,375 - 122,103,408 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,534,147 - 131,543,179 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AP2M1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,242,025 - 5,251,272 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606314,021,045 - 14,030,446 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap2m1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473072,386,376 - 72,395,392 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ap2m1
57 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:67
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000058092
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
RH128689  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,355,314 - 80,355,501 (+)MAPPERmRatBN7.2
Rnor_6.01184,041,041 - 84,041,227NCBIRnor6.0
Rnor_5.01187,113,353 - 87,113,539UniSTSRnor5.0
RGSC_v3.41182,585,331 - 82,585,517UniSTSRGSC3.4
Celera1179,194,709 - 79,194,895UniSTS
RH 3.4 Map11657.3UniSTS
Cytogenetic Map11q23UniSTS
AA874911  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,355,583 - 80,355,779 (+)MAPPERmRatBN7.2
Rnor_6.01184,041,310 - 84,041,505NCBIRnor6.0
Rnor_5.01187,113,622 - 87,113,817UniSTSRnor5.0
RGSC_v3.41182,585,600 - 82,585,795UniSTSRGSC3.4
Celera1179,194,978 - 79,195,173UniSTS
RH 3.4 Map11657.9UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000058092   ⟹   ENSRNOP00000054900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,328,041 - 80,364,140 (-)Ensembl
Rnor_6.0 Ensembl1184,041,184 - 84,047,546 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088821   ⟹   ENSRNOP00000070202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,328,041 - 80,364,140 (-)Ensembl
Rnor_6.0 Ensembl1184,041,630 - 84,047,497 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100870   ⟹   ENSRNOP00000079141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,328,041 - 80,364,140 (-)Ensembl
RefSeq Acc Id: NM_053837   ⟹   NP_446289
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,859,690 - 93,868,480 (-)NCBI
mRatBN7.21180,355,307 - 80,364,098 (-)NCBI
Rnor_6.01184,041,184 - 84,047,542 (-)NCBI
Rnor_5.01187,113,496 - 87,119,854 (-)NCBI
RGSC_v3.41182,585,474 - 82,591,832 (-)RGD
Celera1179,194,852 - 79,201,210 (-)RGD
Sequence:
RefSeq Acc Id: XM_039087902   ⟹   XP_038943830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,859,832 - 93,868,600 (-)NCBI
mRatBN7.21180,355,449 - 80,364,218 (-)NCBI
RefSeq Acc Id: XM_063270241   ⟹   XP_063126311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,859,832 - 93,862,944 (-)NCBI
RefSeq Acc Id: NP_446289   ⟸   NM_053837
- UniProtKB: P84092 (UniProtKB/Swiss-Prot),   A0A8I5ZME4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054900   ⟸   ENSRNOT00000058092
Ensembl Acc Id: ENSRNOP00000070202   ⟸   ENSRNOT00000088821
RefSeq Acc Id: XP_038943830   ⟸   XM_039087902
- Peptide Label: isoform X1
- UniProtKB: A0A140TAH5 (UniProtKB/TrEMBL),   A0A8I5ZME4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079141   ⟸   ENSRNOT00000100870
RefSeq Acc Id: XP_063126311   ⟸   XM_063270241
- Peptide Label: isoform X2
- UniProtKB: A6JSB0 (UniProtKB/TrEMBL)
Protein Domains
MHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P84092-F1-model_v2 AlphaFold P84092 1-435 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698279
Promoter ID:EPDNEW_R8803
Type:single initiation site
Name:Ap2m1_1
Description:adaptor-related protein complex 2, mu 1 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01184,047,461 - 84,047,521EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620135 AgrOrtholog
BioCyc Gene G2FUF-20731 BioCyc
Ensembl Genes ENSRNOG00000001709 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055004882 UniProtKB/Swiss-Prot
  ENSRNOG00060011929 UniProtKB/Swiss-Prot
  ENSRNOG00065004219 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000058092.5 UniProtKB/TrEMBL
  ENSRNOT00000088821.2 UniProtKB/Swiss-Prot
  ENSRNOT00000100870.1 UniProtKB/TrEMBL
  ENSRNOT00055007791 UniProtKB/Swiss-Prot
  ENSRNOT00060020201 UniProtKB/Swiss-Prot
  ENSRNOT00065006162 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.450.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mu homology domain, subdomain B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7320615 IMAGE-MGC_LOAD
InterPro Adaptor_comp_med_subunit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AP2_Mu_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AP2_Mu_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AP_mu_sigma_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_mu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_mu_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Longin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mu2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116563 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105352 IMAGE-MGC_LOAD
NCBI Gene 116563 ENTREZGENE
PANTHER AP COMPLEX SUBUNIT MU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AP-2 COMPLEX SUBUNIT MU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Adap_comp_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clat_adaptor_s UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ap2m1 PhenoGen
PIRSF Clathrin_mu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CLATHRINADPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CLAT_ADAPTOR_M_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLAT_ADAPTOR_M_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001709 RatGTEx
  ENSRNOG00055004882 RatGTEx
  ENSRNOG00060011929 RatGTEx
  ENSRNOG00065004219 RatGTEx
Superfamily-SCOP SSF49447 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF64356 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TAH5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZME4 ENTREZGENE, UniProtKB/TrEMBL
  A6JSB0 ENTREZGENE, UniProtKB/TrEMBL
  AP2M1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P20172 UniProtKB/Swiss-Prot
  P53679 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Ap2m1  adaptor related protein complex 2 subunit mu 1  Ap2m1  adaptor-related protein complex 2, mu 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ap2m1  adaptor-related protein complex 2, mu 1 subunit      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ap2m1  adaptor-related protein complex 2, mu 1 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL