Ap2m1 (adaptor related protein complex 2 subunit mu 1) - Rat Genome Database

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Gene: Ap2m1 (adaptor related protein complex 2 subunit mu 1) Chinchilla lanigera
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Symbol: Ap2m1
Name: adaptor related protein complex 2 subunit mu 1
RGD ID: 8725054
Description: ENCODES a protein that exhibits disordered domain specific binding (ortholog); low-density lipoprotein particle receptor binding (ortholog); signal sequence binding (ortholog); INVOLVED IN clathrin-dependent endocytosis (ortholog); negative regulation of protein localization to plasma membrane (ortholog); positive regulation of receptor internalization (ortholog); PARTICIPATES IN Arf family mediated signaling pathway; clathrin-dependent synaptic vesicle endocytosis; ASSOCIATED WITH 3-methylcrotonyl-CoA carboxylase 1 deficiency (ortholog); autistic disorder (ortholog); Autosomal Dominant Intellectual Developmental Disorder 60 (ortholog); FOUND IN AP-2 adaptor complex (ortholog); clathrin-coated pit (ortholog); extrinsic component of presynaptic endocytic zone membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adaptor related protein complex 2 mu 1 subunit; adaptor-related protein complex 2, mu 1 subunit; AP-2 complex subunit mu
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,281,720 - 23,290,430 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,281,720 - 23,290,430 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ap2m1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,281,720 - 23,290,430 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,281,720 - 23,290,430 (-)NCBIChiLan1.0ChiLan1.0
AP2M1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383184,174,855 - 184,184,091 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3184,174,689 - 184,184,214 (+)EnsemblGRCh38hg38GRCh38
GRCh373183,892,643 - 183,901,879 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,375,328 - 185,384,573 (+)NCBINCBI36Build 36hg18NCBI36
Build 343185,375,357 - 185,384,580NCBI
Celera3182,334,345 - 182,343,591 (+)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3181,299,526 - 181,308,773 (+)NCBIHuRef
CHM1_13183,857,039 - 183,866,284 (+)NCBICHM1_1
T2T-CHM13v2.03186,983,791 - 186,993,030 (+)NCBIT2T-CHM13v2.0
Ap2m1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,354,230 - 20,363,659 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,354,228 - 20,363,659 (+)EnsemblGRCm39 Ensembl
GRCm381620,535,480 - 20,544,909 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,535,478 - 20,544,909 (+)EnsemblGRCm38mm10GRCm38
MGSCv371620,535,577 - 20,544,126 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361620,449,047 - 20,457,596 (+)NCBIMGSCv36mm8
Celera1621,099,579 - 21,108,128 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.46NCBI
Ap2m1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,859,690 - 93,868,600 (-)NCBIGRCr8
mRatBN7.21180,355,307 - 80,364,218 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,328,041 - 80,364,140 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,077,793 - 89,086,551 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,731,213 - 81,739,971 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,792,278 - 80,801,037 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,041,184 - 84,047,542 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,041,184 - 84,047,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,113,496 - 87,119,854 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,585,474 - 82,591,832 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,643,062 - 82,649,421 (-)NCBI
Celera1179,194,852 - 79,201,210 (-)NCBICelera
Cytogenetic Map11q23NCBI
AP2M1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22182,046,087 - 182,055,438 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13182,050,873 - 182,060,155 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03181,210,045 - 181,219,327 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13189,692,898 - 189,702,261 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,692,898 - 189,702,261 (+)Ensemblpanpan1.1panPan2
AP2M1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,071,199 - 17,080,445 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3417,071,235 - 17,080,445 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3421,158,482 - 21,167,628 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03416,979,339 - 16,988,512 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3416,979,372 - 16,989,773 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13417,016,696 - 17,025,849 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03417,012,627 - 17,021,768 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03417,242,835 - 17,251,997 (+)NCBIUU_Cfam_GSD_1.0
Ap2m1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,588,894 - 119,599,828 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365785,682,541 - 5,689,521 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365785,680,748 - 5,691,666 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP2M1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,094,437 - 122,104,802 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113122,094,375 - 122,103,408 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,534,147 - 131,543,179 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AP2M1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,242,025 - 5,251,272 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606314,021,045 - 14,030,446 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap2m1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473072,386,376 - 72,395,392 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000021091   ⟹   ENSCLAP00000020890
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542023,281,720 - 23,290,430 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000021092   ⟹   ENSCLAP00000020891
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542023,282,199 - 23,288,352 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000021093   ⟹   ENSCLAP00000020892
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542023,282,199 - 23,288,352 (-)Ensembl
RefSeq Acc Id: XM_005383348   ⟹   XP_005383405
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542023,281,720 - 23,290,430 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005383349   ⟹   XP_005383406
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542023,281,720 - 23,290,430 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005383405 (Get FASTA)   NCBI Sequence Viewer  
  XP_005383406 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000020890
  ENSCLAP00000020890.1
  ENSCLAP00000020891.1
  ENSCLAP00000020892
  ENSCLAP00000020892.1
RefSeq Acc Id: XP_005383406   ⟸   XM_005383349
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VZ11 (UniProtKB/TrEMBL),   A0A8C2W1Q0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005383405   ⟸   XM_005383348
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VXD5 (UniProtKB/TrEMBL),   A0A8C2W1Q0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000020890   ⟸   ENSCLAT00000021091
Ensembl Acc Id: ENSCLAP00000020892   ⟸   ENSCLAT00000021093
Ensembl Acc Id: ENSCLAP00000020891   ⟸   ENSCLAT00000021092
Protein Domains
MHD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014315 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021091 ENTREZGENE
  ENSCLAT00000021091.1 UniProtKB/TrEMBL
  ENSCLAT00000021092.1 UniProtKB/TrEMBL
  ENSCLAT00000021093 ENTREZGENE
  ENSCLAT00000021093.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.60 UniProtKB/TrEMBL
  Mu homology domain, subdomain B UniProtKB/TrEMBL
InterPro Adaptor_comp_med_subunit UniProtKB/TrEMBL
  AP2_Mu_C_sf UniProtKB/TrEMBL
  AP2_Mu_N UniProtKB/TrEMBL
  AP_mu_sigma_su UniProtKB/TrEMBL
  Clathrin_mu UniProtKB/TrEMBL
  Clathrin_mu_CS UniProtKB/TrEMBL
  Longin-like_dom_sf UniProtKB/TrEMBL
  MHD UniProtKB/TrEMBL
  Mu2_C UniProtKB/TrEMBL
NCBI Gene Ap2m1 ENTREZGENE
PANTHER AP COMPLEX SUBUNIT MU UniProtKB/TrEMBL
  AP-2 COMPLEX SUBUNIT MU UniProtKB/TrEMBL
Pfam Adap_comp_sub UniProtKB/TrEMBL
  Clat_adaptor_s UniProtKB/TrEMBL
PIRSF Clathrin_mu UniProtKB/TrEMBL
PRINTS CLATHRINADPT UniProtKB/TrEMBL
PROSITE CLAT_ADAPTOR_M_1 UniProtKB/TrEMBL
  CLAT_ADAPTOR_M_2 UniProtKB/TrEMBL
  MHD UniProtKB/TrEMBL
Superfamily-SCOP SSF49447 UniProtKB/TrEMBL
  SSF64356 UniProtKB/TrEMBL
UniProt A0A8C2VXD5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VZ11 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2W1Q0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 Ap2m1  adaptor related protein complex 2 subunit mu 1    adaptor related protein complex 2 mu 1 subunit  Symbol and/or name change 5135510 APPROVED
2016-08-03 Ap2m1  adaptor related protein complex 2 mu 1 subunit    adaptor-related protein complex 2, mu 1 subunit  Symbol and/or name change 5135510 APPROVED