Gtpbp10 (GTP binding protein 10) - Rat Genome Database

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Gene: Gtpbp10 (GTP binding protein 10) Rattus norvegicus
Analyze
Symbol: Gtpbp10
Name: GTP binding protein 10
RGD ID: 1305878
Description: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in ribosome biogenesis. Predicted to be active in mitochondrion. Orthologous to human GTPBP10 (GTP binding protein 10); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: claudin 12; Cldn12; GTP-binding protein 10; GTP-binding protein 10 (putative); LOC312054
RGD Orthologs
Human
Mouse
Dog
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8429,431,683 - 29,449,201 (+)NCBIGRCr8
mRatBN7.2428,476,857 - 28,494,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl428,476,857 - 28,494,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx433,447,999 - 33,465,505 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0429,374,088 - 29,391,594 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0427,771,777 - 27,789,296 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0425,635,765 - 25,653,283 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl425,635,765 - 25,653,283 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0425,542,933 - 25,560,451 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4425,162,478 - 25,179,996 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1425,145,010 - 25,180,773 (+)NCBI
Celera423,921,450 - 23,938,968 (+)NCBICelera
Cytogenetic Map4q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:18614015   PMID:22658674  


Genomics

Comparative Map Data
Gtpbp10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8429,431,683 - 29,449,201 (+)NCBIGRCr8
mRatBN7.2428,476,857 - 28,494,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl428,476,857 - 28,494,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx433,447,999 - 33,465,505 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0429,374,088 - 29,391,594 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0427,771,777 - 27,789,296 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0425,635,765 - 25,653,283 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl425,635,765 - 25,653,283 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0425,542,933 - 25,560,451 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4425,162,478 - 25,179,996 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1425,145,010 - 25,180,773 (+)NCBI
Celera423,921,450 - 23,938,968 (+)NCBICelera
Cytogenetic Map4q13NCBI
GTPBP10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38790,346,716 - 90,391,453 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl790,335,223 - 90,391,453 (+)EnsemblGRCh38hg38GRCh38
GRCh37789,976,030 - 90,020,767 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map7q21.13NCBI
HuRef784,585,277 - 84,630,067 (+)NCBIHuRef
CHM1_1789,906,101 - 89,950,891 (+)NCBICHM1_1
T2T-CHM13v2.0791,595,008 - 91,639,742 (+)NCBIT2T-CHM13v2.0
Gtpbp10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3955,587,454 - 5,609,541 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl55,587,454 - 5,609,538 (-)EnsemblGRCm39 Ensembl
GRCm3855,537,454 - 5,559,541 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl55,537,454 - 5,559,538 (-)EnsemblGRCm38mm10GRCm38
MGSCv3755,537,457 - 5,559,501 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3655,543,463 - 5,565,507 (-)NCBIMGSCv36mm8
Celera55,484,141 - 5,506,186 (-)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.02NCBI
GTPBP10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11416,247,715 - 16,274,823 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1416,247,812 - 16,274,393 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1415,818,052 - 15,845,242 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01416,053,515 - 16,080,724 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1416,053,713 - 16,081,501 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11416,213,367 - 16,240,958 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01415,932,944 - 15,960,940 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01416,218,224 - 16,245,814 (+)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in Gtpbp10
81 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:47
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000009340
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 24 51 37 19 37 1 3 57 35 35 11 1
Low 19 6 4 4 7 8 17 6 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009340   ⟹   ENSRNOP00000009340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl428,476,857 - 28,494,375 (+)Ensembl
Rnor_6.0 Ensembl425,635,765 - 25,653,283 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100262   ⟹   ENSRNOP00000081302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl428,476,857 - 28,494,375 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112784   ⟹   ENSRNOP00000090971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl428,478,433 - 28,494,375 (+)Ensembl
RefSeq Acc Id: NM_001100815   ⟹   NP_001094285
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8429,431,683 - 29,449,201 (+)NCBI
mRatBN7.2428,476,857 - 28,494,375 (+)NCBI
Rnor_6.0425,635,765 - 25,653,283 (+)NCBI
Rnor_5.0425,542,933 - 25,560,451 (+)NCBI
RGSC_v3.4425,162,478 - 25,179,996 (+)RGD
Celera423,921,450 - 23,938,968 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001094285 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL84342 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009340
  ENSRNOP00000009340.4
  ENSRNOP00000081302.1
  ENSRNOP00000090971.1
Reference Protein Sequences
RefSeq Acc Id: NP_001094285   ⟸   NM_001100815
- UniProtKB: D4A3U1 (UniProtKB/TrEMBL),   A6K260 (UniProtKB/TrEMBL),   A0A8I6ADM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009340   ⟸   ENSRNOT00000009340
RefSeq Acc Id: ENSRNOP00000090971   ⟸   ENSRNOT00000112784
RefSeq Acc Id: ENSRNOP00000081302   ⟸   ENSRNOT00000100262
Protein Domains
Obg   OBG-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A3U1-F1-model_v2 AlphaFold D4A3U1 1-369 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692837
Promoter ID:EPDNEW_R3362
Type:initiation region
Name:Gtpbp10_1
Description:GTP binding protein 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0425,635,777 - 25,635,837EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305878 AgrOrtholog
BioCyc Gene G2FUF-45794 BioCyc
Ensembl Genes ENSRNOG00000007098 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009340 ENTREZGENE
  ENSRNOT00000009340.5 UniProtKB/TrEMBL
  ENSRNOT00000100262.1 UniProtKB/TrEMBL
  ENSRNOT00000112784.1 UniProtKB/TrEMBL
Gene3D-CATH 2.70.210.12 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro G_OBG UniProtKB/TrEMBL
  GTP-bd_Obg/CgtA UniProtKB/TrEMBL
  GTP1_OBG UniProtKB/TrEMBL
  GTP1_OBG_dom_sf UniProtKB/TrEMBL
  GTP1_OBG_sub UniProtKB/TrEMBL
  OBG_GTPase UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:312054 UniProtKB/TrEMBL
NCBI Gene 312054 ENTREZGENE
PANTHER GTP-BINDING PROTEIN 10 UniProtKB/TrEMBL
  PTHR11702 UniProtKB/TrEMBL
Pfam GTP1_OBG UniProtKB/TrEMBL
  MMR_HSR1 UniProtKB/TrEMBL
PhenoGen Gtpbp10 PhenoGen
PIRSF GTP_bd_Obg/CgtA UniProtKB/TrEMBL
PRINTS GTP1OBG UniProtKB/TrEMBL
PROSITE G_OBG UniProtKB/TrEMBL
  OBG UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007098 RatGTEx
Superfamily-SCOP GTP1_OBG_sub UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5ZRC6_RAT UniProtKB/TrEMBL
  A0A8I6ADM1 ENTREZGENE, UniProtKB/TrEMBL
  A6K260 ENTREZGENE, UniProtKB/TrEMBL
  D4A3U1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Gtpbp10  GTP binding protein 10  Gtpbp10  GTP-binding protein 10 (putative)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27     Gtpbp10  GTP-binding protein 10 (putative)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Gtpbp10  GTP-binding protein 10 (putative)  Gtpbp10  GTP-binding protein 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-09-27 Gtpbp10  GTP-binding protein 10  Cldn12_predicted  claudin 12 (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-12 Cldn12_predicted  claudin 12 (predicted)      Symbol and Name status set to approved 70820 APPROVED