Stxbp1 (syntaxin binding protein 1) - Rat Genome Database

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Gene: Stxbp1 (syntaxin binding protein 1) Rattus norvegicus
Analyze
Symbol: Stxbp1
Name: syntaxin binding protein 1
RGD ID: 3785
Description: Enables several functions, including enzyme binding activity; identical protein binding activity; and syntaxin-1 binding activity. Involved in several processes, including positive regulation of secretion by cell; positive regulation of vesicle docking; and regulation of protein-containing complex assembly. Acts upstream of or within protein stabilization. Located in several cellular components, including perinuclear region of cytoplasm; postsynapse; and presynapse. Part of protein-containing complex. Human ortholog(s) of this gene implicated in West syndrome and developmental and epileptic encephalopathy 4. Orthologous to human STXBP1 (syntaxin binding protein 1); PARTICIPATES IN insulin secretion pathway; synaptic vesicle exocytosis - neurotransmitter release pathway; INTERACTS WITH 1,3-dinitrobenzene; 2-ethoxyethanol; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A; p67; protein unc-18 homolog 1; protein unc-18 homolog A; rbSec1; rbSec1A; rbSec1B; Sec1; syntaxin-binding protein 1; unc-18 homolog; unc-18-1; unc-18A; Unc18-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,474,428 - 36,536,120 (-)NCBIGRCr8
mRatBN7.2316,076,725 - 16,138,431 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl316,076,391 - 16,138,369 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx319,144,972 - 19,206,215 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,729,979 - 27,791,223 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,981,796 - 26,042,989 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,823,779 - 11,885,479 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,823,785 - 11,885,417 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0317,160,752 - 17,221,893 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,762,105 - 11,825,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,658,476 - 11,721,903 (-)NCBI
Celera310,816,317 - 10,877,576 (-)NCBICelera
RH 3.4 Map379.6RGD
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Stxbp1RatBardet-Biedl syndrome 1  ISOStxbp1 (Mus musculus)11532386 RGD 
Stxbp1RatBardet-Biedl syndrome 17  ISOStxbp1 (Mus musculus)11532386protein:increased expression:photoreceptor outer segment layer RGD 
Stxbp1Ratdevelopmental and epileptic encephalopathy 4  ISOSTXBP1 (Homo sapiens)12903960DNA:deletion and missense mutations:exon:multipleRGD 
Stxbp1Ratdevelopmental and epileptic encephalopathy 4  ISOSTXBP1 (Homo sapiens)11068998DNA:deletions more ...RGD 
Stxbp1RatDuchenne muscular dystrophy  ISOStxbp1 (Mus musculus)12903957 RGD 
Stxbp1RatWest syndrome  ISOSTXBP1 (Homo sapiens)12903963DNA:missense mutations more ...RGD 
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Stxbp1Ratautism spectrum disorder  ISOSTXBP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disordersClinVarPMID:23858467 more ...
Stxbp1Ratautistic disorder  ISOSTXBP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Autistic disorderClinVarPMID:23708187 more ...
Stxbp1Ratautistic disorder  ISOSTXBP1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23708187 more ...
Stxbp1Ratcerebellar ataxia  ISOSTXBP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Cerebellar ataxiaClinVarPMID:20887364 more ...
Stxbp1Ratcerebellar hypoplasia  ISOSTXBP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital cerebellar hypoplasiaClinVarPMID:21193638 more ...
Stxbp1Ratcongenital disorder of glycosylation Iu  ISOSTXBP1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23109149 and PMID:28492532
Stxbp1Ratdevelopmental and epileptic encephalopathy  ISOSTXBP1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16199547 more ...
Stxbp1Ratdevelopmental and epileptic encephalopathy  ISOSTXBP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:16199547 more ...
Stxbp1Ratdevelopmental and epileptic encephalopathy 31A  ISOSTXBP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Epileptic encephalopathy more ...ClinVarPMID:18469812 more ...
Stxbp1Ratdevelopmental and epileptic encephalopathy 4  ISOSTXBP1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16199547 more ...
Stxbp1RatDevelopmental Disabilities  ISOSTXBP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVarPMID:20887364 more ...
Stxbp1RatDevelopmental Disease  ISOSTXBP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental disorderClinVarPMID:22495311 more ...
Stxbp1Ratdystonia  ISOSTXBP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Dystonic disorderClinVarPMID:28492532
Stxbp1Ratearly infantile epileptic encephalopathy  ISOSTXBP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:16199547 more ...
Stxbp1Ratearly infantile epileptic encephalopathy  ISOSTXBP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:16199547 more ...
Stxbp1Ratearly infantile epileptic encephalopathy  ISOSTXBP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:16199547 more ...
Stxbp1Ratepilepsy  ISOSTXBP1 (Homo sapiens)8554872ClinVar Annotator: match by term: SeizureClinVarPMID:21204804 more ...
Stxbp1Ratgeneralized epilepsy  ISOSTXBP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Epileptic encephalopathyClinVarPMID:20887364 more ...
Stxbp1Ratgenetic disease  ISOSTXBP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:16806828 more ...
Stxbp1Ratintellectual disability  ISOSTXBP1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:20887364 more ...
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Stxbp1Ratdevelopmental and epileptic encephalopathy 4  ISOSTXBP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Stxbp1Ratepilepsy  ISOSTXBP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29942082
Stxbp1RatMyoclonic Epilepsies  ISOSTXBP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18469812 and PMID:29929108
Stxbp1RatNeurodevelopmental Disorders  ISOSTXBP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28191889 and PMID:29942082
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Stxbp1Ratdevelopmental and epileptic encephalopathy 4  ISOSTXBP1 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Stxbp1Rat1,3-dinitrobenzene increases oxidationEXP 64804643-dinitrobenzene results in increased oxidation of STXBP1 proteinCTDPMID:25716674
Stxbp1Rat17alpha-ethynylestradiol multiple interactionsISOStxbp1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STXBP1 mRNACTDPMID:17942748
Stxbp1Rat17beta-estradiol decreases expressionISOSTXBP1 (Homo sapiens)6480464Estradiol results in decreased expression of STXBP1 mRNACTDPMID:21185374
Stxbp1Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOSTXBP1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Stxbp1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOStxbp1 (Mus musculus)6480464[Tetrachlorodibenzodioxin affects the methylation of STXBP1 intron] which results in decreased expression of STXBP1 mRNA and [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STXBP1 mRNACTDPMID:17942748 and PMID:33017471
Stxbp1Rat2-ethoxyethanol increases expressionEXP 64804642-ethoxyethanol results in increased expression of STXBP1 mRNACTDPMID:19643169
Stxbp1Rat2-methoxyethanol increases expressionEXP 6480464methyl cellosolve results in increased expression of STXBP1 mRNACTDPMID:19643169 and PMID:21061450
Stxbp1Rat4,4'-sulfonyldiphenol increases expressionISOSTXBP1 (Homo sapiens)6480464bisphenol S results in increased expression of STXBP1 proteinCTDPMID:34186270
Stxbp1Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of STXBP1 mRNACTDPMID:24780913
Stxbp1Ratacetamide increases expressionEXP 6480464acetamide results in increased expression of STXBP1 mRNACTDPMID:31881176
Stxbp1Ratacetohydrazide decreases expressionISOStxbp1 (Mus musculus)6480464acetylhydrazine results in decreased expression of STXBP1 mRNACTDPMID:15282401
Stxbp1Ratacetylsalicylic acid affects expressionEXP 6480464Aspirin affects the expression of STXBP1 mRNACTDPMID:12800193
Stxbp1Rataconitine decreases expressionEXP 6480464Aconitine results in decreased expression of STXBP1 proteinCTDPMID:33236894
Stxbp1RatAflatoxin B2 alpha decreases methylationISOSTXBP1 (Homo sapiens)6480464aflatoxin B2 results in decreased methylation of STXBP1 intronCTDPMID:30157460
Stxbp1Ratall-trans-retinoic acid decreases expressionISOSTXBP1 (Homo sapiens)6480464Tretinoin results in decreased expression of STXBP1 mRNACTDPMID:33167477
Stxbp1Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of STXBP1 mRNACTDPMID:16483693
Stxbp1Ratandrogen antagonist multiple interactionsEXP 6480464[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of STXBP1 mRNACTDPMID:25607892
Stxbp1Ratarsenite(3-) multiple interactionsISOSTXBP1 (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to STXBP1 mRNA]CTDPMID:32406909
Stxbp1Ratarsenite(3-) increases expressionISOStxbp1 (Mus musculus)6480464arsenite results in increased expression of STXBP1 proteinCTDPMID:37955338
Stxbp1Ratbenzo[a]pyrene decreases expressionISOStxbp1 (Mus musculus)6480464Benzo(a)pyrene results in decreased expression of STXBP1 mRNACTDPMID:19770486

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Biological Process
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Stxbp1Rataxon target recognition acts_upstream_of_or_withinISOStxbp1 (Mus musculus)1624291MGI:2183278 PMID:15182301RGDPMID:15182301
Stxbp1Rataxon target recognition acts_upstream_of_or_withinIEAUniProtKB:O08599 and ensembl:ENSMUSP000000890511600115GO_REF:0000107EnsemblGO_REF:0000107
Stxbp1Ratcellular response to type II interferon acts_upstream_of_or_withinISOStxbp1 (Mus musculus)1624291 PMID:19144319RGDPMID:19144319
Stxbp1Ratcellular response to type II interferon acts_upstream_of_or_withinIEAUniProtKB:O08599 and ensembl:ENSMUSP000000890511600115GO_REF:0000107EnsemblGO_REF:0000107
Stxbp1Ratdevelopmental process involved in reproduction  IMP 12904030 RGD 
Stxbp1Ratestablishment of localization in cell acts_upstream_of_or_withinISOStxbp1 (Mus musculus)1624291MGI:2183278 PMID:11545717RGDPMID:11545717
Stxbp1Ratestablishment of localization in cell acts_upstream_of_or_withinIEAUniProtKB:O08599 and ensembl:ENSMUSP000000890511600115GO_REF:0000107EnsemblGO_REF:0000107
Stxbp1Ratexocytosis acts_upstream_of_or_withinISOStxbp1 (Mus musculus)1624291MGI:2183278 PMID:11545717RGDPMID:11545717
Stxbp1Ratexocytosis acts_upstream_of_or_withinIEAUniProtKB:O08599 and ensembl:ENSMUSP000000890511600115GO_REF:0000107EnsemblGO_REF:0000107
Stxbp1Ratintracellular protein transport involved_inIBAFB:FBgn0000257 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Stxbp1Ratlong-term synaptic depression acts_upstream_of_or_withinISOStxbp1 (Mus musculus)1624291MGI:2183278 PMID:17110441RGDPMID:17110441
Stxbp1Ratlong-term synaptic depression acts_upstream_of_or_withinIEAUniProtKB:O08599 and ensembl:ENSMUSP000000890511600115GO_REF:0000107EnsemblGO_REF:0000107
Stxbp1Ratnegative regulation of neuron apoptotic process acts_upstream_of_or_withinISOStxbp1 (Mus musculus)1624291MGI:2183278 PMID:15255974RGDPMID:15255974
Stxbp1Ratnegative regulation of neuron apoptotic process acts_upstream_of_or_withinIEAUniProtKB:O08599 and ensembl:ENSMUSP000000890511600115GO_REF:0000107EnsemblGO_REF:0000107
Stxbp1Ratnegative regulation of protein-containing complex assembly involved_inIDA 730238PMID:12093152ParkinsonsUK-UCL 
Stxbp1Ratnegative regulation of SNARE complex assembly involved_inTAS 730238PMID:12093152ParkinsonsUK-UCL 
Stxbp1Ratnegative regulation of synaptic transmission, GABAergic acts_upstream_of_or_withinISOStxbp1 (Mus musculus)1624291 PMID:17167098RGDPMID:17167098
Stxbp1Ratnegative regulation of synaptic transmission, GABAergic acts_upstream_of_or_withinIEAUniProtKB:O08599 and ensembl:ENSMUSP000000890511600115GO_REF:0000107EnsemblGO_REF:0000107
Stxbp1Ratneuromuscular synaptic transmission acts_upstream_of_or_withinISOStxbp1 (Mus musculus)1624291MGI:2183278 PMID:17110441RGDPMID:17110441
Stxbp1Ratneuromuscular synaptic transmission acts_upstream_of_or_withinIEAUniProtKB:O08599 and ensembl:ENSMUSP000000890511600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Stxbp1Rataxon  IDA 12903987 RGD 
Stxbp1Rataxon located_inIEAUniProtKB:O08599 and ensembl:ENSMUSP000000890511600115GO_REF:0000107EnsemblGO_REF:0000107
Stxbp1Rataxon located_inISOStxbp1 (Mus musculus)1624291 PMID:23821748RGDPMID:23821748
Stxbp1Ratcytoplasm located_inIDA 2312426PMID:17442889BHF-UCL 
Stxbp1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Stxbp1Ratcytosol located_inISOSTXBP1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Stxbp1Ratcytosol located_inIEAUniProtKB-SubCell:SL-00911600115GO_REF:0000044UniProtGO_REF:0000044
Stxbp1Ratcytosol located_inIEAUniProtKB:P61764 and ensembl:ENSP000003623961600115GO_REF:0000107EnsemblGO_REF:0000107
Stxbp1Ratcytosol located_inTAS 1600115Reactome:R-RNO-6794339ReactomeReactome:R-RNO-6794339
Stxbp1Ratextrinsic component of presynaptic membrane located_inISOStxbp1 (Mus musculus)1624291 PMID:18703708RGDPMID:18703708
Stxbp1Ratextrinsic component of presynaptic membrane is_active_inIEAUniProtKB:O08599 and ensembl:ENSMUSP000000890511600115GO_REF:0000107EnsemblGO_REF:0000107
Stxbp1Ratextrinsic component of presynaptic membrane is_active_inISOStxbp1 (Mus musculus)1624291 PMID:24590174RGDPMID:24590174
Stxbp1Ratglutamatergic synapse is_active_inISOStxbp1 (Mus musculus)1624291 PMID:17110441RGDPMID:17110441
Stxbp1Ratglutamatergic synapse is_active_inIEAUniProtKB:O08599 and ensembl:ENSMUSP000000890511600115GO_REF:0000107EnsemblGO_REF:0000107
Stxbp1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Stxbp1Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Stxbp1Ratnucleoplasm located_inIEAUniProtKB:P61764 and ensembl:ENSP000003623961600115GO_REF:0000107EnsemblGO_REF:0000107
Stxbp1Ratnucleoplasm located_inISOSTXBP1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Stxbp1Ratparallel fiber to Purkinje cell synapse is_active_inIEAUniProtKB:O08599 and ensembl:ENSMUSP000000890511600115GO_REF:0000107EnsemblGO_REF:0000107
Stxbp1Ratparallel fiber to Purkinje cell synapse is_active_inISOStxbp1 (Mus musculus)1624291 PMID:32494600RGDPMID:32494600
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Molecular Function
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Stxbp1Ratidentical protein binding enablesIPIUniProtKB:P617652312426PMID:17442889BHF-UCL 
Stxbp1Ratmolecular adaptor activity enablesEXP 13432275PMID:21193638DisProt 
Stxbp1Ratphospholipase binding  IDA 12904032 RGD 
Stxbp1Ratprotein binding  IPIStx1a (Rattus norvegicus)2311128 RGD 
Stxbp1Ratprotein binding enablesISOStxbp1 (Mus musculus) and PR:O08599-11624291UniProtKB:P31423 and PMID:19822743RGDPMID:19822743
Stxbp1Ratprotein binding enablesIPIUniProtKB:O35431727250PMID:9395480IntAct 
Stxbp1Ratprotein binding enablesIPIUniProtKB:P6301214390056PMID:21689256UniProt 
Stxbp1Ratprotein binding enablesIPIUniProtKB:P328518553871PMID:18337752IntAct 
Stxbp1Ratprotein binding enablesIPIUniProtKB:P502792312426PMID:17442889BHF-UCL 
Stxbp1Ratprotein binding enablesIPIUniProtKB:Q91ZS3-22312426PMID:17442889BHF-UCL 
Stxbp1Ratprotein binding enablesIPIUniProtKB:P3285111573385PMID:26876096IntAct 
Stxbp1Ratprotein binding enablesIPIUniProtKB:P328518553704PMID:10746715IntAct 
Stxbp1Ratprotein binding enablesIPIUniProtKB:P3285110412295PMID:26359495IntAct 
Stxbp1Ratprotein binding enablesIPIUniProtKB:P7045213432275PMID:21193638IntAct 
Stxbp1Ratprotein binding enablesISOSTXBP1 (Homo sapiens)1624291UniProtKB:O00635 more ...RGDPMID:16049941 more ...
Stxbp1Ratprotein binding enablesIPIUniProtKB:Q9BRK5-52312426PMID:17442889BHF-UCL 
Stxbp1Ratprotein binding enablesIPIUniProtKB:O35430727250PMID:9395480IntAct 
Stxbp1Ratprotein binding enablesIPIUniProtKB:Q635372312426PMID:17442889BHF-UCL 
Stxbp1Ratprotein binding enablesIPIUniProtKB:O704412312426PMID:17442889BHF-UCL 
Stxbp1Ratprotein binding enablesIPIUniProtKB:Q088492312426PMID:17442889BHF-UCL 
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RGD Manual Annotations


  
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Stxbp1Ratinsulin secretion pathway   ISOStxbp1 (Mus musculus)2311087 RGD 
Stxbp1Ratsynaptic vesicle exocytosis - neurotransmitter release pathway  TAS 1299066 RGD 

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#
Reference Title
Reference Citation
1. Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins. Bhaskar K, etal., Neurochem Int. 2004 Jan;44(1):35-44.
2. Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation. Bin NR, etal., Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4610-5. doi: 10.1073/pnas.1214887110. Epub 2013 Mar 4.
3. Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. Burkhardt P, etal., EMBO J. 2008 Apr 9;27(7):923-33. doi: 10.1038/emboj.2008.37. Epub 2008 Mar 13.
4. Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome. Datta P, etal., Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4400-9. doi: 10.1073/pnas.1510111112. Epub 2015 Jul 27.
5. Munc18-1 and the Syntaxin-1 N Terminus Regulate Open-Closed States in a t-SNARE Complex. Dawidowski D and Cafiso DS, Structure. 2016 Mar 1;24(3):392-400. doi: 10.1016/j.str.2016.01.005. Epub 2016 Feb 11.
6. Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming. Deak F, etal., J Cell Biol. 2009 Mar 9;184(5):751-64. Epub 2009 Mar 2.
7. Clinical spectrum of early-onset epileptic encephalopathies associated with STXBP1 mutations. Deprez L, etal., Neurology. 2010 Sep 28;75(13):1159-65. doi: 10.1212/WNL.0b013e3181f4d7bf.
8. Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins. Dulubova I, etal., Proc Natl Acad Sci U S A 2003 Jan 7;100(1):32-7.
9. Munc18-1 binds directly to the neuronal SNARE complex. Dulubova I, etal., Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2697-702. Epub 2007 Feb 14.
10. rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin. Garcia EP, etal., J Cell Biol 1995 Apr;129(1):105-20.
11. A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin. Garcia EP, etal., Proc Natl Acad Sci U S A 1994 Mar 15;91(6):2003-7.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes. Guan R, etal., Biochemistry. 2008 Feb 12;47(6):1474-81. Epub 2008 Jan 18.
14. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Hata Y, etal., Nature 1993 Nov 25;366(6453):347-51.
15. Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Hu SH, etal., Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1040-5. doi: 10.1073/pnas.0914906108. Epub 2010 Dec 30.
16. Involvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1. Huang CC, etal., Traffic. 2011 Oct;12(10):1356-70. doi: 10.1111/j.1600-0854.2011.01237.x. Epub 2011 Jul 20.
17. Munc18 plays an important role in the regulation of glutamate release during female puberty onset. Kim BU, etal., Mol Cells. 2006 Aug 31;22(1):30-5.
18. The Q-Soluble-N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor (Q-SNARE) SNAP-47 Regulates Trafficking of Selected Vesicle-Associated Membrane Proteins (VAMPs). Kuster A, etal., J Biol Chem. 2015 Sep 10. pii: jbc.M115.666362.
19. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
20. A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini. Lam PP, etal., Mol Biol Cell. 2007 Jul;18(7):2473-80. Epub 2007 Apr 18.
1 to 20 of 45 rows
PMID:7536802   PMID:7768895   PMID:7890599   PMID:8631738   PMID:8996080   PMID:11036064   PMID:11545717   PMID:12058058   PMID:12477932   PMID:12730201   PMID:12773094   PMID:14651853  
PMID:15123626   PMID:15145078   PMID:15175344   PMID:15182301   PMID:15255974   PMID:15489334   PMID:15563604   PMID:17002520   PMID:17027648   PMID:17110441   PMID:17167098   PMID:17218264  
PMID:17293448   PMID:17543282   PMID:17617378   PMID:17634366   PMID:18077557   PMID:18703708   PMID:18829865   PMID:19056867   PMID:19144319   PMID:19344701   PMID:19483085   PMID:19573021  
PMID:19748891   PMID:19812250   PMID:19822743   PMID:21266332   PMID:21390273   PMID:21614099   PMID:21730064   PMID:21900493   PMID:21900502   PMID:22411134   PMID:22658674   PMID:22871113  
PMID:23091057   PMID:23223447   PMID:23258414   PMID:23525015   PMID:23761923   PMID:23821748   PMID:23904609   PMID:23962429   PMID:24835618   PMID:25517944   PMID:25716318   PMID:25716321  
PMID:26264872   PMID:26888187   PMID:27597756   PMID:28477408   PMID:28483813   PMID:28827281   PMID:29476059   PMID:29997244   PMID:30622273   PMID:31962145   PMID:32357304   PMID:32643828  
PMID:32669573   PMID:33159991   PMID:33468652   PMID:33590815   PMID:36335177   PMID:38755165  



Stxbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,474,428 - 36,536,120 (-)NCBIGRCr8
mRatBN7.2316,076,725 - 16,138,431 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl316,076,391 - 16,138,369 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx319,144,972 - 19,206,215 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,729,979 - 27,791,223 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,981,796 - 26,042,989 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,823,779 - 11,885,479 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,823,785 - 11,885,417 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0317,160,752 - 17,221,893 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,762,105 - 11,825,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,658,476 - 11,721,903 (-)NCBI
Celera310,816,317 - 10,877,576 (-)NCBICelera
RH 3.4 Map379.6RGD
Cytogenetic Map3p11NCBI
STXBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,611,912 - 127,696,029 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9127,579,370 - 127,696,027 (+)EnsemblGRCh38hg38GRCh38
GRCh379130,374,191 - 130,458,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,414,390 - 129,494,816 (+)NCBINCBI36Build 36hg18NCBI36
Build 349127,454,121 - 127,534,549NCBI
Celera9101,025,378 - 101,105,881 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef999,990,647 - 100,071,101 (+)NCBIHuRef
CHM1_19130,525,679 - 130,606,190 (+)NCBICHM1_1
T2T-CHM13v2.09139,818,871 - 139,902,984 (+)NCBIT2T-CHM13v2.0
Stxbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,677,619 - 32,737,249 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,677,614 - 32,737,257 (-)EnsemblGRCm39 Ensembl
GRCm38232,787,607 - 32,847,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,787,602 - 32,847,245 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,643,127 - 32,702,757 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,609,971 - 32,669,135 (-)NCBIMGSCv36mm8
Celera232,494,462 - 32,554,183 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Stxbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419963,829 - 1,000,759 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955419963,829 - 1,000,759 (-)NCBIChiLan1.0ChiLan1.0
STXBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,662,956 - 11,743,095 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,665,339 - 11,745,425 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0998,731,527 - 98,811,608 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,434,080 - 127,483,971 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,434,080 - 127,486,152 (+)Ensemblpanpan1.1panPan2
STXBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,690,939 - 55,768,008 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,678,264 - 55,727,680 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,884,147 - 54,958,397 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,612,796 - 56,687,174 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,581,112 - 56,723,342 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,372,644 - 55,447,116 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,687,749 - 55,761,958 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,778,988 - 55,853,304 (-)NCBIUU_Cfam_GSD_1.0
Stxbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,532,283 - 195,598,947 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,300,952 - 15,365,713 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,300,758 - 15,367,475 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STXBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,116,120 - 268,205,778 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,116,124 - 268,205,805 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,023,293 - 302,098,188 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STXBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,440,061 - 10,519,798 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1210,439,801 - 10,519,777 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660795,699,673 - 5,781,129 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stxbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247607,842,640 - 7,914,484 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247607,843,741 - 7,914,444 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Stxbp1
331 total Variants

Predicted Target Of
Summary Value
Count of predictions:238
Count of miRNA genes:159
Interacting mature miRNAs:182
Transcripts:ENSRNOT00000021178, ENSRNOT00000021189
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat

1 to 10 of 25 rows
AI326233  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,078,026 - 16,078,111 (+)MAPPERmRatBN7.2
Rnor_6.0311,825,081 - 11,825,165NCBIRnor6.0
Rnor_5.0317,162,051 - 17,162,135UniSTSRnor5.0
RGSC_v3.4311,763,402 - 11,763,486UniSTSRGSC3.4
Celera310,817,614 - 10,817,698UniSTS
Cytogenetic Map3p11UniSTS
D45903  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,076,943 - 16,077,048 (+)MAPPERmRatBN7.2
Rnor_6.0311,823,998 - 11,824,102NCBIRnor6.0
Rnor_5.0317,160,968 - 17,161,072UniSTSRnor5.0
RGSC_v3.4311,762,319 - 11,762,423UniSTSRGSC3.4
Celera310,816,531 - 10,816,635UniSTS
Cytogenetic Map3p11UniSTS
RH132234  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,082,121 - 16,082,311 (+)MAPPERmRatBN7.2
Rnor_6.0311,829,176 - 11,829,365NCBIRnor6.0
Rnor_5.0317,166,146 - 17,166,335UniSTSRnor5.0
RGSC_v3.4311,767,497 - 11,767,686UniSTSRGSC3.4
Celera310,821,710 - 10,821,899UniSTS
RH 3.4 Map379.9UniSTS
Cytogenetic Map3p11UniSTS
RH144382  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,080,887 - 16,080,990 (+)MAPPERmRatBN7.2
Rnor_6.0311,827,941 - 11,828,043NCBIRnor6.0
Rnor_5.0317,164,911 - 17,165,013UniSTSRnor5.0
RGSC_v3.4311,766,262 - 11,766,364UniSTSRGSC3.4
Celera310,820,473 - 10,820,575UniSTS
RH 3.4 Map381.7UniSTS
Cytogenetic Map3p11UniSTS
RH139424  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,082,121 - 16,082,290 (+)MAPPERmRatBN7.2
Rnor_6.0311,829,176 - 11,829,344NCBIRnor6.0
Rnor_5.0317,166,146 - 17,166,314UniSTSRnor5.0
RGSC_v3.4311,767,497 - 11,767,665UniSTSRGSC3.4
Celera310,821,710 - 10,821,878UniSTS
RH 3.4 Map372.7UniSTS
Cytogenetic Map3p11UniSTS
Stxbp1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,077,599 - 16,077,844 (+)MAPPERmRatBN7.2
Rnor_6.0311,824,654 - 11,824,898NCBIRnor6.0
Rnor_5.0317,161,624 - 17,161,868UniSTSRnor5.0
RGSC_v3.4311,762,975 - 11,763,219UniSTSRGSC3.4
Celera310,817,187 - 10,817,431UniSTS
RH 3.4 Map379.6UniSTS
Cytogenetic Map3p11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000021178   ⟹   ENSRNOP00000021178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,076,391 - 16,138,319 (-)Ensembl
Rnor_6.0 Ensembl311,823,785 - 11,885,417 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000021189   ⟹   ENSRNOP00000021189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,078,344 - 16,138,369 (-)Ensembl
Rnor_6.0 Ensembl311,830,046 - 11,885,311 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106791   ⟹   ENSRNOP00000091076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,076,391 - 16,113,068 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110071   ⟹   ENSRNOP00000089501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,082,227 - 16,138,369 (-)Ensembl
RefSeq Acc Id: NM_013038   ⟹   NP_037170
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,474,428 - 36,536,058 (-)NCBI
mRatBN7.2316,076,730 - 16,138,369 (-)NCBI
Rnor_6.0311,823,784 - 11,885,417 (-)NCBI
Rnor_5.0317,160,752 - 17,221,893 (-)NCBI
RGSC_v3.4311,762,105 - 11,825,531 (-)RGD
Celera310,816,317 - 10,877,576 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233939   ⟹   XP_006234001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,476,096 - 36,536,120 (-)NCBI
mRatBN7.2316,076,725 - 16,138,431 (-)NCBI
Rnor_6.0311,823,779 - 11,885,479 (-)NCBI
Rnor_5.0317,160,752 - 17,221,893 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063283163   ⟹   XP_063139233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,479,728 - 36,536,120 (-)NCBI
RefSeq Acc Id: NP_037170   ⟸   NM_013038
- UniProtKB: P61765 (UniProtKB/Swiss-Prot),   A6JU89 (UniProtKB/TrEMBL),   A0A8I6ABE0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234001   ⟸   XM_006233939
- Peptide Label: isoform X1
- UniProtKB: A6JU90 (UniProtKB/TrEMBL),   A0A8I6A8W2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021189   ⟸   ENSRNOT00000021189
Ensembl Acc Id: ENSRNOP00000021178   ⟸   ENSRNOT00000021178
Ensembl Acc Id: ENSRNOP00000089501   ⟸   ENSRNOT00000110071

Name Modeler Protein Id AA Range Protein Structure
AF-P61765-F1-model_v2 AlphaFold P61765 1-594 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691996
Promoter ID:EPDNEW_R2521
Type:multiple initiation site
Name:Stxbp1_1
Description:syntaxin binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,885,426 - 11,885,486EPDNEW


1 to 39 of 39 rows
Database
Acc Id
Source(s)
BIND 134444
  134446
  134479
  134480
BioCyc Gene G2FUF-50118 BioCyc
Ensembl Genes ENSRNOG00000015420 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021178 ENTREZGENE
  ENSRNOT00000021178.9 UniProtKB/Swiss-Prot
  ENSRNOT00000021189 ENTREZGENE
  ENSRNOT00000021189.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.60 UniProtKB/Swiss-Prot
  3.40.50.1910 UniProtKB/Swiss-Prot
  3.40.50.2060 UniProtKB/Swiss-Prot
  Syntaxin Binding Protein 1, Chain A, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7315868 IMAGE-MGC_LOAD
InterPro Sec-1-like_dom1 UniProtKB/Swiss-Prot
  Sec-1-like_dom2 UniProtKB/Swiss-Prot
  Sec-1-like_dom3a UniProtKB/Swiss-Prot
  Sec1-like UniProtKB/Swiss-Prot
  Sec1-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:25558 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105262 IMAGE-MGC_LOAD
NCBI Gene 25558 ENTREZGENE
PANTHER PTHR11679 UniProtKB/Swiss-Prot
Pfam Sec1 UniProtKB/Swiss-Prot
PhenoGen Stxbp1 PhenoGen
PIRSF VPS45_Sec1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015420 RatGTEx
Superfamily-SCOP SSF56815 UniProtKB/Swiss-Prot
TIGR TC228377
UniProt A0A8I6A8W2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABE0 ENTREZGENE, UniProtKB/TrEMBL
  A6JU89 ENTREZGENE, UniProtKB/TrEMBL
  A6JU90 ENTREZGENE, UniProtKB/TrEMBL
  P61765 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q28208 UniProtKB/Swiss-Prot
  Q62759 UniProtKB/Swiss-Prot
  Q64320 UniProtKB/Swiss-Prot
  Q96TG8 UniProtKB/Swiss-Prot
1 to 39 of 39 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Stxbp1  Syntaxin binding protein 1      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_cellular_localization localized to cytosol and membranes in neuronal tissues 730116
gene_cellular_localization found along axonal plasmalemma in both soluble and membrane-associated forms 729999
gene_expression expressed in brain but not in non-neuronal tissues 1299067
gene_homology 65% identity to D. melanogaster rop; 59% identity to C. elegans unc-18; 27% identity to S. cerevisiae Sec1p 730116
gene_homology homolog of C. elegans gene unc-18 1299066
gene_physical_interaction binding to syntaxin requires N-terminus of syntaxin; binding to SNAP-25 requires C-terminus 1299066
gene_physical_interaction when created as a GST fusion protein, binds with syntaxin but not with SNAP-25 or synaptobrevin/VAMP 1299067
gene_physical_interaction binds syntaxins 1A and 1B 730238
gene_physical_interaction binds to syntaxin 1a, 2, and 3 fusion proteins but not to syntaxin 4 fusion protein 730116
gene_physical_interaction not part of the synaptic SNARE or syntaxin 1/SNAP-25 complexes in situ; associations with syntaxin may not be stable 729999
gene_process may be essential for synaptic vesicle docking and fusion 730116
gene_process may be essential for synaptic vesicle docking and fusion 1299066
gene_process may modulate formation of SNARE complexes in nerve endings 730238
gene_protein 593 amino acid protein 1299067
gene_transcript found as two alternatively spliced isoforms rbSec1A and rbSec1B in axon 729999
gene_transcript mRNA upregulated in frontal cortex of AA rat strain compared to ANA rat strain 1358772