Symbol:
Spsb4
Name:
splA/ryanodine receptor domain and SOCS box containing 4
Description:
ENCODES a protein that exhibits protein binding, bridging involved in substrate recognition for ubiquitination (ortholog); INVOLVED IN positive regulation of protein polyubiquitination (ortholog); protein ubiquitination (ortholog); regulation of circadian rhythm (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; benzo[a]pyrene
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
D030068E18Rik; SPRY domain-containing SOCS box 4; SPRY domain-containing SOCS box protein 4; SPRY domain-containing SOCS box protein SSB-4; SSB-4; Ssb4
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):
Spsb4 (splA/ryanodine receptor domain and SOCS box containing 4) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Spsb4 (splA/ryanodine receptor domain and SOCS box containing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Spsb4 (splA/ryanodine receptor domain and SOCS box containing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1) HGNC
OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Spsb4 (splA/ryanodine receptor domain and SOCS box containing 4)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, TreeFam)
Homo sapiens (human):
SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4)
Alliance
DIOPT (Ensembl Compara, HGNC, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, Roundup, TreeFam)
Danio rerio (zebrafish):
spsb4a (splA/ryanodine receptor domain and SOCS box containing 4a)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, Roundup, TreeFam, ZFIN)
Danio rerio (zebrafish):
spsb4b (splA/ryanodine receptor domain and SOCS box containing 4b)
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
gus
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
spsb-2
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 96,943,482 - 97,018,355 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 96,843,901 - 96,918,774 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 96,752,834 - 96,827,707 (-) NCBI mm8 Celera 9 96,503,220 - 96,578,054 (-) NCBI Celera Cytogenetic Map 9 E3.3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(+)-schisandrin B multiple interactions ISO RGD:1562307 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SPSB4 mRNA] CTD PMID:31150632 1-naphthyl isothiocyanate increases expression ISO RGD:1562307 6480464 1-Naphthylisothiocyanate results in increased expression of SPSB4 mRNA CTD PMID:25380136 , PMID:30723492 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RGD:1562307 6480464 2 more ... CTD PMID:27291303 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SPSB4 mRNA CTD PMID:21570461 4,4'-diaminodiphenylmethane increases expression ISO RGD:1562307 6480464 4, 4'-diaminodiphenylmethane results in increased expression of SPSB4 mRNA CTD PMID:25380136 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of SPSB4 mRNA CTD PMID:28973697 4-hydroxyphenyl retinamide decreases expression EXP 6480464 Fenretinide results in decreased expression of SPSB4 mRNA CTD PMID:28973697 6-propyl-2-thiouracil increases expression ISO RGD:1562307 6480464 Propylthiouracil results in increased expression of SPSB4 mRNA CTD PMID:24780913 acrylamide decreases expression ISO RGD:1562307 6480464 Acrylamide results in decreased expression of SPSB4 mRNA CTD PMID:28959563 all-trans-retinoic acid increases expression ISO RGD:1562307 6480464 Tretinoin results in increased expression of SPSB4 mRNA CTD PMID:20488242 antirheumatic drug increases expression ISO RGD:1603370 6480464 Antirheumatic Agents results in increased expression of SPSB4 mRNA CTD PMID:24449571 arsane affects methylation ISO RGD:1603370 6480464 Arsenic affects the methylation of SPSB4 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1603370 6480464 Arsenic affects the methylation of SPSB4 gene CTD PMID:25304211 arsenic(3+) affects methylation ISO RGD:1603370 6480464 Arsenic affects the methylation of SPSB4 gene CTD PMID:25304211 arsenite(3-) increases methylation ISO RGD:1603370 6480464 arsenite results in increased methylation of SPSB4 promoter CTD PMID:23974009 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of SPSB4 mRNA CTD PMID:19770486 , PMID:27195522 bisphenol A affects expression ISO RGD:1562307 6480464 bisphenol A affects the expression of SPSB4 mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:1562307 6480464 bisphenol A results in increased methylation of SPSB4 gene CTD PMID:28505145 buta-1,3-diene decreases expression EXP 6480464 1, 3-butadiene results in decreased expression of SPSB4 mRNA CTD PMID:29038090 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of SPSB4 mRNA, Nanotubes, Carbon results in decreased expression of SPSB4 mRNA CTD PMID:25620056 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of SPSB4 mRNA CTD PMID:25554681 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SPSB4 gene CTD PMID:20938992 ciguatoxin CTX1B affects expression EXP 6480464 Ciguatoxins affects the expression of SPSB4 mRNA CTD PMID:18353800 decabromodiphenyl ether decreases expression ISO RGD:1562307 6480464 decabromobiphenyl ether results in decreased expression of SPSB4 mRNA CTD PMID:23640034 decabromodiphenyl ether increases expression ISO RGD:1562307 6480464 decabromobiphenyl ether results in increased expression of SPSB4 mRNA CTD PMID:23640034 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of SPSB4 mRNA CTD PMID:17361019 , PMID:21266533 dichloroacetic acid increases expression EXP 6480464 Dichloroacetic Acid results in increased expression of SPSB4 mRNA CTD PMID:28962523 dorsomorphin multiple interactions ISO RGD:1603370 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1603370 6480464 Doxorubicin results in decreased expression of SPSB4 mRNA CTD PMID:29803840 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SPSB4 gene CTD PMID:20938992 furan increases expression ISO RGD:1562307 6480464 furan results in increased expression of SPSB4 mRNA CTD PMID:25539665 glafenine increases expression ISO RGD:1562307 6480464 Glafenine results in increased expression of SPSB4 mRNA CTD PMID:24136188 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SPSB4 gene CTD PMID:20938992 mercury dibromide increases expression ISO RGD:1603370 6480464 mercuric bromide results in increased expression of SPSB4 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:1603370 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPSB4 mRNA CTD PMID:27188386 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SPSB4 mRNA] CTD PMID:25566086 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal decreases expression EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SPSB4 mRNA CTD PMID:25566086 N-nitrosodimethylamine increases expression ISO RGD:1562307 6480464 Dimethylnitrosamine results in increased expression of SPSB4 mRNA CTD PMID:25380136 panobinostat multiple interactions ISO RGD:1603370 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPSB4 mRNA CTD PMID:27188386 panobinostat increases expression ISO RGD:1603370 6480464 panobinostat results in increased expression of SPSB4 mRNA CTD PMID:26272509 phenylmercury acetate increases expression ISO RGD:1603370 6480464 Phenylmercuric Acetate results in increased expression of SPSB4 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1603370 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPSB4 mRNA CTD PMID:27188386 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of SPSB4 mRNA CTD PMID:18301758 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of SPSB4 mRNA CTD PMID:20813756 more ... pirinixic acid multiple interactions EXP 6480464 PPARA protein affects the reaction [pirinixic acid results in decreased expression of SPSB4 mRNA] CTD PMID:21318169 potassium dichromate decreases expression EXP 6480464 Potassium Dichromate results in decreased expression of SPSB4 mRNA CTD PMID:23608068 resveratrol multiple interactions ISO RGD:1562307 6480464 [resveratrol co-treated with Streptozocin] results in increased expression of SPSB4 mRNA CTD PMID:25905778 SB 431542 multiple interactions ISO RGD:1603370 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of SPSB4 mRNA CTD PMID:23221170 streptozocin multiple interactions ISO RGD:1562307 6480464 [resveratrol co-treated with Streptozocin] results in increased expression of SPSB4 mRNA CTD PMID:25905778 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of SPSB4 mRNA CTD PMID:20937368 testosterone increases expression EXP 6480464 Testosterone results in increased expression of SPSB4 mRNA CTD PMID:21669218 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of SPSB4 mRNA CTD PMID:17484886 tetrachloromethane multiple interactions ISO RGD:1562307 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SPSB4 mRNA] CTD PMID:31150632 tetrachloromethane decreases expression ISO RGD:1562307 6480464 Carbon Tetrachloride results in decreased expression of SPSB4 mRNA CTD PMID:31150632 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of SPSB4 mRNA CTD PMID:27339419 thioacetamide increases expression ISO RGD:1562307 6480464 Thioacetamide results in increased expression of SPSB4 mRNA CTD PMID:23411599 trichloroethene increases methylation ISO RGD:1562307 6480464 Trichloroethylene results in increased methylation of SPSB4 gene CTD PMID:27618143 trichostatin A increases expression ISO RGD:1603370 6480464 trichostatin A results in increased expression of SPSB4 mRNA CTD PMID:26272509 trichostatin A multiple interactions ISO RGD:1603370 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPSB4 mRNA CTD PMID:27188386 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of SPSB4 mRNA CTD PMID:21427059 valproic acid multiple interactions ISO RGD:1603370 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPSB4 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:1603370 6480464 Valproic Acid results in increased expression of SPSB4 mRNA CTD PMID:23179753 more ... valproic acid decreases methylation ISO RGD:1603370 6480464 Valproic Acid results in decreased methylation of SPSB4 gene CTD PMID:29154799 vancomycin increases expression EXP 6480464 Vancomycin results in increased expression of SPSB4 mRNA CTD PMID:18930951 
Gene-Chemical Interaction Annotations
