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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1affects expressionEXP 6480464CTDEthanol affects the expression of GPX1 mRNAPMID:23273579
Gpx1decreases expressionEXP 6480464CTDEthanol results in decreased expression of GPX1 proteinPMID:37499997
Gpx1multiple interactionsEXP 6480464CTDcarvacrol inhibits the reaction [Ethanol results in decreased expression of GPX1 protein]PMID:37499997
Gpx1decreases expressionISOGpx1 (Mus musculus)6480464CTDEthanol results in decreased expression of GPX1 mRNA; Ethanol results in decreased expression of GPX1 proteinPMID:15920153 PMID:18926900 PMID:18992320 PMID:35639301
Gpx1multiple interactionsISOGpx1 (Mus musculus)6480464CTDCapsaicin inhibits the reaction [Ethanol results in decreased expression of GPX1 mRNA]; Plant Extracts inhibits the reaction [Ethanol results in decreased expression of GPX1 mRNA]; Zinc Sulfate inhibits the reaction [Ethanol results in decreased expression of GPX1 protein]PMID:15920153 PMID:18926900 PMID:18992320
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