| 620804 | Ssb | small RNA binding exonuclease protection factor La | ENCODES a protein that exhibits poly(U) RNA binding (ortholog); RNA binding (ortholog); sequence-specific mRNA binding (ortholog); INVOLVED IN tRNA processing; IRES-dependent viral translational initiation (ortholog); nuclear histone mRNA catabolic process (ortholog); PARTICIPATES IN tRNA maturation pathway; systemic lupus erythematosus pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene | 3 | 75024385 | 75034016 | Rat | 127 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733285 | Ssb | small RNA binding exonuclease protection factor La | Enables RNA binding activity. Predicted to be involved in several processes, including IRES-dependent viral translational initiation; RNA metabolic process; and protein localization to cytoplasmic stress granule. Located in nucleus. Is expressed in several structures, including central nervous syste m; early conceptus; gonad; sensory organ; and spleen. Orthologous to human SSB (small RNA binding exonuclease protection factor La). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 69691963 | 69702185 | Mouse | 159 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1348902 | SSB | small RNA binding exonuclease protection factor La | The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RN As associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014] | 2 | 169798871 | 169812064 | Human | 138 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8803265 | Ssb | small RNA binding exonuclease protection factor La | ENCODES a protein that exhibits poly(U) RNA binding (ortholog); RNA binding (ortholog); sequence-specific mRNA binding (ortholog); INVOLVED IN IRES-dependent viral translational initiation (ortholog); nuclear histone mRNA catabolic process (ortholog); protein localization to cytoplasmic stress granu le (ortholog); PARTICIPATES IN tRNA maturation pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | NW_004955449 | 4806468 | 4815175 | Chinchilla | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11930046 | SSB | small RNA binding exonuclease protection factor La | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); poly(U) RNA binding (inferred); INVOLVED IN tRNA processing (ortholog); PARTICIPATES IN tRNA maturation pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic stress granule (i nferred); cytosol (inferred) | 2B | 57071158 | 57084428 | Bonobo | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12056569 | SSB | small RNA binding exonuclease protection factor La | ENCODES a protein that exhibits nucleic acid binding (inferred); poly(U) RNA binding (inferred); RNA binding (inferred); INVOLVED IN tRNA processing (ortholog); PARTICIPATES IN tRNA maturation pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); ribonucleo protein complex (inferred) | 36 | 14465088 | 14476786 | Dog | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12611114 | Ssb | small RNA binding exonuclease protection factor La | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); poly(U) RNA binding (inferred); INVOLVED IN tRNA processing (ortholog); PARTICIPATES IN tRNA maturation pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic stress granule (i nferred); cytosol (inferred) | NW_004936509 | 286397 | 295779 | Squirrel | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13938868 | SSB | small RNA binding exonuclease protection factor La | ENCODES a protein that exhibits nucleic acid binding (inferred); poly(U) RNA binding (inferred); RNA binding (inferred); INVOLVED IN tRNA processing (ortholog); PARTICIPATES IN tRNA maturation pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); ribonucleo protein complex (inferred) | | | | Pig | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18480827 | SSB | small RNA binding exonuclease protection factor La | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); poly(U) RNA binding (inferred); INVOLVED IN tRNA processing (ortholog); PARTICIPATES IN tRNA maturation pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic stress granule (i nferred); cytosol (inferred) | | | | Green Monkey | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18924262 | Ssb | small RNA binding exonuclease protection factor La | ENCODES a protein that exhibits poly(U) RNA binding (ortholog); sequence-specific mRNA binding (ortholog); tRNA binding (ortholog); INVOLVED IN IRES-dependent viral translational initiation (ortholog); nuclear histone mRNA catabolic process (ortholog); protein localization to cytoplasmic stress gran ule (ortholog); PARTICIPATES IN tRNA maturation pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245045 | ssb | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626059107 | Ssb | small RNA binding exonuclease protection factor La | ENCODES a protein that exhibits poly(U) RNA binding (ortholog); RNA binding (ortholog); sequence-specific mRNA binding (ortholog); INVOLVED IN IRES-dependent viral translational initiation (ortholog); nuclear histone mRNA catabolic process (ortholog); protein localization to cytoplasmic stress granu le (ortholog); PARTICIPATES IN tRNA maturation pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14380394 | ssb-1 | | | | | | Roundworm | | symbol | gene, null |
| 155238804 | ssb.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243510 | ssb.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 14379641 | Ssb-c31a | | | | | | Fly | | symbol | gene, null |
| 1604788 | SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | Enables ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 9292894 | 9369532 | Human | 173 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1619953 | Spsb1 | splA/ryanodine receptor domain and SOCS box containing 1 | Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in cytosol. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to hum an SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 149980740 | 150039494 | Mouse | 174 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1310854 | Spsb2 | splA/ryanodine receptor domain and SOCS box containing 2 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); ubiquitin-dependent protein catabolic process (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 2,6-dinitrotoluene; all-trans-retinoic acid; alpha-Zearala nol | 4 | 159298362 | 159301568 | Rat | 91 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1603193 | SPSB2 | splA/ryanodine receptor domain and SOCS box containing 2 | | 12 | 6875764 | 6889358 | Human | | old_gene_name , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 1620906 | Spsb2 | splA/ryanodine receptor domain and SOCS box containing 2 | This gene encodes a member of the SSB family of proteins that contain a central SPRY (repeats in splA and ryanodine receptors) domain and a C-terminal SOCS (suppressor of cytokine signaling) box. The encoded protein is an adaptor protein in the E3 ubiquitin liga se complex that ubiquitinates inducible nitric oxide synthase and targets it for proteasomal degradation. Mice lacking the encoded protein exhibit lower blood urea nitrogen levels and mild thrombocytopenia due to reduced platelet production. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] | 6 | 124785640 | 124787582 | Mouse | 88 | description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1558086 | Spsb4 | splA/ryanodine receptor domain and SOCS box containing 4 | Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including positive regulation of protein polyubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be located in cytosol. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 96825535 | 96900408 | Mouse | 136 | old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1603370 | SPSB4 | splA/ryanodine receptor domain and SOCS box containing 4 | Enables ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including positive regulation of protein polyubiquitination; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 141051347 | 141148611 | Human | 131 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 3760 | Ssbp1 | single stranded DNA binding protein 1 | ENCODES a protein that exhibits chromatin binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN mitochondrial DNA replication (ortholog); mitochondrion organization (ortholog); positive regulation of helicase activity (ortholog); PARTICIP ATES IN DNA replication pathway; homologous recombination pathway of double-strand break repair; mismatch repair pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); cone-rod dystrophy (ortholog); fundus dystrophy (ortholog); FOUND IN mitochondrial nucleoid (ortholog); mitochondrion (ortholog); INTERACTS WITH 2,4-dinitrotoluene; 3H-1,2-dithiole-3-thione; aconitine | 4 | 70232740 | 70242824 | Rat | 169 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 736464 | SSBP1 | single stranded DNA binding protein 1 | SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501 ].[supplied by OMIM, Feb 2010] | 7 | 141738321 | 141750488 | Human | 175 | symbol , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 736465 | Ssbp1 | single-stranded DNA binding protein 1 | Predicted to enable several functions, including chromatin binding activity; protein homodimerization activity; and single-stranded DNA binding activity. Acts upstream of or within mitochondrion organization. Located in mitochondrion. Is expressed in brain ventricular layer; foregut; renal cortex; a nd submandibular gland primordium. Human ortholog(s) of this gene implicated in optic atrophy. Orthologous to human SSBP1 (single stranded DNA binding protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 40448302 | 40458757 | Mouse | 164 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16556661 | SSBL2P | SSB like 2, pseudogene | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, processed_pseudogene |
| 16554858 | SSBL4P | SSB like 4, pseudogene | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, processed_pseudogene |
| 16562243 | AC009268.1 | Sjogren syndrome antigen B (autoantigen La) (SSB) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16555961 | AL161449.1 | Sjogren syndrome antigen B (autoantigen La) (SSB) pseudogene | | 9 | 13021476 | 13049754 | Human | | name | gene, pseudo, MODEL [RefSeq] |
| 27095971 | SSBL2P | small RNA binding exonuclease protection factor La like 2, pseudogene | | X | 62779133 | 62780626 | Human | | symbol , GTEx , old_gene_name , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 27095977 | SSBL3P | small RNA binding exonuclease protection factor La like 3, pseudogene | | 12 | 45071774 | 45073035 | Human | | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 27095978 | SSBL4P | small RNA binding exonuclease protection factor La like 4, pseudogene | | 1 | 147082034 | 147083650 | Human | | symbol , GTEx , old_gene_name , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 27095972 | SSBL5P | small RNA binding exonuclease protection factor La like 5, pseudogene | | 7 | 12471342 | 12472826 | Human | | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1317489 | INIP | INTS3 and NABP interacting protein | The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination repair. [provided by RefSeq, Jul 2016] | 9 | 112683926 | 112718117 | Human | 76 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1614381 | Inip | INTS3 and NABP interacting protein | Predicted to be involved in double-strand break repair via homologous recombination; mitotic G2/M transition checkpoint; and response to ionizing radiation. Predicted to be located in nucleus and site of double-strand break. Predicted to be part of SOSS complex. Predicted to be active in nucleoplasm . Is expressed in several structures, including brain ventricular layer; submandibular gland primordium; thymus primordium; tooth; and vibrissa. Orthologous to human INIP (INTS3 and NABP interacting protein). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 59769637 | 59783855 | Mouse | 90 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 35315959 | SPSB2 | splA/ryanodine receptor domain and SOCS box containing 2 | This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] | 12 | 6870935 | 6873303 | Human | 90 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1603939 | SPSB3 | splA/ryanodine receptor domain and SOCS box containing 3 | Enables ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including negative regulation of cGAS/STING signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein K48-linked ubiquitination. Part of Cul5-RING ubiquitin ligase complex. Is a ctive in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 1776712 | 1782571 | Human | 81 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1615788 | Spsb3 | splA/ryanodine receptor domain and SOCS box containing 3 | Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including negative regulation of cGAS/STING signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein K48-linked ubiquitination. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human SPSB3 (splA/ryanodine receptor domain and SOCS box containing 3). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 25104956 | 25111124 | Mouse | 96 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1309319 | Spsb1 | splA/ryanodine receptor domain and SOCS box containing 1 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); ubiquitin-dependent protein catabolic process (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH (+)-schisandrin B; (R,R,R)-alpha-tocopherol; 17alpha-ethyn ylestradiol | 5 | 165641255 | 165701482 | Rat | 166 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 16557889 | SSBL6P | small RNA binding exonuclease protection factor La like 6, pseudogene | | | | | Human | | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, processed_pseudogene |
| 14388106 | SSB1 | | | | | | Yeast | | symbol | gene, null |
| 14388107 | SSB2 | | | | | | Yeast | | symbol | gene, null |
| 1592944 | Ssbl1 | small RNA binding exonuclease protection factor La like 1 | ENCODES a protein that exhibits nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN RNA processing (inferred); FOUND IN nucleus (inferred); ribonucleoprotein complex (inferred) | 4 | 150749998 | 150752268 | Rat | 15 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 15003376 | Ssbl1 | small RNA binding exonuclease protection factor La like 1 | | | | | Rat | | symbol , PhenoGen | gene, protein-coding |
| 8865728 | Ssbp1 | single stranded DNA binding protein 1 | ENCODES a protein that exhibits chromatin binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN mitochondrial DNA replication (ortholog); mitochondrion organization (ortholog); positive regulation of helicase activity (ortholog); ASSOCIAT ED WITH Arsenic Poisoning (ortholog); cone-rod dystrophy (ortholog); fundus dystrophy (ortholog); FOUND IN mitochondrial nucleoid (ortholog); mitochondrion (ortholog) | NW_004955494 | 1807885 | 1826375 | Chinchilla | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11980052 | SSBP1 | single stranded DNA binding protein 1 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); identical protein binding (inferred); INVOLVED IN mitochondrion organization (ortholog); positive regulation of helicase activity (ortholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); cone-rod dystrophy (orthol og); fundus dystrophy (ortholog); FOUND IN mitochondrial nucleoid (inferred); mitochondrion (inferred); nucleoid (inferred) | 7 | 133670085 | 133682228 | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12400671 | SSBP1 | single stranded DNA binding protein 1 | ENCODES a protein that exhibits chromatin binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN mitochondrial DNA replication (ortholog); mitochondrion organization (ortholog); positive regulation of helicase activity (ortholog); ASSOCIAT ED WITH Arsenic Poisoning (ortholog); cone-rod dystrophy (ortholog); fundus dystrophy (ortholog); FOUND IN mitochondrial nucleoid (inferred); mitochondrion (inferred) | 16 | 7445351 | 7461513 | Dog | 30 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12461833 | Ssbp1 | single stranded DNA binding protein 1 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); identical protein binding (inferred); INVOLVED IN mitochondrion organization (ortholog); positive regulation of helicase activity (ortholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); cone-rod dystrophy (orthol og); fundus dystrophy (ortholog); FOUND IN mitochondrial nucleoid (inferred); mitochondrion (inferred); nucleoid (inferred) | NW_004936592 | 5611775 | 5620846 | Squirrel | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14290038 | SSBP1 | single stranded DNA binding protein 1 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); identical protein binding (inferred); INVOLVED IN mitochondrion organization (ortholog); positive regulation of helicase activity (ortholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); cone-rod dystrophy (orthol og); fundus dystrophy (ortholog); FOUND IN mitochondrial nucleoid (inferred); mitochondrion (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18733610 | SSBP1 | single stranded DNA binding protein 1 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); identical protein binding (inferred); INVOLVED IN mitochondrion organization (ortholog); positive regulation of helicase activity (ortholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); cone-rod dystrophy (orthol og); fundus dystrophy (ortholog); FOUND IN mitochondrial nucleoid (inferred); mitochondrion (inferred); nucleoid (inferred) | | | | Green Monkey | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18918425 | Ssbp1 | single stranded DNA binding protein 1 | ENCODES a protein that exhibits chromatin binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN mitochondrion organization (ortholog); positive regulation of helicase activity (ortholog); positive regulation of mitochondrial DNA replicati on (ortholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); cone-rod dystrophy (ortholog); fundus dystrophy (ortholog); FOUND IN mitochondrial nucleoid (inferred); mitochondrion (inferred); nucleoid (inferred) | | | | Naked Mole-Rat | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252906 | ssbp1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626075379 | Ssbp1 | single stranded DNA binding protein 1 | ENCODES a protein that exhibits chromatin binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN mitochondrial DNA replication (ortholog); mitochondrion organization (ortholog); positive regulation of helicase activity (ortholog); ASSOCIAT ED WITH Arsenic Poisoning (ortholog); cone-rod dystrophy (ortholog); fundus dystrophy (ortholog); FOUND IN mitochondrial nucleoid (ortholog); mitochondrion (ortholog) | | | | Black Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1344325 | SSBP2 | single stranded DNA binding protein 2 | This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene may be associated with survival in human gliobl astoma patients. [provided by RefSeq, Sep 2016] | 5 | 81412804 | 81751807 | Human | 138 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1558429 | Ssbp2 | single-stranded DNA binding protein 2 | Predicted to enable single-stranded DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; alimentary system; c entral nervous system; genitourinary system; and limb. Orthologous to human SSBP2 (single stranded DNA binding protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 91608449 | 91854299 | Mouse | 169 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1562968 | Ssbp2 | single-stranded DNA binding protein 2 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); ASSOCIATED WITH bipolar disorder (ortholog); prostate cancer (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 4,4'-sulfon yldiphenol; 6-propyl-2-thiouracil | 2 | 24385494 | 24673768 | Rat | 135 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8704248 | Ssbp2 | single stranded DNA binding protein 2 | ASSOCIATED WITH bipolar disorder (ortholog); prostate cancer (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog) | NW_004955418 | 28562735 | 28813541 | Chinchilla | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11736278 | SSBP2 | single stranded DNA binding protein 2 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH bipolar disorder (ortholog); prostate cancer (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplas m (ortholog) | 5 | 33535213 | 33859595 | Bonobo | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12301358 | SSBP2 | single stranded DNA binding protein 2 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); ASSOCIATED WITH bipolar disorder (ortholog); prostate cancer (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog) | 3 | 25616750 | 25900991 | Dog | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12622678 | Ssbp2 | single stranded DNA binding protein 2 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH bipolar disorder (ortholog); prostate cancer (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplas m (ortholog) | NW_004936469 | 713077 | 1046187 | Squirrel | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13879393 | SSBP2 | single stranded DNA binding protein 2 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); ASSOCIATED WITH bipolar disorder (ortholog); prostate cancer (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog) | | | | Pig | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18712552 | SSBP2 | single stranded DNA binding protein 2 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH bipolar disorder (ortholog); prostate cancer (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplas m (ortholog) | | | | Green Monkey | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18923452 | Ssbp2 | single stranded DNA binding protein 2 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH bipolar disorder (ortholog); prostate cancer (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplas m (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233611 | ssbp2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625846466 | Ssbp2 | single stranded DNA binding protein 2 | ASSOCIATED WITH bipolar disorder (ortholog); prostate cancer (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 621502 | Ssbp3 | single stranded DNA binding protein 3 | ENCODES a protein that exhibits transcription coactivator activity (ortholog); INVOLVED IN head development (ortholog); head morphogenesis (ortholog); hematopoietic progenitor cell differentiation (ortholog); ASSOCIATED WITH Developmental Disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN protein-containing complex (ortholog); transcription regulator complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil | 5 | 126920145 | 127057968 | Rat | 134 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731988 | SSBP3 | single stranded DNA binding protein 3 | Predicted to enable single-stranded DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be part of transc ription regulator complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 54225432 | 54413490 | Human | 125 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 736343 | Ssbp3 | single-stranded DNA binding protein 3 | This gene encodes a member of the Ssdp (sequence-specific single-stranded DNA binding protein) family of proteins. The encoded protein binds specifically to single-stranded pyrimidine-rich DNA elements. The encoded protein has been shown to be important for head development and may play a role in th e differentiation of spinal interneurons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] | 4 | 106768667 | 106906891 | Mouse | 164 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8956351 | Ssbp3 | single stranded DNA binding protein 3 | ENCODES a protein that exhibits transcription coactivator activity (ortholog); INVOLVED IN head development (ortholog); head morphogenesis (ortholog); hematopoietic progenitor cell differentiation (ortholog); ASSOCIATED WITH Developmental Disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN protein-containing complex (ortholog); transcription regulator complex (ortholog) | NW_004955464 | 4901150 | 5049341 | Chinchilla | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12004028 | SSBP3 | single stranded DNA binding protein 3 | ENCODES a protein that exhibits transcription coactivator activity (ortholog); INVOLVED IN head development (ortholog); head morphogenesis (ortholog); hematopoietic progenitor cell differentiation (ortholog); ASSOCIATED WITH Developmental Disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN protein-containing complex (ortholog); transcription regulator complex (ortholog) | 1 | 53501656 | 53680682 | Bonobo | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12380694 | SSBP3 | single stranded DNA binding protein 3 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); transcription coactivator activity (inferred); INVOLVED IN hematopoietic progenitor cell differentiation (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH D evelopmental Disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN nucleus (inferred); protein-containing complex (inferred); transcription regulator complex (inferred) | 5 | 54690632 | 54826691 | Dog | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12540692 | Ssbp3 | single stranded DNA binding protein 3 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); transcription coactivator activity (inferred); INVOLVED IN hematopoietic progenitor cell differentiation (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH D evelopmental Disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN nucleus (inferred); protein-containing complex (inferred); transcription regulator complex (inferred) | NW_004936522 | 6802057 | 6957640 | Squirrel | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13886195 | SSBP3 | single stranded DNA binding protein 3 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); transcription coactivator activity (inferred); INVOLVED IN hematopoietic progenitor cell differentiation (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH D evelopmental Disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN nucleus (inferred); protein-containing complex (inferred); transcription regulator complex (inferred) | | | | Pig | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18397534 | SSBP3 | single stranded DNA binding protein 3 | ENCODES a protein that exhibits transcription coactivator activity (ortholog); INVOLVED IN head development (ortholog); head morphogenesis (ortholog); hematopoietic progenitor cell differentiation (ortholog); ASSOCIATED WITH Developmental Disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN protein-containing complex (ortholog); transcription regulator complex (ortholog) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18924346 | Ssbp3 | single stranded DNA binding protein 3 | ENCODES a protein that exhibits transcription coactivator activity (ortholog); INVOLVED IN head development (ortholog); head morphogenesis (ortholog); hematopoietic progenitor cell differentiation (ortholog); ASSOCIATED WITH Developmental Disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN protein-containing complex (ortholog); transcription regulator complex (ortholog) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234669 | ssbp3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625838125 | Ssbp3 | single stranded DNA binding protein 3 | ENCODES a protein that exhibits transcription coactivator activity (ortholog); INVOLVED IN head development (ortholog); head morphogenesis (ortholog); hematopoietic progenitor cell differentiation (ortholog); ASSOCIATED WITH Developmental Disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN protein-containing complex (ortholog); transcription regulator complex (ortholog) | | | | Black Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1350792 | SSBP4 | single stranded DNA binding protein 4 | Predicted to enable single-stranded DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 19 | 18402725 | 18434562 | Human | 84 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1359619 | Ssbp4 | single stranded DNA binding protein 4 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); FOUND IN nucleus (inferred); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol | 16 | 18862007 | 18872917 | Rat | 79 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1557483 | Ssbp4 | single stranded DNA binding protein 4 | Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; gonad; limb; retina; and trunk somite. Orthologous to human SSBP4 (sin gle stranded DNA binding protein 4). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 71050135 | 71061084 | Mouse | 78 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8781257 | Ssbp4 | single stranded DNA binding protein 4 | | NW_004955524 | 3101935 | 3109178 | Chinchilla | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11720643 | SSBP4 | single stranded DNA binding protein 4 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (inferred); FOUND IN nucleus (inferred) | 19 | 17897548 | 17913159 | Bonobo | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12261301 | SSBP4 | single stranded DNA binding protein 4 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); FOUND IN nucleus (inferred) | 20 | 44599576 | 44613344 | Dog | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12585944 | Ssbp4 | single stranded DNA binding protein 4 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (inferred); FOUND IN nucleus (inferred) | NW_004936596 | 2819551 | 2833117 | Squirrel | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14139375 | SSBP4 | single stranded DNA binding protein 4 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); FOUND IN nucleus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18604044 | SSBP4 | single stranded DNA binding protein 4 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (inferred); FOUND IN nucleus (inferred) | | | | Green Monkey | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930630 | Ssbp4 | single stranded DNA binding protein 4 | ENCODES a protein that exhibits DNA binding (inferred); single-stranded DNA binding (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (inferred); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243392 | ssbp4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626113922 | Ssbp4 | single stranded DNA binding protein 4 | | | | | Black Rat | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155783003 | SSBL6P | small RNA binding exonuclease protection factor La like 6, pseudogene | | 3 | 166293756 | 166294353 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 155238306 | ssbp1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258881 | ssbp1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 625776950 | SSBP1P1 | SSBP1 pseudogene 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 625776956 | SSBP1P2 | SSBP1 pseudogene 2 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 625776953 | SSBP1P3 | SSBP1 pseudogene 3 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo |
| 625776963 | SSBP1P4 | SSBP1 pseudogene 4 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 155235168 | ssbp2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155233612 | ssbp2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155242299 | ssbp3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155253725 | ssbp3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 14995371 | SSBP3P1 | SSBP3 pseudogene 1 | | 7 | 39833371 | 39834915 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 14995388 | SSBP3P2 | SSBP3 pseudogene 2 | | 2 | 131351886 | 131353438 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16552064 | SSBP3P3 | SSBP3 pseudogene 3 | | 22 | 15572087 | 15573263 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16561410 | SSBP3P4 | SSBP3 pseudogene 4 | | 14 | 18645045 | 18646221 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16561448 | SSBP3P5 | SSBP3 pseudogene 5 | | 14 | 19668829 | 19670000 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16552289 | SSBP3P6 | SSBP3 pseudogene 6 | | 2 | 129992889 | 129994037 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 155251072 | ssbp4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243393 | ssbp4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2320195 | Ssbp1-ps1 | single stranded DNA binding protein 1, pseudogene 1 | | 4 | 128441430 | 128447078 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1587045 | Ssbp1-ps2 | single stranded DNA binding protein 1, pseudogene 2 | | 13 | 42487193 | 42488869 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 2318551 | Ssbp1-ps3 | single stranded DNA binding protein 1, pseudogene 3 | | 19 | 69812797 | 69819653 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 7627001 | Ssbp1-ps4 | single stranded DNA binding protein 1, pseudogene 4 | | 8 | 67076302 | 67084715 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 2323751 | Ssbp2-ps1 | single-stranded DNA binding protein 2, pseudogene 1 | | 5 | 172022942 | 172028770 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 7246238 | SSBP3-AS1 | SSBP3 antisense RNA 1 | Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 54236443 | 54239063 | Human | 6 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 616336040 | SSBP3-AS2 | SSBP3 antisense RNA 2 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 1331947 | Nabp1 | nucleic acid binding protein 1 | Enables RNA binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; mitotic G2/M transition checkpoint; and response to ionizing radiation. Located in chromosome, telomeric region and nucleus. Is expressed in sev eral structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human NABP1 (nucleic acid binding protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 51504127 | 51517634 | Mouse | 218 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1603967 | NABP1 | nucleic acid binding protein 1 | Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008] | 2 | 191678136 | 191686943 | Human | 239 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1331927 | Nabp2 | nucleic acid binding protein 2 | Predicted to enable DNA polymerase binding activity and G-rich strand telomeric DNA binding activity. Involved in DNA repair and positive regulation of telomere capping. Located in chromosome, telomeric region. Is expressed in several structures, including genitourinary system; heart; liver; lung; a nd spleen. Orthologous to human NABP2 (nucleic acid binding protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 128237263 | 128247426 | Mouse | 199 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1601970 | NABP2 | nucleic acid binding protein 2 | Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008] | 12 | 56222015 | 56229854 | Human | 88 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1351802 | KIR2DL1 | killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | 19 | 54769793 | 54784322 | Human | 29 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1347662 | KIR2DL2 | killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | | | | Human | 23 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1351159 | KIR2DL3 | killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | 19 | 54738513 | 54753052 | Human | 35 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1353116 | KIR2DL4 | killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. [provided by RefSeq, Jul 2016] | 19 | 54803610 | 54814517 | Human | 37 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1607012 | KIR2DL5A | killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | | | | Human | 11 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1347492 | KIR2DS1 | killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | | | | Human | 18 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1344459 | KIR2DS2 | killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene represents a haplotype-specific family member that encodes a protein with a short cytoplasmic tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] | | | | Human | 19 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1348050 | KIR2DS4 | killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4 (gene/pseudogene) | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | 19 | 54832707 | 54848575 | Human | 21 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1345824 | KIR2DS5 | killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | | | | Human | 21 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 735895 | KIR3DL1 | killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | 19 | 54816468 | 54830778 | Human | 51 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1343393 | KIR3DL2 | killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011] | 19 | 54850443 | 54867207 | Human | 24 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1352085 | KIR3DL3 | killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The g ene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. [provided by RefSeq, Jul 2008] | 19 | 54724442 | 54736632 | Human | 24 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 11867458 | LOC106634337 | immunoglobulin kappa variable 1-39-like | | 2A | 102259496 | 102260021 | Bonobo | | GenBank Nucleotide | gene, gene, MODEL [RefSeq] |
| 1352429 | RNY1 | RNA, Ro60-associated Y1 | Y RNAs are small noncoding RNAs that were originally identified as the RNA component of soluble ribonucleoproteins (RNPs) termed Ro RNPs. Ro RNPs are detected by autoimmune sera of patients suffering from rheumatic diseases, such as from systemic lupus erythematosus (MIM 152700) and Sjogren syndrome (MIM 270200). Ro RNPs consist of a Y RNA that is associated with the autoimmune antigen proteins Ro60 (TROVE2; MIM 600063) and La (SSB; MIM 109090), as well as other proteins. Four human Y RNAs have been identified: Y1, Y3 (RNY3; MIM 601822), Y4 (RNY4; MIM 601823), and Y5 (RNY5; MIM 601824). (Y2 is a truncated form of Y1.) Y RNAs are transcribed by RNA polymerase III and range in size from 83 to 112 nucleotides. They appear to have a functional role in chromosomal DNA replication (Christov et al., 2006 [PubMed 16943439]).[supplied by OMIM, Apr 2009] | 7 | 148987136 | 148987248 | Human | 9 | description | gene, ncrna, PROVISIONAL [RefSeq] |
| 1313129 | Smc2 | structural maintenance of chromosomes 2 | The protein encoded by this gene is a component of both condensin I and condensin II complexes, and forms a heterodimer with structural maintenance of chromosome 4 (Smc4). This heterodimer is the catalytic subunit for both condensin complexes, and is involved in several processes, including chromoso me condensation during mitosis and meiosis, cohesin removal during mitosis and meiosis, and single-strand break (SSB) repair. Reduced expression of this gene results in chromosome segregation defects during mitosis and meiosis, with a more severe defect observed in embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] | 4 | 52438966 | 52488365 | Mouse | 212 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 16555349 | AL357134.1 | single-stranded DNA binding protein (SSBP1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16555560 | AC004987.2 | single stranded DNA binding protein 3 (SSBP3) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16552241 | AL024474.1 | single-stranded DNA binding protein 1 (SSBP1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16564692 | AP002414.4 | single stranded DNA binding protein 4 (SSBP4) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16557009 | AL353093.1 | single-stranded DNA binding protein (SSBP1)(SSBP) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16554206 | AC016909.1 | pseudogene similar to part of single-stranded DNA binding protein 1 (SSBP1) | | | | | Human | | name | gene, processed_pseudogene |
