| 68422 | Cldn1 | claudin 1 | ENCODES a protein that exhibits identical protein binding (ortholog); virus receptor activity (ortholog); INVOLVED IN cellular response to butyrate; cellular response to lead ion; cellular response to transforming growth factor beta stimulus; PARTICIPATES IN hepatitis C pathway; ASSOCIATED WITH alco hol-associated liver disease; Burns; Chronic Hepatitis C; FOUND IN apical plasma membrane; bicellular tight junction; lateral plasma membrane; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol | 11 | 87926376 | 87941533 | Rat | 457 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 68626 | CLDN1 | claudin 1 | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of cont inuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008] | 3 | 190305707 | 190322446 | Human | 494 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 68627 | Cldn1 | claudin 1 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene die soon after birth as a consequence of dehydration from trandermal water loss, indicating that this gene is indispensable for creating and maintaining the epidermal barrier. The protein encoded by this gene also has gastric tumor suppressive activity, and is a key factor for hepatitis C virus (HCV) entry. [provided by RefSeq, Aug 2010] | 16 | 26175395 | 26190589 | Mouse | 476 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 9016772 | Cldn1 | claudin 1 | ENCODES a protein that exhibits identical protein binding (ortholog); virus receptor activity (ortholog); INVOLVED IN bicellular tight junction assembly (ortholog); calcium-independent cell-cell adhesion (ortholog); cell junction maintenance (ortholog); ASSOCIATED WITH alcohol-associated liver disea se (ortholog); atopic dermatitis (ortholog); Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog) | NW_004955420 | 17798974 | 17815049 | Chinchilla | 94 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11707452 | CLDN1 | claudin 1 | ENCODES a protein that exhibits identical protein binding (inferred); structural molecule activity (inferred); virus receptor activity (inferred); INVOLVED IN cell-cell junction organization (ortholog); cellular response to butyrate (ortholog); cellular response to lead ion (ortholog); ASSOCIATED WI TH alcohol-associated liver disease (ortholog); atopic dermatitis (ortholog); Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); bicellular tight junction (ortholog); cell junction (ortholog) | 3 | 187328629 | 187345360 | Bonobo | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12182321 | CLDN1 | claudin 1 | ENCODES a protein that exhibits identical protein binding (inferred); structural molecule activity (inferred); virus receptor activity (inferred); INVOLVED IN cell-cell junction organization (ortholog); cellular response to butyrate (ortholog); cellular response to lead ion (ortholog); ASSOCIATED WI TH alcohol-associated liver disease (ortholog); atopic dermatitis (ortholog); Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); bicellular tight junction (ortholog); cell junction (ortholog); INTERACTS WITH all-trans-retinoic acid; bisphenol A | 34 | 22303058 | 22319101 | Dog | 105 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12693174 | Cldn1 | claudin 1 | ENCODES a protein that exhibits identical protein binding (inferred); structural molecule activity (inferred); virus receptor activity (inferred); INVOLVED IN cell-cell junction organization (ortholog); cellular response to butyrate (ortholog); cellular response to lead ion (ortholog); ASSOCIATED WI TH alcohol-associated liver disease (ortholog); atopic dermatitis (ortholog); Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); bicellular tight junction (ortholog); cell junction (ortholog) | NW_004936578 | 98489 | 113125 | Squirrel | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13948182 | CLDN1 | claudin 1 | ENCODES a protein that exhibits hydrolase activity (inferred); identical protein binding (inferred); structural molecule activity (inferred); INVOLVED IN cell-cell junction organization (ortholog); cellular response to butyrate (ortholog); cellular response to lead ion (ortholog); ASSOCIATED WITH al cohol-associated liver disease (ortholog); atopic dermatitis (ortholog); Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); bicellular tight junction (ortholog); cell junction (ortholog); INTERACTS WITH 3-acetyldeoxynivalenol; 4-phenylbutyric acid; benzo[a]pyrene | | | | Pig | 139 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18739478 | CLDN1 | claudin 1 | ENCODES a protein that exhibits identical protein binding (inferred); structural molecule activity (inferred); virus receptor activity (inferred); INVOLVED IN cell-cell junction organization (ortholog); cellular response to butyrate (ortholog); cellular response to lead ion (ortholog); ASSOCIATED WI TH alcohol-associated liver disease (ortholog); atopic dermatitis (ortholog); Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); bicellular tight junction (ortholog); cell junction (ortholog) | | | | Green Monkey | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18933915 | Cldn1 | claudin 1 | ENCODES a protein that exhibits identical protein binding (inferred); structural molecule activity (inferred); virus receptor activity (inferred); INVOLVED IN cell-cell junction organization (ortholog); cellular response to butyrate (ortholog); cellular response to lead ion (ortholog); ASSOCIATED WI TH alcohol-associated liver disease (ortholog); atopic dermatitis (ortholog); Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); bicellular tight junction (ortholog); cell junction (ortholog) | | | | Naked Mole-Rat | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244096 | cldn1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626164317 | Cldn1 | claudin 1 | ENCODES a protein that exhibits identical protein binding (ortholog); virus receptor activity (ortholog); INVOLVED IN bicellular tight junction assembly (ortholog); calcium-independent cell-cell adhesion (ortholog); cell junction maintenance (ortholog); ASSOCIATED WITH alcohol-associated liver disea se (ortholog); atopic dermatitis (ortholog); Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog) | | | | Black Rat | 94 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235159 | cldn1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155244095 | cldn1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1317559 | Cldn10 | claudin 10 | This intronless gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight unction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endot helial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Six alternatively spliced transcript variants have been identified, which encode different isoforms with distinct electric charge of the first extracellular loop and with or without the fourth transmembrane region. These isoforms exhibit distinct localization and function in paracellular anion or cation permeability. [provided by RefSeq, Aug 2010] | 14 | 119025283 | 119111937 | Mouse | 131 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1308027 | Cldn10 | claudin 10 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); INVOLVED IN paracellular transport (ortholog); regulation of monoatomic ion transport (ortholog); PARTICIPATES IN hepatitis C pathway; ASSOCIATED WITH genetic disease (ortho log); HELIX syndrome (ortholog); hypokalemia (ortholog); FOUND IN bicellular tight junction (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine | 15 | 102269858 | 102361589 | Rat | 122 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1317558 | CLDN10 | claudin 10 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010] | 13 | 95433755 | 95579759 | Human | 131 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9005810 | Cldn10 | claudin 10 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); INVOLVED IN paracellular transport (ortholog); regulation of monoatomic ion transport (ortholog); ASSOCIATED WITH genetic disease (ortholog); HELIX syndrome (ortholog); hypo kalemia (ortholog); FOUND IN bicellular tight junction (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog) | NW_004955404 | 14483217 | 14597912 | Chinchilla | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11923660 | CLDN10 | claudin 10 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); INVOLVED IN paracellular transport (ortholog); ASSOCIATED WITH genetic disease (ortholog); HELIX syndrome (ortholog); hypokalemia (ortholog); FOUND IN endoplasmic reticulum (ortholog); tight junction (ortholog) | 13 | 76728572 | 76755685 | Bonobo | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12374840 | CLDN10 | claudin 10 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN regulation of monoatomic ion transport (inferred); ASSOCIATED WITH genetic disease (ortholog); HELIX syndrome (ortholog); hypokalemia (ortholog); FOUND IN endoplasmic reticulum (ortholog); tight junction (ortholog) | 22 | 46098671 | 46225239 | Dog | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12631582 | Cldn10 | claudin 10 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); INVOLVED IN paracellular transport (ortholog); ASSOCIATED WITH genetic disease (ortholog); HELIX syndrome (ortholog); hypokalemia (ortholog); FOUND IN endoplasmic reticulum (ortholog); tight junction (ortholog) | NW_004936472 | 14205311 | 14308932 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13849560 | CLDN10 | claudin 10 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN regulation of monoatomic ion transport (inferred); ASSOCIATED WITH genetic disease (ortholog); HELIX syndrome (ortholog); hypokalemia (ortholog); FOUND IN endoplasmic reticulum (ortholog); tight junction (ortholog); IN TERACTS WITH deoxynivalenol | | | | Pig | 27 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18576014 | CLDN10 | claudin 10 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); INVOLVED IN paracellular transport (ortholog); ASSOCIATED WITH genetic disease (ortholog); HELIX syndrome (ortholog); hypokalemia (ortholog); FOUND IN endoplasmic reticulum (ortholog); tight junction (ortholog) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18918620 | Cldn10 | claudin 10 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); INVOLVED IN paracellular transport (ortholog); ASSOCIATED WITH genetic disease (ortholog); HELIX syndrome (ortholog); hypokalemia (ortholog); FOUND IN endoplasmic reticulum (ortholog); tight junction (ortholog) | | | | Naked Mole-Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 287732233 | cldn10 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625871844 | Cldn10 | claudin 10 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); INVOLVED IN paracellular transport (ortholog); regulation of monoatomic ion transport (ortholog); ASSOCIATED WITH genetic disease (ortholog); HELIX syndrome (ortholog); hypo kalemia (ortholog); FOUND IN bicellular tight junction (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog) | | | | Black Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 71081 | Cldn11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon ensheathment (ortholog); calcium-independent cell-cell adhesion (ortholog); cell adhesion (ortholog); PARTICIPATES IN hepatitis C pathway; ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodys trophy 22 (ortholog); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (ortholog); basal part of cell (ortholog); bicellular tight junction (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 2 | 114136234 | 114149539 | Rat | 202 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732844 | CLDN11 | claudin 11 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010] | 3 | 170418868 | 170434691 | Human | 213 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737604 | Cldn11 | claudin 11 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of CNS (central nervous system) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. The basal cell tight junctions in stria vascularis are primarily composed of this protein, and the gene-null mice suffer severe deafness. This protein is also an obligatory protein for tight junction formation and barrier integrity in the testis and the gene deficiency results in loss of the Sertoli cell epithelial phenotype in the testis. [provided by RefSeq, Aug 2010] | 3 | 31204069 | 31218475 | Mouse | 229 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8802328 | Cldn11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (ortholog); basal part of cell (ortholog); bicellular tight junction (ortholog) | NW_004955420 | 580588 | 595052 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11886845 | CLDN11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (inferred); structural molecule activity (inferred); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog ); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (inferred); basal part of cell (inferred); bicellular tight junction (inferred) | 3 | 167432856 | 167448053 | Bonobo | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12398087 | CLDN11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (ortholog); basal part of cell (ortholog); cell junction (ortholog) | 34 | 34912903 | 34929441 | Dog | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12732055 | Cldn11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (inferred); structural molecule activity (inferred); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog ); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (inferred); basal part of cell (inferred); bicellular tight junction (inferred) | NW_004936593 | 2072368 | 2087820 | Squirrel | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14091010 | CLDN11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (inferred); structural molecule activity (inferred); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog ); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (inferred); basal part of cell (inferred); bicellular tight junction (inferred) | | | | Pig | 35 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18692543 | CLDN11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (inferred); structural molecule activity (inferred); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog ); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (inferred); basal part of cell (inferred); bicellular tight junction (inferred) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18931671 | Cldn11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (ortholog); basal part of cell (ortholog); cell junction (ortholog) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257640 | cldn11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626084890 | Cldn11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (ortholog); basal part of cell (ortholog); bicellular tight junction (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1314174 | CLDN12 | claudin 12 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011] | 7 | 90403461 | 90415954 | Human | 92 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1314175 | Cldn12 | claudin 12 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene, along with several other family members, is expressed in the inner ear. The protein encoded by this gene and another family member, claudin 2, are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found. [provided by RefSeq, Oct 2011] | 5 | 5555109 | 5564953 | Mouse | 131 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1561053 | Cldn12 | claudin 12 | INVOLVED IN tight junction assembly (ortholog); FOUND IN cell periphery (ortholog); lateral plasma membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A | 4 | 29477468 | 29488465 | Rat | 86 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8950289 | Cldn12 | claudin 12 | INVOLVED IN tight junction assembly (ortholog); FOUND IN cell periphery (ortholog); lateral plasma membrane (ortholog); plasma membrane (ortholog) | NW_004955432 | 7632382 | 7640024 | Chinchilla | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11774880 | CLDN12 | claudin 12 | INVOLVED IN tight junction assembly (ortholog); FOUND IN cell periphery (ortholog); lateral plasma membrane (ortholog); plasma membrane (ortholog) | 7 | 82417687 | 82430167 | Bonobo | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12398239 | CLDN12 | claudin 12 | INVOLVED IN tight junction assembly (ortholog); FOUND IN bicellular tight junction (inferred); cell periphery (inferred); lateral plasma membrane (inferred) | 14 | 16286030 | 16296649 | Dog | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12637836 | Cldn12 | claudin 12 | INVOLVED IN tight junction assembly (ortholog); FOUND IN bicellular tight junction (inferred); cell periphery (inferred); lateral plasma membrane (inferred) | NW_004936621 | 3643518 | 3652899 | Squirrel | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14205402 | CLDN12 | claudin 12 | INVOLVED IN tight junction assembly (ortholog); FOUND IN cell periphery (ortholog); lateral plasma membrane (ortholog); tight junction (ortholog) | | | | Pig | 8 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18373246 | CLDN12 | claudin 12 | INVOLVED IN tight junction assembly (ortholog); FOUND IN bicellular tight junction (inferred); cell periphery (inferred); lateral plasma membrane (inferred) | | | | Green Monkey | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18916030 | Cldn12 | claudin 12 | INVOLVED IN tight junction assembly (ortholog); FOUND IN bicellular tight junction (inferred); cell periphery (inferred); lateral plasma membrane (inferred) | | | | Naked Mole-Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238897 | cldn12 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626099735 | Cldn12 | claudin 12 | INVOLVED IN tight junction assembly (ortholog); FOUND IN cell periphery (ortholog); lateral plasma membrane (ortholog); plasma membrane (ortholog) | | | | Black Rat | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1624020 | Cldn13 | claudin 13 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a developmentally expressed renal tight junction protein. This gene is expressed in the cecum, colon, liver and kidney of mice, but is not identified in rat tissues. Humans and chimpanzees lack this gene. [provided by RefSeq, Aug 2010] | 5 | 134943104 | 134944384 | Mouse | 38 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1309165 | Cldn14 | claudin 14 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN response to ethanol (inferred); PARTICIPATES IN hepatitis C pathway; ASSOCIATED WITH Acidoses; autosomal recessive nonsyndromic deafness 29 (ortholog); Deafness (ortholog); FOUND IN bicellular tight junction (orthol og); plasma membrane (ortholog); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acetamide | 11 | 46701940 | 46799049 | Rat | 105 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319353 | CLDN14 | claudin 14 | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of cont inuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010] | 21 | 36460621 | 36576569 | Human | 109 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1319354 | Cldn14 | claudin 14 | This gene encodes a member of the claudin family of tight junction proteins. The encoded protein is an integral membrane protein that may function in maintaining apical membrane polarization in tight junctions located between outer hair cells and supporting cells. Loss of function of this gene is as sociated with hearing problems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] | 16 | 93715919 | 93809733 | Mouse | 110 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8876498 | Cldn14 | claudin 14 | ASSOCIATED WITH Acidoses (ortholog); autosomal recessive nonsyndromic deafness 29 (ortholog); Deafness (ortholog); FOUND IN bicellular tight junction (ortholog); plasma membrane (ortholog) | NW_004955407 | 35641560 | 35728105 | Chinchilla | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11852122 | CLDN14 | claudin 14 | ENCODES a protein that exhibits structural molecule activity (inferred); ASSOCIATED WITH Acidoses (ortholog); autosomal recessive nonsyndromic deafness 29 (ortholog); Deafness (ortholog); FOUND IN bicellular tight junction (inferred); membrane (inferred); plasma membrane (inferred) | 21 | 22830770 | 22946594 | Bonobo | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12251923 | CLDN14 | claudin 14 | ENCODES a protein that exhibits structural molecule activity (inferred); ASSOCIATED WITH Acidoses (ortholog); autosomal recessive nonsyndromic deafness 29 (ortholog); Deafness (ortholog); FOUND IN bicellular tight junction (inferred); membrane (inferred); plasma membrane (inferred) | 31 | 31677410 | 31725794 | Dog | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12679728 | Cldn14 | claudin 14 | ENCODES a protein that exhibits structural molecule activity (inferred); ASSOCIATED WITH Acidoses (ortholog); autosomal recessive nonsyndromic deafness 29 (ortholog); Deafness (ortholog); FOUND IN bicellular tight junction (inferred); membrane (inferred); plasma membrane (inferred) | NW_004936500 | 6207856 | 6227582 | Squirrel | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13940257 | CLDN14 | claudin 14 | ENCODES a protein that exhibits structural molecule activity (inferred); ASSOCIATED WITH Acidoses (ortholog); autosomal recessive nonsyndromic deafness 29 (ortholog); Deafness (ortholog); FOUND IN bicellular tight junction (inferred); membrane (inferred); plasma membrane (inferred) | | | | Pig | 19 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18752657 | CLDN14 | claudin 14 | ENCODES a protein that exhibits structural molecule activity (inferred); ASSOCIATED WITH Acidoses (ortholog); autosomal recessive nonsyndromic deafness 29 (ortholog); Deafness (ortholog); FOUND IN bicellular tight junction (inferred); membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18926257 | Cldn14 | claudin 14 | ENCODES a protein that exhibits structural molecule activity (inferred); ASSOCIATED WITH Acidoses (ortholog); autosomal recessive nonsyndromic deafness 29 (ortholog); Deafness (ortholog); FOUND IN bicellular tight junction (inferred); membrane (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247013 | cldn14 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625864165 | Cldn14 | claudin 14 | ASSOCIATED WITH Acidoses (ortholog); autosomal recessive nonsyndromic deafness 29 (ortholog); Deafness (ortholog); FOUND IN bicellular tight junction (ortholog); plasma membrane (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1310678 | Cldn15 | claudin 15 | ENCODES a protein that exhibits paracellular tight junction channel activity (ortholog); INVOLVED IN paracellular transport (ortholog); regulation of intestinal D-glucose absorption (ortholog); regulation of intestinal lipid absorption (ortholog); PARTICIPATES IN hepatitis C pathway; ASSOCIATED WITH malignant mesothelioma (ortholog); FOUND IN lateral plasma membrane (ortholog); tight junction (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol | 12 | 25334849 | 25345104 | Rat | 97 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1321720 | CLDN15 | claudin 15 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010] | 7 | 101232094 | 101238820 | Human | 89 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1321721 | Cldn15 | claudin 15 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein increases permeability for sodium ions in anion-selective epithelial cell sheets. The gene deficiency leads to megaintestine and decreases in intestinal epithelial paracellular ion permeability. This gene is a direct target for hepatocyte-nuclear-factor-4alpha, a mediator of ion epithelial transport, and is down-modulated in inflammatory bowel disease. [provided by RefSeq, Aug 2010] | 5 | 136996723 | 137004699 | Mouse | 102 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8943424 | Cldn15 | claudin 15 | ENCODES a protein that exhibits paracellular tight junction channel activity (ortholog); INVOLVED IN paracellular transport (ortholog); regulation of intestinal D-glucose absorption (ortholog); regulation of intestinal lipid absorption (ortholog); ASSOCIATED WITH malignant mesothelioma (ortholog); F OUND IN lateral plasma membrane (ortholog); tight junction (ortholog) | NW_004955456 | 16062044 | 16067612 | Chinchilla | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11944413 | CLDN15 | claudin 15 | ENCODES a protein that exhibits paracellular tight junction channel activity (inferred); structural molecule activity (inferred); INVOLVED IN paracellular transport (inferred); regulation of intestinal D-glucose absorption (inferred); regulation of intestinal lipid absorption (inferred); ASSOCIATED WITH malignant mesothelioma (ortholog); FOUND IN bicellular tight junction (inferred); lateral plasma membrane (inferred); membrane (inferred) | 7 | 93373450 | 93380912 | Bonobo | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12279014 | CLDN15 | claudin 15 | ENCODES a protein that exhibits paracellular tight junction channel activity (inferred); structural molecule activity (inferred); INVOLVED IN paracellular transport (inferred); regulation of intestinal D-glucose absorption (inferred); regulation of intestinal lipid absorption (inferred); ASSOCIATED WITH malignant mesothelioma (ortholog); FOUND IN bicellular tight junction (inferred); lateral plasma membrane (inferred); membrane (inferred) | 6 | 8647372 | 8651869 | Dog | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12656771 | Cldn15 | claudin 15 | ENCODES a protein that exhibits paracellular tight junction channel activity (inferred); structural molecule activity (inferred); INVOLVED IN paracellular transport (inferred); regulation of intestinal D-glucose absorption (inferred); regulation of intestinal lipid absorption (inferred); ASSOCIATED WITH malignant mesothelioma (ortholog); FOUND IN bicellular tight junction (inferred); lateral plasma membrane (inferred); membrane (inferred) | NW_004936543 | 1106846 | 1112669 | Squirrel | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13874669 | CLDN15 | claudin 15 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN regulation of intestinal D-glucose absorption (ortholog); regulation of intestinal lipid absorption (ortholog); ASSOCIATED WITH malignant mesothelioma (ortholog); FOUND IN lateral plasma membrane (ortholog); tight j unction (ortholog) | | | | Pig | 18 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18343034 | CLDN15 | claudin 15 | ENCODES a protein that exhibits paracellular tight junction channel activity (inferred); structural molecule activity (inferred); INVOLVED IN paracellular transport (inferred); regulation of intestinal D-glucose absorption (inferred); regulation of intestinal lipid absorption (inferred); ASSOCIATED WITH malignant mesothelioma (ortholog); FOUND IN bicellular tight junction (inferred); lateral plasma membrane (inferred); membrane (inferred) | | | | Green Monkey | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18915651 | Cldn15 | claudin 15 | ENCODES a protein that exhibits paracellular tight junction channel activity (inferred); structural molecule activity (inferred); INVOLVED IN paracellular transport (inferred); regulation of intestinal D-glucose absorption (inferred); regulation of intestinal lipid absorption (inferred); ASSOCIATED WITH malignant mesothelioma (ortholog); FOUND IN bicellular tight junction (inferred); lateral plasma membrane (inferred); membrane (inferred) | | | | Naked Mole-Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625909049 | Cldn15 | claudin 15 | ENCODES a protein that exhibits paracellular tight junction channel activity (ortholog); INVOLVED IN paracellular transport (ortholog); regulation of intestinal D-glucose absorption (ortholog); regulation of intestinal lipid absorption (ortholog); ASSOCIATED WITH malignant mesothelioma (ortholog); F OUND IN lateral plasma membrane (ortholog); tight junction (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 620322 | Cldn16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); PDZ domain binding (ortholog); INVOLVED IN paracellular transport; positive regulation of calcium ion transport; transepithelial transport; PARTICIPATES IN hepatitis C pathw ay; ASSOCIATED WITH hypertension; genetic disease (ortholog); Hypercalciuria (ortholog); FOUND IN bicellular tight junction; tight junction (ortholog); INTERACTS WITH bisphenol A; tributylstannane; vinclozolin | 11 | 87795106 | 87814396 | Rat | 85 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 733040 | Cldn16 | claudin 16 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is critical for renal paracellular epithelial transport of Ca(2+) and Mg(2+) in the thick ascending loop of Henle. The gene deficiency leads to specific alterations in renal Ca(2+) and Mg(2+) balance and also to disturbances in Na(+) handling. The interaction of this gene and the Cldn 19 gene is required for their assembly into tight junctions and for renal Mg(2+) reabsorption. This gene and the Cldn1 gene are clustered on chromosome 16. [provided by RefSeq, Aug 2010] | 16 | 26281885 | 26301515 | Mouse | 92 | symbol , PhenoGen , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1351544 | CLDN16 | claudin 16 | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of cont inuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. [provided by RefSeq, Jun 2010] | 3 | 190290361 | 190412138 | Human | 165 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8896979 | Cldn16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); PDZ domain binding (ortholog); INVOLVED IN paracellular transport (ortholog); positive regulation of calcium ion transport (ortholog); renal absorption (ortholog); ASSOCIATE D WITH genetic disease (ortholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog); tight junction (ortholog) | NW_004955420 | 17684752 | 17714639 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11668443 | CLDN16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); PDZ domain binding (ortholog); INVOLVED IN positive regulation of calcium ion transport (ortholog); transepithelial transport (ortholog); ASSOCIATED WITH genetic disease (or tholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog) | 3 | 187141710 | 187436909 | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12239235 | CLDN16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (inferred); paracellular tight junction channel activity (inferred); PDZ domain binding (inferred); INVOLVED IN positive regulation of calcium ion transport (ortholog); transepithelial transport (ortholog); ASSOCIATED WITH genetic disease (or tholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog) | 34 | 22392108 | 22414250 | Dog | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12507243 | Cldn16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (inferred); paracellular tight junction channel activity (inferred); PDZ domain binding (inferred); INVOLVED IN positive regulation of calcium ion transport (ortholog); transepithelial transport (ortholog); ASSOCIATED WITH genetic disease (or tholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog) | NW_004936578 | 5774 | 25621 | Squirrel | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14070464 | CLDN16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (inferred); paracellular tight junction channel activity (inferred); PDZ domain binding (inferred); INVOLVED IN positive regulation of calcium ion transport (ortholog); transepithelial transport (ortholog); ASSOCIATED WITH genetic disease (or tholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog) | | | | Pig | 38 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18406474 | CLDN16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (inferred); paracellular tight junction channel activity (inferred); PDZ domain binding (inferred); INVOLVED IN positive regulation of calcium ion transport (ortholog); transepithelial transport (ortholog); ASSOCIATED WITH genetic disease (or tholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog) | | | | Green Monkey | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934713 | Cldn16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); PDZ domain binding (ortholog); INVOLVED IN positive regulation of calcium ion transport (ortholog); renal absorption (ortholog); transepithelial transport (ortholog); ASSOCI ATED WITH genetic disease (ortholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog); tight junction (ortholog) | | | | Naked Mole-Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245840 | cldn16 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626019446 | Cldn16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); PDZ domain binding (ortholog); INVOLVED IN paracellular transport (ortholog); positive regulation of calcium ion transport (ortholog); renal absorption (ortholog); ASSOCIATE D WITH genetic disease (ortholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog); tight junction (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1307462 | Cldn17 | claudin 17 | ENCODES a protein that exhibits channel activity (ortholog); paracellular tight junction channel activity (ortholog); INVOLVED IN cellular respiration (ortholog); gene expression (ortholog); inflammatory response (ortholog); PARTICIPATES IN hepatitis C pathway; FOUND IN plasma membrane (ortholog); t ight junction (ortholog); INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; cadmium dichloride | 11 | 41313675 | 41314851 | Rat | 36 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1316669 | CLDN17 | claudin 17 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010] | 21 | 30165565 | 30166805 | Human | 55 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1316670 | Cldn17 | claudin 17 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with the Cldn8 gene on chromosome 16. [provided by RefSeq, Aug 2010] | 16 | 88302695 | 88303866 | Mouse | 78 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 9013733 | Cldn17 | claudin 17 | ENCODES a protein that exhibits channel activity (ortholog); paracellular tight junction channel activity (ortholog); INVOLVED IN cellular respiration (ortholog); gene expression (ortholog); inflammatory response (ortholog); FOUND IN plasma membrane (ortholog); tight junction (ortholog) | NW_004955407 | 29519400 | 29520625 | Chinchilla | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11778402 | CLDN17 | claudin 17 | ENCODES a protein that exhibits channel activity (inferred); paracellular tight junction channel activity (inferred); structural molecule activity (inferred); INVOLVED IN cellular respiration (ortholog); gene expression (ortholog); inflammatory response (ortholog); FOUND IN bicellular tight junction (inferred); membrane (inferred); plasma membrane (inferred) | 21 | 16585223 | 16586444 | Bonobo | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12359975 | CLDN17 | claudin 17 | ENCODES a protein that exhibits channel activity (inferred); paracellular tight junction channel activity (inferred); structural molecule activity (inferred); INVOLVED IN cellular respiration (ortholog); gene expression (ortholog); inflammatory response (ortholog); FOUND IN bicellular tight junction (inferred); membrane (inferred); plasma membrane (inferred) | 31 | 25040700 | 25042210 | Dog | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12690821 | Cldn17 | claudin 17 | ENCODES a protein that exhibits channel activity (inferred); paracellular tight junction channel activity (inferred); structural molecule activity (inferred); INVOLVED IN cellular respiration (ortholog); gene expression (ortholog); inflammatory response (ortholog); FOUND IN bicellular tight junction (inferred); membrane (inferred); plasma membrane (inferred) | NW_004936500 | 11951381 | 11952076 | Squirrel | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13926901 | CLDN17 | claudin 17 | ENCODES a protein that exhibits paracellular tight junction channel activity (ortholog); INVOLVED IN cellular respiration (ortholog); gene expression (ortholog); inflammatory response (ortholog); FOUND IN tight junction (ortholog) | | | | Pig | 35 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18476429 | CLDN17 | claudin 17 | ENCODES a protein that exhibits channel activity (inferred); paracellular tight junction channel activity (inferred); structural molecule activity (inferred); INVOLVED IN cellular respiration (ortholog); gene expression (ortholog); inflammatory response (ortholog); FOUND IN bicellular tight junction (inferred); membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18935023 | Cldn17 | claudin 17 | ENCODES a protein that exhibits channel activity (inferred); paracellular tight junction channel activity (inferred); structural molecule activity (inferred); INVOLVED IN cellular respiration (ortholog); gene expression (ortholog); inflammatory response (ortholog); FOUND IN bicellular tight junction (inferred); membrane (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 598277094 | cldn17 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626063132 | Cldn17 | claudin 17 | ENCODES a protein that exhibits channel activity (ortholog); paracellular tight junction channel activity (ortholog); INVOLVED IN cellular respiration (ortholog); gene expression (ortholog); inflammatory response (ortholog); FOUND IN plasma membrane (ortholog); tight junction (ortholog) | | | | Black Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1351425 | CLDN18 | claudin 18 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010] | 3 | 137998816 | 138033649 | Human | 91 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1359696 | Cldn18 | claudin 18 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN response to ethanol; cellular response to estrogen stimulus (ortholog); digestive tract development (ortholog); PARTICIPATES IN hepatitis C pathway; ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN cell-cell junction (ortholog); plasma membrane (ortholog); tight junction (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A | 8 | 109125819 | 109145110 | Rat | 86 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1552402 | Cldn18 | claudin 18 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is a downstream target gene regulated by the T/EBP/NKX2.1 homeodomain transcription factor. Four alternatively spliced transcript variants resulted from alternative promoters and alternative splicing have been identified, which encode two lung-specific isoforms and two stomach-specific isoforms respectively. This gene is also expressed in colons, inner ear and skin, and its expression is increased in both experimental colitis and ulcerative colitis. [provided by RefSeq, Aug 2010] | 9 | 99572849 | 99599320 | Mouse | 106 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8849903 | Cldn18 | claudin 18 | INVOLVED IN cellular response to estrogen stimulus (ortholog); digestive tract development (ortholog); epithelial cell proliferation (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN cell-cell junction (ortholog); plasma membrane (ortholog); tight junction (ortholog) | NW_004955501 | 962188 | 991922 | Chinchilla | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12037168 | CLDN18 | claudin 18 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN digestive tract development (ortholog); negative regulation of bone resorption (ortholog); negative regulation of osteoclast development (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred); membrane (inferred) | 3 | 135037555 | 135061105 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12260633 | CLDN18 | claudin 18 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN digestive tract development (ortholog); negative regulation of bone resorption (ortholog); negative regulation of osteoclast development (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred); membrane (inferred) | 23 | 34229115 | 34257431 | Dog | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12688411 | Cldn18 | claudin 18 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN digestive tract development (ortholog); negative regulation of bone resorption (ortholog); negative regulation of osteoclast development (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred); membrane (inferred) | NW_004936540 | 373889 | 401535 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13932853 | CLDN18 | claudin 18 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN digestive tract development (ortholog); negative regulation of bone resorption (ortholog); negative regulation of osteoclast development (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred); membrane (inferred) | | | | Pig | 34 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18625946 | CLDN18 | claudin 18 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN digestive tract development (ortholog); negative regulation of bone resorption (ortholog); negative regulation of osteoclast development (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred); membrane (inferred) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18910727 | Cldn18 | claudin 18 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN digestive tract development (ortholog); negative regulation of bone resorption (ortholog); negative regulation of osteoclast development (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred); membrane (inferred) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255233 | cldn18 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626015042 | Cldn18 | claudin 18 | INVOLVED IN cellular response to estrogen stimulus (ortholog); digestive tract development (ortholog); epithelial cell proliferation (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN cell-cell junction (ortholog); plasma membrane (ortholog); tight junction (ortholog) | | | | Black Rat | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1305000 | Cldn19 | claudin 19 | ENCODES a protein that exhibits cell-cell adhesion mediator activity (ortholog); identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); apical junction assembly (ortholog); cell junction assembly (ortholo g); PARTICIPATES IN hepatitis C pathway; ASSOCIATED WITH genetic disease (ortholog); nephrocalcinosis (ortholog); renal hypomagnesemia 3 (ortholog); FOUND IN apical junction complex (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; copper atom | 5 | 138148234 | 138155672 | Rat | 128 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1312766 | CLDN19 | claudin 19 | The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010] | 1 | 42733093 | 42740236 | Human | 144 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1312767 | Cldn19 | claudin 19 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. siRNA knockdown of this gene in mice develops the FHHNC (familial hypomagnesemia with hypercalciuria and nephrocalcinosis) symptoms of chronic renal wasting of magnesium and calcium together with defective renal salt handling. The protein encoded by this gene interacts with another family member, Claudin 16, and their interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. This protein is a constituent of tight junctions in the Schwann cells of peripheral myelinated nerves and the gene deficiency affects the nerve conduction of peripheral myelinated fibers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010] | 4 | 119112638 | 119119635 | Mouse | 122 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8880653 | Cldn19 | claudin 19 | ENCODES a protein that exhibits cell-cell adhesion mediator activity (ortholog); identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); apical junction assembly (ortholog); cell junction assembly (ortholo g); ASSOCIATED WITH genetic disease (ortholog); nephrocalcinosis (ortholog); renal hypomagnesemia 3 (ortholog); FOUND IN apical junction complex (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog) | NW_004955537 | 2265711 | 2271096 | Chinchilla | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11797476 | CLDN19 | claudin 19 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN apical junction assembly (ortholog); neuronal action potential propagation (ortholog); tight junction organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); nephrocalcinosis (ortholog); renal hypomagnesem ia 3 (ortholog); FOUND IN apical junction complex (inferred); basolateral plasma membrane (inferred); bicellular tight junction (inferred) | 1 | 42032999 | 42040006 | Bonobo | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12383874 | CLDN19 | claudin 19 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN apical junction assembly (ortholog); neuronal action potential propagation (ortholog); tight junction organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); nephrocalcinosis (ortholog); renal hypomagnesem ia 3 (ortholog); FOUND IN apical junction complex (inferred); basolateral plasma membrane (inferred); bicellular tight junction (inferred) | 15 | 626721 | 631643 | Dog | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12711103 | Cldn19 | claudin 19 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN apical junction assembly (ortholog); neuronal action potential propagation (ortholog); tight junction organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); nephrocalcinosis (ortholog); renal hypomagnesem ia 3 (ortholog); FOUND IN apical junction complex (inferred); basolateral plasma membrane (inferred); bicellular tight junction (inferred) | NW_004936474 | 24067009 | 24070838 | Squirrel | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14101637 | CLDN19 | claudin 19 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN apical junction assembly (ortholog); neuronal action potential propagation (ortholog); tight junction organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); nephrocalcinosis (ortholog); renal hypomagnesem ia 3 (ortholog); FOUND IN apical junction complex (inferred); basolateral plasma membrane (inferred); bicellular tight junction (inferred) | | | | Pig | 57 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18752833 | CLDN19 | claudin 19 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN apical junction assembly (ortholog); neuronal action potential propagation (ortholog); tight junction organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); nephrocalcinosis (ortholog); renal hypomagnesem ia 3 (ortholog); FOUND IN apical junction complex (inferred); basolateral plasma membrane (inferred); bicellular tight junction (inferred) | | | | Green Monkey | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18933682 | Cldn19 | claudin 19 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN apical junction assembly (ortholog); neuronal action potential propagation (ortholog); tight junction organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); nephrocalcinosis (ortholog); renal hypomagnesem ia 3 (ortholog); FOUND IN apical junction complex (inferred); basolateral plasma membrane (inferred); bicellular tight junction (inferred) | | | | Naked Mole-Rat | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20865691 | CLDN19 | claudin 19 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 155233715 | cldn19 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625905915 | Cldn19 | claudin 19 | ENCODES a protein that exhibits cell-cell adhesion mediator activity (ortholog); identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); apical junction assembly (ortholog); cell junction assembly (ortholo g); ASSOCIATED WITH genetic disease (ortholog); nephrocalcinosis (ortholog); renal hypomagnesemia 3 (ortholog); FOUND IN apical junction complex (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog) | | | | Black Rat | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 287731823 | cldn10.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859140 | cldn11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860492 | cldn11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863137 | cldn11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864940 | cldn11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626469340 | cldn11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856018 | cldn11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858841 | cldn11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860729 | cldn11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865344 | cldn11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626176647 | cldn11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626181371 | cldn11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626185114 | cldn11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155238896 | cldn12.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155248641 | cldn12.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155245882 | cldn14.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155247012 | cldn14.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155257671 | cldn15.1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155250612 | cldn15.2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405859161 | cldn16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859916 | cldn16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863667 | cldn16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865601 | cldn16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626467916 | cldn16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 598151892 | cldn17.3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 598153690 | cldn17.3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 598153938 | cldn17.3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155251411 | cldn18.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259775 | cldn18.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155254775 | cldn19.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249889 | cldn19.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6481149 | CLDN10-AS1 | CLDN10 antisense RNA 1 | | 13 | 95479444 | 95533910 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 38637361 | CLDN14-AS1 | CLDN14 antisense RNA 1 | | 21 | 36430325 | 36498526 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 155250335 | cldn15.1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259741 | cldn15.1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155250613 | cldn15.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626173565 | cldn15.2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1305878 | Gtpbp10 | GTP binding protein 10 | ENCODES a protein that exhibits mitochondrial large ribosomal subunit binding (ortholog); rRNA binding (ortholog); INVOLVED IN mitochondrial large ribosomal subunit assembly (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxi ne; 3-chloropropane-1,2-diol; bisphenol A | 4 | 29431683 | 29449201 | Rat | 59 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 155791660 | LNCTSI | lncRNA TGF-beta/SMAD3 pathway interacting | | | | | Human | | old_gene_symbol | gene, ncrna |
| 16566467 | AC016252.1 | novel transcript, antisense to CLDN18 | | | | | Human | | name | gene, lncrna |
| 1558320 | Cldn2 | claudin 2 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene display normal appearance, activity, growth and behavior, but are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. The proteins encoded by this gene and another family member Cldn12 are also critical for vitamin D-dependent Ca2+ absorption between enterocytes. [provided by RefSeq, Aug 2010] | X | 138701552 | 138712135 | Mouse | 232 | description | gene, protein-coding, REVIEWED [RefSeq] |
