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Munc18 plays an important role in the regulation of glutamate release during female puberty onset.

Authors: Kim, Byung U  Choi, Jungil  Ahn, Kook Hee  Jeong, Jin Kwon  Ha, Chang Man  Jeong, Choon Soo  Lee, Chae Kwan  Kang, Sung Goo  Lee, Byung Ju 
Citation: Kim BU, etal., Mol Cells. 2006 Aug 31;22(1):30-5.
Pubmed: (View Article at PubMed) PMID:16951547

Munc18, a mammalian homolog of C. elegans Unc, is essential for neurotransmitter release. The aim of this study was to identify estrogen-dependent expression of Munc18-1 and its role in the regulation of glutamate release for puberty onset. Hypothalamic munc18-1 mRNA levels were significantly increased by estrogen treatment in ovariectomized, immature female rats. During pubertal development, the munc18-1 mRNA levels dramatically increased between the juvenile period and the anestrous phase of puberty. Intracerebroventricular administration of an antisense oligodeoxynucleotide against munc18-1 mRNA significantly decreased glutamate release and delayed the day of puberty onset. These results suggest that Munc18-1, expressed in an estrogen-dependent manner, plays an important role in the onset of female puberty via the regulation of glutamate release.


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RGD Object Information
RGD ID: 12904030
Created: 2017-05-15
Species: All species
Last Modified: 2017-05-15
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.