RGD Reference Report - Glutathione peroxidase codon 198 polymorphism variant increases lung cancer risk. - Rat Genome Database

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Glutathione peroxidase codon 198 polymorphism variant increases lung cancer risk.

Authors: Ratnasinghe, D  Tangrea, J A  Andersen, M R  Barrett, M J  Virtamo, J  Taylor, P R  Albanes, D 
Citation: Ratnasinghe D, etal., Cancer Res. 2000 Nov 15;60(22):6381-3.
RGD ID: 152995449
Pubmed: PMID:11103801   (View Abstract at PubMed)

Human cellular glutathione peroxidase 1 (hGPX1) is a selenium-dependent enzyme that participates in the detoxification of hydrogen peroxide and a wide range of organic peroxides. We conducted a case-control study nested within the alpha-Tocopherol, beta-Carotene Cancer Prevention Study cohort to evaluate the association between the proline to leucine polymorphism at codon 198 of hGPX1 and lung cancer risk. Cases (n = 315) were matched to controls on age (+/-5 years), intervention group, and study clinic using incidence density sampling in a 1:1 ratio. The prevalence of the hGPX1 Pro198Leu variant allele was 58% for controls and 71% for cases (P < 0.001). Using conditional logistic regression, we found a significant association between hGPX1 genotype and lung cancer risk. The odds ratio for heterozygotes was 1.8 (95% confidence interval, 1.2-2.8) and 2.3 (95% confidence interval, 1.3-3.8) for homozygous variants compared to wild-type individuals. Due to its high prevalence, the hGPX1 variant may contribute significantly to lung cancer risk among Caucasians but not among ethnic Chinese who do not exhibit this polymorphism.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GPX1Humanlung cancer susceptibilityIAGP DNA:missense mutation:CDS:p.P198L (human)RGD 
Gpx1Ratlung cancer susceptibilityISOGPX1 (Homo sapiens)DNA:missense mutation:CDS:p.P198L (human)RGD 
Gpx1Mouselung cancer susceptibilityISOGPX1 (Homo sapiens)DNA:missense mutation:CDS:p.P198L (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gpx1  (glutathione peroxidase 1)

Genes (Mus musculus)
Gpx1  (glutathione peroxidase 1)

Genes (Homo sapiens)
GPX1  (glutathione peroxidase 1)


Additional Information