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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1decreases expressionEXP 6480464CTDlead acetate results in decreased expression of GPX1 mRNA; lead acetate results in decreased expression of GPX1 proteinPMID:15014207 PMID:22197700 PMID:32116774 PMID:33862172
Gpx1multiple interactionsEXP 6480464CTD[Cadmium Chloride co-treated with lead acetate co-treated with manganese chloride] results in increased activity of GPX1 protein; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of GPX1 mRNA]PMID:27599793 PMID:32116774
Gpx1decreases expressionISOGpx1 (Mus musculus)6480464CTDlead acetate results in decreased expression of GPX1 mRNAPMID:29746905
Gpx1increases expressionISOGpx1 (Mus musculus)6480464CTDlead acetate results in increased expression of GPX1 mRNAPMID:30623991
Gpx1increases expressionISOGPX1 (Homo sapiens)6480464CTDlead acetate results in increased expression of GPX1 mRNAPMID:31610155
Gpx1multiple interactionsISOGPX1 (Homo sapiens)6480464CTD[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX1 mRNA; Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX1 mRNA]; Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX1 mRNA]PMID:31610155
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