Tmem69 (transmembrane protein 69)

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Gene: Tmem69 (transmembrane protein 69) Rattus norvegicus

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Symbol:

Tmem69

Name:

transmembrane protein 69

RGD ID:

1561569

Description:

Predicted to be located in mitochondrion. Orthologous to human TMEM69 (transmembrane protein 69); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMEM69 (transmembrane protein 69)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Tmem69 (transmembrane protein 69)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmem69 (transmembrane protein 69)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMEM69 (transmembrane protein 69)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMEM69 (transmembrane protein 69)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmem69 (transmembrane protein 69)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMEM69 (transmembrane protein 69)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMEM69 (transmembrane protein 69)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmem69 (transmembrane protein 69)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TMEM69 (transmembrane protein 69)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tmem69 (transmembrane protein 69)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem69 (transmembrane protein 69)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tmem69	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	135,241,557 - 135,247,323 (-)	NCBI		GRCr8
mRatBN7.2	5	130,004,888 - 130,008,466 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	130,004,901 - 130,010,655 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	132,629,107 - 132,632,686 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	134,383,704 - 134,387,283 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	134,406,130 - 134,409,709 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	135,394,013 - 135,397,591 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	135,394,016 - 135,397,591 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	139,190,198 - 139,193,776 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	136,831,040 - 136,834,619 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	128,532,638 - 128,536,216 (-)	NCBI		Celera
Cytogenetic Map	5	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amenorrhea (ISO)

Charcot-Marie-Tooth disease dominant intermediate C (ISO)

developmental and epileptic encephalopathy (ISO)

early infantile epileptic encephalopathy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dinitrotoluene (EXP)

4-amino-2,6-dinitrotoluene (EXP)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

caffeine (EXP)

cisplatin (ISO)

clopidogrel (ISO)

crocidolite asbestos (ISO)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

ethanol (ISO)

finasteride (EXP)

flutamide (EXP)

gentamycin (EXP)

hydroxyurea (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

methoxyacetic acid (EXP)

methylmercury chloride (EXP)

Monobutylphthalate (EXP)

monosodium L-glutamate (ISO)

N-methyl-N-nitrosourea (ISO)

nefazodone (EXP)

nickel atom (ISO)

nimesulide (EXP)

ozone (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (EXP)

pregnenolone 16alpha-carbonitrile (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

trichloroethene (EXP)

troglitazone (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

membrane (IEA)

mitochondrion (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
2.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:34800366

Genomics

Comparative Map Data

Tmem69
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	135,241,557 - 135,247,323 (-)	NCBI		GRCr8
mRatBN7.2	5	130,004,888 - 130,008,466 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	130,004,901 - 130,010,655 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	132,629,107 - 132,632,686 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	134,383,704 - 134,387,283 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	134,406,130 - 134,409,709 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	135,394,013 - 135,397,591 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	135,394,016 - 135,397,591 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	139,190,198 - 139,193,776 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	136,831,040 - 136,834,619 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	128,532,638 - 128,536,216 (-)	NCBI		Celera
Cytogenetic Map	5	q35	NCBI

TMEM69
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	45,688,181 - 45,694,436 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	45,688,181 - 45,694,436 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	46,153,853 - 46,160,108 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	45,926,434 - 45,932,695 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	44,437,828 - 44,444,089 (+)	NCBI		Celera
Cytogenetic Map	1	p34.1	NCBI
HuRef	1	44,264,905 - 44,271,130 (+)	NCBI		HuRef
CHM1_1	1	46,271,022 - 46,277,283 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	45,560,527 - 45,566,780 (+)	NCBI		T2T-CHM13v2.0

Tmem69
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	116,408,725 - 116,414,262 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	116,409,102 - 116,413,132 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	116,551,528 - 116,557,116 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	116,551,633 - 116,555,936 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	116,224,133 - 116,228,548 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	116,049,460 - 116,053,859 (-)	NCBI		MGSCv36	mm8
Celera	4	115,285,168 - 115,289,623 (-)	NCBI		Celera
Cytogenetic Map	4	D1	NCBI
cM Map	4	53.22	NCBI

Tmem69
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955464	12,594,788 - 12,597,711 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955464	12,594,544 - 12,602,137 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMEM69
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	181,117,559 - 181,123,861 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	180,259,110 - 180,265,415 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	44,987,380 - 44,993,900 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	46,345,285 - 46,351,530 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	46,345,285 - 46,351,530 (+)	Ensembl	panpan1.1		panPan2

TMEM69
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	14,666,926 - 14,671,839 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	14,667,231 - 14,671,622 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	14,787,965 - 14,793,842 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	14,821,462 - 14,827,164 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	14,821,473 - 14,828,197 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	14,618,690 - 14,624,436 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	14,688,383 - 14,694,273 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	14,758,524 - 14,764,204 (-)	NCBI		UU_Cfam_GSD_1.0

Tmem69
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	60,969,227 - 60,974,688 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	26,795,499 - 26,801,242 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	26,793,410 - 26,799,451 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM69
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	165,704,617 - 165,709,964 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	165,704,599 - 165,708,983 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TMEM69
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	87,105,289 - 87,111,450 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	87,105,508 - 87,108,728 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	29,858,305 - 29,864,440 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem69
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624906	1,581,018 - 1,584,166 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624906	1,577,993 - 1,583,380 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tmem69
4 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	150
Count of miRNA genes:	118
Interacting mature miRNAs:	137
Transcripts:	ENSRNOT00000050434
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	111416838	156416838	Rat
1300122	Wbc1	White blood cell count QTL 1	2.75		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	5	125392826	139989768	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	94858972	143070159	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	129132447	151006154	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	106906205	151906205	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	97570330	136479578	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	87468046	132468046	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	108938288	153938288	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	105999803	150999803	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	120740824	151018848	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	103689353	148689353	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55805606	132207589	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	106906205	151906205	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	111416838	156416838	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	106906205	151906205	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	111416838	156416838	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	108845856	153845856	Rat
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	97059760	147465714	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
7365049	Bp359	Blood pressure QTL 359			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128071929	134724733	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	129132428	143070159	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	106906205	151906205	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	106906205	151906205	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	128033842	133011550	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	120740824	143608494	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
7394710	Emca12	Estrogen-induced mammary cancer QTL 12			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	124160767	133749643	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	108845856	153845856	Rat
631527	Tls1	T-lymphoma susceptibility QTL 1	0	0.001	thymus integrity trait (VT:0010555)	post-insult time to onset of T-cell lymphoma (CMO:0001907)	5	90450144	135450144	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	111416838	156416838	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	59793399	143070159	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
6903316	Bw113	Body weight QTL 113	2	0.0103	body mass (VT:0001259)	body weight (CMO:0000012)	5	87765973	132765973	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	99216724	148607142	Rat

Markers in Region

RH132860

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	130,004,946 - 130,005,141 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	135,394,072 - 135,394,266	NCBI	Rnor6.0
Rnor_5.0	5	139,190,257 - 139,190,451	UniSTS	Rnor5.0
RGSC_v3.4	5	136,831,099 - 136,831,293	UniSTS	RGSC3.4
Celera	5	128,532,697 - 128,532,891	UniSTS
RH 3.4 Map	5	837.2	UniSTS
Cytogenetic Map	5	q35	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001035001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063288339	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120450	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083906	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC161923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000050434 ⟹ ENSRNOP00000042975

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	130,004,901 - 130,010,655 (-)	Ensembl
Rnor_6.0 Ensembl	5	135,394,016 - 135,397,591 (-)	Ensembl

RefSeq Acc Id:

NM_001035001 ⟹ NP_001030173

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	135,241,557 - 135,245,135 (-)	NCBI
mRatBN7.2	5	130,004,888 - 130,008,466 (-)	NCBI
Rnor_6.0	5	135,394,013 - 135,397,591 (-)	NCBI
Rnor_5.0	5	139,190,198 - 139,193,776 (-)	NCBI
RGSC_v3.4	5	136,831,040 - 136,834,619 (-)	RGD
Celera	5	128,532,638 - 128,536,216 (-)	RGD

Sequence:

show sequence

GTTCAATTTGTCGTGCAACTCTGGCGCCGCGTGATGGTGGCAGGACATTGCTTTAAATTCAGCT
ATCCTCCTCAACTGTAAAAATACATGAATCAGAATTGCATCTTCTGGGAACAAAACTCTTGAGT
AGAAACCAGAATGCTTCACTTCATCCAGAAAATTTCTGGAGCATCTTCAAAGATACTAAAGAAC
CCTTTTACAGTGAGACTCAGAGCCAGCAGACTAGATATACTTTCTCCCAAGACATGTCTTCCAC
GGGACTTTTCCTCTTTGTCTCCAAGAACTTGGCTTTCCACGTCATTTCAAGTGTGTATGAGGAA
GATACAATGTTATCATGCGTCACCATGCAACTCTAAAAAGCAGCAGAAGGAGGCAGTCCTTCCC
CCCAAGAAACCAAGCACCATCACTTACCTACGCGATAGCCCAAAGCCAGCCTTATATACAACTC
TGGTGGGGTTAATCCCCTTTGCTGCCCCACCACTCATCATGGTAATAACAAAGTCTTATCTCCC
CATACTAGCTTTTACTCAGATGGCCTATGGAGCCAGTTTCTTAGCTTTCCTGGGAGGCATTAGA
TGGGGCTTTGTTCTGCCGGAAGGTAGTCCGGCCAAACCAGACTACATTAATTTAGCTAGTAGTA
TGAGTCCTGTTCTGTTTTCATGGGTAGCCATCCTATTTTCTGAAAGACTCAATGAAGCCATAGT
TACATTAATAATAGGTTTAGGGATAGCATTACATAATGAACTTTTCCTCTTACCACATTATCCC
AACTGGTTCAAAGCCTTACGGATCATAAGTACTTTGGTGGCTTTTATCTCACTTGTAATCACTT
TAATCCTTGAAAATATTTATCCAGAAAAAGGGCCCAGGAGATTTGACTAAGTAGAAATATAAAA
CTACTTTCTTGATATCATGTGCAGTGTCTGTGTAGGCCAGAAGTTTGTTGAATGCCCTGGAGCT
AATGTTACAGGCGGTTCTGAGCCACCCAGTGTCTAGGCTGGGAACTAAACTTGTGTCCATAGCA
GTACAGTCTTGAGCACTGAGCCTGTATCTCTACACTGAAAAGCTTCATTTTAGCATCACAATCC
TGTTTCTCTTGTTTGGTTCTTTTTTCTCCCTCCCACTGGTAGGAATTTATTCTTCATACATTGT
TTGTTTTTGTTTTTTTCTAAAGAGTTATCTCTTTTAGCCAGATAGTAGTAATACACACTTTTTA
TCCCAGCAGAAAGGTGGCAAAAGCAGGTGGATCTTTGAGTTTGAGGCCAGTTTGGTCTATAAAG
CAAGTTCCAGGACAGCCAGGGTTCCATGAGAAACCCTATCTGGGGGGGAAAAAAGTTACACTTA
CCTGCCTTTTGCCTCCTAAGTGTTGGGATTATAAAAATTATTTCTAAGTAATTTATCTTGAAAA
TTTTCCTAATTAATGTTAGTTTACATTTTTGTGTGTGACTTATATAGTCACATAAGTAAATATT
TCAGTGTTTGATTATACTGAGAATAGTAAAAGACAAGATGAAAAATCCTGTATTAGAGTCTAGC
AATCATGAAGTCATATTTCATGAGAATTCTACTTGTAGTGGTTTGAAGAGGTTTGGCCCCCATC
GACTCATGTGTTTGAATATGCTTGGCCCAGAGAGTGGCACTATTAGTAGTGTGGACTTGTTGGA
AGAAGTGCGACACTGTGGAAGTGAGCTTTGAGACCTTCTCCTAGCTGCCTGGAAGACAGTCTTC
TGGTTTCCTTTGGAACAAGATGTAGAACTCTCAGCAGTGCCAGTACTGCCCATGTTTCCCATCT
TGATGATAATGGACTGAAACTCTGAACCTGTAAACCAGCCCCATTTAAGTGTTGTCTAAGAGTT
GCCTTGTCCATGGTGGTCAGAGATGGAAACCTAACTAAGGTACTACCAGGAAGTTCATGACACC
TTAAAAATAAAAGTATTTCTGTCAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063288339 ⟹ XP_063144409

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	135,241,557 - 135,247,323 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001030173	(Get FASTA)	NCBI Sequence Viewer
	XP_063144409	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83906	(Get FASTA)	NCBI Sequence Viewer
	AAI61923	(Get FASTA)	NCBI Sequence Viewer
	EDL90276	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000042975.3

RefSeq Acc Id:

NP_001030173 ⟸ NM_001035001

- UniProtKB:

B1WBX2 (UniProtKB/TrEMBL), A6JZ76 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLHFIQKISGASSKILKNPFTVRLRASRLDILSPKTCLPRDFSSLSPRTWLSTSFQVCMRKIQC
YHASPCNSKKQQKEAVLPPKKPSTITYLRDSPKPALYTTLVGLIPFAAPPLIMVITKSYLPILA
FTQMAYGASFLAFLGGIRWGFVLPEGSPAKPDYINLASSMSPVLFSWVAILFSERLNEAIVTLI
IGLGIALHNELFLLPHYPNWFKALRIISTLVAFISLVITLILENIYPEKGPRRFD

hide sequence

Ensembl Acc Id:

ENSRNOP00000042975 ⟸ ENSRNOT00000050434

RefSeq Acc Id:	XP_063144409 ⟸ XM_063288339
- Peptide Label:	isoform X1
- UniProtKB:	B1WBX2 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B1WBX2-F1-model_v2	AlphaFold	B1WBX2	1-247	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693935

Promoter ID:

EPDNEW_R4460

Type:

initiation region

Name:

Tmem69_1

Description:

transmembrane protein 69

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	135,397,598 - 135,397,658	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561569	AgrOrtholog
BioCyc Gene	G2FUF-40249	BioCyc
Ensembl Genes	ENSRNOG00000029152	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000050434.5	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7133962	IMAGE-MGC_LOAD
	IMAGE:8370867	IMAGE-MGC_LOAD
InterPro	DUF3429	UniProtKB/TrEMBL
KEGG Report	rno:619582	UniProtKB/TrEMBL
MGC_CLONE	MGC:187670	IMAGE-MGC_LOAD
	MGC:95268	IMAGE-MGC_LOAD
NCBI Gene	619582	ENTREZGENE
PANTHER	PTHR15887	UniProtKB/TrEMBL
	TRANSMEMBRANE PROTEIN 69	UniProtKB/TrEMBL
Pfam	DUF3429	UniProtKB/TrEMBL
PhenoGen	Tmem69	PhenoGen
RatGTEx	ENSRNOG00000029152	RatGTEx
UniProt	A6JZ76	ENTREZGENE, UniProtKB/TrEMBL
	B1WBX2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-02-09	Tmem69	transmembrane protein 69			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar