Spsb4 (splA/ryanodine receptor domain and SOCS box containing 4) - Rat Genome Database
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Gene: Spsb4 (splA/ryanodine receptor domain and SOCS box containing 4) Mus musculus
Analyze
Symbol: Spsb4
Name: splA/ryanodine receptor domain and SOCS box containing 4
RGD ID: 1558086
MGI Page MGI
Description: Predicted to have ubiquitin ligase-substrate adaptor activity. Predicted to be involved in cellular protein metabolic process; positive regulation of protein polyubiquitination; and regulation of circadian rhythm. Predicted to localize to SCF ubiquitin ligase complex and cytosol. Orthologous to human SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4); INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: D030068E18Rik; SPRY domain-containing SOCS box 4; SPRY domain-containing SOCS box protein 4; SPRY domain-containing SOCS box protein SSB-4; Ss; SSB-4; Ssb4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39996,825,535 - 96,900,408 (-)NCBIGRCm39mm39
GRCm38996,943,482 - 97,018,355 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl996,943,482 - 97,018,843 (-)EnsemblGRCm38mm10GRCm38
MGSCv37996,843,901 - 96,918,774 (-)NCBIGRCm37mm9NCBIm37
MGSCv36996,752,834 - 96,827,707 (-)NCBImm8
Celera996,503,220 - 96,578,054 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:15172686   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16369487   PMID:16672355  
PMID:18799693   PMID:20561531   PMID:20603330   PMID:21677750   PMID:21873635  


Genomics

Comparative Map Data
Spsb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39996,825,535 - 96,900,408 (-)NCBIGRCm39mm39
GRCm38996,943,482 - 97,018,355 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl996,943,482 - 97,018,843 (-)EnsemblGRCm38mm10GRCm38
MGSCv37996,843,901 - 96,918,774 (-)NCBIGRCm37mm9NCBIm37
MGSCv36996,752,834 - 96,827,707 (-)NCBImm8
Celera996,503,220 - 96,578,054 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
SPSB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3141,051,347 - 141,148,611 (+)EnsemblGRCh38hg38GRCh38
GRCh383141,051,347 - 141,148,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373140,770,743 - 140,867,453 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363142,253,433 - 142,350,143 (+)NCBINCBI36hg18NCBI36
Celera3139,194,129 - 139,290,840 (+)NCBI
Cytogenetic Map3q23NCBI
HuRef3138,145,605 - 138,242,314 (+)NCBIHuRef
CHM1_13140,733,237 - 140,830,404 (+)NCBICHM1_1
Spsb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08104,840,939 - 104,912,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8104,840,940 - 104,912,959 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08104,287,498 - 104,359,356 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48102,034,525 - 102,107,618 (-)NCBIRGSC3.4rn4RGSC3.4
Celera896,977,033 - 97,049,836 (-)NCBICelera
Cytogenetic Map8q31NCBI
Spsb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555084,539,516 - 4,615,439 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555084,539,531 - 4,615,439 (-)NCBIChiLan1.0ChiLan1.0
SPSB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13145,682,533 - 145,779,049 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3145,682,533 - 145,779,049 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03138,085,136 - 138,181,747 (+)NCBIMhudiblu_PPA_v0panPan3
SPSB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2336,997,705 - 37,077,401 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12336,998,124 - 37,082,576 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Spsb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365402,953,837 - 3,021,430 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPSB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1381,867,740 - 81,926,762 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11381,849,908 - 81,926,764 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21389,692,304 - 89,769,847 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPSB4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1549,442,864 - 49,515,357 (-)Ensembl
ChlSab1.11549,442,817 - 49,529,654 (-)NCBI
Spsb4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473017,692,124 - 17,774,321 (+)NCBI

Position Markers
UniSTS:236231  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38996,943,877 - 96,944,188UniSTSGRCm38
MGSCv37996,844,296 - 96,844,607UniSTSGRCm37
Celera996,503,615 - 96,503,929UniSTS
Cytogenetic Map9E3.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966207024100207122Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96936046598819654Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:822
Count of miRNA genes:532
Interacting mature miRNAs:614
Transcripts:ENSMUST00000055433, ENSMUST00000064445, ENSMUST00000159298, ENSMUST00000162307
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000055433   ⟹   ENSMUSP00000057849
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl996,943,482 - 97,018,843 (-)Ensembl
RefSeq Acc Id: ENSMUST00000064445
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl996,994,049 - 97,018,764 (-)Ensembl
RefSeq Acc Id: ENSMUST00000159298
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl996,943,972 - 96,971,975 (-)Ensembl
RefSeq Acc Id: ENSMUST00000162307
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl996,943,485 - 96,984,195 (-)Ensembl
RefSeq Acc Id: NM_145134   ⟹   NP_660116
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39996,825,535 - 96,900,408 (-)NCBI
GRCm38996,943,482 - 97,018,355 (-)ENTREZGENE
MGSCv37996,843,901 - 96,918,774 (-)RGD
Celera996,503,220 - 96,578,054 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_660116   ⟸   NM_145134
- UniProtKB: Q8R5B6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000057849   ⟸   ENSMUST00000055433
Protein Domains
B30.2/SPRY   SOCS box

Promoters
RGD ID:6845211
Promoter ID:MM_KWN:58441
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000071896
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36996,872,026 - 96,872,526 (-)MPROMDB
RGD ID:6845210
Promoter ID:MM_KWN:58442
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000071895
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36996,884,376 - 96,884,876 (-)MPROMDB
RGD ID:6845209
Promoter ID:MM_KWN:58445
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Kidney,   Lung
Transcripts:ENSMUST00000064445,   OTTMUST00000071893
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36996,919,026 - 96,919,732 (-)MPROMDB
RGD ID:8670512
Promoter ID:EPDNEW_M13287
Type:initiation region
Name:Spsb4_1
Description:Mus musculus splA/ryanodine receptor domain and SOCS box containing4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38997,018,279 - 97,018,339EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2183445 AgrOrtholog
Ensembl Genes ENSMUSG00000046997 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000057849 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000055433 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.920 UniProtKB/Swiss-Prot
InterPro B30.2/SPRY UniProtKB/Swiss-Prot
  B30.2/SPRY_sf UniProtKB/Swiss-Prot
  ConA-like_dom_sf UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot
  SPRY_dom UniProtKB/Swiss-Prot
KEGG Report mmu:211949 UniProtKB/Swiss-Prot
MGD MGI:2183445 ENTREZGENE
NCBI Gene 211949 ENTREZGENE
Pfam SOCS_box UniProtKB/Swiss-Prot
  SPRY UniProtKB/Swiss-Prot
PhenoGen Spsb4 PhenoGen
PROSITE B302_SPRY UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
SMART SOCS_box UniProtKB/Swiss-Prot
  SPRY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF158235 UniProtKB/Swiss-Prot
  SSF49899 UniProtKB/Swiss-Prot
UniGene Mm.491271 ENTREZGENE
UniProt Q8R5B6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8BJI9 UniProtKB/Swiss-Prot
  Q8VHS8 UniProtKB/Swiss-Prot