Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CLDN1 (claudin 1) Homo sapiens
Analyze
Symbol: CLDN1
Name: claudin 1
Description: Exhibits identical protein binding activity and virus receptor activity. Involved in several processes, including bicellular tight junction assembly; establishment of skin barrier; and positive regulation of epithelial cell proliferation involved in wound healing. Localizes to several cellular components, including basolateral plasma membrane; bicellular tight junction; and integral component of plasma membrane. Implicated in Crohn's disease and atopic dermatitis. Biomarker of atopic dermatitis and irritable bowel syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: claudin-1; CLD1; ILVASC; SEMP1; senescence-associated epithelial membrane protein 1
Orthologs:
Mus musculus (house mouse) : Cldn1 (claudin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cldn1 (claudin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cldn1 (claudin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CLDN1 (claudin 1)
Canis lupus familiaris (dog) : CLDN1 (claudin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cldn1 (claudin 1)
Sus scrofa (pig) : CLDN1 (claudin 1)
Chlorocebus sabaeus (African green monkey) : CLDN1 (claudin 1)
Heterocephalus glaber (naked mole-rat) : Cldn1 (claudin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl3190,305,707 - 190,322,446 (-)EnsemblGRCh38hg38GRCh38
GRCh383190,305,707 - 190,322,446 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373190,023,490 - 190,040,235 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363191,506,187 - 191,522,909 (-)NCBINCBI36hg18NCBI36
Build 343191,506,195 - 191,522,917NCBI
Celera3188,453,968 - 188,470,713 (-)NCBI
Cytogenetic Map3q28NCBI
HuRef3187,423,222 - 187,439,968 (-)NCBIHuRef
CHM1_13189,986,455 - 190,003,201 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CLDN1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68626
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.