Gpx1 (glutathione peroxidase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gpx1 (glutathione peroxidase 1) Rattus norvegicus
Analyze
Symbol: Gpx1
Name: glutathione peroxidase 1
RGD ID: 2729
Description: Enables glutathione peroxidase activity. Involved in several processes, including cellular response to glucose stimulus; response to estradiol; and response to vitamin E. Predicted to be located in Lewy body and cytoplasm. Predicted to be active in cytosol and mitochondrion. Used to study several diseases, including cataract; gestational diabetes; hypertension; hyperthyroidism; and hypothyroidism. Biomarker of several diseases, including hyperhomocysteinemia; iron deficiency anemia; obesity; steatotic liver disease; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cardiovascular system disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and respiratory system cancer (multiple). Orthologous to human GPX1 (glutathione peroxidase 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (+)-taxifolin.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cellular glutathione peroxidase; GPx-1; GSHPx; GSHPx-1; phospholipid-hydroperoxide glutathione peroxidase GPX1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,905,462 - 117,906,588 (+)NCBIGRCr8
mRatBN7.28109,026,905 - 109,028,031 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,026,905 - 109,028,024 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,654,127 - 114,655,253 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,853,454 - 112,854,580 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,696,094 - 110,697,220 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,117,430 - 117,118,528 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,117,430 - 117,118,522 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,466,118 - 116,467,216 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,329,847 - 108,330,945 (+)ENTREZGENECelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
Aicardi-Goutieres Syndrome 1  (ISO)
alpha thalassemia  (ISO)
anemia  (IDA,ISO)
Anorexia  (ISO)
arteriosclerosis  (ISO)
autistic disorder  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2P  (ISO)
Binge Drinking  (IEP)
Brain Injuries  (IEP)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Cadmium Poisoning  (IEP)
calcinosis  (ISO)
Carbon Tetrachloride Poisoning  (IEP)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
carnitine-acylcarnitine translocase deficiency  (ISO)
carotid stenosis  (ISO)
cataract  (IDA)
Chronic Hepatitis  (ISO)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (ISO)
colon cancer  (ISO)
colorectal cancer  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
depressive disorder  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (IEP,ISO)
dilated cardiomyopathy  (ISO)
epilepsy  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
gastric adenocarcinoma  (ISO)
Genetic Predisposition to Disease  (ISO)
gestational diabetes  (IDA)
Glutathione Peroxidase Deficiency, Hemolytic Anemia possibly due to  (ISO)
glycine encephalopathy  (ISO)
hairy cell leukemia  (ISO)
Head and Neck Neoplasms  (ISO)
Hemolysis  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (IEP)
hyperinsulinism  (ISO)
hypertension  (IDA,IEP,ISO)
Hyperthermia  (ISO)
hyperthyroidism  (IDA,ISO)
hypothyroidism  (IDA)
iron deficiency anemia  (IEP,ISO)
Iron Overload  (ISO)
Keshan disease  (ISO)
laryngeal squamous cell carcinoma  (ISO)
larynx cancer  (ISO)
leukemia  (ISO)
Liver Injury  (IDA)
Liver Neoplasms  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Mercury Poisoning  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
multiple myeloma  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
nasopharynx carcinoma  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (IEP)
non-Hodgkin lymphoma  (ISO)
obesity  (IEP,ISO)
oral squamous cell carcinoma  (ISO)
osteoporosis  (ISO)
Pierson syndrome  (ISO)
pre-eclampsia  (ISO)
pseudoxanthoma elasticum  (ISO)
Reperfusion Injury  (ISO)
Reticulocytosis  (ISO)
senile cataract  (ISO)
sickle cell anemia  (ISO)
skin melanoma  (ISO)
squamous cell carcinoma  (ISO)
steatotic liver disease  (IEP,ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
vascular dementia  (IEP)
Venous Thrombosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-catechin  (EXP)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-quinic acid  (ISO)
(E)-thiamethoxam  (EXP,ISO)
(R)-camphor  (ISO)
(R)-carnitine  (EXP)
(R)-linalyl acetate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (EXP)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4,7-triazonane  (ISO)
1,8-cineole  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
11-deoxycorticosterone  (EXP)
12(S)-HPETE  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-tert-butylhydroquinone  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3-(Methylthio)-1-propene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP,ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-aminolevulinic acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acetylcholine  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha,alpha-trehalose  (EXP)
alpha-D-galactose  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
AM-251  (ISO)
aminoglutethimide  (ISO)
aminoguanidine  (EXP)
amiodarone  (EXP,ISO)
amitrole  (EXP)
amlexanox  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
ampicillin  (EXP)
apigenin  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atrasentan  (EXP)
atrazine  (EXP,ISO)
auranofin  (ISO)
barium chloride  (EXP)
benidipine  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzopyran  (EXP)
berberine  (EXP)
Bergenin  (ISO)
beta-naphthoflavone  (EXP)
bifenthrin  (ISO)
bilirubin IXalpha  (EXP)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bosentan  (ISO)
bromobenzene  (EXP)
brucine  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium dichloride  (ISO)
camphene  (EXP)
camphor  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capecitabine  (EXP)
capsaicin  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carnosic acid  (ISO)
carnosine  (ISO)
carteolol  (ISO)
carvacrol  (EXP)
celecoxib  (ISO)
chitosan  (EXP)
chloramine T  (EXP)
chloroform  (EXP)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
Cholestane-3,5,6-triol  (EXP)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
ciprofibrate  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
coenzyme Q10  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumarin  (EXP)
crotonaldehyde  (EXP)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
Cyanoginosin  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (EXP,ISO)
cypermethrin  (EXP,ISO)
cyprodinil  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
daunorubicin  (ISO)
DDE  (EXP)
Dendrobine  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dicyclanil  (ISO)
dieldrin  (EXP,ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
difenoconazole  (EXP)
dihydrogen  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
diosmin  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
Diphenyl disulfide  (ISO)
diprotium  (ISO)
diprotium oxide  (ISO)
diquat  (ISO)
disodium cromoglycate  (EXP)
disodium selenite  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
emamectin benzoate  (EXP)
emodin  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
enniatin  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
fipronil  (ISO)
flavonoids  (EXP)
fludioxonil  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
galactose  (ISO)
Galbanic acid  (ISO)
gallein  (EXP)
geneticin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (EXP)
ginkgolide B  (ISO)
ginsenoside Re  (ISO)
Ginsenoside Rh4  (ISO)
glafenine  (EXP)
glucoraphanin  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glyphosate  (EXP)
GW 4064  (ISO)
haloperidol  (ISO)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hypochlorous acid  (ISO)
ifosfamide  (EXP)
iloprost  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-acetic acid  (ISO)
indometacin  (EXP,ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoflavones  (EXP)
isoliquiritigenin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
jaspamide  (ISO)
kainic acid  (ISO)
ketorolac tromethamine  (EXP)
kojic acid  (EXP)
kresoxim-methyl  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leptomycin B  (ISO)
levetiracetam  (EXP)
limonene  (EXP)
linalool  (ISO)
linalyl acetate  (ISO)
linoleic acid hydroperoxide  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lovastatin  (ISO)
lutein  (ISO)
luteolin  (ISO)
LY294002  (EXP)
lycopene  (EXP,ISO)
magnesium sulfate  (EXP)
Magnolol  (EXP)
mancozeb  (ISO)
maneb  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP,ISO)
meloxicam  (ISO)
menadione  (ISO)
mephedrone  (EXP,ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylglyoxal  (EXP)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (ISO)
metronidazole  (EXP)
microcystin  (EXP)
microcystin-LR  (ISO)
minocycline  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (ISO)
morin  (EXP)
motexafin gadolinium  (ISO)
myricitrin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (ISO)
naringin  (ISO)
nefazodone  (EXP)
neomycin  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel subsulfide  (ISO)
nicotine  (EXP,ISO)
nimesulide  (EXP,ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
nitroglycerin  (ISO)
Nodularin  (ISO)
NONOate(1-)  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
NSC 23766  (ISO)
Nutlin-3  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
omeprazole  (EXP)
organoselenium compound  (ISO)
orlistat  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (EXP)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
peroxynitrous acid  (ISO)
phencyclidine  (ISO)
phenobarbital  (EXP,ISO)
phenylpropanolamine  (EXP)
PhIP  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphamidon  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP)
porphyrins  (ISO)
potassium iodide  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
probucol  (EXP,ISO)
propanal  (ISO)
propiconazole  (EXP)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
pterostilbene  (ISO)
purines  (EXP)
Pyridostigmine bromide  (ISO)
pyrimethanil  (ISO)
pyrogallol  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
raspberry ketone  (ISO)
reactive oxygen species  (EXP,ISO)
resolvin D1  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
sabinene  (ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SB-239063  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenic acid  (ISO)
selenium atom  (EXP,ISO)
selenomethionine  (EXP,ISO)
silicic acid  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP,ISO)
spathulenol  (ISO)
stanozolol  (EXP)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
sucrose  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
T-2 toxin  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
tannic acid  (EXP)
tert-butyl ethyl ether  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thalidomide  (EXP)
Theaflavin 3,3'-digallate  (ISO)
theophylline  (EXP)
thiacloprid  (EXP)
thiamethoxam  (EXP,ISO)
thioacetamide  (EXP,ISO)
thiomalic acid  (ISO)
thiram  (ISO)
thymoquinone  (EXP,ISO)
thyroxine  (EXP)
titanium atom  (ISO)
titanium dioxide  (EXP,ISO)
triadimefon  (EXP)
tributyl phosphate  (EXP)
Tributyltin oxide  (EXP)
trichlorfon  (EXP)
triclosan  (ISO)
trilobatin  (EXP)
triolein  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (EXP,ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
uranium atom  (EXP,ISO)
usnic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vancomycin  (EXP)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
water  (ISO)
zearalenone  (EXP)
zerumbone  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis involved in wound healing  (IEA,ISO)
apoptotic process  (ISO)
arachidonate metabolic process  (IEA,ISO,ISS)
biological process involved in interaction with symbiont  (IEA,ISO)
blood vessel endothelial cell migration  (IEA,ISO)
cell redox homeostasis  (IEA,ISO)
cellular oxidant detoxification  (IEA)
cellular response to glucose stimulus  (IDA)
endothelial cell development  (IEA,ISO)
epigenetic regulation of gene expression  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
glutathione metabolic process  (IBA,IEA,ISO)
heart contraction  (IEA,ISO)
hydrogen peroxide catabolic process  (IBA,IEA,ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IEA,ISO)
lipid metabolic process  (ISO)
lipoxygenase pathway  (IEA,ISO,ISS)
myoblast differentiation  (IEA,ISO)
myoblast proliferation  (IEA,ISO)
myotube differentiation  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
negative regulation of inflammatory response to antigenic stimulus  (IEA,ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of release of cytochrome c from mitochondria  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
protein oxidation  (ISO)
regulation of mammary gland epithelial cell proliferation  (IEA,ISO)
regulation of proteasomal protein catabolic process  (IEA,ISO)
response to estradiol  (IEP)
response to folic acid  (IEP)
response to gamma radiation  (IEA,ISO)
response to glucose  (IEP)
response to hormone  (IEP)
response to hydrogen peroxide  (IBA,IEA,ISO)
response to hydroperoxide  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to nicotine  (IEP)
response to oxidative stress  (ISO)
response to reactive oxygen species  (ISO)
response to selenium ion  (IBA,IEA,IEP,ISO)
response to symbiotic bacterium  (IEA,ISO)
response to toxic substance  (ISO)
response to vitamin E  (IEP)
response to wounding  (ISO)
response to xenobiotic stimulus  (IEA,ISO)
sensory perception of sound  (IEA,ISO)
skeletal muscle fiber development  (IEA,ISO)
skeletal muscle tissue regeneration  (IEA,ISO)
temperature homeostasis  (IEA,ISO)
triglyceride metabolic process  (IEA,ISO)
UV protection  (IEA,ISO)
vasodilation  (IEA,ISO)

Cellular Component
cytoplasm  (ISO)
cytosol  (IBA,IEA,ISO,ISS)
Lewy body  (IEA,ISO)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
amyotrophic lateral sclerosis pathway  (IEA)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (IEA,ISO)
celecoxib pharmacodynamics pathway  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
glutathione metabolic pathway  (IEA,ISO)
glutathione synthase deficiency pathway  (ISO)
glutathionuria disease pathway   (ISO)
Huntington's disease pathway  (IEA)
ibuprofen pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway   (ISO)
paracetamol drug pathway  (ISO)
piroxicam pharmacodynamics pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Selenium inadequacy is not associated with oxidative stress in child and adolescent acute lymphocytic leukemia survivors. Almondes KG, etal., Nutrition. 2014 May;30(5):563-8. doi: 10.1016/j.nut.2013.10.012. Epub 2013 Oct 30.
2. Glutathione peroxidase, reduced glutathione, superoxide dismutase and catalase in red cells of patients with hairy cell leukemia. Arruda VR, etal., Neoplasma. 1996;43(2):99-102.
3. Polymorphic variants of MnSOD Val16Ala, CAT-262 C < T and GPx1 Pro198Leu genotypes and the risk of laryngeal cancer in a smoking population. Aynali G, etal., J Laryngol Otol. 2013 Oct;127(10):997-1000. doi: 10.1017/S0022215113002028. Epub 2013 Sep 30.
4. CAT, GPX1, MnSOD, GSTM1, GSTT1, and GSTP1 genetic polymorphisms in chronic myeloid leukemia: a case-control study. Banescu C, etal., Oxid Med Cell Longev. 2014;2014:875861. doi: 10.1155/2014/875861. Epub 2014 Nov 11.
5. From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia. Banescu C, etal., Oxid Med Cell Longev. 2016;2016:2536705. doi: 10.1155/2016/2536705. Epub 2015 Dec 28.
6. Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice. Barati MT, etal., Am J Physiol Renal Physiol. 2007 Oct;293(4):F1157-65. Epub 2007 Jul 3.
7. Phase 2 study of imexon, a prooxidant molecule, in relapsed and refractory B-cell non-Hodgkin lymphoma. Barr PM, etal., Blood. 2014 Aug 21;124(8):1259-65. doi: 10.1182/blood-2014-04-570044. Epub 2014 Jul 11.
8. Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. Blankenberg S, etal., N Engl J Med. 2003 Oct 23;349(17):1605-13.
9. Feeding of selenium alone or in combination with glucoraphanin differentially affects intestinal and hepatic antioxidant and phase II enzymes in growing rats. Blum NM, etal., Biol Trace Elem Res. 2013 Mar;151(3):384-99. doi: 10.1007/s12011-012-9567-6. Epub 2012 Dec 29.
10. Maternal nicotine exposure increases oxidative stress in the offspring. Bruin JE, etal., Free Radic Biol Med. 2008 Jun 1;44(11):1919-25. Epub 2008 Mar 4.
11. Proteomic analysis reveals changes in the liver protein pattern of rats exposed to dietary folate deficiency. Chanson A, etal., J Nutr. 2005 Nov;135(11):2524-9.
12. Differential expression profiles of antioxidant enzymes and glutathione redox status in hyperthyroid rats: a temporal analysis. Chattopadhyay S, etal., Comp Biochem Physiol C Toxicol Pharmacol. 2007 Sep;146(3):383-91. Epub 2007 May 3.
13. Inadequate cytoplasmic antioxidant enzymes response contributes to the oxidative stress in human hypertension. Chaves FJ, etal., Am J Hypertens. 2007 Jan;20(1):62-9.
14. Effect of blood-retinal barrier development on formation of selenite nuclear cataract in rat. Chen H, etal., Toxicol Lett. 2013 Feb 4;216(2-3):181-8. doi: 10.1016/j.toxlet.2012.11.016. Epub 2012 Nov 27.
15. Absent effect of zinc deficiency on the oxidative stress of erythrocytes in chronic uremic rats. Chen SM, etal., Chin J Physiol. 2002 Mar 31;45(1):9-17.
16. Metabolic pathways related to oxidative stress in patients with hemoglobin h disease and iron overload. Chiou SS, etal., J Clin Lab Anal. 2014 Jul;28(4):261-8. doi: 10.1002/jcla.21676. Epub 2014 Feb 27.
17. Hydroxyurea-induced expression of glutathione peroxidase 1 in red blood cells of individuals with sickle cell anemia. Cho CS, etal., Antioxid Redox Signal. 2010 Jul 1;13(1):1-11. doi: 10.1089/ars.2009.2978.
18. Dietary selenium stabilizes glutathione peroxidase mRNA in rat liver. Christensen MJ and Burgener KW, J Nutr 1992 Aug;122(8):1620-6.
19. Blueberry treatment attenuates D-galactose-induced oxidative stress and tissue damage in rat liver. Coban J, etal., Geriatr Gerontol Int. 2014 Apr;14(2):490-7. doi: 10.1111/ggi.12096. Epub 2013 Jun 10.
20. Parameters of antioxidative defense in type 2 diabetic patients with cardiovascular complications. Colak E, etal., Ann Med. 2005;37(8):613-20.
21. Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population. Corredor Z, etal., Sci Rep. 2020 Jan 10;10(1):144. doi: 10.1038/s41598-019-56695-2.
22. Are there possible associations between MnSOD and GPx1 gene variants for laryngeal cancer risk or disease progression? Coskun C, etal., Cell Mol Biol (Noisy-le-grand). 2016 Apr 30;62(5):25-30.
23. Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis. Dayal S, etal., Circulation. 2013 Mar 26;127(12):1308-16. doi: 10.1161/CIRCULATIONAHA.112.000966. Epub 2013 Feb 20.
24. [Activity of superoxide dismutase and glutathione peroxidase and concentrations of malonyldialdehyde, vitamin E, total antioxidant status and extracellular cytokines concentrations in children with acute lymphoblastic leukaemia (ALL)]. Drabko K, etal., Med Wieku Rozwoj. 2006 Jul-Sep;10(3 Pt 1):861-8.
25. Salicylic acid modulates oxidative stress and glutathione peroxidase activity in the rat colon. Drew JE, etal., Biochem Pharmacol. 2005 Sep 15;70(6):888-93. doi: 10.1016/j.bcp.2005.06.011.
26. Protective effects of selenium against cadmium induced hematological disturbances, immunosuppressive, oxidative stress and hepatorenal damage in rats. El-Boshy ME, etal., J Trace Elem Med Biol. 2015 Jan;29:104-10. doi: 10.1016/j.jtemb.2014.05.009. Epub 2014 Jun 4.
27. Influence of chemotherapy on the lipid peroxidation and antioxidant status in patients with acute myeloid leukemia. Esfahani A, etal., Acta Med Iran. 2012;50(7):454-8.
28. Assessment of 115 candidate genes for diabetic nephropathy by transmission/disequilibrium test. Ewens KG, etal., Diabetes. 2005 Nov;54(11):3305-18.
29. Polymorphisms in antioxidant defence genes and susceptibility to hepatocellular carcinoma in a Moroccan population. Ezzikouri S, etal., Free Radic Res. 2010 Feb;44(2):208-16. doi: 10.3109/10715760903402906.
30. Functional and physical interaction between the selenium-binding protein 1 (SBP1) and the glutathione peroxidase 1 selenoprotein. Fang W, etal., Carcinogenesis. 2010 Aug;31(8):1360-6. doi: 10.1093/carcin/bgq114. Epub 2010 Jun 7.
31. Mice lacking glutathione peroxidase-1 activity show increased TUNEL staining and an accelerated inflammatory response in brain following a cold-induced injury. Flentjar NJ, etal., Exp Neurol 2002 Sep;177(1):9-20.
32. Differential expression of glutathione reductase and cytosolic glutathione peroxidase, GPX1, in developing rat lungs and kidneys. Fujii T, etal., Free Radic Res. 2002 Oct;36(10):1041-9.
33. Effects of Tianshu Capsule on Spontaneously Hypertensive Rats as Revealed by 1H-NMR-Based Metabolic Profiling. Gao J, etal., Front Pharmacol. 2019 Sep 11;10:989. doi: 10.3389/fphar.2019.00989. eCollection 2019.
34. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
35. A protein from Cajanus indicus Spreng protects liver and kidney against mercuric chloride-induced oxidative stress. Ghosh A and Sil PC, Biol Pharm Bull. 2008 Sep;31(9):1651-8.
36. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
37. Genetic variants involved in oxidative stress, base excision repair, DNA methylation, and folate metabolism pathways influence myeloid neoplasias susceptibility and prognosis. Goncalves AC, etal., Mol Carcinog. 2016 Mar 7. doi: 10.1002/mc.22478.
38. Impaired glomerular and tubular antioxidative defense mechanisms in nephrotic syndrome. Granqvist A, etal., Am J Physiol Renal Physiol. 2010 Oct;299(4):F898-904. doi: 10.1152/ajprenal.00124.2010. Epub 2010 Aug 4.
39. Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in japanese type 2 diabetic patients. Hamanishi T, etal., Diabetes. 2004 Sep;53(9):2455-60.
40. Significance of glutathione peroxidase 1 and caudal-related homeodomain transcription factor in human gastric adenocarcinoma. Han JJ, etal., Gastroenterol Res Pract. 2013;2013:380193. doi: 10.1155/2013/380193. Epub 2013 Oct 21.
41. RORalpha decreases oxidative stress through the induction of SOD2 and GPx1 expression and thereby protects against nonalcoholic steatohepatitis in mice. Han YH, etal., Antioxid Redox Signal. 2014 Nov 20;21(15):2083-94. doi: 10.1089/ars.2013.5655. Epub 2014 Apr 10.
42. GPX1 Pro(198)Leu polymorphism, erythrocyte GPX activity, interaction with alcohol consumption and smoking, and risk of colorectal cancer. Hansen RD, etal., Mutat Res. 2009 May 12;664(1-2):13-9. doi: 10.1016/j.mrfmmm.2009.01.009. Epub 2009 Feb 5.
43. beta-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice. Harmon JS, etal., Endocrinology. 2009 Nov;150(11):4855-62. doi: 10.1210/en.2009-0708. Epub 2009 Oct 9.
44. Traumatic brain injury and hemorrhagic hypotension suppress neuroprotective gene expression in injured hippocampal neurons. Hellmich HL, etal., Anesthesiology. 2005 Apr;102(4):806-14.
45. Cloning and characterization of the rat glutathione peroxidase gene. Ho YS and Howard AJ, FEBS Lett 1992 Apr 13;301(1):5-9.
46. Nucleotide sequence of a rat glutathione peroxidase cDNA. Ho YS, etal., Nucleic Acids Res 1988 Jun 10;16(11):5207.
47. Glutathione peroxidase activity and expression levels are significantly increased in acute coronary syndromes. Holley A, etal., J Investig Med. 2017 Jun;65(5):919-925. doi: 10.1136/jim-2016-000361. Epub 2017 Mar 15.
48. Resveratrol modulates mRNA transcripts of genes related to redox metabolism and cell proliferation in non-small-cell lung carcinoma cells. Hu Y, etal., Biol Chem. 2007 Feb;388(2):207-19. doi: 10.1515/BC.2007.023.
49. Decreased selenium-binding protein 1 enhances glutathione peroxidase 1 activity and downregulates HIF-1α to promote hepatocellular carcinoma invasiveness. Huang C, etal., Clin Cancer Res. 2012 Jun 1;18(11):3042-53. doi: 10.1158/1078-0432.CCR-12-0183. Epub 2012 Apr 18.
50. A low selenium level is associated with lung and laryngeal cancers. Jaworska K, etal., PLoS One. 2013;8(3):e59051. doi: 10.1371/journal.pone.0059051. Epub 2013 Mar 13.
51. Proteomics analysis of human placenta reveals glutathione metabolism dysfunction as the underlying pathogenesis for preeclampsia. Jin X, etal., Biochim Biophys Acta Proteins Proteom. 2017 Sep;1865(9):1207-1214. doi: 10.1016/j.bbapap.2017.07.003. Epub 2017 Jul 10.
52. Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization. Kaneko H, etal., Atherosclerosis. 2011 Aug;217(2):350-7. doi: 10.1016/j.atherosclerosis.2011.03.042. Epub 2011 Apr 8.
53. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
54. Genetic variants of GPX1 and SOD2 and breast cancer risk at the Ontario site of the Breast Cancer Family Registry. Knight JA, etal., Cancer Epidemiol Biomarkers Prev. 2004 Jan;13(1):146-9. doi: 10.1158/1055-9965.epi-03-0164.
55. Impaired erythrocyte antioxidant defense in active inflammatory bowel disease: impact of anemia and treatment. Krzystek-Korpacka M, etal., Inflamm Bowel Dis. 2010 Sep;16(9):1467-75. doi: 10.1002/ibd.21234.
56. Decreased Expression of Selenoproteins as a Poor Prognosticator of Gastric Cancer in Humans. Lan X, etal., Biol Trace Elem Res. 2017 Jul;178(1):22-28. doi: 10.1007/s12011-016-0908-8. Epub 2016 Dec 13.
57. Human glutathione peroxidase codon 198 variant increases nasopharyngeal carcinoma risk and progression. Laribi A, etal., Eur Arch Otorhinolaryngol. 2021 Oct;278(10):4027-4034. doi: 10.1007/s00405-021-06628-5. Epub 2021 Feb 22.
58. Glutathione peroxidase activity in selenium-deficient rat liver. Lawrence RA and Burk RF, Biochem Biophys Res Commun. 1976 Aug 23;71(4):952-8.
59. [Effects of oxidative DNA damage and genetic polymorphism of the glutathione peroxidase 1 (GPX1) and 8-oxoguanine glycosylase 1 (hOGG1) on lung cancer]. Lee CH, etal., J Prev Med Public Health. 2006 Mar;39(2):130-4.
60. Antioxidant and hepatoprotective activities of Cirsium setidens Nakai against CCl4-induced liver damage. Lee SH, etal., Am J Chin Med. 2008;36(1):107-14.
61. Effects of antenatal, postpartum and post-weaning melatonin supplementation on blood pressure and renal antioxidant enzyme activities in spontaneously hypertensive rats. Lee SK, etal., J Physiol Biochem. 2011 Jun;67(2):249-57. doi: 10.1007/s13105-010-0070-2. Epub 2011 Jan 6.
62. Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy. Lei C, etal., Clin Chim Acta. 2009 Jan;399(1-2):102-8. Epub 2008 Oct 2.
63. [Polymorphisms in the glutathione peroxidase-1 gene associated with increased risk of Keshan disease]. Lei C, etal., Zhonghua Yu Fang Yi Xue Za Zhi. 2010 Jul;44(7):617-21.
64. Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E-deficient mice. Lewis P, etal., Circulation. 2007 Apr 24;115(16):2178-87. Epub 2007 Apr 9.
65. Effect of exercise training on liver antioxidant enzymes in STZ-diabetic rats. Lima TI, etal., Life Sci. 2015 May 1;128:64-71. doi: 10.1016/j.lfs.2015.01.031. Epub 2015 Mar 2.
66. Selenium-enriched Agaricus bisporus increases expression and activity of glutathione peroxidase-1 and expression of glutathione peroxidase-2 in rat colon. Maseko T, etal., Food Chem. 2014 Mar 1;146:327-33. doi: 10.1016/j.foodchem.2013.09.074. Epub 2013 Sep 21.
67. Analysis of Epithelial-Mesenchymal Transition Metabolism Identifies Possible Cancer Biomarkers Useful in Diverse Genetic Backgrounds. Matadamas-Guzman M, etal., Front Oncol. 2020 Jul 30;10:1309. doi: 10.3389/fonc.2020.01309. eCollection 2020.
68. Overexpression of glutathione peroxidase attenuates myocardial remodeling and preserves diastolic function in diabetic heart. Matsushima S, etal., Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2237-45. Epub 2006 Jul 14.
69. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
70. Prognostic significance of glutathione peroxidase 1 (GPX1) down-regulation and correlation with aberrant promoter methylation in human gastric cancer. Min SY, etal.
71. Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies. Mistry HD, etal., Hypertension. 2008 Nov;52(5):881-8. doi: 10.1161/HYPERTENSIONAHA.108.116103. Epub 2008 Oct 13.
72. Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy. Mistry HD, etal., Placenta. 2010 May;31(5):401-8. doi: 10.1016/j.placenta.2010.02.011. Epub 2010 Mar 19.
73. Phospholipid hydroperoxides are detoxified by phospholipase A2 and GSH peroxidase in rat gastric mucosa. Miyamoto S, etal., Lipids. 2003 Jun;38(6):641-9.
74. Classical selenium-dependent glutathione peroxidase expression is decreased secondary to iron deficiency in rats. Moriarty PM, etal., J Nutr. 1995 Feb;125(2):293-301.
75. Effect of high glucose on gene expression in mesangial cells: upregulation of the thiol pathway is an adaptational response. Morrison J, etal., Physiol Genomics. 2004 May 19;17(3):271-82.
76. Loss of heterozygosity of the human cytosolic glutathione peroxidase I gene in lung cancer. Moscow JA, etal., Carcinogenesis. 1994 Dec;15(12):2769-73. doi: 10.1093/carcin/15.12.2769.
77. Targeting NADPH oxidase decreases oxidative stress in the transgenic sickle cell mouse penis. Musicki B, etal., J Sex Med. 2012 Aug;9(8):1980-7. doi: 10.1111/j.1743-6109.2012.02798.x. Epub 2012 May 23.
78. Peroxidative stress and antioxidant enzymes in children with beta-thalassemia major. Naithani R, etal., Pediatr Blood Cancer. 2006 Jun;46(7):780-5.
79. Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats. Nakamura M, etal., J Toxicol Sci. 2018;43(10):611-621. doi: 10.2131/jts.43.611.
80. Determination of gene expression and serum levels of MnSOD and GPX1 in colorectal cancer. Nalkiran I, etal., Anticancer Res. 2015 Jan;35(1):255-9.
81. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
82. Homozygous erythrocyte glutathione-peroxidase deficiency: clinical and biochemical studies. Necheles TF, etal., Blood. 1969 Feb;33(2):164-9.
83. Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography. Nemoto M, etal., Cardiovasc Diabetol. 2007 Sep 7;6:23.
84. Tumor-educated leukocytes mRNA as a diagnostic biomarker for non-small cell lung cancer. Niu L, etal., Thorac Cancer. 2021 Mar;12(6):737-745. doi: 10.1111/1759-7714.13833. Epub 2021 Jan 21.
85. Bilirubin is highly effective in preventing in vivo delta-aminolevulinic acid-induced oxidative cell damage. Noriega GO, etal., Biochim Biophys Acta 2003 Jul 14;1638(2):173-8.
86. Preventive effects of astaxanthin on diethylnitrosamine-induced liver tumorigenesis in C57/BL/KsJ-db/db obese mice. Ohno T, etal., Hepatol Res. 2016 Mar;46(3):E201-9. doi: 10.1111/hepr.12550. Epub 2015 Jul 27.
87. Binge drinking during adolescence disrupts Se homeostasis and its main hepatic selenoprotein expression. Ojeda ML, etal., Alcohol Clin Exp Res. 2015 May;39(5):818-26. doi: 10.1111/acer.12707. Epub 2015 Apr 10.
88. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
89. Erythrocyte PAF-acetylhydrolase activity in various stages of chronic kidney disease: effect of long-term therapy with erythropoietin. Papavasiliou EC, etal., Kidney Int. 2005 Jul;68(1):246-55.
90. The role of the oxidative state of glutathione and glutathione-related enzymes in anemia of hemodialysis patients. Pasaoglu H, etal., Clin Biochem. 1996 Dec;29(6):567-72.
91. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
92. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
93. Oxidative stress markers in predicting response to treatment with ferric carboxymaltose in nondialysis chronic kidney disease patients. Prats M, etal., Clin Nephrol. 2014 Jun;81(6):419-26. doi: 10.5414/CN108166.
94. GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer. Raaschou-Nielsen O, etal., Cancer Lett. 2007 Mar 18;247(2):293-300. doi: 10.1016/j.canlet.2006.05.006. Epub 2006 Jun 23.
95. Glutathione peroxidase codon 198 polymorphism variant increases lung cancer risk. Ratnasinghe D, etal., Cancer Res. 2000 Nov 15;60(22):6381-3.
96. Expression of glutathione peroxidase I gene in selenium-deficient rats. Reddy AP, etal., Nucleic Acids Res 1988 Jun 24;16(12):5557-68.
97. GOA pipeline RGD automated data pipeline
98. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
99. Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years. Rosenberger A, etal., BMC Cancer. 2008 Feb 25;8:60. doi: 10.1186/1471-2407-8-60.
100. Oxidative stress status, clinical outcome, and beta-globin gene cluster haplotypes in pediatric patients with sickle cell disease. Rusanova I, etal., Eur J Haematol. 2010 Dec;85(6):529-37. doi: 10.1111/j.1600-0609.2010.01528.x.
101. Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression. Rybka J, etal., Free Radic Biol Med. 2013 Oct;63:187-94. doi: 10.1016/j.freeradbiomed.2013.05.019. Epub 2013 May 23.
102. Gene expressions of Mn-SOD and GPx-1 in streptozotocin-induced diabetes: effect of antioxidants. Sadi G and Guray T, Mol Cell Biochem. 2009 Feb 20.
103. Haematological and biochemical toxicity induced by methanol in rats: ameliorative effects of Opuntia vulgaris fruit extract. Saoudi M, etal., Hum Exp Toxicol. 2011 Dec;30(12):1963-71. doi: 10.1177/0960327111403175. Epub 2011 Mar 21.
104. Correlation between Oxidative Stress and Thyroid Function in Patients with Nephrotic Syndrome. Sawant SU, etal., Int J Nephrol. 2011;2011:256420. doi: 10.4061/2011/256420. Epub 2011 Oct 13.
105. Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer. Saxena A, etal., Cancer Biol Ther. 2017 Apr 3;18(4):257-267. doi: 10.1080/15384047.2016.1276130. Epub 2017 Jan 3.
106. Selenium requirements are higher for glutathione peroxidase-1 mRNA than gpx1 activity in rat testis. Schriever SC, etal., Exp Biol Med (Maywood). 2009 May;234(5):513-21. Epub 2009 Feb 20.
107. Proteomic and oxidative stress analysis in human brain samples of Huntington disease. Sorolla MA, etal., Free Radic Biol Med. 2008 Sep 1;45(5):667-78. doi: 10.1016/j.freeradbiomed.2008.05.014. Epub 2008 May 28.
108. Association of Catalase and Glutathione Peroxidase 1 Polymorphisms with Chronic Hepatitis C Outcome. Sousa VC, etal., Ann Hum Genet. 2016 May;80(3):145-53. doi: 10.1111/ahg.12152. Epub 2016 Mar 18.
109. Genetic polymorphisms in antioxidant enzyme genes and susceptibility to hepatocellular carcinoma in Chinese population: a case-control study. Su S, etal., Tumour Biol. 2015 Jun;36(6):4627-32. doi: 10.1007/s13277-015-3110-2. Epub 2015 Apr 19.
110. Expression of hepatic antioxidant genes in l-thyroxine-induced hyperthyroid rats: regulation by vitamin E and curcumin. Subudhi U and Chainy GB, Chem Biol Interact. 2010 Jan 27;183(2):304-16. doi: 10.1016/j.cbi.2009.11.004. Epub 2009 Nov 13.
111. Curcumin and vitamin E modulate hepatic antioxidant gene expression in PTU-induced hypothyroid rats. Subudhi U and Chainy GB, Mol Biol Rep. 2012 Nov;39(11):9849-61. Epub 2012 Jun 24.
112. Dietary selenium requirements based on glutathione peroxidase-1 activity and mRNA levels and other Se-dependent parameters are not increased by pregnancy and lactation in rats. Sunde RA, etal., J Nutr. 2005 Sep;135(9):2144-50.
113. Genetic polymorphisms in antioxidant enzymes modulate hepatic iron accumulation and hepatocellular carcinoma development in patients with alcohol-induced cirrhosis. Sutton A, etal., Cancer Res. 2006 Mar 1;66(5):2844-52. doi: 10.1158/0008-5472.CAN-05-2566.
114. Among a panel of polymorphisms in genes related to oxidative stress, CAT-262 C>T, GPX1 Pro198Leu and GSTP1 Ile105Val influence the risk of developing BCR-ABL negative myeloproliferative neoplasms. Trifa AP, etal., Hematology. 2016 Mar 30:1-6.
115. Pyrimidine 5'nucleotidase and several other red cell enzyme activities in beta-thalassaemia trait. Vives Corrons JL, etal., Br J Haematol. 1984 Mar;56(3):483-94.
116. [Association of genetic polymorphisms in selenoprotein GPX1 and TXNRD2 with genetic susceptibility of gastric cancer]. Wang J, etal., Zhonghua Yu Fang Yi Xue Za Zhi. 2008 Jul;42(7):511-4.
117. Quercetin reduces oxidative stress and inhibits activation of c‑Jun N‑terminal kinase/activator protein‑1 signaling in an experimental mouse model of abdominal aortic aneurysm. Wang L, etal., Mol Med Rep. 2014 Feb;9(2):435-42. doi: 10.3892/mmr.2013.1846. Epub 2013 Dec 6.
118. Oxidative stress in rats with hyperhomo-cysteinemia and intervention effect of lutein. Wang S, etal., Eur Rev Med Pharmacol Sci. 2014;18(3):359-64.
119. Spermatozoa have decreased antioxidant enzymatic capacity and increased reactive oxygen species production during aging in the Brown Norway rat. Weir CP and Robaire B, J Androl. 2007 Mar-Apr;28(2):229-40. Epub 2006 Oct 4.
120. Glutathione peroxidase 1 genotype is associated with an increased risk of coronary artery disease. Winter JP, etal., Coron Artery Dis. 2003 Apr;14(2):149-53.
121. Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence. Wolf N, etal., Exp Eye Res. 2005 Sep;81(3):276-85.
122. Expression of selenium-containing proteins in human colon carcinoma tissue. Yagublu V, etal., Anticancer Res. 2011 Sep;31(9):2693-8.
123. Glutathione pathway genes and lung cancer risk in young and old populations. Yang P, etal., Carcinogenesis. 2004 Oct;25(10):1935-44. doi: 10.1093/carcin/bgh203. Epub 2004 Jun 10.
124. Evaluation of glutathione metabolic genes on outcomes in advanced non-small cell lung cancer patients after initial treatment with platinum-based chemotherapy: an NCCTG-97-24-51 based study. Yang P, etal., J Thorac Oncol. 2009 Apr;4(4):479-85. doi: 10.1097/jto.0b013e31819c7a2c.
125. O-GlcNAcylation regulates hyperglycemia-induced GPX1 activation. Yang WH, etal., Biochem Biophys Res Commun. 2010 Jan 1;391(1):756-61. doi: 10.1016/j.bbrc.2009.11.133. Epub 2009 Nov 26.
126. Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion. Ye S, etal., Mol Med Rep. 2014 Sep;10(3):1635-41. doi: 10.3892/mmr.2014.2355. Epub 2014 Jun 26.
127. DNA low-density array analysis of colchicine neurotoxicity in rat cerebellar granular neurons. Yeste-Velasco M, etal., Neurotoxicology. 2008 Mar;29(2):309-17. Epub 2007 Dec 31.
128. Determination of nucleotide sequence of cDNA coding rat glutathione peroxidase and diminished expression of the mRNA in selenium deficient rat liver. Yoshimura S, etal., Biochem Biophys Res Commun 1988 Aug 15;154(3):1024-8.
129. Altered uterine perfusion is involved in fetal outcome of diabetic rats. Zabihi S, etal., Placenta. 2008 May;29(5):413-21. Epub 2008 Apr 2.
130. Decreased antioxidant activity in hypercholesterolemic children with nephrotic syndrome. Zachwieja J, etal., Med Sci Monit. 2003 Jun;9(6):CR235-9.
131. Pseudoxanthoma elasticum: genetic variations in antioxidant genes are risk factors for early disease onset. Zarbock R, etal., Clin Chem. 2007 Oct;53(10):1734-40. Epub 2007 Aug 10.
132. Effects of peroxisome proliferator-activated receptor-beta activation in endothelin-dependent hypertension. Zarzuelo MJ, etal., Cardiovasc Res. 2013 Sep 1;99(4):622-31. doi: 10.1093/cvr/cvt152. Epub 2013 Jun 10.
133. A high-selenium diet induces insulin resistance in gestating rats and their offspring. Zeng MS, etal., Free Radic Biol Med. 2012 Apr 15;52(8):1335-42. doi: 10.1016/j.freeradbiomed.2012.01.017. Epub 2012 Feb 1.
134. Effect of oestrogen on reactive oxygen species production in the aortas of ovariectomized Dahl salt-sensitive rats. Zhang L, etal., J Hypertens. 2007 Feb;25(2):407-14.
135. Pyrroloquinoline Quinone Inhibits Oxidative Stress in Rats with Diabetic Nephropathy. Zhang M, etal., Med Sci Monit. 2020 Jun 27;26:e924372. doi: 10.12659/MSM.924372.
136. High Gpx1 expression predicts poor survival in laryngeal squamous cell carcinoma. Zhang Q, etal., Auris Nasus Larynx. 2018 Feb;45(1):13-19. doi: 10.1016/j.anl.2017.05.012. Epub 2017 Jun 20.
137. [Lipid peroxidation and activity of antioxidative enzymes in patients with multiple myeloma]. Zima T, etal., Cas Lek Cesk. 1996 Jan 4;135(1):14-7.
138. Levels of selenium, zinc, copper, and antioxidant enzyme activity in patients with leukemia. Zuo XL, etal., Biol Trace Elem Res. 2006 Winter;114(1-3):41-53.
Additional References at PubMed
PMID:6217842   PMID:8889548   PMID:9126277   PMID:9386101   PMID:9788901   PMID:10428770   PMID:10490281   PMID:10627575   PMID:10754271   PMID:10833429   PMID:10915565   PMID:10915653  
PMID:11115402   PMID:11311045   PMID:11518697   PMID:11545230   PMID:11562367   PMID:11579147   PMID:11893559   PMID:12117267   PMID:12196344   PMID:12221075   PMID:12368211   PMID:12477932  
PMID:12521604   PMID:12646716   PMID:12751788   PMID:12751789   PMID:12810669   PMID:12829378   PMID:12893824   PMID:14651853   PMID:14713308   PMID:14732290   PMID:15182862   PMID:15203190  
PMID:15663476   PMID:15777843   PMID:15821744   PMID:15827346   PMID:16132718   PMID:16189290   PMID:16229841   PMID:16373599   PMID:16723478   PMID:16934683   PMID:16945136   PMID:16962942  
PMID:17097614   PMID:17145560   PMID:18226427   PMID:18267129   PMID:18614015   PMID:18853169   PMID:19398061   PMID:19855070   PMID:20063054   PMID:20524817   PMID:22614831   PMID:22905402  
PMID:22981416   PMID:23376485   PMID:23472740   PMID:23911387   PMID:24389817   PMID:24401635   PMID:24740756   PMID:24867493   PMID:24962481   PMID:26142204   PMID:28755400   PMID:29016640  
PMID:35968584   PMID:36868433   PMID:37761814  


Genomics

Comparative Map Data
Gpx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,905,462 - 117,906,588 (+)NCBIGRCr8
mRatBN7.28109,026,905 - 109,028,031 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,026,905 - 109,028,024 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,654,127 - 114,655,253 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,853,454 - 112,854,580 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,696,094 - 110,697,220 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,117,430 - 117,118,528 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,117,430 - 117,118,522 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,466,118 - 116,467,216 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,329,847 - 108,330,945 (+)ENTREZGENECelera
Cytogenetic Map8q32NCBI
GPX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,357,176 - 49,358,353 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,357,174 - 49,358,605 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,394,609 - 49,395,786 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,369,613 - 49,370,795 (-)NCBINCBI36Build 36hg18NCBI36
Build 34349,369,614 - 49,370,795NCBI
Celera349,359,484 - 49,360,663 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,454,091 - 49,455,270 (-)NCBIHuRef
CHM1_1349,347,422 - 49,348,601 (-)NCBICHM1_1
T2T-CHM13v2.0349,386,555 - 49,387,726 (-)NCBIT2T-CHM13v2.0
Gpx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,216,279 - 108,217,541 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,216,102 - 108,217,542 (+)EnsemblGRCm39 Ensembl
GRCm389108,339,080 - 108,340,342 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,338,903 - 108,340,343 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,241,607 - 108,242,671 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,197,368 - 108,198,432 (+)NCBIMGSCv36mm8
Celera9107,948,378 - 107,949,442 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.24NCBI
Gpx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555321,298,336 - 1,298,830 (-)NCBIChiLan1.0ChiLan1.0
GPX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,334,513 - 49,336,253 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,339,284 - 49,340,757 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,280,038 - 49,281,455 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,360,736 - 50,362,274 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,360,947 - 50,361,826 (-)Ensemblpanpan1.1panPan2
GPX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,889,165 - 39,890,253 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,889,174 - 39,890,260 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,807,516 - 39,808,604 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,245,494 - 40,246,582 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,245,503 - 40,246,589 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,612,973 - 39,614,061 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,016,432 - 40,017,520 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,296,220 - 40,297,308 (+)NCBIUU_Cfam_GSD_1.0
Gpx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,237,446 - 64,238,592 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529998,150 - 998,987 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936529997,943 - 999,123 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,916,246 - 31,917,433 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,916,269 - 31,917,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,147,277 - 35,148,345 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,754,976 - 10,756,617 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041156,259,200 - 156,261,033 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,313,972 - 3,314,626 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,313,773 - 3,314,870 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpx1
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:33
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000073247
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
PMC302051P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,027,242 - 109,027,461 (+)MAPPERmRatBN7.2
Rnor_6.08117,117,741 - 117,117,959NCBIRnor6.0
Rnor_5.08116,466,429 - 116,466,647UniSTSRnor5.0
Celera8108,330,158 - 108,330,376UniSTS
PMC305564P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,026,997 - 109,027,817 (+)MAPPERmRatBN7.2
Rnor_6.08117,117,496 - 117,118,315NCBIRnor6.0
Rnor_5.08116,466,184 - 116,467,003UniSTSRnor5.0
Celera8108,329,913 - 108,330,732UniSTS
WI-18922  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,025,491 - 109,025,637 (+)MAPPERmRatBN7.2
Rnor_6.08117,115,990 - 117,116,135NCBIRnor6.0
Rnor_5.08116,464,678 - 116,464,823UniSTSRnor5.0
Celera8108,328,407 - 108,328,552UniSTS
Cytogenetic Map16q12.5UniSTS
RH127950  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,027,817 - 109,028,004 (+)MAPPERmRatBN7.2
Rnor_6.08117,118,316 - 117,118,502NCBIRnor6.0
Rnor_5.08116,467,004 - 116,467,190UniSTSRnor5.0
Celera8108,330,733 - 108,330,919UniSTS
RH 3.4 Map81118.6UniSTS
RH129553  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,027,823 - 109,028,011 (+)MAPPERmRatBN7.2
Rnor_6.08117,118,322 - 117,118,509NCBIRnor6.0
Rnor_5.08116,467,010 - 116,467,197UniSTSRnor5.0
Celera8108,330,739 - 108,330,926UniSTS
RH 3.4 Map81120.9UniSTS
AI195024  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,027,572 - 109,027,660 (+)MAPPERmRatBN7.2
Rnor_6.08117,118,071 - 117,118,158NCBIRnor6.0
Rnor_5.08116,466,759 - 116,466,846UniSTSRnor5.0
Celera8108,330,488 - 108,330,575UniSTS
PMC164851P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,027,109 - 109,027,605 (+)MAPPERmRatBN7.2
Rnor_6.08117,117,608 - 117,118,103NCBIRnor6.0
Rnor_5.08116,466,296 - 116,466,791UniSTSRnor5.0
Celera8108,330,025 - 108,330,520UniSTS
D3S1330E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,025,162 - 109,025,271 (+)MAPPERmRatBN7.2
Rnor_6.08117,115,661 - 117,115,769NCBIRnor6.0
Rnor_5.08116,464,349 - 116,464,457UniSTSRnor5.0
Celera8108,328,078 - 108,328,186UniSTS
Cytogenetic Map16q12.5UniSTS
UniSTS:532286  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,025,304 - 109,025,687 (+)MAPPERmRatBN7.2
Rnor_6.08117,115,803 - 117,116,185NCBIRnor6.0
Rnor_5.08116,464,491 - 116,464,873UniSTSRnor5.0
Celera8108,328,220 - 108,328,602UniSTS
Cytogenetic Map16q12.5UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_030826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB004231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC128721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI281978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB579218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ139913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S50336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000073247   ⟹   ENSRNOP00000066577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,026,905 - 109,028,024 (+)Ensembl
Rnor_6.0 Ensembl8117,117,430 - 117,118,522 (+)Ensembl
RefSeq Acc Id: NM_030826   ⟹   NP_110453
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,905,462 - 117,906,588 (+)NCBI
mRatBN7.28109,026,905 - 109,028,031 (+)NCBI
Rnor_6.08117,117,430 - 117,118,528 (+)NCBI
Rnor_5.08116,466,118 - 116,467,216 (+)NCBI
Celera8108,329,847 - 108,330,945 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: NP_110453   ⟸   NM_030826
- UniProtKB: Q4PIY2 (UniProtKB/Swiss-Prot),   O08946 (UniProtKB/Swiss-Prot),   Q91WZ5 (UniProtKB/Swiss-Prot),   P04041 (UniProtKB/Swiss-Prot),   M0RAM5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066577   ⟸   ENSRNOT00000073247

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696297
Promoter ID:EPDNEW_R6821
Type:initiation region
Name:Gpx1_1
Description:glutathione peroxidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,117,462 - 117,117,522EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2729 AgrOrtholog
BioCyc Gene G2FUF-29147 BioCyc
BioCyc Pathway DETOX1-PWY-1 [reactive oxygen species degradation] BioCyc
  PWY-4081 [glutathione-peroxide redox reactions] BioCyc
BioCyc Pathway Image DETOX1-PWY-1 BioCyc
  PWY-4081 BioCyc
Ensembl Genes ENSRNOG00000048812 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055013502 UniProtKB/Swiss-Prot
  ENSRNOG00060022938 UniProtKB/Swiss-Prot
  ENSRNOG00065006611 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073247 UniProtKB/TrEMBL
  ENSRNOT00000073247.3 UniProtKB/Swiss-Prot
  ENSRNOT00055023147 UniProtKB/Swiss-Prot
  ENSRNOT00060039711 UniProtKB/Swiss-Prot
  ENSRNOT00065010211 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6918849 IMAGE-MGC_LOAD
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_AS UniProtKB/Swiss-Prot
  GPX_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24404 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72654 IMAGE-MGC_LOAD
NCBI Gene 24404 ENTREZGENE
PANTHER GLUTATHIONE PEROXIDASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GSHPx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GPX1 RGD
PhenoGen Gpx1 PhenoGen
PIRSF Glutathion_perox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048812 RatGTEx
  ENSRNOG00055013502 RatGTEx
  ENSRNOG00060022938 RatGTEx
  ENSRNOG00065006611 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GPX1_RAT UniProtKB/Swiss-Prot
  M0RAM5 ENTREZGENE, UniProtKB/TrEMBL
  O08946 ENTREZGENE
  P04041 ENTREZGENE
  Q4PIY2 ENTREZGENE
  Q6PDW8_RAT UniProtKB/TrEMBL
  Q91WZ5 ENTREZGENE
UniProt Secondary O08946 UniProtKB/Swiss-Prot
  Q4PIY2 UniProtKB/Swiss-Prot
  Q91WZ5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gpx1  Glutathione peroxidase 1      Symbol and Name status set to approved 70586 APPROVED